H D Pedersen

Summary

Affiliation: The Royal Veterinary and Agricultural University
Country: Denmark

Publications

  1. ncbi Auscultation in mild mitral regurgitation in dogs: observer variation, effects of physical maneuvers, and agreement with color Doppler echocardiography and phonocardiography
    H D Pedersen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 13:56-64. 1999
  2. ncbi Neuroendocrine changes in Dachshunds with mitral valve prolapse examined under different study conditions
    H D Pedersen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Res Vet Sci 66:11-7. 1999
  3. ncbi Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation
    Henrik D Pedersen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 17:178-84. 2003
  4. ncbi Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait
    Henrik D Pedersen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 16:169-73. 2002
  5. doi Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease
    N E Zois
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 26:1309-19. 2012
  6. doi Left ventricular twist and circumferential strain in dogs with myxomatous mitral valve disease
    N E Zois
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 27:875-83. 2013
  7. doi Heart rate, heart rate variability, and arrhythmias in dogs with myxomatous mitral valve disease
    C E Rasmussen
    Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 26:76-84. 2012
  8. ncbi Increased platelet aggregation response in Cavalier King Charles Spaniels with mitral valve prolapse
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 15:209-16. 2001
  9. ncbi Body size, but neither age nor asymptomatic mitral regurgitation, influences plasma concentrations of dimethylarginines in dogs
    L G Pedersen
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg C, Copenhagen, Denmark
    Res Vet Sci 80:336-42. 2006
  10. ncbi Epidemiology and inheritance of mitral valve prolapse in Dachshunds
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 13:448-56. 1999

