Messoud Ashina

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Eur J Neurol 8:173-8. 2001
  2. ncbi request reprint Nitric oxide synthase inhibitors for the treatment of chronic tension-type headache
    Messoud Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Expert Opin Pharmacother 3:395-9. 2002
  3. ncbi request reprint [A new therapeutic principle for migraine]
    Messoud Ashina
    Dansk Hovedpinecenter, Neurologisk afdeling, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 170:1029. 2008
  4. doi request reprint Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience
    Messoud Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Cephalalgia 33:540-53. 2013
  5. ncbi request reprint Tender points are not sites of ongoing inflammation -in vivo evidence in patients with chronic tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 23:109-16. 2003
  6. ncbi request reprint Calcitonin gene-related peptide in tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    ScientificWorldJournal 2:1527-31. 2002
  7. ncbi request reprint Current and potential future drug therapies for tension-type headache
    Sait Ashina
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, DK 2600 Glostrup, Copenhagen, Denmark
    Curr Pain Headache Rep 7:466-74. 2003
  8. ncbi request reprint Neurobiology of chronic tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 24:161-72. 2004
  9. ncbi request reprint No release of interstitial glutamate in experimental human model of muscle pain
    Messoud Ashina
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Eur J Pain 9:337-43. 2005
  10. doi request reprint Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects
    Messoud Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 31:683-90. 2011

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Eur J Neurol 8:173-8. 2001
    ..36). Both in patients and controls, CGRP levels changed significantly over time, on both the GTN and placebo days (P < 0.05). The present study indicates that NO-induced immediate headache is not associated with release of CGRP...
  2. ncbi request reprint Nitric oxide synthase inhibitors for the treatment of chronic tension-type headache
    Messoud Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Expert Opin Pharmacother 3:395-9. 2002
    ..Furthermore, inhibition of nitric oxide synthase may become a novel principle in the future treatment of chronic headache...
  3. ncbi request reprint [A new therapeutic principle for migraine]
    Messoud Ashina
    Dansk Hovedpinecenter, Neurologisk afdeling, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 170:1029. 2008
  4. doi request reprint Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience
    Messoud Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Cephalalgia 33:540-53. 2013
    ..New additions to the model, such as advanced neuroimaging, may lead to a better understanding of the complex events that constitute a migraine attack, and better and more targeted ways of intervention...
  5. ncbi request reprint Tender points are not sites of ongoing inflammation -in vivo evidence in patients with chronic tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 23:109-16. 2003
    ..Thus, our data suggest that tender points in these patients are not sites of ongoing inflammation...
  6. ncbi request reprint Calcitonin gene-related peptide in tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    ScientificWorldJournal 2:1527-31. 2002
    ..Investigation of CGRP in other compartments with new sensitive methods of analysis is necessary to clarify its role in tension-type headache...
  7. ncbi request reprint Current and potential future drug therapies for tension-type headache
    Sait Ashina
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, DK 2600 Glostrup, Copenhagen, Denmark
    Curr Pain Headache Rep 7:466-74. 2003
    ..It has been demonstrated that inhibition of nitric oxide is effective in chronic tension-type headache. These interesting data indicate that more specific and effective treatment possibilities will emerge in the future...
  8. ncbi request reprint Neurobiology of chronic tension-type headache
    M Ashina
    Department of Neurology and Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 24:161-72. 2004
  9. ncbi request reprint No release of interstitial glutamate in experimental human model of muscle pain
    Messoud Ashina
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Eur J Pain 9:337-43. 2005
    ..05). In conclusion, the present study demonstrates no signs of increased release of glutamate from myofascial nociceptors during and after acute experimentally induced muscle pain and tenderness...
  10. doi request reprint Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects
    Messoud Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 31:683-90. 2011
    ..Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter...
  11. ncbi request reprint [Headache]
    Sait Ashina
    Hovedpinecenter og Neurologisk Afdeling, Amtssygehuset i Glostrup, DK 2600 Glostrup
    Ugeskr Laeger 167:3192. 2005
  12. ncbi request reprint Pathophysiology of tension-type headache
    Sait Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Curr Pain Headache Rep 9:415-22. 2005
    ....
