Arne Astrup

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, 30 Rolighedsvej, 1958 Frederiksberg C, Denmark
    Obesity (Silver Spring) 15:1717-31. 2007
  2. pmc A proposed potential role for increasing atmospheric CO2 as a promoter of weight gain and obesity
    L G Hersoug
    Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, Frederiksberg, Denmark
    Nutr Diabetes 2:e31. 2012
  3. pmc Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women
    N T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Nutr Diabetes 1:e4. 2011
  4. pmc Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    A Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, Denmark
    Int J Obes (Lond) 36:843-54. 2012
  5. pmc Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type
    Mette Kristensen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Nutr Metab (Lond) 9:8. 2012
  6. pmc High throughput prediction of chylomicron triglycerides in human plasma by nuclear magnetic resonance and chemometrics
    Francesco Savorani
    Dept, of Food Science, Quality and Technology, Faculty of Life Sciences, University of Copenhagen, DK 1958 Frederiksberg C, Denmark
    Nutr Metab (Lond) 7:43. 2010
  7. doi request reprint The relevance of increased fat oxidation for body-weight management: metabolic inflexibility in the predisposition to weight gain
    A Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obes Rev 12:859-65. 2011
  8. doi request reprint Dietary management of obesity
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, Denmark
    JPEN J Parenter Enteral Nutr 32:575-7. 2008
  9. doi request reprint Can bioactive foods affect obesity?
    A Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Ann N Y Acad Sci 1190:25-41. 2010
  10. doi request reprint Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Lancet 374:1606-16. 2009

Detail Information

Publications99

  1. ncbi request reprint Randomized controlled trials of the D1/D5 antagonist ecopipam for weight loss in obese subjects
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, 30 Rolighedsvej, 1958 Frederiksberg C, Denmark
    Obesity (Silver Spring) 15:1717-31. 2007
    ..To evaluate the efficacy and safety of the selective dopamine D1/D5 antagonist ecopipam for the treatment of obesity...
  2. pmc A proposed potential role for increasing atmospheric CO2 as a promoter of weight gain and obesity
    L G Hersoug
    Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, Frederiksberg, Denmark
    Nutr Diabetes 2:e31. 2012
    ..1 units. We hypothesize that an increased acidic load from atmospheric CO may potentially lead to increased appetite and energy intake, and decreased energy expenditure, and thereby contribute to the current obesity epidemic...
  3. pmc Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women
    N T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Nutr Diabetes 1:e4. 2011
    ....
  4. pmc Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    A Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, Denmark
    Int J Obes (Lond) 36:843-54. 2012
    ..Having demonstrated short-term weight loss with liraglutide in this group of obese adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for sustaining weight loss (secondary outcome) over 2 years...
  5. pmc Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type
    Mette Kristensen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Nutr Metab (Lond) 9:8. 2012
    ..abstract:..
  6. pmc High throughput prediction of chylomicron triglycerides in human plasma by nuclear magnetic resonance and chemometrics
    Francesco Savorani
    Dept, of Food Science, Quality and Technology, Faculty of Life Sciences, University of Copenhagen, DK 1958 Frederiksberg C, Denmark
    Nutr Metab (Lond) 7:43. 2010
    ..The lipid content of the chylomicrons is a key biomarker and risk factor of cardiovascular diseases and for the understanding of obesity. A high throughput determination of chylomicrons in human blood plasma is outlined...
  7. doi request reprint The relevance of increased fat oxidation for body-weight management: metabolic inflexibility in the predisposition to weight gain
    A Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obes Rev 12:859-65. 2011
    ....
  8. doi request reprint Dietary management of obesity
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, Denmark
    JPEN J Parenter Enteral Nutr 32:575-7. 2008
    ....
  9. doi request reprint Can bioactive foods affect obesity?
    A Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Ann N Y Acad Sci 1190:25-41. 2010
    ..Manipulation of diet composition with an aim to prevent weight gain and weight regain is a promising avenue of research...
