Research Topics
| H D PedersenSummaryAffiliation: The Royal Veterinary and Agricultural University Country: Denmark Publications
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Detail Information
Publications
Auscultation in mild mitral regurgitation in dogs: observer variation, effects of physical maneuvers, and agreement with color Doppler echocardiography and phonocardiographyH D Pedersen
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 13:56-64. 1999..Auscultatory findings in mild regurgitation appear to depend on observer experience, circulatory status, and how difficult the dog is to auscultate...- Neuroendocrine changes in Dachshunds with mitral valve prolapse examined under different study conditionsH D Pedersen
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
Res Vet Sci 66:11-7. 1999..We conclude that the increased renin release found in early canine mitral disease is not reproducible under all study conditions, and that it correlates with the severity of MVP and not of MR... - Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive traitHenrik D Pedersen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 16:169-73. 2002..We conclude that idiopathic, asymptomatic thrombocytopenia in CKCS is inherited in an autosomal recessive manner. The condition most likely constitutes an inherited macrothrombocytopenia in dogs... - Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitationHenrik D Pedersen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 17:178-84. 2003..9-17.1 microM; P = .02) MR. In conclusion, CKCSs with mild to severe, clinically silent MR have decreased plasma NOx concentrations, suggesting that endothelial dysfunction develops early in the course of developing MR in dogs... 
Heart rate, heart rate variability, and arrhythmias in dogs with myxomatous mitral valve diseaseC E Rasmussen
Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Frederiksberg, Denmark
J Vet Intern Med 26:76-84. 2012..Autonomic modulation of heart rhythm is thought to influence the pathophysiology of myxomatous mitral valve disease (MMVD)...- Increased platelet aggregation response in Cavalier King Charles Spaniels with mitral valve prolapseL H Olsen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 15:209-16. 2001.... - Epidemiology and inheritance of mitral valve prolapse in DachshundsL H Olsen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 13:448-56. 1999..A polygenic mode of inheritance is suggested... - Body size, but neither age nor asymptomatic mitral regurgitation, influences plasma concentrations of dimethylarginines in dogsL G Pedersen
Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg C, Copenhagen, Denmark
Res Vet Sci 80:336-42. 2006..33). Body weight was directly associated with ADMA (P = 0.0004) and creatinine was directly associated with SDMA (P<0.0001). Furthermore, the plasma concentration of ADMA was three to four times higher than found in healthy humans... - Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve diseaseN E Zois
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
J Vet Intern Med 26:1309-19. 2012..Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR)... - Determinants of weak femoral artery pulse in dogs with mitral valve prolapseI Tarnow
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Gronnegaardsvej, C Dk 1870, Frederiksberg, Denmark
Res Vet Sci 76:113-20. 2004..In conclusion, weak femoral artery pulses in dogs with MMVD seem to be associated with regional/local reductions in blood flow and not arteriosclerosis or platelet count... - Increased NADPH-diaphorase activity in canine myxomatous mitral valve leafletsL H Olsen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK-1870, Frederiksberg C, Denmark
J Comp Pathol 129:120-30. 2003..In conclusion, increased NADPH-d activity, suggesting increased NOS expression, was found in areas of the mitral valve with myxomatous changes. This indicates that nitric oxide (NO) may play a role in the pathogenesis of MMVD in dogs... - Effects of CO2 anaesthesia on central nervous system activity in swineL Martoft
Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Grønnegårdsvej 7, 1870 Frederiksberg C, Denmark
Lab Anim 36:115-26. 2002..The two studies indicated a good temporal relationship between changes in amplitude, depth of anaesthesia index, spectral edge frequency, and arterial PCO2 during the induction period... - CO2 induced acute respiratory acidosis and brain tissue intracellular pH: a 31P NMR study in swineL Martoft
Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Grønnegårdsvej 7, 1870 Frederiksberg C, Denmark
Lab Anim 37:241-8. 2003..The fast decrease in intracellular pH supports the conclusion that high concentration CO(2) leads to anaesthesia soon after the start of inhalation... - Direct measurements of nitric oxide release in relation to expression of endothelial nitric oxide synthase in isolated porcine mitral valvesS G Moesgaard
Department of Basic Animal and Veterinary Sciences, The Royal Vetinary and Agricultural University, Fredriksberg, Denmark
J Vet Med A Physiol Pathol Clin Med 54:156-60. 2007..It is concluded that direct NO release from porcine mitral valves coincides with eNOS expression. This study documents useful techniques for investigations into the role of local NO release in mitral valve diseases... - Increased expression of endothelin B receptor in static stretch exposed porcine mitral valve leafletsL G Pedersen
Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK 1870 Frederiksberg, Copenhagen, Denmark
Res Vet Sci 82:232-8. 2007..90) and ET-1 (P=0.51) remained unchanged. Stretch increased the expression of ET(B)-receptors in porcine mitral valve leaflets. The finding could lead to a better understanding of the pathogenesis of myxomatous mitral valve disease... - Intramyocardial arterial narrowing in dogs with subaortic stenosisT Falk
