H Brauner-Osborne

Summary

Affiliation: The Royal Danish School of Pharmacy
Country: Denmark

Publications

  1. ncbi Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medical Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, Copenhagen, DK 2100, Denmark
    Genomics 65:121-8. 2000
  2. ncbi A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Center, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100, Copenhagen, Denmark
    Eur J Pharmacol 406:41-4. 2000
  3. ncbi Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medicinal Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1518:237-48. 2001
  4. ncbi The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
    H Brauner-Osborne
    Department of Medicinal Chemistry, NeuroScience PharmaBiotec Research Centre, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Biol Chem 274:18382-6. 1999
  5. ncbi Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
    U Madsen
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Med Chem 44:1051-9. 2001
  6. ncbi Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells
    H Brauner-Osborne
    NeuroScience PharmaBiotec Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 128:1370-4. 1999
  7. ncbi New analogues of ACPD with selective activity for group II metabotropic glutamate receptors
    H Brauner-Osborne
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Denmark
    Eur J Pharmacol 332:327-31. 1997
  8. ncbi Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid
    U Madsen
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Bioorg Med Chem Lett 8:1563-8. 1998
  9. ncbi Molecular basis for amino acid sensing by family C G-protein-coupled receptors
    P Wellendorph
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Br J Pharmacol 156:869-84. 2009

Detail Information

Publications9

  1. ncbi Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medical Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, Copenhagen, DK 2100, Denmark
    Genomics 65:121-8. 2000
    ..This mRNA expression pattern is markedly different from that of RAIG1, which shows a slightly more restricted expression pattern with highest abundance in lung tissue...
  2. ncbi A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Center, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100, Copenhagen, Denmark
    Eur J Pharmacol 406:41-4. 2000
    ..S)-TDPA thus represents a new structural class of EAAT2 inhibitor that will serve as a lead for the design of EAAT selective inhibitors...
  3. ncbi Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
    H Brauner-Osborne
    NeuroScience PharmaBiotec Research Centre, Department of Medicinal Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1518:237-48. 2001
    ....
  4. ncbi The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
    H Brauner-Osborne
    Department of Medicinal Chemistry, NeuroScience PharmaBiotec Research Centre, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Biol Chem 274:18382-6. 1999
    ..These data demonstrate that Ser-170 and to some extent Ser-147 are involved in the Ca2+ activation of the CaR, and taken together, our results reveal a close resemblance of the activation mechanism between the CaR and the mGlu receptors...
  5. ncbi Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
    U Madsen
    Centre for Drug Design and Transport, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Med Chem 44:1051-9. 2001
    ..Compounds 9 and 11 were resolved using chiral HPLC, and the configurational assignments of the enantiomers were based on X-ray crystallographic analyses...
  6. ncbi Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells
    H Brauner-Osborne
    NeuroScience PharmaBiotec Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Br J Pharmacol 128:1370-4. 1999
    ..Finally, we can conclude that the functional pharmacological profiles of the two GABABR1 splice variants are very similar...
  7. ncbi New analogues of ACPD with selective activity for group II metabotropic glutamate receptors
    H Brauner-Osborne
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Denmark
    Eur J Pharmacol 332:327-31. 1997
    ..These homo-ACPD's show a higher degree of subtype selectivity than the parent compound (1SR,3RS)-ACPD. In addition none of the compounds demonstrated any activity at ionotropic Glu receptors...
  8. ncbi Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid
    U Madsen
    Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Bioorg Med Chem Lett 8:1563-8. 1998
    ..Molecular mechanics calculations have been performed on Ibo, 1a-c and the potent NMDA agonist 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid (AMAA) in order to elucidate the observed structure-activity data...
  9. ncbi Molecular basis for amino acid sensing by family C G-protein-coupled receptors
    P Wellendorph
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Br J Pharmacol 156:869-84. 2009
    ....