  10. doi request reprint Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Lancet 374:1606-16. 2009
    ..We assessed the effect of liraglutide on bodyweight and tolerability in obese individuals without type 2 diabetes...
  11. doi request reprint Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obesity (Silver Spring) 16:1363-9. 2008
    ..Tesofensine (TE) is a norepinephrine, dopamine, and serotonin reuptake inhibitor. We conducted a meta-analysis of TE's effect on body weight in trials investigating its potential for treatment of Parkinson's or Alzheimer's disease...
  12. doi request reprint Nutrition transition and its relationship to the development of obesity and related chronic diseases
    Arne Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, The University of Copenhagen, Frederiksberg, Denmark
    Obes Rev 9:48-52. 2008
    ....
  13. ncbi request reprint Health effect of the New Nordic Diet in adults with increased waist circumference: a 6-mo randomized controlled trial
    Sanne K Poulsen
    Department of Nutrition, Exercise and Sports NEXS, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark SKP, AD, AA, and TML the NEXS, Faculty of Science, University of Copenhagen, København N, Denmark ABJ and BK the Department of Kinesiology, University of Waterloo, Waterloo, Canada KDS the Department of Clinical Biochemistry, Gentofte University Hospital, Hellerup, Denmark SS and the Institute of Preventive Medicine, Copenhagen University Hospitals, Frederiksberg Hospital, Frederiksberg, Denmark CH
    Am J Clin Nutr 99:35-45. 2014
    ..The regional Mediterranean Diet has been associated with lower risk of disease...
  14. ncbi request reprint The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period
    Birgitte Sloth
    Department of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, Frederiksberg 1958, Denmark
    Br J Nutr 101:1846-58. 2009
    ....
  15. ncbi request reprint Associations between dairy protein intake and body weight and risk markers of diabetes and CVD during weight maintenance
    Line Q Bendtsen
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Br J Nutr 111:944-53. 2014
    ..Therefore, the present study does not report that dairy proteins are more favourable than other proteins for body weight regulation...
  16. ncbi request reprint Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
    Anette Due
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Am J Clin Nutr 87:855-62. 2008
    ..The effect of dietary fat and carbohydrate on glucose metabolism has been debated for decades...
  17. ncbi request reprint Comparison of 3 ad libitum diets for weight-loss maintenance, risk of cardiovascular disease, and diabetes: a 6-mo randomized, controlled trial
    Anette Due
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Am J Clin Nutr 88:1232-41. 2008
    ..The optimal dietary content and type of fat and carbohydrate for weight management has been debated for decades...
  18. doi request reprint n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys
    Camilla T Damsgaard
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark
    Br J Nutr 110:1304-12. 2013
    ..This is the third time we have observed such tendencies in Danish children...
  19. doi request reprint Acute effect of alginate-based preload on satiety feelings, energy intake, and gastric emptying rate in healthy subjects
    Morten Georg Jensen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obesity (Silver Spring) 20:1851-8. 2012
    ..However, further investigation on the volume of alginate administered is needed before inferring that this fiber has a possible role in short-term energy regulation...
  20. doi request reprint A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women
    Inger Krog-Mikkelsen
    Department of Human Nutrition, University of Copenhagen, Frederiksberg, Denmark
    J Nutr 141:1679-84. 2011
    ..EE and substrate oxidation rates were, however, not affected. These findings give some support to recommendations to consume a LGI diet...
  21. ncbi request reprint A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women
    Lotte Jensen
    Department of Veterinary Pathobiology, and the Center for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 87:97-105. 2008
    ..Plasma PAI-1 is elevated in obesity. A low-glycemic-index (LGI) diet may have a beneficial effect on obesity through a decrease in plasma PAI-1, but whether it affects plasma TIMP-1 in healthy humans has not been studied...
  22. ncbi request reprint Glycemic and insulinemic responses as determinants of appetite in humans
    Anne Flint
    Department of Human Nutrition, The Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 84:1365-73. 2006
    ..The importance of the postprandial glycemic and insulinemic responses for appetite and energy intake (EI) is controversial...