  13. ncbi request reprint Pathophysiology of tension-type headache: potential drug targets
    Messoud Ashina
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    CNS Neurol Disord Drug Targets 6:238-9. 2007
    ..Future studies should focus on the identification of the source of peripheral nociception in patients with tension-type headache and the development of more effective and specific treatment modalities...
  14. doi request reprint Matrix metalloproteinases during and outside of migraine attacks without aura
    M Ashina
    Department of Neurology, Glostrup Hospital, Danish Headache Centre, Copenhagen, Denmark
    Cephalalgia 30:303-10. 2010
    ..05). Our data suggest that plasma MMP-9 cannot be used as a biomarker of BBB disruption in migraine without aura. Decreased MMP-3 levels are an interesting and unexpected finding warranting further investigation...
  15. ncbi request reprint Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Pain 86:133-8. 2000
    ..It is hypothesized that this finding may reflect a long-lasting or permanent abnormal neurogenic vascular control in patients with migraine...
  16. ncbi request reprint Nitric oxide-induced headache in patients with chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Brain 123:1830-7. 2000
    ..This suggests that NO contributes to the mechanisms of several types of primary headaches and that NO-related central sensitization may be an important common denominator in the pain mechanisms of primary headaches...
  17. ncbi request reprint Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark and Department of Medicine, Kitasato University, Sagamihara, Japan
    Brain 122:1629-35. 1999
    ....
  18. ncbi request reprint Muscle hardness in patients with chronic tension-type headache: relation to actual headache state
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Pain 79:201-5. 1999
    ..In addition, the positive correlation between muscle hardness and tenderness supports the common clinical observation that tender muscles are harder than normal muscles...
  19. ncbi request reprint Plasma levels of calcitonin gene-related peptide in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 55:1335-40. 2000
    ..Calcitonin gene-related peptide (CGRP) is involved in the pathophysiology of migraine and cluster headache. Whether CGRP has any role in chronic tension-type headache is unknown...
  20. ncbi request reprint Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Lancet 353:287-9. 1999
    ..We aimed to show whether N(G)-monomethyl-L-arginine hydrochloride (L-NMMA), an inhibitor of NOS, is effective in relieving pain in such patients...
  21. ncbi request reprint Possible mechanisms of glyceryl-trinitrate-induced immediate headache in patients with chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 20:919-24. 2000
    ..05). The unchanged sensitivity of pericranial myofascial pain pathways indicates that peripheral and central sensitization is not involved in the mechanisms of GTN-induced immediate headache...
  22. ncbi request reprint Glyceryl trinitrate may trigger endogenous nitric oxide production in patients with chronic tension-type headache
    M Ashina
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 24:967-72. 2004
    ..12) and controls (P = 0.18). We suggest that GTN administration may trigger endogenous production of NO in patients with chronic tension-type headache resulting in activation of perivascular sensory afferents...
  23. ncbi request reprint In vivo evidence of altered skeletal muscle blood flow in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Brain 125:320-6. 2002
    ..This may lead to enhanced sympathetically mediated vasoconstriction and thereby a decreased blood flow in response to static exercise...
  24. ncbi request reprint Plasma levels of substance P, neuropeptide Y and vasoactive intestinal polypeptide in patients with chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Pain 83:541-7. 1999
    ..05). In summary, the present study indicates that plasma levels of SP, NPY and VIP are normal in chronic tension-type headache patients and largely unrelated to headache state...
  25. doi request reprint Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
    Faisal Mohammad Amin
    University of Copenhagen, Denmark
    Cephalalgia 32:140-9. 2012
    ....
  26. doi request reprint Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study
    Faisal Mohammad Amin
    Danish Headache Center and Department of Neurology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Lancet Neurol 12:454-61. 2013
    ..To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura...
  27. doi request reprint PACAP38 induces migraine-like attacks in patients with migraine without aura
    Henrik Winther Schytz
    Department of Neurology, Faculty of Health Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Brain 132:16-25. 2009
    ..In migraine sufferers, PACAP38 caused delayed migraine-like attacks. The findings stimulate further investigation of the neuronal and vascular mechanisms of PACAP38...
  28. pmc Low frequency oscillations in cephalic vessels assessed by near infrared spectroscopy
    Dorte Phillip
    Danish Headache Center, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Eur J Clin Invest 42:1180-8. 2012
    ..We examined 44 healthy volunteers by simultaneous recordings of ABP, oxyHb and Vmca during spontaneous and paced breathing at 6 breaths per minute on two separate days...
