H Brauner-Osborne

Summary

Affiliation: The Royal Danish School of Pharmacy
Country: Denmark

Publications

  1. ncbi request reprint A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Center, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100, Copenhagen, Denmark
    Eur J Pharmacol 406:41-4. 2000
  2. ncbi request reprint Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medicinal Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1518:237-48. 2001
  3. ncbi request reprint Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medical Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, Copenhagen, DK 2100, Denmark
    Genomics 65:121-8. 2000
  4. ncbi request reprint The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
    H Brauner-Osborne
    Department of Medicinal Chemistry, NeuroScience PharmaBiotec Research Centre, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Biol Chem 274:18382-6. 1999
  5. pmc Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells
    H Brauner-Osborne
    NeuroScience PharmaBiotec Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 128:1370-4. 1999
  6. ncbi request reprint Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
    U Madsen
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Med Chem 44:1051-9. 2001
  7. ncbi request reprint New analogues of ACPD with selective activity for group II metabotropic glutamate receptors
    H Brauner-Osborne
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Denmark
    Eur J Pharmacol 332:327-31. 1997
  8. ncbi request reprint Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid
    U Madsen
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Bioorg Med Chem Lett 8:1563-8. 1998
  9. pmc Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations
    B Christiansen
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Br J Pharmacol 150:798-807. 2007
  10. pmc Molecular basis for amino acid sensing by family C G-protein-coupled receptors
    P Wellendorph
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Br J Pharmacol 156:869-84. 2009

Collaborators

Detail Information

Publications10

  1. ncbi request reprint A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Center, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100, Copenhagen, Denmark
    Eur J Pharmacol 406:41-4. 2000
    ..S)-TDPA thus represents a new structural class of EAAT2 inhibitor that will serve as a lead for the design of EAAT selective inhibitors...
  2. ncbi request reprint Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medicinal Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1518:237-48. 2001
    ....
  3. ncbi request reprint Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medical Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, Copenhagen, DK 2100, Denmark
    Genomics 65:121-8. 2000
    ..This mRNA expression pattern is markedly different from that of RAIG1, which shows a slightly more restricted expression pattern with highest abundance in lung tissue...
  4. ncbi request reprint The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
    H Brauner-Osborne
    Department of Medicinal Chemistry, NeuroScience PharmaBiotec Research Centre, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Biol Chem 274:18382-6. 1999
    ..These data demonstrate that Ser-170 and to some extent Ser-147 are involved in the Ca2+ activation of the CaR, and taken together, our results reveal a close resemblance of the activation mechanism between the CaR and the mGlu receptors...
  5. pmc Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells
    H Brauner-Osborne
    NeuroScience PharmaBiotec Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 128:1370-4. 1999
    ..Finally, we can conclude that the functional pharmacological profiles of the two GABABR1 splice variants are very similar...
  6. ncbi request reprint Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
    U Madsen
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Med Chem 44:1051-9. 2001
    ..Compounds 9 and 11 were resolved using chiral HPLC, and the configurational assignments of the enantiomers were based on X-ray crystallographic analyses...
  7. ncbi request reprint New analogues of ACPD with selective activity for group II metabotropic glutamate receptors
    H Brauner-Osborne
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Denmark
    Eur J Pharmacol 332:327-31. 1997
    ..These homo-ACPD's show a higher degree of subtype selectivity than the parent compound (1SR,3RS)-ACPD. In addition none of the compounds demonstrated any activity at ionotropic Glu receptors...
  8. ncbi request reprint Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid
    U Madsen
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Bioorg Med Chem Lett 8:1563-8. 1998
    ..Molecular mechanics calculations have been performed on Ibo, 1a-c and the potent NMDA agonist 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid (AMAA) in order to elucidate the observed structure-activity data...
  9. pmc Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations
    B Christiansen
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
    Br J Pharmacol 150:798-807. 2007
    ..The aim of this study was thus to develop such an assay and extend the pharmacological characterization of GPRC6A...
  10. pmc Molecular basis for amino acid sensing by family C G-protein-coupled receptors
    P Wellendorph
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Br J Pharmacol 156:869-84. 2009
    ....