  23. ncbi request reprint Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults
    Pia Christensen
    The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obesity (Silver Spring) 21:1982-90. 2013
    ....
  24. doi request reprint Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety
    Anita Belza
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 97:980-9. 2013
    ..Effects of protein intake on appetite-regulating hormones and their dynamics are unclear...
  25. doi request reprint Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study
    Lesli H Larsen
    Department of Human Nutrition, Life, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 95:1254-60. 2012
    ..Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes...
  26. doi request reprint Whole grain compared with refined wheat decreases the percentage of body fat following a 12-week, energy-restricted dietary intervention in postmenopausal women
    Mette Kristensen
    Department of Human Nutrition, University of Copenhagen, Denmark
    J Nutr 142:710-6. 2012
    ..Serum total and LDL cholesterol, two important risk factors of cardiovascular disease, increased with RW but not WW consumption, which may suggest a cardioprotective role for whole grain...
  27. ncbi request reprint The effect of salatrim, a low-calorie modified triacylglycerol, on appetite and energy intake
    Lone B Sørensen
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 87:1163-9. 2008
    ....
  28. ncbi request reprint Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain
    Thomas Meinert Larsen
    Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 83:606-12. 2006
    ..However, most previous studies have been of short duration and inconclusive, and some recent studies have questioned the safety of long-term supplementation with CLA...
  29. doi request reprint Wholegrain vs. refined wheat bread and pasta. Effect on postprandial glycemia, appetite, and subsequent ad libitum energy intake in young healthy adults
    Mette Kristensen
    Department of Human Nutrition, University of Copenhagen, Denmark
    Appetite 54:163-9. 2010
    ..Ad libitum EI did not differ. In conclusion, the results show that wholemeal breads increased satiety measures compared to their refined counterparts; however no significant effect on subsequent EI was observed...
  30. ncbi request reprint Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men
    Karina V Soerensen
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 99:984-91. 2014
    ..Calcium from different dairy sources might affect blood lipids and fecal fat excretion differently because of differences in the food matrix and nutritional composition...
  31. ncbi request reprint Yogurt and dairy product consumption to prevent cardiometabolic diseases: epidemiologic and experimental studies
    Arne Astrup
    Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 99:1235S-42S. 2014
    ..The consumption of yogurt, and other dairy products, in observational studies is associated with a reduced risk of weight gain and obesity as well as of CVD, and these findings are, in part, supported by randomized trials...
  32. ncbi request reprint Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
    Birgitte Sloth
    Dept of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, Univ of Copenhagen, 30 Rolighedsvej, DK 1958 Frederiksberg, Denmark
    Am J Physiol Endocrinol Metab 293:E604-9. 2007
    ..PYY(1-36) is unlikely to be important in regulating energy intake. The PYY(3-36) administrations caused a non-dose-dependent mobilization of FFA, likely through a direct effect...
  33. doi request reprint Higher protein diets consumed ad libitum improve cardiovascular risk markers in children of overweight parents from eight European countries
    Camilla T Damsgaard
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    J Nutr 143:810-7. 2013
    ..004). No consistent effect of GI was seen and the MetS scores were not affected. In conclusion, increased protein intake improved cardiovascular markers in high-risk children, particularly in those undergoing most intensive intervention...
  34. ncbi request reprint No difference in body weight decrease between a low-glycemic-index and a high-glycemic-index diet but reduced LDL cholesterol after 10-wk ad libitum intake of the low-glycemic-index diet
    Birgitte Sloth
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, 30 Rolighedsvej, DK 1958 Frederiksberg C, Denmark
    Am J Clin Nutr 80:337-47. 2004
    ..The role of glycemic index (GI) in appetite and body-weight regulation is still not clear...
  35. ncbi request reprint Effect on 24-h energy expenditure of a moderate-fat diet high in monounsaturated fatty acids compared with that of a low-fat, carbohydrate-rich diet: a 6-mo controlled dietary intervention trial
    Lone G Rasmussen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 85:1014-22. 2007
    ..Dietary fat has a lower thermogenic effect than does carbohydrate. A moderate-fat diet, high in monounsaturated fatty acids (MUFA diet), may decrease energy expenditure (EE) and thereby induce weight gain...
