Thomas Sparsø

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. doi Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 52:1308-14. 2009
  2. ncbi Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
    Thomas Sparsø
    Steno Diabetes Center, 521, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 90:205-9. 2007
  3. pmc G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans
    Thomas Sparsø
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1450-6. 2009
  4. ncbi Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 51:1646-52. 2008
  5. ncbi The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Diabetologia 51:70-5. 2008
  6. ncbi Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
  7. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
  8. ncbi Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
    Kristoffer Sølvsten Burgdorf
    Hagedorn Research Institute, Niels Steensens Vej 1, NLD 2 13, 2820 Gentofte, Copenhagen, Denmark
    Eur J Endocrinol 163:81-7. 2010
  9. pmc Combined analyses of 20 common obesity susceptibility variants
    Camilla Helene Sandholt
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1667-73. 2010
  10. doi Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    Marie N Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E801-6. 2013

Detail Information

Publications16

  1. doi Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 52:1308-14. 2009
    ....
  2. ncbi Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
    Thomas Sparsø
    Steno Diabetes Center, 521, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 90:205-9. 2007
    ..If replicated, the Val162Val variant may, however, confer an increase in fasting levels of serum lipids...
  3. pmc G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans
    Thomas Sparsø
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1450-6. 2009
    ....
  4. ncbi Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 51:1646-52. 2008
    ..Recently, variants in WFS1 have been shown to be associated with type 2 diabetes. We aimed to examine metabolic risk phenotypes of WFS1 variants in glucose-tolerant people and in individuals with abnormal glucose regulation...
  5. ncbi The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Diabetologia 51:70-5. 2008
    ..Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function...
  6. ncbi Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
    ....
  7. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
    ..The aims of this study were to evaluate whether nonsynonymous variants in MTNR1B associate with monogenic forms of hyperglycemia, type 2 diabetes, or related metabolic traits...
  8. ncbi Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
    Kristoffer Sølvsten Burgdorf
    Hagedorn Research Institute, Niels Steensens Vej 1, NLD 2 13, 2820 Gentofte, Copenhagen, Denmark
    Eur J Endocrinol 163:81-7. 2010
    ..Our aim was to validate the reported findings in the Danish population...
  9. pmc Combined analyses of 20 common obesity susceptibility variants
    Camilla Helene Sandholt
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1667-73. 2010
    ..Genome-wide association studies and linkage studies have identified 20 validated genetic variants associated with obesity and/or related phenotypes. The variants are common, and they individually exhibit small-to-modest effect sizes...
  10. doi Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    Marie N Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E801-6. 2013
    ....
  11. pmc No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes
    Anette P Gjesing
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 4:e7206. 2009
    ..The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults...
  12. ncbi Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
    ....
  13. ncbi AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820 Gentofte, Denmark
    Diabetes 57:1427-32. 2008
    ..We related seven frequent AHSG tag single nucleotide polymorphisms to a range of metabolic traits, including type 2 diabetes, obesity, and dyslipidemia...
  14. pmc The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
    Karina Banasik
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Denmark
    BMC Med Genet 13:10. 2012
    ..Secondly, we investigated whether rs1205923 in FOXA2 associated with other glucose-related phenotypes...
  15. pmc Physiologic characterization of type 2 diabetes-related loci
    Niels Grarup
    Diabetes Genetics, Hagedorn Research Institute, Gentofte, Denmark
    Curr Diab Rep 10:485-97. 2010
    ....
  16. pmc Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
    Niels Grarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 9:e1003530. 2013
    ..Yet, the study demonstrates the value of combining whole genome and exome sequencing approaches to ascertain the genetic and molecular architectures underlying quantitative trait associations...