Research Topics
| Jens LykkesfeldtSummaryAffiliation: The Royal Veterinary and Agricultural University Country: Denmark Publications
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Detail Information
Publications
Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementationJ Lykkesfeldt
Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA
FASEB J 12:1183-9. 1998..These results provide further evidence for the potential of alpha-lipoic acid in treatment of diseases related to oxidative stress. Furthermore, the study extends the value of ascorbic acid as a biomarker of oxidative stress...- Age-dependent change in Vitamin C status: a phenomenon of maturation rather than of ageingJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, 9 Ridebanevej, DK 1870 Frederiksberg C, Copenhagen, Denmark
Mech Ageing Dev 126:892-8. 2005..05). The present data suggest that the decline in Vitamin C status with age occur early in life and is a phenomenon of maturation rather than of ageing. Data from other species and humans are discussed... - Ascorbic acid recycling in human erythrocytes is induced by smoking in vivoJens Lykkesfeldt
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
Free Radic Biol Med 35:1439-47. 2003..The induction of ascorbic acid recycling as a potential adaptation mechanism of the antioxidant defense to oxidative insults is discussed... - Oxidants and antioxidants in disease: oxidative stress in farm animalsJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
Vet J 173:502-11. 2007..The present knowledge on oxidative stress in farm animals is the topic of this review... - Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profilesJens Lykkesfeldt
Section of Pharmacology, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, 9 Ridebanevej, DK 1870 Frederiksberg C, Copenhagen, Denmark
Br J Nutr 92:203-6. 2004..While poor antioxidant status presumably also affects lipid peroxidation, it is only partly responsible for the increased level found in smokers in general... - Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigsJens Lykkesfeldt
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Copenhagen, Denmark
Free Radic Res 36:567-74. 2002..The results suggest that young guinea pigs may have a more adaptable antioxidant defense system compared to mature animals while also being more susceptible to oxidative stress... - Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochlorideJ Lykkesfeldt
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 9 Ridebanevej, Frederiksberg C, DK 1870, Denmark
Anal Biochem 282:89-93. 2000..The within- and between-day coefficients of variation for the complete assay are less than 1.5 and 3.5% for all analytes. As a whole, the method presented here is simpler and more reliable than existing methods... 
Role of vitamin C and E supplementation on IL-6 in response to trainingChristina Yfanti
The Centre of Inflammation and Metabolism, Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
J Appl Physiol 112:990-1000. 2012..In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training...- Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigsPernille Tveden-Nyborg
Section of Biomedicine, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
Basic Clin Pharmacol Toxicol 110:524-9. 2012..Consistent with previous findings, we show that ageing per se constitutes a considerable oxidative insult in the brain. However, our data also suggest that a long-term poor vitamin C status does not accelerate this process... - Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brainJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 9 Ridebanevej, DK 1870 Frederiksberg C, Denmark
Br J Nutr 98:1116-9. 2007..Vitamin C deficiency may therefore be particularly adverse during the neonatal period... - Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149:F4Gerda M Jensen
Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Ridebanevej 9, DK-1870 Frederiksberg C, Denmark
Am J Vet Res 67:648-53. 2006..coli O149:F4... - High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigsHenriette Frikke-Schmidt
Section of Biomedicine, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 9, DK 1870 Frederiksberg C, Denmark
Br J Nutr 105:54-61. 2011..The present findings suggest that this type of diet increases the turnover of Asc; hence, individuals consuming high-lipid diets may be at increased risk of vitamin C deficiency... - Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigsPeter Ø Jensen
Department of Clinical Microbiology, University Hospital, Copenhagen, Denmark
Basic Clin Pharmacol Toxicol 110:353-8. 2012..Our data show that poor antioxidant status exacerbates the outcome of biofilm-related infections... - Effect of smoking on erythorbic acid pharmacokineticsJens Lykkesfeldt
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
Br J Nutr 89:667-71. 2003.... - Pharmacokinetics of amoxicillin after oral administration in recently weaned piglets with experimentally induced Escherichia coli subtype O149:F4 diarrheaGerda M Jensen
Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, , DK-1870 Frederiksberg C, Denmark
Am J Vet Res 65:992-5. 2004..coli O149:F4-induced diarrhea may be appropriate... - Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cellsHenriette Frikke-Schmidt
Section of Biomedicine, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Denmark
Toxicol Lett 203:181-9. 2011..The study shows that exposure to carbon black and DEP in HUVECs can generate both oxidative stress and expression of cell surface adhesion molecules and that these effects can in part be attenuated by vitamin C and desferrioxamine... - Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammationQing Jiang
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
Free Radic Biol Med 33:1534-42. 2002.... - Oxidative stress and damage in liver, but not in brain, of Fischer 344 rats subjected to dietary iron supplementation with lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene]Jens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, University of Copenhagen, Denmark
J Biochem Mol Toxicol 21:145-55. 2007.... - Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinizationJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 9 Ridebanevej DK 1870, Frederiksberg, Copenhagen, Denmark
Cancer Epidemiol Biomarkers Prev 16:2513-6. 2007..In conclusion, ascorbate and dehydroascorbic acid could be adequately preserved in plasma stored at -80 degrees C following acidic deproteinization with meta-phosphoric acid containing 2 mmol/L of EDTA... - Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studiesHenriette Frikke-Schmidt
Section of Biomedicine, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
Basic Clin Pharmacol Toxicol 104:419-33. 2009..In this perspective, the present review examines the evidence for a specific link between vitamin C deficiency and increased risk of atherosclerosis as well as the possible mechanisms by which vitamin C may exert its protective function... - Antioxidant supplementation does not alter endurance training adaptationChristina Yfanti
Center of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Med Sci Sports Exerc 42:1388-95. 2010..However, RONS production may also activate redox-sensitive signaling pathways and transcription factors, which subsequently, may promote training adaptation... - Malondialdehyde as biomarker of oxidative damage to lipids caused by smokingJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, 9 Ridebanevej, DK 1870 Frederiksberg C, Denmark
Clin Chim Acta 380:50-8. 2007.... - Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumoniaBrian Lauritzen
Department of Pharmacology and Pathobiology, The Royal Veterinary and Agricultural University, Copenhagen, Denmark
Pharmacol Res 51:509-14. 2005..No signs of adverse effects of the HBP-infusion were observed. More studies are needed to elucidate of the effects of HBP further and to optimise the dosage regimen for further improvement the efficacy and safety... - Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system usedJens Lykkesfeldt
Section of Biomedicine, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, DK 1870 Frederiksberg C, Denmark
Nutr Res 32:66-9. 2012..In comparison, K(3)-EDTA vacutainers were superior in maintaining low ex vivo oxidation of vitamin C... - Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposureGünaj Rakipovski
Section of Biomedicine, Department of Veterinary Disease Biology, University of Copenhagen, Denmark
Diab Vasc Dis Res 8:295-8. 2011..To compare the effect of fluctuating glucose with sustained hyperglycaemia on systemic oxidative stress during 72 h of glucose infusion... 
Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigsPernille Tveden-Nyborg
Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
PLoS ONE 7:e48488. 2012..Our findings place attention on a yet unrecognized consequence of marginal VitC deficiency during pregnancy...- Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigsBrian Lauritzen
Department of Pharmacology and Pathobiology, The Royal Veterinary and Agricultural University, 9 Ridebanevej, 1870 Frederiksberg C, Copenhagen, Denmark
Res Vet Sci 74:271-7. 2003..The use of the more convenient single dose regimen was appropriate, as it was at least equivalent to the fractionated regimen... - Does vitamin C deficiency result in impaired brain development in infants?Pernille Tveden-Nyborg
Section of Biomedicine, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
Redox Rep 14:2-6. 2009..Recent data from our laboratory suggest that the neonatal brain is particularly susceptible to vitamin C deficiency and that this condition may adversely affect early brain development... - Keeping the intracellular vitamin C at a physiologically relevant level in endothelial cell cultureHenriette Frikke-Schmidt
Section of Biomedicine, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg CDK 1870, Denmark
Anal Biochem 397:135-7. 2010..We found that a single supplement of ascorbate and 2-phosphoascorbate adequately maintains intracellular vitamin C at physiological levels for up to 72 h... - Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitisManuela Schaper
Institute for Infectious Diseases, University of Berne, Switzerland
J Neuropathol Exp Neurol 61:605-13. 2002.... - Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stressTory M Hagen
Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Proc Natl Acad Sci U S A 99:1870-5. 2002..Feeding ALCAR in combination with LA increased metabolism and lowered oxidative stress more than either compound alone... - Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokersPeter Møller
Institute of Public Health c o Dept of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
Eur J Nutr 43:267-74. 2004..Such effects have been shown in mononuclear blood cells in the first few hours after ingestion, whereas studies of longer-term effects in well-nourished humans have been mainly negative... - Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscleYlva Hellsten
Department of Exercise and Sport Science, Copenhagen Muscle Research Center, University of Copenhagen, DK 2100 Copenhagen, Denmark
Free Radic Biol Med 43:353-61. 2007..The data show that ROS are formed within skeletal muscle during exercise and that oral intake of antioxidants can enhance the exercise-induced adaptive mRNA responses of eNOS and UCP3... - Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operationStephan Christen
Institute for Infectious Diseases, University of Berne, Friedbuehlstrasse 51, CH 3010 Berne, Switzerland
Free Radic Biol Med 38:1323-32. 2005..g., off-pump surgery) or the resultant oxidative stress (e.g., antioxidant treatment) should be considered as possible strategies to lower the rate of postoperative complications in pediatric CPB... - Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxoneTobias Böttcher
Department of Neurology, University of Rostock, Rostock, Germany
J Neurochem 91:1450-60. 2004..This study suggests neuroprotection to be a group effect of bactericidal protein synthesis-inhibiting antimicrobial agents compared with the standard therapy with beta-lactam antibiotics in meningitis... - Vitamin C pharmacokinetics of plain and slow release formulations in smokersMichael Viscovich
Department of Clinical Pharmacology Q 7642, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100, Denmark
Clin Nutr 23:1043-50. 2004..CONCLUSIONS: This study shows that there were pharmacokinetic differences between plain and slow release formulations of ascorbic acid. However, these effects are small and unlikely to be of significant clinical importance... - Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable?Bernard Schmitt
University Children s Hospital, Zurich, Switzerland
Pediatr Res 58:771-8. 2005..However, our data do not support the notion that EEG slowing is associated with adverse neurologic outcome. This is supported by the fact that EEG slowing was associated with less oxido-inflammatory stress... - Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young menJudith R Turnlund
US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
Am J Clin Nutr 79:1037-44. 2004..Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown... - Utility of melatonin to treat surgical stress after major vascular surgery--a safety studyBülent Kücükakin
Department of Surgical Gastroenterology D, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark
J Pineal Res 44:426-31. 2008..Melatonin may decrease oxidative damage resulting from surgery, but randomized clinical trials are required before definitive conclusions can be drawn regarding the clinical benefit of melatonin in surgical situations...