  36. ncbi request reprint Increased 24-h energy expenditure in type 2 diabetes
    Christian Bitz
    Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Diabetes Care 27:2416-21. 2004
    ....
  37. pmc Linseed dietary fibers reduce apparent digestibility of energy and fat and weight gain in growing rats
    Mette Kristensen
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 1958 Frederiksberg C, Denmark
    Nutrients 5:3287-98. 2013
    ..9 g) (p < 0.05). The 10-LDF diet reduced body fat compared to 5-CEL (p < 0.01). In conclusion, DF extracted from linseed reduced apparent energy and fat digestibility and resulted in restriction of body weight gain in growing rats. ..
  38. doi request reprint Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study
    Lena K Brahe
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Br J Nutr 110:790-6. 2013
    ....
  39. ncbi request reprint Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
    Birgitte Sloth
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, 30 Rolighedsvej, DK 1958 Frederiksberg C, Denmark
    Am J Physiol Endocrinol Metab 292:E1062-8. 2007
    ..Furthermore, high-dose [corrected] PYY(3-36) (0.8 [corrected] pmol x kg(-1) x min(-1)) produced decreased [corrected] EI and increased postprandial [corrected] glucose concentrations and tendency to reduced EE [corrected]..
  40. ncbi request reprint Effects of dietary protein and glycaemic index on biomarkers of bone turnover in children
    Stine Mathilde Dalskov
    Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Br J Nutr 111:1253-62. 2014
    ..However, the difference in the change in the level of osteocalcin between the high-protein/high-GI group and the low-protein/high-GI group warrants further investigation and should be confirmed in other studies...
  41. pmc Effect of dairy proteins on appetite, energy expenditure, body weight, and composition: a review of the evidence from controlled clinical trials
    Line Q Bendtsen
    Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Adv Nutr 4:418-38. 2013
    ..However, data indicate that amino acid composition, rate of absorption, and protein/food texture may be important factors for protein-stimulated metabolic effects. ..
  42. ncbi request reprint The use of glycaemic index tables to predict glycaemic index of breakfast meals
    Anne Flint
    Department of Human Nutrition, The Royal Veterinary and Agricultural University Centre for Advanced Food Studies, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 94:135-6. 2005
  43. pmc Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women
    Nathalie T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Lipid Res 52:1821-8. 2011
    ..In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNFα system...
  44. ncbi request reprint Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions
    Nikolaj T Gregersen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 102:1187-94. 2009
    ..The specific mechanisms and conditions that may underpin observed longer-term benefits of catechin-enriched green tea consumption on body composition remain to be confirmed...
  45. ncbi request reprint Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake
    Anne Raben
    Research Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:91-100. 2003
    ..It has been suggested that the satiating power of the 4 macronutrients follows the oxidation hierarchy: alcohol > protein > carbohydrate > fat. However, the experimental evidence for this is still scarce...
  46. pmc TFAP2B influences the effect of dietary fat on weight loss under energy restriction
    Tanja Stocks
    Institute of Preventive Medicine, Copenhagen University Hospital, Frederiksberg, Denmark
    PLoS ONE 7:e43212. 2012
    ..We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction...
  47. doi request reprint Center-size as a predictor of weight-loss outcome in multicenter trials including a low-calorie diet
    Christoph Gasteyger
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Obesity (Silver Spring) 18:2160-4. 2010
    ..5%. This is the first study suggesting that the number of recruited subjects per center may impact weight loss, and could therefore be considered as a new predictor for weight loss that is independent from the individual...
  48. ncbi request reprint A paradoxical diurnal movement pattern in obese subjects with type 2 diabetes: a contributor to impaired appetite and glycemic control?
