Henrik Hjalgrim

Summary

Affiliation: Statens Serum Institut
Country: Denmark

Publications

  1. pmc A meta-analysis of genome-wide association studies of follicular lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    BMC Genomics 13:516. 2012
  2. ncbi request reprint On the aetiology of Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark
    Dan Med J 59:B4485. 2012
  3. ncbi request reprint Risk of second cancers in classical Kaposi's sarcoma
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen
    Int J Cancer 73:840-3. 1997
  4. ncbi request reprint Cancer incidence in blood transfusion recipients
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen South, Denmark
    J Natl Cancer Inst 99:1864-74. 2007
  5. ncbi request reprint [Epstein-Barr virus and Hodgkin's lymphoma]
    Henrik Hjalgrim
    Afdeling for Epidemiologisk Forskning, Statens Serum Institut, DK 2300 København S
    Ugeskr Laeger 164:5924-7. 2002
  6. ncbi request reprint [Infectious causes of non-Hodgkin lymphomas]
    Lars Munksgaard
    Afdeling for Epidemiologisk Forskning, Statens Serum Institut, Artillerivej 5, DK 2300 København S
    Ugeskr Laeger 164:5927-32. 2002
  7. ncbi request reprint Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 85:639-42. 2000
  8. ncbi request reprint Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, University of Copenhagen, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Cancer Res 67:2382-8. 2007
  9. ncbi request reprint Risk of Hodgkin's disease and other cancers after infectious mononucleosis
    H Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 92:1522-8. 2000
  10. doi request reprint Infectious aetiology of Hodgkin and non-Hodgkin lymphomas: a review of the epidemiological evidence
    H Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    J Intern Med 264:537-48. 2008

Detail Information

Publications93

  1. pmc A meta-analysis of genome-wide association studies of follicular lymphoma
    Christine F Skibola
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    BMC Genomics 13:516. 2012
    ....
  2. ncbi request reprint On the aetiology of Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen S, Denmark
    Dan Med J 59:B4485. 2012
    ..Meanwhile, the aetiology of EBV-negative Hodgkin lymphoma remains elusive. Possible clinical implications of the aetiological heterogeneity should also be considered and assessed...
  3. ncbi request reprint Risk of second cancers in classical Kaposi's sarcoma
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen
    Int J Cancer 73:840-3. 1997
    ..The high relative risk of malignant lymphoma immediately after KS was based on a limited number of cases, and this observation is unlikely to indicate a common etiology...
  4. ncbi request reprint Cancer incidence in blood transfusion recipients
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen South, Denmark
    J Natl Cancer Inst 99:1864-74. 2007
    ..Blood transfusions may influence the recipients' cancer risks both through transmission of biologic agents and by modulation of the immune system. However, cancer occurrence in transfusion recipients remains poorly characterized...
  5. ncbi request reprint [Epstein-Barr virus and Hodgkin's lymphoma]
    Henrik Hjalgrim
    Afdeling for Epidemiologisk Forskning, Statens Serum Institut, DK 2300 København S
    Ugeskr Laeger 164:5924-7. 2002
    ..We present the current epidemiological, serological and molecular biological evidence for an infectious etiology to Hodgkin's lymphoma with emphasis on the association with Epstein-Barr virus...
  6. ncbi request reprint [Infectious causes of non-Hodgkin lymphomas]
    Lars Munksgaard
    Afdeling for Epidemiologisk Forskning, Statens Serum Institut, Artillerivej 5, DK 2300 København S
    Ugeskr Laeger 164:5927-32. 2002
    ..In this article we present an overview of the current evidence of infectious causes to non-Hodgkin's lymphomas...
  7. ncbi request reprint Non-melanoma skin cancer may be a marker of poor prognosis in patients with non-Hodgkin's lymphoma
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 85:639-42. 2000
    ..If substantiated in other settings, NHL patients with prior non-melanoma skin cancer may constitute a subgroup of lymphoma patients in need of particular therapeutic attention...
  8. ncbi request reprint Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, University of Copenhagen, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Cancer Res 67:2382-8. 2007
    ..68; 95% CI, 1.40-5.12). We found further evidence that IM is associated only with EBV-positive HL. This finding is compatible with the notion that EBV-positive and EBV-negative HL may have different etiologies...