  29. pmc Nitric oxide modulation of low-frequency oscillations in cortical vessels in FHM--a NIRS study
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Headache 52:1146-54. 2012
    ....
  30. doi request reprint The effect of sodium nitroprusside on cerebral hemodynamics and headache in healthy subjects
    Song Guo
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cephalalgia 33:301-7. 2013
    ..Nevertheless, it has already been used in animal models without any knowledge of its headache-inducing potential. We hypothesized that SNP would induce headache and vasodilation of cephalic and radial but not cerebral arteries...
  31. doi request reprint Pharmacological modulation of the BOLD response: a study of acetazolamide and glyceryl trinitrate in humans
    Mohammad S Asghar
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Magn Reson Imaging 34:921-7. 2011
    ....
  32. doi request reprint Low-frequency oscillations and vasoreactivity of cortical vessels in obstructive sleep apnea during wakefulness: a near infrared spectroscopy study
    Henrik Winther Schytz
    Danish Headache Center and Department of Neurology, Glostrup University Hospital, Glostrup, Denmark
    Sleep Med 14:416-21. 2013
    ....
  33. doi request reprint Prostaglandins in migraine: update
    Maria Antonova
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Curr Opin Neurol 26:269-75. 2013
    ..This review presents recent findings on the role of prostaglandins in migraine pathophysiology...
  34. pmc Effect of CGRP and sumatriptan on the BOLD response in visual cortex
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Faculty of Health Sciences, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, Glostrup, 2600 Copenhagen, Denmark
    J Headache Pain 13:159-66. 2012
    ..98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier...
  35. doi request reprint Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man
    Maria Antonova
    University of Copenhagen, Denmark
    Cephalalgia 31:1532-41. 2011
    ....
  36. ncbi request reprint Magnetic resonance angiography shows dilatation of the middle cerebral artery after infusion of glyceryl trinitrate in healthy volunteers
    J M Hansen
    Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 27:118-27. 2007
    ..The present study shows that the MRA method gives a reliable semi-quantitative index of the vascular changes in the intra-cerebral arteries after infusion of GTN and may be useful for headache research...
  37. pmc Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP
    Henrik Winther Schytz
    Department of Neurology, Faculty of Health Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup 2600, Copenhagen, Denmark
    J Headache Pain 11:309-16. 2010
    ..This suggests that acute pain and vasomotor responses following intradermal injections of PACAP38 and VIP are primarily mediated by VPAC receptors...
  38. ncbi request reprint [Medication overuse headache]
    Sait Ashina
    Amtssygehuset i Glostrup, Neurologisk afdeling, Dansk Hovedpinecenter
    Ugeskr Laeger 168:1015-9. 2006
    ..It is a severely disabling condition that has a huge economic impact on society. Treatment includes complete drug withdrawal, and the prognosis is good. Preventive measures and providing information to the patients are very important...
  39. pmc The pharmacological effect of BGC20-1531, a novel prostanoid EP4 receptor antagonist, in the prostaglandin E2 human model of headache
    Maria Antonova
    Danish Headache Center and Department of Neurology, Faculty of Health Sciences, Glostrup Hospital, University of Copenhagen, Ndr Ringvej 67, Glostrup, Denmark
    J Headache Pain 12:551-9. 2011
    ..In conclusion, these data suggest that the other EP receptors may be involved in PGE(2) induced headache and dilatation in normal subjects...
  40. doi request reprint Hemiplegic migraine aura begins with cerebral hypoperfusion: imaging in the acute phase
    Jakob M Hansen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Headache 51:1289-96. 2011
    ..Furthermore, in the time of ready access to acute systemic thrombolysis treatment, these cases underscore the importance of an accurate headache history, especially in younger patients...
  41. doi request reprint Prostacyclin (epoprostenol) induces headache in healthy subjects
    Troels Wienecke
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pain 139:106-16. 2008
    ..001), but no significant dilatation of the MCA (AUC, p=0.508). These data indicate that PGI(2) induced headache might be due to activation and sensitization of sensory afferents around extracranial arteries...