    Christian Bitz
    Department of Human Nutrition, Centre for Advanced Food Research, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Diabetes Care 28:2040-1. 2005
  49. doi request reprint Dairy beverages and energy balance
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Behav 100:67-75. 2010
    ..These mechanisms may be part of the explanation for the protective effects of dairy products with regard to obesity and metabolic syndrome...
  50. doi request reprint Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Lancet 372:1906-13. 2008
    ..We assessed the efficacy and safety of tesofensine-an inhibitor of the presynaptic uptake of noradrenaline, dopamine, and serotonin-in patients with obesity...
  51. ncbi request reprint Calcium supplementation for 1 y does not reduce body weight or fat mass in young girls
    Janne K Lorenzen
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 83:18-23. 2006
    ..Accumulating evidence from observational studies indicates that a high calcium intake may reduce body weight and body fat. However, few randomized trials have been conducted...
  52. ncbi request reprint Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake
    Janne Kunchel Lorenzen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 85:678-87. 2007
    ..High calcium intake has been shown to increase fecal fat excretion...
  53. ncbi request reprint The N363S polymorphism of the glucocorticoid receptor and metabolic syndrome factors in men
    Benjamin Buemann
    Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark
    Obes Res 13:862-7. 2005
    ..To test the associations between the N363S polymorphism of the glucocorticoid receptor gene (NR3C1) and factors related to the metabolic syndrome in middle-aged men with and without juvenile-onset obesity...
  54. ncbi request reprint Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men
    Thomas M Larsen
    Department of Human Nutrition, LMC Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    Obes Res 13:953-8. 2005
    ..In conclusion, the identified novel variants in the PPARgamma2 promoter region do not explain the reported discrepancies in the association of previously identified variants with obesity and type 2 diabetes...
  55. ncbi request reprint Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet
    Janne K Lorenzen
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 105:1823-31. 2011
    ..In conclusion, we observed that dairy Ca seems to partly counteract the raising effect of dairy fat on total and LDL-cholesterol, without reducing HDL-cholesterol. ..
  56. doi request reprint Dietary composition and nutrient content of the New Nordic Diet
    Charlotte Mithril
    Department of Human Nutrition, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark
    Public Health Nutr 16:777-85. 2013
    ..To describe the dietary composition of the New Nordic Diet (NND) and to compare it with the Nordic Nutrition Recommendations (NNR)/Danish Food-based Dietary Guidelines (DFDG) and with the average Danish diet...
  57. doi request reprint Sleep restriction is not associated with a positive energy balance in adolescent boys
    Lars Klingenberg
    Department of Human Nutrition, Faculty of Science, University of Copenhagen, Denmark
    Am J Clin Nutr 96:240-8. 2012
    ..However, experimental evidence of the potential mechanisms of sleep restriction on energy balance is conflicting and, to our knowledge, nonexistent in adolescents...
  58. doi request reprint Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial
    Morten Georg Jensen
    Department of Human Nutrition, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 96:5-13. 2012
    ..However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking...
  59. ncbi request reprint Effect of sucrose on inflammatory markers in overweight humans
    Lone B Sørensen
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 82:421-7. 2005
    ..Observational studies have found that dietary glycemic load is positively associated with C-reactive protein (CRP) concentrations in healthy humans, which suggests that the type of carbohydrate ingested influences inflammatory activity...
  60. pmc Diets with high or low protein content and glycemic index for weight-loss maintenance
    Thomas Meinert Larsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 363:2102-13. 2010
    ..Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power...
  61. doi request reprint Risk factors for adult overweight and obesity: the importance of looking beyond the 'big two'
    Jean Philippe Chaput
    Department of Human Nutrition, University of Copenhagen, Copenhagen, Denmark
    Obes Facts 3:320-7. 2010
    ....
  62. ncbi request reprint Effects of different dietary fat types on postprandial appetite and energy expenditure
    Anne Flint
    Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultrual University, Frederiksberg C, Denmark
    Obes Res 11:1449-55. 2003
    ..Therefore, the aim of this study was to investigate the acute effect of intake of PUFA, MUFA, or TRANS on appetite and energy expenditure (EE)...
