Niels Grarup

Summary

Affiliation: Steno Diabetes Center
Country: Denmark

Publications

  1. ncbi The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
  2. doi Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
  3. ncbi Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
  4. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
  5. ncbi Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people
    N Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 50:1201-8. 2007
  6. ncbi Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:363-6. 2007
  7. ncbi Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
    N Grarup
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2 6, NSP1 14, 2820, Gentofte, Copenhagen, Denmark
    Diabetologia 49:2097-104. 2006
  8. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
  9. pmc The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation
    Nikolaj Thure Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e40376. 2012
  10. doi Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    Marie N Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E801-6. 2013

Detail Information

Publications34

  1. ncbi The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    J Clin Endocrinol Metab 93:2294-9. 2008
    ..Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein...
  2. doi Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
    ..Due to the previous inconclusive quantitative trait associations, we also did studies of intermediate quantitative phenotypes...
  3. ncbi Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
    ..Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants...
  4. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  5. ncbi Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people
    N Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 50:1201-8. 2007
    ..Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits...
  6. ncbi Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:363-6. 2007
    ..A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been reported to associate with insulin resistance...
  7. ncbi Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
    N Grarup
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2 6, NSP1 14, 2820, Gentofte, Copenhagen, Denmark
    Diabetologia 49:2097-104. 2006
    ..We assessed the impact of the ENPP1 K121Q polymorphism on type 2 diabetes, obesity and quantitative metabolic traits in 7,333 Danes...
  8. pmc MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1539-48. 2010
    ..The aims of this study were to evaluate whether nonsynonymous variants in MTNR1B associate with monogenic forms of hyperglycemia, type 2 diabetes, or related metabolic traits...
  9. pmc The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation
    Nikolaj Thure Krarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e40376. 2012
    ..We aimed at studying the potential impact of the NAFLD-associated PNPLA3 rs738409 G-allele on NAFLD-related metabolic traits in hyperglycaemic individuals...
  10. doi Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort
    Marie N Harder
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E801-6. 2013
    ....
  11. pmc Combined analyses of 20 common obesity susceptibility variants
    Camilla Helene Sandholt
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 59:1667-73. 2010
    ..Genome-wide association studies and linkage studies have identified 20 validated genetic variants associated with obesity and/or related phenotypes. The variants are common, and they individually exhibit small-to-modest effect sizes...
  12. pmc The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge
    Ehm A Andersson
    Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e27096. 2011
    ....
  13. pmc Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
    Dorit P Zobel
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:757-64. 2009
    ..We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals...
  14. pmc G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans
    Thomas Sparsø
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 58:1450-6. 2009
    ....
  15. ncbi Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites
    Lise Wegner
    Steno Diabetes Center, Niels Steensens Vej 2, NSP1 03, DK 2820 Gentofte, Denmark
    Diabetes 56:694-8. 2007
    ....
  16. pmc Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle
    Rasmus Ribel-Madsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 59:1108-12. 2010
    ..The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes...
  17. doi The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes
    Trine Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    J Hypertens 26:2142-6. 2008
    ..The previous studies have, however, been conflicting, and the aim of the present study was to clarify the impact of the Glu65Lys polymorphism on hypertension at the population level of middle-aged people...
  18. pmc Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease
    Karina Banasik
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 6:e16542. 2011
    ..Candidate genes for non-alcoholic fatty liver disease (NAFLD) identified by a bioinformatics approach were examined for variant associations to quantitative traits of NAFLD-related phenotypes...
  19. pmc Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals
    Ehm A Andersson
    Hagedorn Research Institute, Gentofte, Denmark
    PLoS ONE 5:e14190. 2010
    ..We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn...
  20. pmc Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans
    Kristoffer Sølvsten Burgdorf
    Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 6:e15813. 2011
    ..Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes...
  21. ncbi Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism
    Niels Grarup
    Steno Diabetes Center, Gentofte, Denmark
    Curr Opin Clin Nutr Metab Care 10:420-6. 2007
    ..This paper provides an update on the current literature investigating gene-environment interactions of type 2 diabetes and metabolic phenotypes, and discusses the future perspectives of this research...
  22. ncbi Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes
    L H Larsen
    Steno Diabetes Center, Gentofte, Denmark
    Int J Obes (Lond) 31:365-70. 2007
    ..Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids...
  23. ncbi Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus
    T Hansen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 44:1330-4. 2001
    ..We aimed to examine the promoter of SUR1 for genetic variation and to determine if variants were associated with Type II (non-insulin-dependent) diabetes mellitus or measures of beta-cell function...
  24. ncbi Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function
    J Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Hum Mutat 18:356-7. 2001
    ..In conclusion, mutations in HNF-1beta and DCoH are not a major cause of MODY or late onset type 2 diabetes in Danish Caucasian subjects...
  25. pmc Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
    Trine Welløv Boesgaard
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 4:e7236. 2009
    ....
  26. ncbi PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
    Peter Jacobsen
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 17:1408-12. 2002
    ..We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique...
  27. pmc Physiologic characterization of type 2 diabetes-related loci
    Niels Grarup
    Diabetes Genetics, Hagedorn Research Institute, Gentofte, Denmark
    Curr Diab Rep 10:485-97. 2010
    ....
  28. ncbi A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads
    C S Rose
    Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 52:2122-9. 2009
    ..Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome...
  29. doi Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
    T Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 52:1308-14. 2009
    ....
  30. ncbi Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients
    L Tarnow
    Steno Diabetes Center, Gentofte, Denmark
    Nephrol Dial Transplant 16:1653-6. 2001
    ....
  31. pmc Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
    Niels Grarup
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 9:e1003530. 2013
    ..Yet, the study demonstrates the value of combining whole genome and exome sequencing approaches to ascertain the genetic and molecular architectures underlying quantitative trait associations...
  32. doi Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people
    T W Boesgaard
    Hagedorn Research Institute, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetologia 53:1647-55. 2010
    ..We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs...
  33. ncbi Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
    E A Andersson
    Hagedorn Research Institute, Niels Steensens Vej 1, Gentofte, Denmark
    Diabetologia 53:1908-16. 2010
    ..We examined associations between 25 confirmed type 2 diabetes risk variants and birthweight in individuals from the Danish Inter99 population and in meta-analyses including Inter99 data and reported studies...
  34. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...