Thomas Grotkjaer

Summary

Affiliation: Technical University of Denmark
Country: Denmark

Publications

  1. ncbi request reprint Robust multi-scale clustering of large DNA microarray datasets with the consensus algorithm
    Thomas Grotkjaer
    Center for Microbial Biotechnology BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Bioinformatics 22:58-67. 2006
  2. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
  3. doi request reprint Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 11:31-9. 2009
  4. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
  5. ncbi request reprint Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose
    Gianni Panagiotou
    Center for Microbial Biotechnology, Technical University of Denmark, BioCentrum DTU, Building 223, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 8:474-82. 2006
  6. pmc Global transcriptional and physiological responses of Saccharomyces cerevisiae to ammonium, L-alanine, or L-glutamine limitation
    Renata Usaite
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800 Kgs Lyngby, Denmark
    Appl Environ Microbiol 72:6194-203. 2006
  7. ncbi request reprint Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains
    Thomas Grotkjaer
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 7:437-44. 2005
  8. ncbi request reprint Impact of transamination reactions and protein turnover on labeling dynamics in (13)C-labeling experiments
    Thomas Grotkjaer
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800 Kgs Lyngby, Denmark
    Biotechnol Bioeng 86:209-16. 2004
  9. pmc Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae
    Birgitte Regenberg
    Institut für Molekulare Biowissenschaften, Johann Wolfgang Goethe Universitat, Max von Laue Str, 9, 60438 Frankfurt am Main, Germany
    Genome Biol 7:R107. 2006

Detail Information

Publications9

  1. ncbi request reprint Robust multi-scale clustering of large DNA microarray datasets with the consensus algorithm
    Thomas Grotkjaer
    Center for Microbial Biotechnology BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Bioinformatics 22:58-67. 2006
    ..The algorithm preserves valuable properties of hierarchical clustering, which is useful for visualization and interpretation of the results...
  2. pmc Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Appl Environ Microbiol 75:2212-20. 2009
    ....
  3. doi request reprint Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 11:31-9. 2009
    ..This conclusion may impact the design of new strains capable of generating reducing power in the form of NADPH, which is crucial for efficient production of many industrially important metabolites and enzymes...
  4. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
    ..niger and A. oryzae. Here we identified the gene coding for a novel metabolic pathway in A. nidulans, namely the phosphoketolase pathway, and investigated the role of an increased phosphoketolase activity...
  5. ncbi request reprint Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose
    Gianni Panagiotou
    Center for Microbial Biotechnology, Technical University of Denmark, BioCentrum DTU, Building 223, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 8:474-82. 2006
    ..It was demonstrated that dissimilatory nitrate reduction allows F. oxysporum to exhibit typical respiratory metabolic behaviour with a highly active TCA cycle and a large demand for NADPH...
  6. pmc Global transcriptional and physiological responses of Saccharomyces cerevisiae to ammonium, L-alanine, or L-glutamine limitation
    Renata Usaite
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800 Kgs Lyngby, Denmark
    Appl Environ Microbiol 72:6194-203. 2006
    ..In conclusion, our results reveal that the nitrogen source has substantial influence on the transcriptome of yeasts and that transcriptional changes may be correlated to physiology via a metabolic model...
  7. ncbi request reprint Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains
    Thomas Grotkjaer
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 7:437-44. 2005
    ..CR4. Furthermore, the analysis indicated that the glyoxylate cycle was activated in CPB.CR4...
  8. ncbi request reprint Impact of transamination reactions and protein turnover on labeling dynamics in (13)C-labeling experiments
    Thomas Grotkjaer
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Building 223, DK 2800 Kgs Lyngby, Denmark
    Biotechnol Bioeng 86:209-16. 2004
    ..These observations suggest that greater caution should be used while also pointing to new opportunities in the design and interpretation of (13)C-labeling experiments...
  9. pmc Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae
    Birgitte Regenberg
    Institut für Molekulare Biowissenschaften, Johann Wolfgang Goethe Universitat, Max von Laue Str, 9, 60438 Frankfurt am Main, Germany
    Genome Biol 7:R107. 2006
    ..We used continuous cultures to control growth rate and studied the transcriptional program of the model eukaryote Saccharomyces cerevisiae, with generation times varying between 2 and 35 hours...