Mads Vilhelm Hollegaard

Summary

Affiliation: Statens Serum Institut
Country: Denmark

Publications

  1. ncbi request reprint Cytokine gene polymorphism in human disease: on-line databases, Supplement 3
    M V Hollegaard
    NANEA at Department of Epidemiology, Institute of Public Health, University of Aarhus, Denmark
    Genes Immun 7:269-76. 2006
  2. doi request reprint Archived neonatal dried blood spot samples can be used for accurate whole genome and exome-targeted next-generation sequencing
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej, Copenhagen, Denmark
    Mol Genet Metab 110:65-72. 2013
  3. doi request reprint DNA methylome profiling using neonatal dried blood spot samples: a proof-of-principle study
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark
    Mol Genet Metab 108:225-31. 2013
  4. doi request reprint Joint analysis of SNPs and proteins identifies regulatory IL18 gene variations decreasing the chance of spastic cerebral palsy
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry, Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    Hum Mutat 34:143-8. 2013
  5. pmc Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis
    Bo G Winkel
    Dept of Cardiology, Rigshospitalet and Danish National Research Foundation Centre for Cardiac Arrhythmia DARC, Copenhagen, Denmark
    BMC Med Genet 12:22. 2011
  6. doi request reprint Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
    Electrophoresis 30:2532-5. 2009
  7. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
  8. pmc Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Ørestads Boulevard, Copenhagen, DK 2300, Denmark
    BMC Genet 12:58. 2011
  9. doi request reprint High-throughput genotyping on archived dried blood spot samples
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Genet Test Mol Biomarkers 13:173-9. 2009
  10. doi request reprint Polymorphisms in the tumor necrosis factor alpha and interleukin 1-beta promoters with possible gene regulatory functions increase the risk of preterm birth
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 87:1285-90. 2008

Detail Information

Publications12

  1. ncbi request reprint Cytokine gene polymorphism in human disease: on-line databases, Supplement 3
    M V Hollegaard
    NANEA at Department of Epidemiology, Institute of Public Health, University of Aarhus, Denmark
    Genes Immun 7:269-76. 2006
    ..nanea.dk/cytokinesnps/. The web pages also contain other features and downloads that could be useful when planning cytokine SNP association studies...
  2. doi request reprint Archived neonatal dried blood spot samples can be used for accurate whole genome and exome-targeted next-generation sequencing
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej, Copenhagen, Denmark
    Mol Genet Metab 110:65-72. 2013
    ....
  3. doi request reprint DNA methylome profiling using neonatal dried blood spot samples: a proof-of-principle study
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark
    Mol Genet Metab 108:225-31. 2013
    ..This further adds to the use of neonatal dried blood spot samples in genetic research and screening and paves the way for unique population-based studies of epigenetic modifications after birth...
  4. doi request reprint Joint analysis of SNPs and proteins identifies regulatory IL18 gene variations decreasing the chance of spastic cerebral palsy
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry, Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    Hum Mutat 34:143-8. 2013
    ..By joining protein data to genetic information, we have provided new data suggesting IL18's involvement in the pathogenesis of spastic CP...
  5. pmc Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis
    Bo G Winkel
    Dept of Cardiology, Rigshospitalet and Danish National Research Foundation Centre for Cardiac Arrhythmia DARC, Copenhagen, Denmark
    BMC Med Genet 12:22. 2011
    ..We wanted to compare melting curves and sequencing results from wgaDNA derived from DBS samples with gDNA derived from whole blood...
  6. doi request reprint Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
    Electrophoresis 30:2532-5. 2009
    ..Based on these results we conclude that DBS samples should be considered a reliable and potential resource for future genotyping studies...
  7. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
    ..Whole-genome amplified DNA from 24 neonatal dried blood spot samples stored between 15 to 25 years was tested, and high-quality genomic DNA from 8 of the same individuals was used as reference...
  8. pmc Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Ørestads Boulevard, Copenhagen, DK 2300, Denmark
    BMC Genet 12:58. 2011
    ..We examined the robustness of using DBS samples for whole-genome amplification following genome-wide scanning, using arrays from Illumina and Affymetrix...
  9. doi request reprint High-throughput genotyping on archived dried blood spot samples
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Genet Test Mol Biomarkers 13:173-9. 2009
    ..For evaluation of the biobank samples, we included variable factors: time of storage, gDNA, and whole-genome amplified DNA (wgaDNA) concentrations and the Illumina quality metric (GenCall score)...
  10. doi request reprint Polymorphisms in the tumor necrosis factor alpha and interleukin 1-beta promoters with possible gene regulatory functions increase the risk of preterm birth
    Mads Vilhelm Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 87:1285-90. 2008
    ..To investigate the relation between 19 selected single nucleotide polymorphisms in three cytokine genes, tumor necrosis factor alpha (TNFA), interleukin 1-beta (IL1B) and interleukin 6 (IL6) and preterm birth (<37 weeks' gestation)...
  11. ncbi request reprint Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth
    Ida Vogel
    Institute for Public Health, University of Aarhus, 8000 Aarhus C, Denmark
    In Vivo 23:1005-9. 2009
    ..Our aim was to investigate if mothers carrying promoter single nucleotide polymorphisms (SNPs) in one of the three relaxin genes (RLN1, RLN2, RLN3) are predisposed for PTB...
  12. doi request reprint The prevalence of mutations in KCNQ1, KCNH2, and SCN5A in an unselected national cohort of young sudden unexplained death cases
    Bo Gregers Winkel
    Department of Cardiology, Rigshospitalet and Danish National Research Foundation Centre for Cardiac Arrhythmia DARC, Copenhagen, Denmark
    J Cardiovasc Electrophysiol 23:1092-8. 2012
    ..We therefore wanted to investigate the prevalence of mutations in an unselected population of sudden unexplained deaths in a nationwide setting...