  42. doi request reprint Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D₂ (PGD₂)
    Troels Wienecke
    Danish Headache Centre and Department ofNeurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Glostrup, Copenhagen, Denmark
    Cephalalgia 31:65-76. 2011
    ..Prostaglandins (PGs) are involved in nociception and mast cell degranulation. Prostaglandin D₂ (PGD₂) is a vasodilatator released during mast cell degranulation. The headache-eliciting effect of PGD₂ has not been studied in man...
  43. doi request reprint Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers
    M S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurology 75:1520-6. 2010
    ....
  44. doi request reprint Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 28:367-75. 2008
    ..GTN infusion failed to induce more migraine in FHM-2 patients than in controls. The pathophysiological pathways underlying migraine headache in FHM-2 may be different from the common types of migraine...
  45. doi request reprint Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38
    Faisal Mohammad Amin
    1 Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Brain 137:779-94. 2014
    ..PACAP38 has a much higher affinity for the PAC1 receptor and we therefore suggest that migraine induction by PACAP38 may be because of activation of the PAC1 receptor, which may be a future anti-migraine drug target. ..
  46. doi request reprint Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Denmark
    Cephalalgia 33:831-41. 2013
    ..We hypothesized that low frequency (LF) SPG stimulation may activate the SPG, causing increased parasympathetic outflow and thereby provoking cluster attacks in CH patients...
  47. doi request reprint Provocation of migraine with aura using natural trigger factors
    Anders Hougaard
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Neurology 80:428-31. 2013
    ..The objective of this study was to expose patients with MA to their self-reported trigger factors in order to assess the causal relation between trigger factors and attacks...
  48. doi request reprint The effect of sumatriptan on cephalic arteries: A 3T MR-angiography study in healthy volunteers
    Faisal Mohammad Amin
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Denmark
    Cephalalgia 33:1009-16. 2013
    ....
  49. doi request reprint Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype
    Jakob Møller Hansen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Bolig 23 24, DK 2600 Glostrup, Copenhagen, Denmark
    Neurology 71:841-7. 2008
    ..FHM shares many phenotypical similarities with common types of migraine, indicating common neurobiological pathways. We tested the hypothesis that the FHM genotype confers a CGRP hypersensitive phenotype...
  50. doi request reprint A new technology for detecting cerebral blood flow: a comparative study of ultrasound tagged NIRS and 133Xe-SPECT
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600, Glostrup, Denmark
    Neurocrit Care 17:139-45. 2012
    ..This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring...
  51. pmc Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers
    Jakob Møller Hansen
    Danish Headache Center and Department of Neurology, Faculty of Health Sciences, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, Bolig 23 24, Glostrup, 2600 Copenhagen, Denmark
    J Headache Pain 10:85-91. 2009
    ..This speaks against a direct CGRP-reducing effect of sumatriptan in vivo in humans when the trigemino vascular system is not activated...
  52. doi request reprint Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
    ..Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra- and intracranial vessels in migraine without aura patients...
  53. doi request reprint What have we learnt from triggering migraine?
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    Curr Opin Neurol 23:259-65. 2010
    ..This review presents what we have learnt from triggering migraine...
  54. doi request reprint Coexisting typical migraine in familial hemiplegic migraine
    Jakob Møller Hansen
    Danish Headache Center and Department of Neurology N01, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Neurology 74:594-600. 2010
    ....
  55. doi request reprint Prostaglandin E(2) induces immediate migraine-like attack in migraine patients without aura
    Maria Antonova
    Danish Headache Center and Department of Neurology, University of Copenhagen, Denmark
    Cephalalgia 32:822-33. 2012
    ..In the present experiment we investigated if an intravenous infusion of PGE(2) would induce migraine-like attacks in patients with migraine...
  56. ncbi request reprint No increase of calcitonin gene-related peptide in jugular blood during migraine
    Jesper Filtenborg Tvedskov
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    Ann Neurol 58:561-8. 2005
    ..Our finding strongly suggests that CGRP is not increased in jugular venous blood during migraine without aura. CGRP cannot be used as a biomarker to validate human or animal models of migraine...
  57. doi request reprint Emerging migraine treatments and drug targets
    Jes Olesen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Ndr Ringvej 57, DK 2600 Glostrup, Denmark
    Trends Pharmacol Sci 32:352-9. 2011
    ..The greatest need is for new prophylactic drugs, and it seems likely that such compounds will be developed in the coming decade...
