Søren Molin

Summary

Affiliation: Technical University of Denmark
Country: Denmark

Publications

  1. pmc Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology, Shanghai Medical School of Fudan University, Shanghai, PR China
    BMC Microbiol 6:96. 2006
  2. ncbi request reprint Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure
    Søren Molin
    Molecular Microbial Ecology Group, BioCentrum DTU, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    Curr Opin Biotechnol 14:255-61. 2003
  3. doi request reprint Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts
    Martin Holm Rau
    Department of Systems Biology, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    Environ Microbiol 12:1643-58. 2010
  4. pmc Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
    Susse Kirkelund Hansen
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    ISME J 6:31-45. 2012
  5. pmc Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts
    Søren Damkiær
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 110:7766-71. 2013
  6. pmc Evolutionary dynamics of bacteria in a human host environment
    Lei Yang
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 108:7481-6. 2011
  7. doi request reprint Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
    Anders Folkesson
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Nat Rev Microbiol 10:841-51. 2012
  8. pmc Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data
    Lei Yang
    Department of Systems Biology, Technical University of Denmark, DK 2800, Lyngby, Denmark
    BMC Microbiol 11:184. 2011
  9. pmc Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6
    Susse Kirkelund Hansen
    Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:4932-43. 2007
  10. pmc Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa
    Rasmus Lykke Marvig
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Antimicrob Agents Chemother 56:4519-21. 2012