  63. ncbi request reprint Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa
    Anja W Dynesen
    Department of Odontology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 87:12-22. 2008
    ..It has been hypothesized that abnormal appetite sensations may be due to bulimia nervosa-related alterations in the release of hormones that are known to be involved in the physiologic regulation of appetite and metabolism...
  64. ncbi request reprint The use of glycaemic index tables to predict glycaemic index of composite breakfast meals
    Anne Flint
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 91:979-89. 2004
    ..Our prediction models show that the GI of mixed meals is more strongly correlated either with fat and protein content, or with energy content, than with carbohydrate content alone. Furthermore, GI was not correlated with II...
  65. ncbi request reprint The role of dietary fat in obesity
    Arne Astrup
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Semin Vasc Med 5:40-7. 2005
    ..Current evidence indicates that the best diet for prevention of weight gain, obesity, type 2 diabetes, and cardiovascular disease is low in fat and sugar-rich beverages and high in carbohydrates, fiber, grains, and protein...
  66. doi request reprint Flaxseed dietary fiber supplements for suppression of appetite and food intake
    Sabine Ibrügger
    Department of Human Nutrition, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Appetite 58:490-5. 2012
    ..3379 kJ). A small dose of flaxseed fiber significantly suppresses appetite and energy intake. Furthermore, flaxseed fibers administered as drinks or tablets produce similar responses...
  67. doi request reprint Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome
    Lone B Sørensen
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Denmark
    Am J Clin Nutr 95:39-48. 2012
    ..Some evidence has suggested that a diet with a higher ratio of protein to carbohydrates has metabolic advantages in the treatment of polycystic ovary syndrome (PCOS)...
  68. ncbi request reprint Increased satiety after intake of a chocolate milk drink compared with a carbonated beverage, but no difference in subsequent ad libitum lunch intake
    Angela Harper
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Br J Nutr 97:579-83. 2007
    ....
  69. ncbi request reprint Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects
    Anne Raben
    Research Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 76:721-9. 2002
    ..The role of artificial sweeteners in body-weight regulation is still unclear...
  70. ncbi request reprint An observational study of slimming behavior in Denmark in 1992 and 1998
    Hanne Bendixen
    Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Obes Res 10:911-22. 2002
    ..To elucidate how frequent weight-loss attempts are made, the methods used to achieve weight loss, and the extent to which the outcome is positive...
  71. ncbi request reprint Reproducibility and power of ad libitum energy intake assessed by repeated single meals
    Nikolaj T Gregersen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Am J Clin Nutr 87:1277-81. 2008
    ..The reproducibility of the measurement of ad libitum energy intake (EI) is not well known. Furthermore, it is not known whether standardized conditions before the test day influence this measure...
  72. doi request reprint Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women
    Nathalie T Bendsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, DK 1958 Frederiksberg, Denmark
    Metabolism 60:906-13. 2011
    ..A study population with a stronger predisposition to insulin resistance and/or a longer duration of exposure may be required for insulin sensitivity to be affected by intake of industrial TFA...
  73. ncbi request reprint Effect of 3 modified fats and a conventional fat on appetite, energy intake, energy expenditure, and substrate oxidation in healthy men
    Hanne Bendixen
    Research Department of Human Nutrition, The Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 75:47-56. 2002
    ..Different dietary fats are metabolized differently in humans and may influence energy expenditure, substrate oxidation, appetite regulation, and body weight regulation...
  74. ncbi request reprint Effect of protein intake on bone mineralization during weight loss: a 6-month trial
    Annebeth R Skov
    Research Departmet of Human Nutrition and Centre of Food Research, The Royal Veterinary and Agricultural University, Frederiksberg C, Copenhagen, Denmark
    Obes Res 10:432-8. 2002
    ..The long-term effect of dietary protein on bone mineralization is not well understood...
  75. ncbi request reprint The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes
    Helle Harder
    Research Department of Human Nutrition, LMC, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg, Denmark
    Diabetes Care 27:1915-21. 2004
    ....
  76. ncbi request reprint The effect of exercise and diet on glucose intolerance and substrate utilization?