  9. ncbi request reprint Risk of Hodgkin's disease and other cancers after infectious mononucleosis
    H Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 92:1522-8. 2000
    ..In addition, the general cancer profile among patients who have had infectious mononucleosis has been sparsely studied...
  10. doi request reprint Infectious aetiology of Hodgkin and non-Hodgkin lymphomas: a review of the epidemiological evidence
    H Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    J Intern Med 264:537-48. 2008
    ..Here, we review the epidemiological evidence linking infections with malignant lymphoma...
  11. ncbi request reprint Familial clustering of Hodgkin lymphoma and multiple sclerosis
    Henrik Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 96:780-4. 2004
    ..We therefore assessed the risk of developing Hodgkin lymphoma for patients with multiple sclerosis and for their families and the risk of developing multiple sclerosis for patients with Hodgkin lymphoma and for their families...
  12. ncbi request reprint Characteristics of Hodgkin's lymphoma after infectious mononucleosis
    Henrik Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    N Engl J Med 349:1324-32. 2003
    ..Infectious mononucleosis-related Epstein-Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear...
  13. ncbi request reprint Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis
    Henrik Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 94:678-81. 2002
    ....
  14. doi request reprint Changing patterns of Hodgkin lymphoma incidence in Singapore
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, Denmark
    Int J Cancer 123:716-9. 2008
    ....
  15. ncbi request reprint Cigarette smoking and risk of Hodgkin lymphoma: a population-based case-control study
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, University of Copenhagen, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Cancer Epidemiol Biomarkers Prev 16:1561-6. 2007
    ..The conflicting finding may reflect etiologic heterogeneity between HL subtypes, warranting further characterization of the relationship...
  16. doi request reprint Hepatitis C infection and risk of malignant lymphoma
    Claudia Schöllkopf
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 122:1885-90. 2008
    ..7 (0.2-16.2; n = 3) for NHL overall. Our findings from a population with a low prevalence of HCV suggest a positive association between HCV and risk of NHL, in particular of B-cell origin...
  17. ncbi request reprint Atopy and risk of non-Hodgkin lymphoma
    Mads Melbye
    Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen, Denmark
    J Natl Cancer Inst 99:158-66. 2007
    ..We investigated this association in a population-based case-control study and in a prospective study with prediagnostic blood specimens...
  18. pmc Borrelia infection and risk of non-Hodgkin lymphoma
    Claudia Schöllkopf
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Blood 111:5524-9. 2008
    ..2 [2.0-8.9]). Our observations suggest a previously unreported association between B. burgdorferi infection and risk of mantle cell lymphoma...
  19. ncbi request reprint Cigarette smoking and risk of non-Hodgkin's lymphoma--a population-based case-control study
    Claudia Schöllkopf
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 14:1791-6. 2005
    ..This may reflect that non-Hodgkin's lymphoma comprises several distinct disease entities with different etiologies, as some studies have indicated an association between smoking and follicular lymphoma...
  20. ncbi request reprint Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland
    Lisa Lyngsie Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    J Natl Cancer Inst 96:1549-56. 2004
    ..We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia...
  21. doi request reprint Blood transfusion exposure in Denmark and Sweden
    Mads Kamper-Jørgensen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Transfusion 49:888-94. 2009
    ..This study estimated the exposure to blood transfusion in the general Scandinavian population...
  22. ncbi request reprint Cancer risk among patients with multiple sclerosis: a population-based register study
    Nete Munk Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 118:979-84. 2006
    ..In general MS patients are not at increased risk of cancer. Women with MS, however, seem to have a small excess risk of breast cancer, which cannot be attributed to reduced parity or delayed first child birth...
  23. doi request reprint Socioeconomic factors in childhood and the risk of multiple sclerosis
    Nete Munk Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 177:1289-95. 2013
    ..Overall, SES in childhood seems of no major importance for the subsequent risk of MS; however, offspring of well-educated mothers may be at a slightly reduced risk of MS...
