Torben Hansen

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi request reprint The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance
    Torben Hansen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 30:257-62. 2007
  2. ncbi request reprint Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population
    S K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark
    Diabetologia 48:452-8. 2005
  3. ncbi request reprint [Genetics in non-autoimmune diabetes. The Danish Society of Endocrinology]
    Torben Hansen
    Steno Diabetes Center, DK 2820 Gentofte
    Ugeskr Laeger 170:1021. 2008
  4. pmc Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
    Camilla Helene Andreasen
    Steno Diabetes Center, 2820 Gentofte, Denmark
    BMC Med Genet 9:118. 2008
  5. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
  6. doi request reprint The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
  7. pmc The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation
    Nikolaj Thure Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e40376. 2012
  8. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
  9. pmc Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
    Dorit P Zobel
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:757-64. 2009
  10. pmc Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue
    Louise G Grunnet
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:2402-8. 2009

Collaborators

Detail Information

Publications67

  1. ncbi request reprint The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance
    Torben Hansen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 30:257-62. 2007
    ....
  2. ncbi request reprint Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population
    S K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark
    Diabetologia 48:452-8. 2005
    ....
  3. ncbi request reprint [Genetics in non-autoimmune diabetes. The Danish Society of Endocrinology]
    Torben Hansen
    Steno Diabetes Center, DK 2820 Gentofte
    Ugeskr Laeger 170:1021. 2008
  4. pmc Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits
    Camilla Helene Andreasen
    Steno Diabetes Center, 2820 Gentofte, Denmark
    BMC Med Genet 9:118. 2008
    ..Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity...
  5. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
    ..The aim of the present study was to investigate the putative association between SNPs and haplotype blocks of CHI3LI and T2D and T2D related quantitative traits...
  6. doi request reprint The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
    ..Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein...
  7. pmc The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation
    Nikolaj Thure Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e40376. 2012
    ..We aimed at studying the potential impact of the NAFLD-associated PNPLA3 rs738409 G-allele on NAFLD-related metabolic traits in hyperglycaemic individuals...
  8. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
    ..The aims of this study were to evaluate whether nonsynonymous variants in MTNR1B associate with monogenic forms of hyperglycemia, type 2 diabetes, or related metabolic traits...
  9. pmc Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
    Dorit P Zobel
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:757-64. 2009
    ..We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals...
  10. pmc Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue
    Louise G Grunnet
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:2402-8. 2009
    ..We investigated the genetic and nongenetic regulation of FTO mRNA in skeletal muscle and adipose tissue and their influence on in vivo glucose and fat metabolism...
  11. ncbi request reprint The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820, Gentofte, Denmark
    J Mol Med (Berl) 85:445-9. 2007
    ..In conclusion, in a large study sample, we were unable to find robust evidence of an association of the Pro129Thr FAAH variant with overweight, obesity, and any related quantitative traits among the examined whites...
  12. ncbi request reprint A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
    Christian S Rose
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Diabetes 54:3026-31. 2005
    ..17-2.24]). In conclusion, the GCK -30G>A polymorphism associates with elevated fasting and post-OGTT glycemia in the middle-aged general population of whites, as well as with IGR and other features of the WHO-defined metabolic syndrome...
  13. ncbi request reprint Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
    ....
  14. ncbi request reprint Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    ..In the present study, the effect of FTO variation on metabolic traits including obesity, type 2 diabetes, and related quantitative phenotypes was examined...
  15. doi request reprint Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes
    Dorit P Zobel
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Eur J Endocrinol 160:603-9. 2009
    ....
  16. doi request reprint Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype
    Sofia Inez Iqbal Kring
    Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    Obes Facts 1:138-45. 2008
    ..In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort...
  17. pmc Combined analyses of 20 common obesity susceptibility variants
    Camilla Helene Sandholt
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1667-73. 2010
    ..Genome-wide association studies and linkage studies have identified 20 validated genetic variants associated with obesity and/or related phenotypes. The variants are common, and they individually exhibit small-to-modest effect sizes...
  18. ncbi request reprint Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites
    Dorit P Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Copenhagen, Denmark
    Mol Genet Metab 89:360-7. 2006
    ....
  19. doi request reprint Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
    Kristoffer Sølvsten Burgdorf
    Hagedorn Research Institute, Niels Steensens Vej 1, NLD 2 13, 2820 Gentofte, Copenhagen, Denmark
    Eur J Endocrinol 163:81-7. 2010
    ..Our aim was to validate the reported findings in the Danish population...
  20. doi request reprint The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins
    Karina Banasik
    Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Clin Endocrinol Metab 96:E119-24. 2011
    ..We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G-allele...
  21. ncbi request reprint Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
    ..In conclusion, the Leu162Val polymorphism of PPARalpha is associated with a decreased level of fasting serum triglyceride in glucose tolerant white subjects...
  22. pmc Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
    Camilla H Andreasen
    Steno Diabetes Center, Copenhagen, Denmark
    PLoS ONE 3:e2872. 2008
    ..We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors...
  23. pmc No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes
    Anette P Gjesing
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 4:e7206. 2009
    ..The aim of the present study was therefore to evaluate if variations within ADRB2 as haplotypes or as haplotype combinations confer an increased prevalence of obesity and hypertension among adults...
  24. ncbi request reprint Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
    ....
  25. doi request reprint Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
    ..Due to the previous inconclusive quantitative trait associations, we also did studies of intermediate quantitative phenotypes...
  26. pmc Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes
    Camilla Helene Andreasen
    Steno Diabetes Center, Gentofte, Denmark
    BMC Med Genet 10:17. 2009
    ..The aim of this study was to investigate the impact of these three variants on obesity, through analyses of obesity-related quantitative traits, and case-control studies in large study samples of Danes...
  27. pmc The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status
    Anette P Gjesing
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 6:e23907. 2011
    ..Data were included in meta-analyses of additional Europeans...
  28. doi request reprint The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes
    Trine Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    J Hypertens 26:2142-6. 2008
    ..The previous studies have, however, been conflicting, and the aim of the present study was to clarify the impact of the Glu65Lys polymorphism on hypertension at the population level of middle-aged people...
  29. doi request reprint Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609
    Louise G Grunnet
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 94:596-602. 2009
    ..We studied the role of the A-allele in the regulation of peripheral organ functions involved in the pathogenesis of obesity and type 2 diabetes...
  30. pmc Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men
    Esther Zimmermann
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 4:e4428. 2009
    ..The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness...
  31. ncbi request reprint Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3629-37. 2005
    ..In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes...
  32. pmc FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness
    Sofia I I Kring
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 3:e2958. 2008
    ..We investigated the association of this SNP with abdominal and peripheral fatness and obesity-related metabolic traits in middle-aged men through a broad range of fatness present already in adolescence...
  33. ncbi request reprint Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    J Mol Med (Berl) 83:353-61. 2005
    ..02) and altered fasting plasma glucose (P=0.03). However, these later findings could not be replicated in additional studies. In conclusion, variants in CDKN1C may contribute to the inter-individual variation in birth weight...
  34. pmc The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge
    Ehm A Andersson
    Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e27096. 2011
    ....
  35. pmc The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
    Johan Holmkvist
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 4:e5872. 2009
    ..The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and rs2237897) on estimates of glucose stimulated insulin release...
  36. ncbi request reprint The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 6, NSK1 14, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3054-9. 2005
    ....
  37. doi request reprint Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins
    Lise Wegner
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 93:4013-9. 2008
    ....
  38. ncbi request reprint Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes
    Lesli H Larsen
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Clin Biochem 38:420-4. 2005
    ..To investigate the preproghrelin gene for variants and their association with obesity and type 2 diabetes...
  39. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  40. ncbi request reprint Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites
    Yasmin H Hamid
    Steno Diabetes Center, Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 53:3342-5. 2004
    ..In conclusion, the Asp358Ala polymorphism of the IL6R associates with type 2 diabetes in Danish whites...
  41. ncbi request reprint The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes 52:573-7. 2003
    ..49, P = 0.00022). In conclusion, the widespread E23K polymorphism may have a diabetogenic effect by impairing glucose-induced insulin release and increasing BMI...
  42. ncbi request reprint PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Hypertension 45:565-70. 2005
    ..001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women...
  43. pmc The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest
    Amra C Alibegovic
    Steno Diabetes Centre, Gentofte, Denmark
    Diabetes 59:836-43. 2010
    ..The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest...
  44. pmc Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle
    Rasmus Ribel-Madsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 59:1108-12. 2010
    ..The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes...
  45. pmc G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans
    Thomas Sparsø
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1450-6. 2009
    ....
  46. ncbi request reprint Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