    Arne Astrup
    Department of Human Nutrition, Centre for Advanced Food Research, RVA University, Copenhagen, Denmark
    Nestle Nutr Workshop Ser Clin Perform Programme 9:93-103; discussion 103-9. 2004
  77. ncbi request reprint Low-fat diets and energy balance: how does the evidence stand in 2002?
    Arne Astrup
    The Research Department of Human Nutrition and The Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Proc Nutr Soc 61:299-309. 2002
    ..The evidence strongly supports the low-fat diet as the optimal choice for the prevention of weight gain and obesity, while the use of a normal-fat high-monounsaturated fatty acid diet is unsubstantiated...
  78. pmc The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Am J Clin Nutr 93:684-8. 2011
    ..Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate alternatives...
  79. ncbi request reprint Effect of a dietary-induced weight loss on liver enzymes in obese subjects
    Christoph Gasteyger
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Clin Nutr 87:1141-7. 2008
    ..However, some evidence also shows that liver enzymes may transiently increase immediately after a dietary-induced weight loss...
  80. doi request reprint Is beer consumption related to measures of abdominal and general obesity? A systematic review and meta-analysis
    Nathalie T Bendsen
    Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Nutr Rev 71:67-87. 2013
    ..Higher intake, however, may be positively associated with abdominal obesity...
  81. pmc Assessment of the effect of high or low protein diet on the human urine metabolome as measured by NMR
    Lone G Rasmussen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, DK 1958 Frederiksberg, Denmark
    Nutrients 4:112-31. 2012
    ..Despite large variations in individual dietary intake, differentiated metabolite profiles were observed at the dietary group-level...
  82. doi request reprint Weight maintenance through behaviour modification with a cooking course or neurolinguistic programming
    Lone Brinkmann Sørensen
    Department ofHuman Nutrition, University of Copenhagen, Frederiksberg, Denmark
    Can J Diet Pract Res 72:181-5. 2011
    ..In conclusion, weight loss in overweight and obese participants was maintained equally efficiently with a healthy cooking course or NLP therapy, but the dropout rate was lower during the active cooking treatment...
  83. pmc Assessment of dietary exposure related to dietary GI and fibre intake in a nutritional metabolomic study of human urine
    Lone G Rasmussen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Genes Nutr 7:281-93. 2012
    ..As our design allowed for large variations in individually selected food items, biomarkers identified at group level may be interpreted as more general and robust markers, largely not confounded with markers from single dietary factors...
  84. ncbi request reprint Leptin and bone mineral density: a cross-sectional study in obese and nonobese men
    Cathrine M Morberg
    Department of Human Nutrition, Centre of Advanced Food Research, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg, Denmark
    J Clin Endocrinol Metab 88:5795-800. 2003
    ....
  85. ncbi request reprint Topiramate: long-term maintenance of weight loss induced by a low-calorie diet in obese subjects
    Arne Astrup
    The Department of Human Nutrition and LMC, The Royal Veterinary and Agricultural University, 30 Rolighedsvej, 1958 Frederiksberg C, Copenhagen, Denmark
    Obes Res 12:1658-69. 2004
    ..To examine the safety and efficacy of topiramate (TPM) for maintaining weight following a low-calorie diet...
  86. ncbi request reprint Change in beta1-adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss
    Mads Rasmussen
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark
    Clin Sci (Lond) 108:323-9. 2005
    ..This relationship is not directly related to energy expenditure and deserves further investigation...
  87. ncbi request reprint Super-sized and diabetic by frequent fast-food consumption?
    Arne Astrup
    Department of Human Nutrition, Centre of Advanced Food Research, RVA University, Copenhagen, 1958 Frederiksberg C, Denmark
    Lancet 365:4-5. 2005
  88. ncbi request reprint Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?
    Arne Astrup
    Department of Human Nutrition, Centre of Advanced Food Research, RVA University, Copenhagen, 1958 Frederiksberg C, Denmark
    Lancet 364:897-9. 2004
    ..Low-carbohydrate diets have been regarded as fad diets, but recent research questions this view...