  24. ncbi request reprint Type 1 diabetes and multiple sclerosis: A Danish population-based cohort study
    Nete M Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen S Denmark
    Arch Neurol 63:1001-4. 2006
    ..Although HLA patterns of T1D and MS are considered mutually exclusive, individual and familial co-occurrence of the 2 diseases has been reported...
  25. ncbi request reprint Familial risk of multiple sclerosis: a nationwide cohort study
    Nete Munk Nielsen
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 162:774-8. 2005
    ..5% in women and 0.3% for men. Spouses of MS patients did not experience an increased risk of MS, suggesting no major role for environmental factors acting in adulthood...
  26. doi request reprint Opposite effects of microchimerism on breast and colon cancer
    Mads Kamper-Jørgensen
    University of Copenhagen, Institute of Public Health, Section of Social Medicine, Øster Farimagsgade 5, Post box 2099, DK 1014 Copenhagen K, Denmark
    Eur J Cancer 48:2227-35. 2012
    ..Data in women with other types of cancer are sparse. The purpose of the study was to determine whether the lower concentrations predate cancer diagnosis, and whether a possible beneficial effect was specific to breast cancer...
  27. ncbi request reprint Multiple sclerosis after infectious mononucleosis
    Trine Rasmussen Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Arch Neurol 64:72-5. 2007
    ..Infectious mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association...
  28. ncbi request reprint Childhood infections and risk of multiple sclerosis
    Peter Bager
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Brain 127:2491-7. 2004
    ..Our findings suggest that measles, rubella, mumps, varicella, pertussis and scarlet fever, even if acquired late in childhood, are not associated with increased risk of multiple sclerosis later in life...
  29. doi request reprint Expensive blood safety initiatives may offer less benefit than we think
    Mads Kamper-Jørgensen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Transfusion 50:240-2. 2010
    ..Although estimation of the cost-effectiveness requires detailed information about the survival of transfusion recipients, previous cost-effectiveness analyses have relied on incorrect survival assumptions...
  30. doi request reprint Cesarean section and offspring's risk of multiple sclerosis: a Danish nationwide cohort study
    Nete M Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Mult Scler 19:1473-7. 2013
    ....
  31. pmc Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma
    Robert J Biggar
    Department of Epidemiology Research, State Serum Institute, Copenhagen, Denmark
    Clin Cancer Res 14:6974-8. 2008
    ..We examined serum YKL-40 and IL-6 levels in patients with Hodgkin lymphoma, a tumor with strong immunologic reaction to relatively few tumor cells, especially in nodular sclerosis Hodgkin lymphoma...
  32. ncbi request reprint Survival after blood transfusion
    Mads Kamper-Jørgensen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Transfusion 48:2577-84. 2008
    ..Long-term survival of transfusion recipients has rarely been studied. This study examines short- and long-term mortality among transfusion recipients and reports these as absolute rates and rates relative to the general population...
  33. doi request reprint Reproductive history and risk of multiple sclerosis
    Nete Munk Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Epidemiology 22:546-52. 2011
    ..It has been suggested that reproductive factors may be involved in the etiology of multiple sclerosis (MS). We studied associations of reproductive history with MS risk in a population-based setting...
  34. doi request reprint Immunoglobulin subclass levels in patients with non-Hodgkin lymphoma
    Robert J Biggar
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 124:2616-20. 2009
    ..Low immunoglobulin levels appear to be a consequence of B-cell NHL presence, and we speculate about molecular mechanisms that could reduce all immunoglobulin subclasses in B-cell NHL...
  35. pmc HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, DK 23005, Copenhagen, Denmark
    Proc Natl Acad Sci U S A 107:6400-5. 2010
    ..Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infection in IM play critical roles in the pathogenesis of EBV-related HL...
  36. pmc Predictors of male microchimerism
    Mads Kamper-Jørgensen
    Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark
    Chimerism 3:1-8. 2012
    ..More research focused on acquisition, retention and clearing of male cells in the maternal circulation is needed...
  37. doi request reprint Birth weight in offspring and leukaemia risk in parents--a nation-wide register-based cohort study from Denmark
    Maria Marklund
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Leuk Res 37:129-33. 2013
    ..These may both be chance findings. Our investigation indicates that offspring birth weight is not strongly associated with parental leukaemia risk...