  58. ncbi request reprint Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 18:27-32. 1998
    ..Symptoms such as phono- and photophobia were also significantly improved. A similar trend for nausea was not significant. We conclude that NO may be involved in the pain mechanisms throughout the course of spontaneous migraine attacks...
  59. ncbi request reprint Induction of prolonged tenderness in patients with tension-type headache by means of a new experimental model of myofascial pain
    H Mørk
    Department of Neurology, Copenhagen Headache Center, University of Copenhagen, Glostrup Hospital, Glostrup, Copenhagen, Denmark
    Eur J Neurol 10:249-56. 2003
    ..The present results suggest an increased excitability of peripheral muscle afferents in TTH...
  60. ncbi request reprint Possible mechanisms of pain perception in patients with episodic tension-type headache. A new experimental model of myofascial pain
    H Mørk
    Copenhagen Headache Centre, University of Copenhagen, Department of Neurology, Glostrup Hospital, Glostrup, Copenhagen, Denmark
    Cephalalgia 24:466-75. 2004
    ..The increased pain response, but similar qualitative pain perception, in ETTH patients may be explained by sensitization of peripheral nociceptors even though central mechanisms may also be involved...
  61. ncbi request reprint Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache
    S Ashina
    Danish Headache Center and Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Copenhagen, Denmark
    Eur J Neurol 12:543-9. 2005
    ..Increased sensitivity in nociceptive pathways from cephalic region may be of importance in the pathophysiology of chronic tension type headache...
  62. doi request reprint The cholinomimetic agent carbachol induces headache in healthy subjects
    H W Schytz
    Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 29:258-68. 2009
    ..003) and an increase in STA diameter (P = 0.006), but no increase in the RA diameter (P = 0.200). In conclusion, the study demonstrated that carbachol caused headache and dilation of cephalic arteries in healthy subjects...
  63. ncbi request reprint Headache in systemic mastocytosis: a case report with pathophysiological considerations
    S Ashina
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Cephalalgia 25:314-6. 2005
  64. ncbi request reprint Vasoactive intestinal polypeptide evokes only a minimal headache in healthy volunteers
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 26:992-1003. 2006
    ..001). These results show that VIP causes a decrease in V(meanMCA) without affecting rCBF. In spite of a marked vasodilator effect in the extracranial vessels and increased plasma VIP, healthy subjects developed only a very mild headache...
  65. doi request reprint Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine
    A Rahmann
    Danish Headache Centre, Department of Neurology, Glostrup Hospital, Copenhagen, Denmark
    Cephalalgia 28:226-36. 2008
    ..9 +/- 13.9%). VIP mediates a marked dilation of cranial arteries, but does not trigger migraine attacks in migraineurs. These data provide further evidence against a purely vascular origin of migraine...
  66. pmc Changes in cerebral blood flow after acetazolamide: an experimental study comparing near-infrared spectroscopy and SPECT
    H W Schytz
    Danish Headache Center and Department of Neurology Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    Eur J Neurol 16:461-7. 2009
    ..To validate if the BFI method can detect relative changes in CBF we compared data with the established method (133)Xenon single photon emission computer tomography ((133)Xe-SPECT)...
  67. doi request reprint Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura
    H W Schytz
    Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Danish Headache Center, Glostrup, Denmark
    Cephalalgia 30:337-45. 2010
    ..687). Carbachol caused a decrease in V(MCA) (P = 0.044), but no change in STA (P = 0.089) compared with placebo. The study demonstrated that carbachol provocation is not a good model for experimental migraine...
  68. doi request reprint Prostaglandin E2(PGE2) induces headache in healthy subjects
    T Wienecke
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 29:509-19. 2009
    ..PGE(2) caused dilatation of the STA (23.5%; 95% CI 14.0, 37.8) and the MCA (8.3%; 95% CI 4.0, 12.6). We suggest that PGE(2) induces headache by activation and sensitization of cranial perivascular sensory afferents...
  69. doi request reprint Origin of pain in migraine: evidence for peripheral sensitisation
    Jes Olesen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Lancet Neurol 8:679-90. 2009
    ..We suggest that migraine can be explained to patients as a disorder of the brain, and that the headache originates in the sensory fibres that convey pain signals from intracranial and extracranial blood vessels...