Collaborators

Detail Information

Publications33

  1. ncbi Auscultation in mild mitral regurgitation in dogs: observer variation, effects of physical maneuvers, and agreement with color Doppler echocardiography and phonocardiography
    H D Pedersen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 13:56-64. 1999
    ..Auscultatory findings in mild regurgitation appear to depend on observer experience, circulatory status, and how difficult the dog is to auscultate...
  2. ncbi Neuroendocrine changes in Dachshunds with mitral valve prolapse examined under different study conditions
    H D Pedersen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Res Vet Sci 66:11-7. 1999
    ..We conclude that the increased renin release found in early canine mitral disease is not reproducible under all study conditions, and that it correlates with the severity of MVP and not of MR...
  3. ncbi Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation
    Henrik D Pedersen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 17:178-84. 2003
    ..9-17.1 microM; P = .02) MR. In conclusion, CKCSs with mild to severe, clinically silent MR have decreased plasma NOx concentrations, suggesting that endothelial dysfunction develops early in the course of developing MR in dogs...
  4. ncbi Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait
    Henrik D Pedersen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 16:169-73. 2002
    ..We conclude that idiopathic, asymptomatic thrombocytopenia in CKCS is inherited in an autosomal recessive manner. The condition most likely constitutes an inherited macrothrombocytopenia in dogs...
  5. doi Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease
    N E Zois
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 26:1309-19. 2012
    ..Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR)...
  6. doi Left ventricular twist and circumferential strain in dogs with myxomatous mitral valve disease
    N E Zois
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 27:875-83. 2013
    ..Decreased and delayed LV twist has been described in experimental MR, but has not been studied in myxomatous mitral valve disease (MMVD)...
  7. doi Heart rate, heart rate variability, and arrhythmias in dogs with myxomatous mitral valve disease
    C E Rasmussen
    Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 26:76-84. 2012
    ..Autonomic modulation of heart rhythm is thought to influence the pathophysiology of myxomatous mitral valve disease (MMVD)...
  8. ncbi Increased platelet aggregation response in Cavalier King Charles Spaniels with mitral valve prolapse
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 15:209-16. 2001
    ....
  9. ncbi Body size, but neither age nor asymptomatic mitral regurgitation, influences plasma concentrations of dimethylarginines in dogs
    L G Pedersen
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg C, Copenhagen, Denmark
    Res Vet Sci 80:336-42. 2006
    ..33). Body weight was directly associated with ADMA (P = 0.0004) and creatinine was directly associated with SDMA (P<0.0001). Furthermore, the plasma concentration of ADMA was three to four times higher than found in healthy humans...
  10. ncbi Epidemiology and inheritance of mitral valve prolapse in Dachshunds
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 13:448-56. 1999
    ..A polygenic mode of inheritance is suggested...
  11. ncbi Determinants of weak femoral artery pulse in dogs with mitral valve prolapse
    I Tarnow
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Gronnegaardsvej, C Dk 1870, Frederiksberg, Denmark
    Res Vet Sci 76:113-20. 2004
    ..In conclusion, weak femoral artery pulses in dogs with MMVD seem to be associated with regional/local reductions in blood flow and not arteriosclerosis or platelet count...
  12. doi Holter monitoring of small breed dogs with advanced myxomatous mitral valve disease with and without a history of syncope
    C E Rasmussen
    Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 28:363-70. 2014
    ..Syncope is a transient loss of consciousness occasionally occurring in dogs with advanced myxomatous mitral valve disease (MMVD)...
  13. ncbi Increased NADPH-diaphorase activity in canine myxomatous mitral valve leaflets
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870, Frederiksberg C, Denmark
    J Comp Pathol 129:120-30. 2003
    ..In conclusion, increased NADPH-d activity, suggesting increased NOS expression, was found in areas of the mitral valve with myxomatous changes. This indicates that nitric oxide (NO) may play a role in the pathogenesis of MMVD in dogs...
  14. ncbi Direct measurements of nitric oxide release in relation to expression of endothelial nitric oxide synthase in isolated porcine mitral valves
    S G Moesgaard
    Department of Basic Animal and Veterinary Sciences, The Royal Vetinary and Agricultural University, Fredriksberg, Denmark
    J Vet Med A Physiol Pathol Clin Med 54:156-60. 2007
    ..It is concluded that direct NO release from porcine mitral valves coincides with eNOS expression. This study documents useful techniques for investigations into the role of local NO release in mitral valve diseases...
  15. ncbi CO2 induced acute respiratory acidosis and brain tissue intracellular pH: a 31P NMR study in swine
    L Martoft
    Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Grønnegårdsvej 7, 1870 Frederiksberg C, Denmark
    Lab Anim 37:241-8. 2003
    ..The fast decrease in intracellular pH supports the conclusion that high concentration CO(2) leads to anaesthesia soon after the start of inhalation...
  16. ncbi Effects of CO2 anaesthesia on central nervous system activity in swine
    L Martoft
    Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Grønnegårdsvej 7, 1870 Frederiksberg C, Denmark
    Lab Anim 36:115-26. 2002
    ..The two studies indicated a good temporal relationship between changes in amplitude, depth of anaesthesia index, spectral edge frequency, and arterial PCO2 during the induction period...
  17. doi Holter monitoring in clinically healthy Cavalier King Charles Spaniels, Wire-haired Dachshunds, and Cairn Terriers
    C E Rasmussen