  38. ncbi request reprint Birth weight as a risk factor for childhood leukemia: a meta-analysis of 18 epidemiologic studies
    Lisa Lyngsie Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 158:724-35. 2003
    ..Our findings support a relation between birth weight and childhood acute lymphoblastic leukemia risk and emphasize the need for additional studies of the biologic mechanisms underlying this association...
  39. doi request reprint Hospitalisation for infection prior to diagnosis of acute lymphoblastic leukaemia in children
    Therese Risom Vestergaard
    Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark
    Pediatr Blood Cancer 60:428-32. 2013
    ..We tested this hypothesis in a register-based study of hospitalisations for infectious diseases prior to diagnosis of childhood ALL...
  40. doi request reprint RT-PCR screening for ETV6-RUNX1-positive clones in cord blood from newborns in the Danish National Birth Cohort
    Marianne Olsen
    The Pediatric Clinics, Juliane Marie Center, Copenhagen University Hospital, H S Rigshospitalet, Copenhagen, Denmark
    J Pediatr Hematol Oncol 34:301-3. 2012
    ..This study explores the feasibility of demonstrating translocation ETV6-RUNX1 transcripts by reverse transcription polymerase chain reaction in newborns enrolled in a large Danish National Birth Cohort...
  41. doi request reprint Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates
    Ulrik Lausten-Thomsen
    Department of Paediatrics, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Blood 117:186-9. 2011
    ....
  42. ncbi request reprint Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries
    Lisa Lyngsie Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 95:1539-44. 2003
    ....
  43. ncbi request reprint Tonsillitis, tonsillectomy and Hodgkin's lymphoma
    Hanne Vestergaard
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 127:633-7. 2010
    ..These results suggest that tonsillitis is a risk factor for HL and not that, as previously reported, only the surgical removal of tonsils is a risk factor...
  44. ncbi request reprint Psychiatric hospitalizations in a cohort of Danish polio patients
    Nete Munk Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Epidemiol 165:319-24. 2007
    ..History of hospitalization for polio might be associated with subsequent risk of hospitalization for psychiatric disorders. The underlying mechanism for this association remains uncertain...
  45. ncbi request reprint Reproductive patterns and non-Hodgkin lymphoma risk in Danish women and men
    Morten Frisch
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, 5 Artillerivej, DK 2300, Copenhagen S, Denmark
    Eur J Epidemiol 21:673-9. 2006
    ..001). Pregnancies have limited impact, if any, on subsequent NHL risk in women. Our findings in men need replication, but, if verified, they may reflect lymphomagenesis-associated male subfertility prior to NHL diagnosis...
  46. doi request reprint Male microchimerism and survival among women
    Mads Kamper-Jørgensen
    Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA, Department of Medicine, University of Washington, Seattle, WA, USA and Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    Int J Epidemiol 43:168-73. 2014
    ..Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status...
  47. doi request reprint Early parental death and risk of hospitalization for affective disorder in adulthood
    Charlotte Weiling Appel
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Epidemiology 24:608-15. 2013
    ..We investigated the association between early parental loss and risk of hospitalization for an affective disorder in adulthood...
  48. doi request reprint Epstein-Barr virus-associated infectious mononucleosis and risk of systemic lupus erythematosus
    Constance J Ulff-Møller
    Department of Epidemiology Research, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
    Rheumatology (Oxford) 49:1706-12. 2010
    ..We evaluated the relationship between EBV-associated IM and subsequent risk of SLE in a population-based cohort study...
  49. doi request reprint Duration of adrenal insufficiency during treatment for childhood acute lymphoblastic leukemia
    Therese Risom Vestergaard
    Pediatric Clinic II, Rigshospitalet, The Faculty of Medicine, University of Copenhagen, Denmark
    J Pediatr Hematol Oncol 33:442-9. 2011
    ....
  50. ncbi request reprint Does pregnancy induce the shedding of premalignant ovarian cells?
    Klaus Rostgaard
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Epidemiology 14:168-73. 2003
    ..High parity is associated with reduced risk of ovarian cancer. One hypothesis is that pregnancy is associated with clearance of a fraction of the genetically modified (premalignant) cells from the ovaries...