  89. doi request reprint Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial
    Henning Bliddal
    The Parker Institute, Copenhagen University Hospital, Frederiksberg, DK 2000F, Denmark
    Ann Rheum Dis 70:1798-803. 2011
    ..To evaluate 1-year symptomatic improvement in obese patients with knee osteoarthritis (OA) on an intensive low-energy diet (LED) maintained by frequent consultations with a dietician compared to minimal attention...
  90. ncbi request reprint Topiramate: a new potential pharmacological treatment for obesity
    Arne Astrup
    Department of Human Nutrition Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Obes Res 12:167S-73S. 2004
    ..Paresthesia was a frequent occurrence, but it did not lead to withdrawal of >5% of the subjects in any study...
  91. ncbi request reprint Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
    Robin Christensen
    The Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Frederiksberg, Denmark
    Lancet 370:1706-13. 2007
    ..We did a meta-analysis of all published randomised controlled trials to assess the efficacy and safety of the newly approved anti-obesity agent rimonabant...
  92. doi request reprint The effect of tesofensine on appetite sensations
    Jo Anne Gilbert
    Division of Kinesiology, Department of Preventive and Social Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Obesity (Silver Spring) 20:553-61. 2012
    ..Whether the attenuated effect on appetite seen after 24 weeks is due to a counteracting effect in the weight reduced state or whether the appetite suppressing effect of TE per se diminishes over time is, however, still unclear...
  93. pmc Radiographs and low field MRI (0.2T) as predictors of efficacy in a weight loss trial in obese women with knee osteoarthritis
    Henrik Gudbergsen
    The Parker Institute, Copenhagen University Hospital, Frederiksberg, Denmark
    BMC Musculoskelet Disord 12:56. 2011
    ..To study the predictive value of baseline radiographs and low-field (0.2T) MRI scans for the symptomatic outcome of clinically significant weight loss in obese patients with knee osteoarthritis...
  94. ncbi request reprint The trans fatty acid story in Denmark
    Arne Astrup
    Department of Human Nutrition, The Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg, Denmark
    Atheroscler Suppl 7:43-6. 2006
    ..The Danish success story might be interesting for other countries where this unnecessary health hazard could be eliminated from their foods...
  95. ncbi request reprint Effect of chewing gum containing nicotine and caffeine on energy expenditure and substrate utilization in men
    Anna B Jessen
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:1442-7. 2003
    ..Nicotine replacement therapy limits weight gain after smoking cessation. This finding is partly attributable to the thermogenic effect of nicotine, which may be enhanced by caffeine...
  96. ncbi request reprint Energy expenditure and respiratory diseases: is there a link?
    Nikolaj Ture Gregersen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Expert Rev Respir Med 2:495-503. 2008
    ..The primary focus is on the oxygen transport system, which may be an important determinant for the relationship between both of these respiratory diseases and EE...
  97. ncbi request reprint [The effect of tesofensine on body weight and body composition in obese subjects--secondary publication]
    Anne Louise Hother Nielsen
    Institut for Human Ernaering, Det Biovidenskabelige Fakultet, Københavns Universitet, DK 1958 Frederiksberg C
    Ugeskr Laeger 171:2974-7. 2009
    ..0 mg, respectively. Tesofensine 0.5 mg might have the potential to produce a weight loss twice that of currently approved anti-obesity drugs. Findings of safety and efficacy of 0.5 mg Tesofensine need confirmation in phase III trials...
  98. ncbi request reprint Fat mass measured by DXA varies with scan velocity
    Eva Black
    Research Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Obes Res 10:69-77. 2002
    ..To study the influence of scan velocities of DXA on the measured size of fat mass, lean body mass, bone mineral content and density, and total body weight...
  99. ncbi request reprint Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies
    Thomas M Larsen
    Department of Human Nutrition, Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, DK 1958 Frederiksberg C, Denmark
    J Lipid Res 44:2234-41. 2003
    ....