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 25:460-8. 2011
    ..Few reported studies describe normal values from 24-hour ECG (Holter) recordings of small breed dogs...
  18. ncbi Intramyocardial arterial narrowing in dogs with subaortic stenosis
    T Falk
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Small Anim Pract 45:448-53. 2004
    ..This study suggests that most dogs with SAS have intramyocardial arterial narrowing and that the risk of dying suddenly is not significantly related to the overall degree of vessel obliteration...
  19. ncbi Early echocardiographic predictors of myxomatous mitral valve disease in dachshunds
    L H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg C, Denmark
    Vet Rec 152:293-7. 2003
    ..The initial index of mitral valve prolapse, the area of the jet and the intensity of the heart murmur were all significant predictors of an increase in LAD...
  20. ncbi Increased expression of endothelin B receptor in static stretch exposed porcine mitral valve leaflets
    L G Pedersen
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg, Copenhagen, Denmark
    Res Vet Sci 82:232-8. 2007
    ..90) and ET-1 (P=0.51) remained unchanged. Stretch increased the expression of ET(B)-receptors in porcine mitral valve leaflets. The finding could lead to a better understanding of the pathogenesis of myxomatous mitral valve disease...
  21. ncbi Middle-latency auditory evoked potentials during induction of thiopentone anaesthesia in pigs
    L Martoft
    Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Frederiksberg C, Denmark
    Lab Anim 35:353-63. 2001
    ..Whether an ARX-based depth of anaesthesia index designed especially for pigs might be better than the present index (designed for man) for assessing depth of anaesthesia must await the results of further studies...
  22. ncbi Hemostatic biomarkers in dogs with chronic congestive heart failure
    Inge Tarnow
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 21:451-7. 2007
    ..Alterations in hemostatic pathways can be involved in the pathogenesis of CHF in dogs, and microthrombosis in the myocardium could contribute to increased mortality...
  23. ncbi Increased nitric oxide release and expression of endothelial and inducible nitric oxide synthases in mildly changed porcine mitral valve leaflets
    Sophia G Moesgaard
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, 1870 Frederiksberg, Denmark
    J Heart Valve Dis 16:67-75. 2007
    ..The study aim was to examine NO release and the expression of both endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) in relation to early local changes in porcine mitral valves...
  24. ncbi Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve disease
    Torkel Falk
    Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Cardiovasc Pathol 15:185-93. 2006
    ..The occurrence of small vessel arteriosclerosis in the myocardium, kidney, and lung in dogs with naturally occurring myxomatous mitral valve disease has not been previously investigated systematically...
  25. ncbi Decreased platelet function in Cavalier King Charles Spaniels with mitral valve regurgitation
    Inge Tarnow
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 17:680-6. 2003
    ..The previous finding of increased platelet reactivity in nonthrombocytopenic CKCS without MR could not be reproduced with the PFA-100 device...
  26. ncbi Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia
    Lisbeth H Olsen
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Diagn Invest 16:167-70. 2004
    ..0001). All platelet counts--except when made with the 2 counting chamber methods--were underestimated at platelet counts < or = 100,000/microl...
  27. ncbi Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease
    Inge Tarnow
    Departments of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
    Am J Vet Res 65:1644-52. 2004
    ..To evaluate markers of hemostasis and their relationship to the degree of mitral regurgitation (MR) and platelet function in Cavalier King Charles Spaniels (CKCSs) with myxomatous mitral valve disease...
  28. ncbi Dogs with heart diseases causing turbulent high-velocity blood flow have changes in platelet function and von Willebrand factor multimer distribution
    Inge Tarnow
    Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 19:515-22. 2005
    ..Aggregation results suggest increased platelet reactivity in Cavaliers, but the platelets did not appear to circulate in a preactivated state in either disease...
  29. ncbi Circulating concentrations of insulin-like growth factor-1 in dogs with naturally occurring mitral regurgitation
    Henrik D Pedersen
    Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 19:528-32. 2005
    ....
  30. ncbi Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney disease
    Karen M Pedersen
    Department of Clinical Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 17:21-7. 2003
    ..None of the cats had echocardiographic evidence of cardiac hypertrophy. In conclusion, cats with PKD had a minor increase in mean arterial pressure compared to control cats, and half of the cats had a high ARR...
  31. ncbi Allometric scaling of M-mode cardiac measurements in normal adult dogs
    Craig C Cornell
    Veterinary Medical Teaching Hospital, University of California, Davis, CA 95616 8747, USA
    J Vet Intern Med 18:311-21. 2004
    ..The equations developed from this study appear to be applicable to adult dogs of most breeds...
  32. ncbi Platelet function in dogs: breed differences and effect of acetylsalicylic acid administration
    Line A Nielsen
    Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Vet Clin Pathol 36:267-73. 2007
    ..Clinical studies investigating platelet function in dogs have had conflicting results that may be caused by normal physiologic variation in platelet response to agonists...
  33. ncbi Evaluation of an oscillometric blood pressure monitor for use in anesthetized cats
    Karen M Pedersen
    J Am Vet Med Assoc 221:646-50. 2002
    ..To determine accuracy of an oscillometric blood pressure monitor used over a wide range of pressures in anesthetized cats...