Collaborators

Detail Information

Publications36

  1. pmc Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology, Shanghai Medical School of Fudan University, Shanghai, PR China
    BMC Microbiol 6:96. 2006
    ..It has an urgent need to design novel antibiotics against staphylococci infections, especially those can kill cells embedded in biofilm...
  2. ncbi request reprint Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure
    Søren Molin
    Molecular Microbial Ecology Group, BioCentrum DTU, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    Curr Opin Biotechnol 14:255-61. 2003
    ..Both of these gene-transfer mechanisms may be autocatalytically promoted in biofilms, presenting new possibilities for efficient bio-enhancement strategies...
  3. doi request reprint Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts
    Martin Holm Rau
    Department of Systems Biology, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    Environ Microbiol 12:1643-58. 2010
    ..In the overall perspective the global phenotype of the adapted variants appears to place them on paths in direction of fully adapted strains residing in long-term chronically infected patients...
  4. pmc Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection
    Susse Kirkelund Hansen
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    ISME J 6:31-45. 2012
    ..Thus, the paranasal sinuses potentially constitute a protected niche of adapted clones of P. aeruginosa, which can intermittently seed the lungs and pave the way for subsequent chronic lung infections...
  5. pmc Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts
    Søren Damkiær
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 110:7766-71. 2013
    ....
  6. pmc Evolutionary dynamics of bacteria in a human host environment
    Lei Yang
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 108:7481-6. 2011
    ..The evolved phenotype of the infecting bacteria further suggests that the opportunistic pathogen has transitioned to become a primary pathogen for cystic fibrosis patients...
  7. doi request reprint Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
    Anders Folkesson
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Nat Rev Microbiol 10:841-51. 2012
    ..We believe that such studies are valuable not only for our understanding of bacterial evolution but also for the future development of new therapeutic strategies to treat severe chronic infections...
  8. pmc Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data
    Lei Yang
    Department of Systems Biology, Technical University of Denmark, DK 2800, Lyngby, Denmark
    BMC Microbiol 11:184. 2011
    ..However, exploitation of the complex, noisy and high-dimensional transcriptomic dataset is difficult and often hindered by low statistical power...
  9. pmc Characterization of a Pseudomonas putida rough variant evolved in a mixed-species biofilm with Acinetobacter sp. strain C6
    Susse Kirkelund Hansen
    Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:4932-43. 2007
    ..The resulting phenotypic characteristics of the P. putida rough variant explain its enhanced fitness and ability to form tight structural associations with Acinetobacter microcolonies...
  10. pmc Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa
    Rasmus Lykke Marvig
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Antimicrob Agents Chemother 56:4519-21. 2012
    ....
  11. pmc In situ growth rates and biofilm development of Pseudomonas aeruginosa populations in chronic lung infections
    Lei Yang
    Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    J Bacteriol 190:2767-76. 2008
    ..This scenario constitutes a new perspective on the adaptation and evolution of P. aeruginosa during chronic infections in CF patients in particular and on long-term infections in general...
  12. pmc Biofilm induced tolerance towards antimicrobial peptides
    Anders Folkesson
    Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e1891. 2008
    ....
  13. doi request reprint Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa
    Liang Yang
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    FEMS Immunol Med Microbiol 65:366-76. 2012
    ..aeruginosa biofilm structure maintenance and phagocytosis resistance. The polysaccharides were further found to protect mucoid P. aeruginosa strain from host immune clearance in a mouse model of acute lung infection...
  14. doi request reprint A Mig-14-like protein (PA5003) affects antimicrobial peptide recognition in Pseudomonas aeruginosa
    Nicholas Jochumsen
    Center for Systems Microbiology, DTU Systems Biology, Building 301, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 157:2647-57. 2011
    ..aeruginosa. Moreover, we show that this gene is also required for the formation of CAMP-tolerant subpopulations in P. aeruginosa hydrodynamic flow chamber biofilms...
  15. doi request reprint Combating biofilms
    Liang Yang
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    FEMS Immunol Med Microbiol 65:146-57. 2012
    ....
  16. doi request reprint Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa
    Liang Yang
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    FEMS Immunol Med Microbiol 62:339-47. 2011
    ..aeruginosa type IV pili are required for this process, probably through their ability to bind to eDNA. Furthermore, P. aeruginosa is able to protect S. aureus against Dictyostelium discoideum phagocytosis in co-culture biofilms...
  17. doi request reprint Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development
    Liang Yang
    Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Environ Microbiol 13:1705-17. 2011
    ..Psl polysaccharide is more important than Pel polysaccharide in P. aeruginosa PAO1 biofilm formation and antibiotic resistance. Our study thus suggests that different EPS materials play distinct roles during bacterial biofilm formation...
  18. doi request reprint High in vitro antimicrobial activity of β-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
    Yang Liu
    Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    Int J Antimicrob Agents 41:20-7. 2013
    ..This class of peptidomimetics may constitute promising antimicrobial alternatives for the prevention and treatment of multidrug-resistant S. epidermidis infections...
  19. doi request reprint Deletion and acquisition of genomic content during early stage adaptation of Pseudomonas aeruginosa to a human host environment
    Martin H Rau
    Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Environ Microbiol 14:2200-11. 2012
    ..Finally, we also describe the complete genome of this highly adapted pathogenic strain of P.aeruginosa to strengthen the genetic basis, which serves to help our understanding of microbial evolution in a natural environment...
  20. doi request reprint Effects of colistin on surface ultrastructure and nanomechanics of Pseudomonas aeruginosa cells
    Ninell P Mortensen
    Danish Polymer Centre, Risoe National Laboratory, Technical University of Denmark, DK 4000 Roskilde, Denmark