    Thomas Sparsø
    Steno Diabetes Center, 521, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 90:205-9. 2007
    ..If replicated, the Val162Val variant may, however, confer an increase in fasting levels of serum lipids...
  47. ncbi request reprint Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
    ..Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants...
  48. ncbi request reprint A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 55:1869-73. 2006
    ..In conclusion, a rare, novel mutation that disrupts a protein binding site in the pancreatic HNF4A promoter associates with late-onset diabetes...
  49. pmc Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?
    Linn Gillberg
    Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 8:e58384. 2013
    ..Taken together, increased DNA methylation of the PPARGC1A promoter is unlikely to play a major causal role for the development of insulin resistance in FDR of patients with T2D...
  50. ncbi request reprint A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Clin Biochem 37:660-5. 2004
    ....
  51. pmc Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease
    Karina Banasik
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 6:e16542. 2011
    ..Candidate genes for non-alcoholic fatty liver disease (NAFLD) identified by a bioinformatics approach were examined for variant associations to quantitative traits of NAFLD-related phenotypes...
  52. pmc Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 5:e14190. 2010
    ..We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn...
  53. pmc Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index
    Esther Zimmermann
    Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e15958. 2011
    ..We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish men...
  54. ncbi request reprint Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes
    Signe S Torekov
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820, Gentofte, Denmark
    Diabetes 54:2261-5. 2005
    ..03), and a lower insulinogenic index (P = 0.01). In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits...
  55. pmc Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
    Trine W Boesgaard
    Steno Diabetes Centre and Hagedorn Research Institute, Gentofte, Denmark
    BMC Med Genet 11:42. 2010
    ..Insulin gene (INS) mutations have recently been described as a common cause of permanent neonatal diabetes (PNDM) and a rare cause of diabetes diagnosed in childhood or adulthood...
  56. ncbi request reprint Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:363-6. 2007
    ..A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance...
  57. doi request reprint AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects
    Gitte Andersen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 12, DK 2820 Gentofte, Denmark
    Diabetes 57:1427-32. 2008
    ..We related seven frequent AHSG tag single nucleotide polymorphisms to a range of metabolic traits, including type 2 diabetes, obesity, and dyslipidemia...
  58. pmc Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
    Camilla Helene Sandholt
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e23531. 2011
    ..Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms...
  59. pmc Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes
    Dorthe S Bille
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e20640. 2011
    ....
  60. ncbi request reprint Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
    Søren K Rasmussen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 51:3561-7. 2002
    ....
  61. doi request reprint Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased β-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort
    Marie N Harder
    The NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DIKU Building Universitetsparken 1, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 98:E801-6. 2013
    ..In addition, we substantiated previous evidence that ANK1 rs516946 confers impaired insulin release and that ANKRD55 rs459193 and GRB14 rs13389219 associate with insulin resistance...
  62. pmc Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes
    Sofia I I Kring
    Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 4:e6696. 2009
    ..We investigated the associations of single nucleotide polymorphisms (SNPs) of these genes with obesity and metabolic traits...
  63. pmc Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus
    Gitte Andersen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, NSH2 16, DK 2820 Gentofte, Denmark
    Diabetes 53:2992-7. 2004
    ..Thus, variation in the coding region of NCB5OR is not a major contributor in the pathogenesis of nonautoimmune diabetes...
  64. ncbi request reprint Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity
    Kirstine L Andersen
    Steno Diabetes Center and Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:225-30. 2005
    ..2% (CI, 10.8-13.6) among 1051 lean men (P = 0.037). In conclusion, it is unlikely that MKKS variants play a major role in the pathogenesis of nonsyndromic obesity, although in rare cases the A242S allele may contribute to obesity...
  65. ncbi request reprint Mutational analysis of the UCP2 core promoter and relationships of variants with obesity
    Louise T Dalgaard
    Steno Diabetes Center and Statens Serum Institute, 5 Artillerivej, Gentofte, DK 2300 Copenhagen, Denmark
    Obes Res 11:1420-7. 2003
    ..To identify polymorphisms in the human uncoupling protein 2 gene (UCP2) promoter and to investigate whether these were associated with obesity or weight gain...
  66. pmc Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study
    Kristine Faerch
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 32:439-44. 2009
    ..The aim of this study was to describe the natural history of insulin secretion and insulin sensitivity in the development of isolated impaired fasting glycemia (i-IFG), isolated impaired glucose tolerance (i-IGT), and combined IFG/IGT...
  67. pmc Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
    Anette P Gjesing
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 5:e10084. 2010
    ..In the present study, we tested the hypothesis that common and rare variation in the GHSR locus are related to increased prevalence of obesity and overweight among Whites...