  51. ncbi request reprint Risk of second cancer after chronic lymphocytic leukemia
    Claudia Schöllkopf
    Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark
    Int J Cancer 121:151-6. 2007
    ..20 (1.57-3.08)) and squamous cell carcinoma (SIR = 1.52 (1.06-2.17)) of the lung. We speculate that shared genetic risk factors may explain the accumulation of lung and other cancers in CLL patients...
  52. doi request reprint Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis
    T R Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Mult Scler 15:431-6. 2009
    ..However, their combined effect and possible interaction on MS risk is not known...
  53. doi request reprint Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: a nationwide cohort study in Denmark
    N M Nielsen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Mult Scler 14:823-9. 2008
    ..Multiple sclerosis (MS) and other autoimmune diseases might cluster. Our aim was to estimate the relative risk (RR) of other autoimmune diseases among MS patients and their first-degree relatives in a population-based cohort study...
  54. ncbi request reprint Correlations between Epstein-Barr virus antibody levels and risk factors for multiple sclerosis in healthy individuals
    T R Nielsen
    Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, Denmark
    Mult Scler 13:420-3. 2007
    ..Female gender, human leukocyte antigen (HLA) DR2, tobacco smoking and Epstein-Barr virus (EBV) are established risk factors for multiple sclerosis (MS). Their possible interaction however, has been sparsely studied...
  55. ncbi request reprint Incidence patterns of lyme disease and cutaneous B-cell non-Hodgkin's lymphoma in the United States
    L Munksgaard
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark
    Dermatology 201:351-2. 2000
    ..Several reports have suggested a link between infection with Borrelia burgdorferi (the spirochete causing Lyme disease) and development of cutaneous B-cell non-Hodgkin's lymphoma (CBCL)...
  56. ncbi request reprint Cancer risk in a cohort of polio patients
    N M Nielsen
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark
    Int J Cancer 92:605-8. 2001
    ..09 [0.72 to 1.60]). Women diagnosed with poliomyelitis, in particular paralytic polio, may be at increased risk of breast cancer. There was no association between malignancies of the CNS and poliomyelitis...
  57. ncbi request reprint Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996
    M Melbye
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen
    Int J Cancer 77:543-8. 1998
    ..The epidemic of KSHV/HHV-8 is now declining. These findings are concordant with the view that KSHV/HHV-8 may have been actively spread simultaneously with and by the same activities that lead to the spread of HIV...
  58. pmc Recent increase in the incidence of non-Hodgkin's lymphoma among young men and women in Denmark
    H Hjalgrim
    Danish Epidemiology Science Centre, Statens Seruminstitut, Copenhagen, Denmark
    Br J Cancer 73:951-4. 1996
    ..The remarkable and parallel time trends observed in young men and women in recent years indicate that factors other than AIDS must be considered...
  59. ncbi request reprint Changing patterns of tonsillar squamous cell carcinoma in the United States
    M Frisch
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Causes Control 11:489-95. 2000
    ..Tonsillar squamous cell carcinoma (SCC) may differ etiologically from other oral cancers. The aim of this study was to provide a detailed description of the incidence patterns of tonsillar SCC in the United States...
  60. ncbi request reprint Analysis of FMR1 (CGG)n alleles and FRAXA microsatellite haplotypes in the population of Greenland: implications for the population of the New World from Asia
    L A Larsen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Eur J Hum Genet 7:771-7. 1999
    ..Thus the data confirm the Asian origin of the Greenlandic (Eskimo) population and indicates that some (CGG)n alleles have remained stable for 15-30,000 years, since the population of the New World arrived from Asia via the Bering Strait...
  61. ncbi request reprint Haplotype and AGG-interspersion analysis of FMR1 (CGG)(n) alleles in the Danish population: implications for multiple mutational pathways towards fragile X alleles
    L A Larsen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Am J Med Genet 93:99-106. 2000
    ..Thus, the data support that (CGG)(n) instability is correlated to the length of uCGG...
  62. pmc Age at childhood infections and risk of atopy
    P Bager
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Thorax 57:379-82. 2002
    ..The objective of our study was to investigate whether early age at exposure to these infections was associated with a decreased risk of atopy using information on exact age at infection...