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Small Anim Pract 45:448-53. 2004..This study suggests that most dogs with SAS have intramyocardial arterial narrowing and that the risk of dying suddenly is not significantly related to the overall degree of vessel obliteration... - Early echocardiographic predictors of myxomatous mitral valve disease in dachshundsL H Olsen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK-1870 Frederiksberg C, Denmark
Vet Rec 152:293-7. 2003..The initial index of mitral valve prolapse, the area of the jet and the intensity of the heart murmur were all significant predictors of an increase in LAD... - Holter monitoring in clinically healthy Cavalier King Charles Spaniels, Wire-haired Dachshunds, and Cairn TerriersC E Rasmussen
Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
J Vet Intern Med 25:460-8. 2011..Few reported studies describe normal values from 24-hour ECG (Holter) recordings of small breed dogs... - Middle-latency auditory evoked potentials during induction of thiopentone anaesthesia in pigsL Martoft
Royal Veterinary and Agricultural University, Department of Anatomy and Physiology, Frederiksberg C, Denmark
Lab Anim 35:353-63. 2001..Whether an ARX-based depth of anaesthesia index designed especially for pigs might be better than the present index (designed for man) for assessing depth of anaesthesia must await the results of further studies... - Increased nitric oxide release and expression of endothelial and inducible nitric oxide synthases in mildly changed porcine mitral valve leafletsSophia G Moesgaard
Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, 1870 Frederiksberg, Denmark
J Heart Valve Dis 16:67-75. 2007..The study aim was to examine NO release and the expression of both endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) in relation to early local changes in porcine mitral valves... - Arteriosclerotic changes in the myocardium, lung, and kidney in dogs with chronic congestive heart failure and myxomatous mitral valve diseaseTorkel Falk
Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Cardiovasc Pathol 15:185-93. 2006..The occurrence of small vessel arteriosclerosis in the myocardium, kidney, and lung in dogs with naturally occurring myxomatous mitral valve disease has not been previously investigated systematically... - Hemostatic biomarkers in dogs with chronic congestive heart failureInge Tarnow
Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 21:451-7. 2007..Alterations in hemostatic pathways can be involved in the pathogenesis of CHF in dogs, and microthrombosis in the myocardium could contribute to increased mortality... - Circulating concentrations of insulin-like growth factor-1 in dogs with naturally occurring mitral regurgitationHenrik D Pedersen
Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 19:528-32. 2005.... - Dogs with heart diseases causing turbulent high-velocity blood flow have changes in platelet function and von Willebrand factor multimer distributionInge Tarnow
Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 19:515-22. 2005..Aggregation results suggest increased platelet reactivity in Cavaliers, but the platelets did not appear to circulate in a preactivated state in either disease... - Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve diseaseInge Tarnow
Departments of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
Am J Vet Res 65:1644-52. 2004..The importance of the changes in plasma fibrinogen concentration and the thromboembolic risk in dogs with MR remain to be investigated... - Allometric scaling of M-mode cardiac measurements in normal adult dogsCraig C Cornell
Veterinary Medical Teaching Hospital, University of California, Davis, CA 95616 8747, USA
J Vet Intern Med 18:311-21. 2004..The equations developed from this study appear to be applicable to adult dogs of most breeds... - Decreased platelet function in Cavalier King Charles Spaniels with mitral valve regurgitationInge Tarnow
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 17:680-6. 2003..The previous finding of increased platelet reactivity in nonthrombocytopenic CKCS without MR could not be reproduced with the PFA-100 device... - Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney diseaseKaren M Pedersen
Department of Clinical Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 17:21-7. 2003..None of the cats had echocardiographic evidence of cardiac hypertrophy. In conclusion, cats with PKD had a minor increase in mean arterial pressure compared to control cats, and half of the cats had a high ARR... - Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopeniaLisbeth H Olsen
Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Diagn Invest 16:167-70. 2004..0001). All platelet counts--except when made with the 2 counting chamber methods--were underestimated at platelet counts < or = 100,000/microl... - Evaluation of an oscillometric blood pressure monitor for use in anesthetized catsKaren M Pedersen
J Am Vet Med Assoc 221:646-50. 2002..CONCLUSIONS AND CLINICAL RELEVANCE: Except for a minor underestimation of SAP during normo- and hypertension, the oscillometric monitor yielded reliable and easily obtainable blood pressure measurements in anesthetized cats... - Platelet function in dogs: breed differences and effect of acetylsalicylic acid administrationLine A Nielsen
Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
Vet Clin Pathol 36:267-73. 2007..Clinical studies investigating platelet function in dogs have had conflicting results that may be caused by normal physiologic variation in platelet response to agonists...