Lotte Jakobsen

Summary

Affiliation: Statens Serum Institut
Country: Denmark

Publications

  1. ncbi request reprint Correlation between apramycin and gentamicin use in pigs and an increasing reservoir of gentamicin-resistant Escherichia coli
    Vibeke F Jensen
    Department of Epidemiology and Risk Assessment, Danish Institute of Food and Veterinary Research Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    J Antimicrob Chemother 58:101-7. 2006
  2. doi request reprint Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model
    Lotte Jakobsen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    J Antimicrob Chemother 67:2438-44. 2012
  3. doi request reprint Is Escherichia coli urinary tract infection a zoonosis? Proof of direct link with production animals and meat
    L Jakobsen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Build 47 213, Ørestads Boulevard 5, 2300, Copenhagen S, Denmark
    Eur J Clin Microbiol Infect Dis 31:1121-9. 2012
  4. doi request reprint Broiler chickens, broiler chicken meat, pigs and pork as sources of ExPEC related virulence genes and resistance in Escherichia coli isolates from community-dwelling humans and UTI patients
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen S, Denmark
    Int J Food Microbiol 142:264-72. 2010
  5. pmc Virulence of Escherichia coli B2 isolates from meat and animals in a murine model of ascending urinary tract infection (UTI): evidence that UTI is a zoonosis
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 48:2978-80. 2010
  6. doi request reprint Escherichia coli isolates from broiler chicken meat, broiler chickens, pork, and pigs share phylogroups and antimicrobial resistance with community-dwelling humans and patients with urinary tract infection
    Lotte Jakobsen
    Statens Serum Institute, Copenhagen, Denmark
    Foodborne Pathog Dis 7:537-47. 2010
  7. ncbi request reprint Characterisation, dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Environ Int 34:108-15. 2008
  8. ncbi request reprint Gentamicin susceptibility in Escherichia coli related to the genetic background: problems with breakpoints
    L Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark
    Clin Microbiol Infect 13:830-2. 2007
  9. pmc Detection of clonal group A Escherichia coli isolates from broiler chickens, broiler chicken meat, community-dwelling humans, and urinary tract infection (UTI) patients and their virulence in a mouse UTI model
    Lotte Jakobsen
    Department for Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Appl Environ Microbiol 76:8281-4. 2010
  10. doi request reprint Microarray-based detection of extended virulence and antimicrobial resistance gene profiles in phylogroup B2 Escherichia coli of human, meat and animal origin
    Lotte Jakobsen
    1Department for Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Med Microbiol 60:1502-11. 2011

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Correlation between apramycin and gentamicin use in pigs and an increasing reservoir of gentamicin-resistant Escherichia coli
    Vibeke F Jensen
    Department of Epidemiology and Risk Assessment, Danish Institute of Food and Veterinary Research Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    J Antimicrob Chemother 58:101-7. 2006
    ....
  2. doi request reprint Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model
    Lotte Jakobsen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    J Antimicrob Chemother 67:2438-44. 2012
    ..To study the impact of qnrA1, qnrB19 and qnrS1 on the ciprofloxacin treatment of urinary tract infection (UTI)...
  3. doi request reprint Is Escherichia coli urinary tract infection a zoonosis? Proof of direct link with production animals and meat
    L Jakobsen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Build 47 213, Ørestads Boulevard 5, 2300, Copenhagen S, Denmark
    Eur J Clin Microbiol Infect Dis 31:1121-9. 2012
    ..coli from meat and humans, providing solid evidence that UTI is zoonosis. The close relationship between community-dwelling human and UTI isolates may indicate a point source spread, e.g. through contaminated meat...
  4. doi request reprint Broiler chickens, broiler chicken meat, pigs and pork as sources of ExPEC related virulence genes and resistance in Escherichia coli isolates from community-dwelling humans and UTI patients
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen S, Denmark
    Int J Food Microbiol 142:264-72. 2010
    ..Thus, these strains from meat and production animals may pose a zoonotic risk...
  5. pmc Virulence of Escherichia coli B2 isolates from meat and animals in a murine model of ascending urinary tract infection (UTI): evidence that UTI is a zoonosis
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 48:2978-80. 2010
    ..All isolates produced positive bladder cultures (10(2) to 10(7) CFU), and nine isolates produced positive kidney cultures (10(2) to 10(5) CFU)...
  6. doi request reprint Escherichia coli isolates from broiler chicken meat, broiler chickens, pork, and pigs share phylogroups and antimicrobial resistance with community-dwelling humans and patients with urinary tract infection
    Lotte Jakobsen
    Statens Serum Institute, Copenhagen, Denmark
    Foodborne Pathog Dis 7:537-47. 2010
    ..Thus, our study provides support for the hypothesis that a food animal and meat reservoir might exist for UTI-causing E. coli...
  7. ncbi request reprint Characterisation, dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment
    Lotte Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Environ Int 34:108-15. 2008
    ..Most of the GEN(R)E. coli isolates from both patients and waste water had a multi-resistant phenotype and contained virulence genes and should therefore be considered reservoirs of antimicrobial resistance and virulence genes...
  8. ncbi request reprint Gentamicin susceptibility in Escherichia coli related to the genetic background: problems with breakpoints
    L Jakobsen
    National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark
    Clin Microbiol Infect 13:830-2. 2007
    ..The MIC distribution, regardless of the GEN(R) mechanism, was 8 - >512 mg/L, which supports the clinical breakpoint of MIC >4 mg/L suggested by EUCAST and questions the breakpoint recommended by the CLSI (> or =16 mg/L)...
  9. pmc Detection of clonal group A Escherichia coli isolates from broiler chickens, broiler chicken meat, community-dwelling humans, and urinary tract infection (UTI) patients and their virulence in a mouse UTI model
    Lotte Jakobsen
    Department for Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Appl Environ Microbiol 76:8281-4. 2010
    ..We conclude that clonal group A isolates are found in both broiler chickens and broiler chicken meat and may cause UTI in humans...
  10. doi request reprint Microarray-based detection of extended virulence and antimicrobial resistance gene profiles in phylogroup B2 Escherichia coli of human, meat and animal origin
    Lotte Jakobsen
    1Department for Microbiological Surveillance and Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Med Microbiol 60:1502-11. 2011
    ..coli based on extended gene profiling. These findings support the hypothesis of a zoonotic link between E. coli causing UTIs and E. coli from meat and animals...
  11. doi request reprint Fluoroquinolone resistance mechanisms in urinary tract pathogenic Escherichia coli isolated during rapidly increasing fluoroquinolone consumption in a low-use country
    Nina Christiansen
    Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen S, Denmark
    Microb Drug Resist 17:395-406. 2011
    ..In Denmark, increasing ciprofloxacin resistance in E. coli is mainly due to mutational events and not to spread of clones...
  12. doi request reprint Role of Urinary Cathelicidin LL-37 and Human β-Defensin 1 in Uncomplicated Escherichia coli Urinary Tract Infections
    Karen L Nielsen
    Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen S, Denmark
    Infect Immun 82:1572-8. 2014
    ..The results indicate that the concentration of LL-37 in the urinary tract and low susceptibility to LL-37 may increase the likelihood of UTI in a complex interplay between host and pathogen attributes. ..