  63. ncbi request reprint A genetic basis for infectious mononucleosis: evidence from a family study of hospitalized cases in Denmark
    Klaus Rostgaard
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Clin Infect Dis 58:1684-9. 2014
    ..However, familial aggregation of IM has scarcely been studied...
  64. doi request reprint Increased risk of ALL among premature infants is not explained by increased prevalence of pre-leukemic cell clones
    Ulrik Lausten-Thomsen
    Department of Paediatrics, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Blood Cells Mol Dis 44:188-90. 2010
    ..This indirectly supports the theory that prevalence and quantity of preleukaemic t(12;21)-positive cells peaks at term or early childhood and that exogenous factors are necessary to initiate their clearance...
  65. ncbi request reprint Cancer and diabetes--a follow-up study of two population-based cohorts of diabetic patients
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Intern Med 241:471-5. 1997
    ..To study the occurrence of cancer amongst patients with diabetes mellitus (DM)...
  66. pmc High incidence of classical Kaposi's sarcoma in Iceland and the Faroe Islands
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen
    Br J Cancer 77:1190-3. 1998
    ..3 (Iceland) and 0.5 (the Faroe Islands). These are among the highest rates ever reported. No explanation for the high rates of Kaposi's sarcoma in these two North Atlantic communities could be identified...
  67. pmc Epidemiology of Kaposi's sarcoma in the Nordic countries before the AIDS epidemic
    H Hjalgrim
    Danish Epidemiology Science Centre, Statens Seruminstitut, Copenhagen S, Denmark
    Br J Cancer 74:1499-502. 1996
    ..These observations cannot be explained by registrational procedures or known risk factors for KS, and argue that environmental factors play an important role in the development of the disease...
  68. pmc Incidence rates of classical Kaposi's sarcoma and multiple myeloma do not correlate
    H Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen
    Br J Cancer 78:419-20. 1998
    ..24, P = 0.42, 13 pairs) did the incidences of the two conditions correlate. This absence of correlation does not support the hypothesis that Kaposi's sarcoma and multiple myeloma share a common aetiology, such as HHV-8...
  69. doi request reprint Etiology of common childhood acute lymphoblastic leukemia: the adrenal hypothesis
    K Schmiegelow
    The Pediatric Clinic, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 22:2137-41. 2008
    ....
  70. ncbi request reprint Cranial and hand skeleton in fragile X syndrome
    I Kjaer
    Department of Orthodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark
    Am J Med Genet 100:156-61. 2001
    ..We suggest that a skeletal analysis be considered in the phenotypic classification of children with fragile X syndrome...
  71. pmc Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia
    L L Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Br J Cancer 87:994-9. 2002
    ..e. leukaemia predisposed cells at birth, and that certain types of childhood acute lymphoblastic leukaemia develop as a multiple step process involving both pre- and postnatal genetic events...
  72. ncbi request reprint Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    J Natl Cancer Inst 95:532-9. 2003
    ..To clarify whether SV40 infection increases risk of these cancers or of cancers arising in children, we examined cancer incidence in three Danish birth cohorts...
  73. ncbi request reprint Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives
    Karin Ekström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 48:963-70. 2003
    ....
  74. ncbi request reprint Demonstration of B. burgdorferi-DNA in two cases of nodal lymphoma
    Lars Munksgaard
    Leuk Lymphoma 45:1721-3. 2004
  75. ncbi request reprint Ultraviolet radiation exposure and risk of malignant lymphomas
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Natl Cancer Inst 97:199-209. 2005
    ..One hypothesis holds that exposure to ultraviolet (UV) radiation increases lymphoma risk. We tested this hypothesis in a population-based case-control study in Denmark and Sweden...
  76. ncbi request reprint Improving health profile of blood donors as a consequence of transfusion safety efforts
    Gustaf Edgren
    Department of Medical Epidemiology and Biostatistics, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    Transfusion 47:2017-24. 2007
    ..Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated...
  77. ncbi request reprint Childhood social environment and risk of non-Hodgkin lymphoma in adults
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 67:11074-82. 2007
    ..Effect mechanisms may be related to early age at onset and high frequency of specific infections or total microbial exposure in childhood...