    Langmuir 25:3728-33. 2009
    ....
  21. pmc Current understanding of multi-species biofilms
    Liang Yang
    Department of Systems Biology, Technical University of Denmark, Lyngby, DK 2800, Denmark
    Int J Oral Sci 3:74-81. 2011
    ..The most recent advances in the understanding of multi-species biofilms are summarized and discussed in the review...
  22. doi request reprint Microbial ecology and adaptation in cystic fibrosis airways
    Lei Yang
    Department of Systems Biology, DTU, 2800 Lyngby, Denmark
    Environ Microbiol 13:1682-9. 2011
    ..Understanding the persistent colonization of microbial pathogens in CF patients in the context of ecology and evolution will expand our knowledge of the pathogenesis of chronic infections and improve therapeutic strategies...
  23. doi request reprint Adhesive properties of Staphylococcus epidermidis probed by atomic force microscopy
    Yifan Hu
    Department of Chemistry, DTU Chemistry, Building 207, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Phys Chem Chem Phys 13:9995-10003. 2011
    ..Treatment of two biofilm positive strains with two chemical inhibitor compounds leads to a loss of adhesion, suggesting that AFM could be a valuable tool to screen for anti-adhesion molecules...
  24. doi request reprint Microfluidic dissolved oxygen gradient generator biochip as a useful tool in bacterial biofilm studies
    Maciej Skolimowski
    Technical University of Denmark, Department of Micro and Nanotechnology, Ørsted Plads, Building 345east, DK 2800, Kgs Lyngby, Denmark
    Lab Chip 10:2162-9. 2010
    ..This demonstrates that the device can be used for studies requiring controlled oxygen levels and for future studies of microaerobic and anaerobic conditions...
  25. pmc Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation
    Yang Liu
    Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Antimicrob Agents Chemother 54:3960-3. 2010
    ..All of the tested iron chelators synergistically inhibited P. aeruginosa growth and biofilm formation with PAbetaN. PAbetaN-EDTA showed the most promising activity against P. aeruginosa growth and biofilm formation...
  26. ncbi request reprint Contribution of alginate and levan production to biofilm formation by Pseudomonas syringae
    Heike Laue
    Molecular Microbial Ecology Group, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 152:2909-18. 2006
    ..syringae derivatives. Production of the as yet uncharacterized additional EPS might be more important for biofilm formation than the syntheses of levan and alginate...
  27. doi request reprint Evaluation of enoyl-acyl carrier protein reductase inhibitors as Pseudomonas aeruginosa quorum-quenching reagents
    Liang Yang
    Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, 2800, Denmark
    Molecules 15:780-92. 2010
    ..aeruginosa and is an efficient quorum-quenching reagent. EGCG treatment was further shown to be able to attenuate the production of virulence factors and biofilm formation of P. aeruginosa...
  28. pmc In vitro biofilm formation of commensal and pathogenic Escherichia coli strains: impact of environmental and genetic factors
    Andreas Reisner
    Molecular Microbial Ecology Group, Center for Biomedical Microbiology, BioCentrum DTU, Technical University of Denmark, Lyngby
    J Bacteriol 188:3572-81. 2006
    ..coli isolates in vitro. This study highlights the complexity of genetic and environmental effectors of the biofilm phenotype within the species E. coli...
  29. pmc Differentiation and distribution of colistin- and sodium dodecyl sulfate-tolerant cells in Pseudomonas aeruginosa biofilms
    Janus A J Haagensen
    Center for Biomedical Microbiology, BioCentrum DTU, Building 301, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Bacteriol 189:28-37. 2007
    ..These results suggest that increased antibiotic tolerance in biofilms may be a consequence of differentiation into distinct subpopulations with different phenotypic properties...
  30. pmc Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators
    Rasmus Lykke Marvig
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS Genet 9:e1003741. 2013
    ..This homopolymer facilitated differential mutagenesis provides a novel genome-wide perspective on the different evolutionary trajectories of hypermutators, which may help explain their emergence in CF infections. ..
  31. ncbi request reprint Evolution of species interactions in a biofilm community
    Susse Kirkelund Hansen
    Infection Microbiology Group, BioCentrum DTU, The Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
    Nature 445:533-6. 2007
    ..Our results show that evolution in a spatially structured environment can stabilize interactions between species, provoke marked changes in their symbiotic nature and affect community function...
  32. doi request reprint Organic compounds inhibiting S. epidermidis adhesion and biofilm formation
    Zhiqiang Qin
    Department of Systems Biology, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Ultramicroscopy 109:881-8. 2009
    ..These results suggest a pretreatment for medically implanted surfaces that can prevent the biofilm formation and reduce infection...
  33. doi request reprint Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa
    María Gómez-Lozano
    Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Environ Microbiol 14:2006-16. 2012
    ..We anticipate that the data will be useful for the study of regulatory sRNAs in bacteria and that the approach described here may be applied to identify sRNAs in any bacterium under different growth and stress conditions...
  34. ncbi request reprint Mini-Tn7 transposons for site-specific tagging of bacteria with fluorescent proteins
    Lotte Lambertsen
    Molecular Microbial Ecology Group, Centre for Biomedical Microbiology, BioCentrum DTU, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Environ Microbiol 6:726-32. 2004
    ..Successful and site-specific tagging was verified by Southern blots as well as by PCR. Furthermore, the effect of fluorescent protein expression on the cellular growth rate was tested by growth competition assays...
  35. ncbi request reprint Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms
    Mikkel Klausen
    Molecular Microbial Ecology Group, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Mol Microbiol 50:61-8. 2003
    ..The migrating bacteria form the mushroom caps by climbing the stalks and aggregating on the tops in a process which is driven by type-IV pili. These results lead to a new model for biofilm formation by P. aeruginosa...
  36. pmc Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients
    Lars Jelsbak
    Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, Building 301, 2800 Lyngby, Denmark
    Infect Immun 75:2214-24. 2007
    ..These findings suggest that hitherto-unrecognized evolutionary pathways may be involved in the development of successful and persistent P. aeruginosa colonizers of CF patient lungs...