Thomas R Mandrup-Poulsen

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi [Auto-antibodies against glutamic acid decarboxylase and diabetes]
    Thomas R Mandrup-Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 169:300-4. 2007
  2. pmc Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
    Lars G Grunnet
    Department of Translational Diabetology, Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1807-15. 2009
  3. ncbi Apoptotic signal transduction pathways in diabetes
    Thomas Mandrup-Poulsen
    Steno Diabetes Center, 2 Niels Steensens Vej, DK 2820 Gentofte, Denmark
    Biochem Pharmacol 66:1433-40. 2003
  4. ncbi Beta cell death and protection
    Thomas Mandrup-Poulsen
    Steno Diabetes Center, Gentofte, Denmark
    Ann N Y Acad Sci 1005:32-42. 2003
  5. ncbi [Treatment of diabetes mellitus with biologic therapeutics]
    Claus Morten Larsen
    Naestved Sygehus, Medicinsk afdeling, Naestved
    Ugeskr Laeger 170:2134-7. 2008
  6. ncbi Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells
    Joachim Størling
    Laboratory for Beta Cell Biology, Steno Diabetes Center, Niels Steensensvej 8, NSPP, DK 2820 Gentofte, Denmark
    Endocrinology 146:3026-36. 2005
  7. ncbi Type 1 database mellitus: an inflammatory disease of the islet
    Regine Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Adv Exp Med Biol 552:129-53. 2004
  8. ncbi [Type 1 diabetes mellitus--an infectious disease?]
    Thomas R Mandrup-Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:5936-40. 2002
  9. ncbi Interleukin-6 and diabetes: the good, the bad, or the indifferent?
    Ole P Kristiansen
    Steno Diabetes Center, 2 Niels Steensens Vej, DK 2820 Gentofte, Denmark
    Diabetes 54:S114-24. 2005
  10. ncbi Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
    Helle Frobøse
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Endocrinol 20:1587-96. 2006

Collaborators

Detail Information

Publications18

  1. ncbi [Auto-antibodies against glutamic acid decarboxylase and diabetes]
    Thomas R Mandrup-Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 169:300-4. 2007
    ..It is recommended that demonstration of GAD auto-antibodies leads to diagnosis, classification or re-classification of diabetes patients as immune mediated type 1 diabetes...
  2. pmc Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
    Lars G Grunnet
    Department of Translational Diabetology, Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1807-15. 2009
    ..Here, cytokine activation of the intrinsic apoptotic pathway and the role of the two proapoptotic Bcl-2 proteins, Bad and Bax, were examined in beta-cells...
  3. ncbi Apoptotic signal transduction pathways in diabetes
    Thomas Mandrup-Poulsen
    Steno Diabetes Center, 2 Niels Steensens Vej, DK 2820 Gentofte, Denmark
    Biochem Pharmacol 66:1433-40. 2003
    ..We hypothesize that immunological stimuli in type 1 diabetes and metabolic/inflammatory signals in type 2 diabetes converge on common signalling pathways leading to beta-cell failure and destruction in these two diseases...
  4. ncbi Beta cell death and protection
    Thomas Mandrup-Poulsen
    Steno Diabetes Center, Gentofte, Denmark
    Ann N Y Acad Sci 1005:32-42. 2003
    ..Proinflammatory cytokines, reactive oxygen species, and other immune mediators seem to be involved in beta cell destruction, but much is to be learned about signaling, molecular mechanisms, and in vivo importance...
  5. ncbi [Treatment of diabetes mellitus with biologic therapeutics]
    Claus Morten Larsen
    Naestved Sygehus, Medicinsk afdeling, Naestved
    Ugeskr Laeger 170:2134-7. 2008
    ..This article summarizes the causal steps of the pathogenesis of type 1 and type 2 diabetes which are targeted by biologic therapeutics and reviews the treatment results...
  6. ncbi Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells
    Joachim Størling
    Laboratory for Beta Cell Biology, Steno Diabetes Center, Niels Steensensvej 8, NSPP, DK 2820 Gentofte, Denmark
    Endocrinology 146:3026-36. 2005
    ..Our data suggest that Ca(2+) plays a permissive role in IL-1beta activation of the JNK signaling pathway in insulin-secreting cells...
  7. ncbi Type 1 database mellitus: an inflammatory disease of the islet
    Regine Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Adv Exp Med Biol 552:129-53. 2004
  8. ncbi [Type 1 diabetes mellitus--an infectious disease?]
    Thomas R Mandrup-Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte
    Ugeskr Laeger 164:5936-40. 2002
    ..There is a need for confirmatory investigations of these observations especially with regard to demonstration of viral genome...
  9. ncbi Interleukin-6 and diabetes: the good, the bad, or the indifferent?
    Ole P Kristiansen
    Steno Diabetes Center, 2 Niels Steensens Vej, DK 2820 Gentofte, Denmark
    Diabetes 54:S114-24. 2005
    ..Thus, the two types of diabetes are also in this respect less apart than apparent. However, the mechanisms are not clear, and we therefore propose future directions for studies in this field...
  10. ncbi Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
    Helle Frobøse
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Endocrinol 20:1587-96. 2006
    ..These results indicate that SOCS-3 inhibits IL-1 signal transduction by inhibiting ubiquitination of TRAF6, thus preventing association and activation of TAK1...
  11. doi The anti-interleukin-1 in type 1 diabetes action trial--background and rationale
    Linda M S Pickersgill
    Steno Diabetes Center and Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Diabetes Metab Res Rev 25:321-4. 2009
    ....
  12. ncbi Antitumorigenic effect of proteasome inhibitors on insulinoma cells
    Joachim Størling
    DMSc, Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Endocrinology 146:1718-26. 2005
    ..Our findings demonstrate that proteasome inhibitors possess antitumorigenic and antiinsulinogenic effects on insulinoma cells...
  13. ncbi Interleukin-1-receptor antagonist in type 2 diabetes mellitus
    Claus M Larsen
    Steno Diabetes Center, Gentofte, Denmark
    N Engl J Med 356:1517-26. 2007
    ....
  14. ncbi Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
    Ole P Kristiansen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Hum Mol Genet 12:1101-10. 2003
    ..In conclusion, higher IL6 promoter activity may confer risk to T1DM in very young females. This excess risk is negated with increasing age, possibly by the increasing E(2) levels in puberty...
  15. ncbi Diabetes and suppressors of cytokine signaling proteins
    Sif G Rønn
    Steno Diabetes Center, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Diabetes 56:541-8. 2007
  16. ncbi Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene
    Runa L Nolsøe
    Steno Diabetes Center, Gentofte, Denmark
    Ann N Y Acad Sci 1005:332-9. 2003
    ..However, none of these were frequent enough to permit association studies in T1DM and we conclude that IL18BP does not contribute to the overall genetic susceptibility to type 1 diabetes...
  17. ncbi [European Nicotinamide Diabetes Intervention Trial (ENDIT)--secondary publication. A randomized, placebo-controlled trial of intervention before the onset of type 1 diabetes]
    Jesper I Reimers
    Afdelingen for Molekylaer Medicin, Steno Diabetes Center, Gentofte
    Ugeskr Laeger 167:293-6. 2005
  18. ncbi [Pregnancy in women with type 2 diabetes]
    Peter Damm
    Obstetrisk Klinik, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 164:2145-6. 2002