  70. ncbi request reprint Experimental muscle pain and tenderness following infusion of endogenous substances in humans
    Hanne Mørk
    Department of Neurology, Copenhagen Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Eur J Pain 7:145-53. 2003
    ....
  71. doi request reprint The PACAP receptor: a novel target for migraine treatment
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
    Neurotherapeutics 7:191-6. 2010
    ..This review summarizes the current evidence supporting the involvement of PACAP in migraine pathophysiology and the PAC(1) receptor as a possible novel target for migraine treatment...
  72. pmc Spontaneous low-frequency oscillations in cerebral vessels: applications in carotid artery disease and ischemic stroke
    Henrik W Schytz
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    J Stroke Cerebrovasc Dis 19:465-74. 2010
    ..Near-infrared spectroscopy is suggested as a future complementary tool for assessing changes affecting the cortical arterial system...
  73. ncbi request reprint Generalized hyperalgesia in patients with chronic tension-type headache
    S Ashina
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 26:940-8. 2006
    ..Furthermore, it indicates that suprathreshold stimulation is more sensitive than recording of pain thresholds for evaluation of generalized pain perception...
  74. doi request reprint Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine
    Jakob M Hansen
    Danish Headache Center, Departments of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Headache 51:544-53. 2011
    ..Whether CGRP triggers migraine-like attacks in FHM patients without known mutations is unknown...
  75. doi request reprint Trigger factors for familial hemiplegic migraine
    Jakob Møller Hansen
    Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Glostrup, Copenhagen, Denmark
    Cephalalgia 31:1274-81. 2011
    ..The aim was to identify and describe migraine trigger factors in patients with familial hemiplegic migraine (FHM) from a population-based sample...
  76. ncbi request reprint [Clinical symptoms and pathophysiology of migraine]
    Peer Tfelt-Hansen
    Neurologisk afdeling N, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 170:3231-4. 2008
    ..Allodynia, most likely caused by central sensitization, often develops during the attack. In conclusion, the migraine attack is a complex neurobiological and neurovascular process...
  77. ncbi request reprint Experimental induction of muscle tenderness and headache in tension-type headache patients
    M B Christensen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 25:1061-7. 2005
    ..These findings demonstrate that tension-type headache patients are more liable to develop shoulder and neck pain in response to static exercise than healthy controls...
  78. doi request reprint Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 28:496-505. 2008
    ..This indicates that the pathophysiological pathways underlying migraine headache in FHM-1 may be different from the common types of migraine...
  79. doi request reprint Prevalence of right-to-left shunts on transcranial Doppler in chronic migraine and medication-overuse headache
    Song Guo
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Cephalalgia 34:37-41. 2014
    ..Since a high proportion of chronic migraineurs also have medication-overuse headache (MOH), one may wonder if they have a more severe form of the disorder and more frequently a PFO...
  80. pmc Migraine and structural changes in the brain: a systematic review and meta-analysis
    Asma Bashir
    From the Danish Headache Center and Department of Neurology A B, M A, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark Montefiore Headache Center R B L, Department of Neurology, Albert Einstein College of Medicine, Bronx and Headache Program S A, Department of Pain Medicine and Palliative Care, Department of Neurology, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY
    Neurology 81:1260-8. 2013
    ....
  81. doi request reprint The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?
    Song Guo
    University of Copenhagen, Denmark
    Cephalalgia 31:1029-38. 2011
    ..Two metabolites of this family have become of interest in relation to migraine and pain processing...
  82. doi request reprint Finding new drug targets for the treatment of migraine attacks
    J Olesen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 29:909-20. 2009
    ..The pharmaceutical industry should pay more attention to human models, although methods are different from normal target validation...
  83. ncbi request reprint Measurement of muscle hardness: a methodological study
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 18:106-11. 1998
    ..We suggest that the muscle hardness meter will be an important tool in future research of the mechanisms leading to myofascial pain...
  84. doi request reprint Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects
    T Wienecke
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cephalalgia 28:1081-5. 2008
    ..We also measured the AVDO2 in the internal jugular and cubital veins. There were no changes in AVDO2 after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system...