  78. pmc Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium
    Karin Ekstrom Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Blood 111:4029-38. 2008
    ..Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis...
  79. ncbi request reprint Incidence of non-Hodgkin's lymphoma in Sweden, Denmark, and Finland from 1960 through 2003: an epidemic that was
    Sven Sandin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 15:1295-300. 2006
    ..Insights into the descriptive epidemiology of NHL may shed light upon its elusive etiology...
  80. doi request reprint Donation frequency, iron loss, and risk of cancer among blood donors
    Gustaf Edgren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77, Stockholm, Sweden
    J Natl Cancer Inst 100:572-9. 2008
    ..To investigate possible effects of blood donation and iron loss through blood donation on cancer incidence while minimizing "healthy donor effects," we made dose-response comparisons within a cohort of Swedish and Danish blood donors...
  81. ncbi request reprint Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 15:258-65. 2006
    ..The link between skin cancer and follicular lymphoma is unlikely to be mediated through common variation in the studied DNA repair gene polymorphisms...
  82. ncbi request reprint Reliability of self-reported family history of cancer in a large case-control study of lymphoma
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:61-8. 2006
    ..To evaluate the reliability of self-reported data, we analyzed questionnaire and registry-based data on familial cancer from a population-based case-control study of malignant lymphoma...
  83. ncbi request reprint Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:51-60. 2006
    ..Because different NHL subtypes develop at different stages of lymphocyte differentiation, associations of autoimmune and inflammatory disorders with specific NHL subtypes could lead to a better understanding of lymphomagenic mechanisms...
  84. ncbi request reprint Family history of hematopoietic malignancy and risk of lymphoma
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 97:1466-74. 2005
    ....
  85. ncbi request reprint Body mass index and risk of malignant lymphoma in Scandinavian men and women
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Natl Cancer Inst 97:210-8. 2005
    ....
  86. ncbi request reprint Dietary factors and risk of non-hodgkin lymphoma in men and women
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 14:512-20. 2005
    ..Diet could influence NHL risk by modulating the immune system, although evidence is limited. We did a population-based case-control study to determine whether differences in diet were associated with NHL risk...
  87. ncbi request reprint Alcohol intake and risk of non-Hodgkin lymphoma in men and women
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Causes Control 15:1067-76. 2004
    ..The effect of alcohol intake on risk of NHL is unclear. We therefore conducted a population-based case-control study to examine the association between alcohol and NHL risk...
  88. ncbi request reprint Personal and family history of autoimmune diabetes mellitus and susceptibility to young-adult-onset Hodgkin lymphoma
    Ola Landgren
    Division of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Int J Cancer 118:449-52. 2006
    ..0) history of diabetes mellitus. These findings suggests that characteristics of the immune system associated with conditions such as diabetes mellitus type I are of importance in the pathogenesis of young-adult-onset HL...
  89. ncbi request reprint Medication use and risk of non-Hodgkin's lymphoma
    Ellen T Chang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 162:965-74. 2005
    ..However, most of the medications examined were not associated with NHL risk...
  90. pmc Maternal and gestational risk factors for hypospadias
    Olof Akre
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Environ Health Perspect 116:1071-6. 2008
    ..An increase in the prevalence of hypospadias has been reported, but the environmental causes remain virtually unknown...
  91. ncbi request reprint Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study
    Gustaf Edgren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 369:1724-30. 2007
    ..Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion...
  92. ncbi request reprint Poliomyelitis and Parkinson disease
    Nete Munk Nielsen
    JAMA 287:1650-1. 2002
  93. ncbi request reprint Preleukemic TEL-AML1-positive clones at cell level of 10(-3) to 10(-4) do not persist into adulthood
    Marianne Olsen
    Copenhagen University Hospital Rigshospitalet, Juliane Marie Center, Bonkolab 5704, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Pediatr Hematol Oncol 28:734-40. 2006
    ..The findings are compatible with the risk of t(12;21)(p13;q22) ALL correlating with the total number of TEL-AML1-positive cells in peripheral blood in both childhood and adulthood...