Research Topics
Genomes and Genes | Jes DietrichSummaryAffiliation: Statens Serum Institut Country: Denmark Publications
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Publications
Prospects for a novel vaccine against tuberculosisJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark
Vet Microbiol 112:163-9. 2006....- Synergistic effect of bacillus calmette guerin and a tuberculosis subunit vaccine in cationic liposomes: increased immunogenicity and protectionJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, Copenhagen, Denmark
J Immunol 178:3721-30. 2007..Thus, these studies suggest an immunization strategy where a novel TB subunit vaccine is administered as part of the child vaccination program together with BCG in neonates and followed by subunit boosting... - Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacyJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
J Immunol 174:6332-9. 2005..4, we show that ESAT-6, apart from being an excellent diagnostic reagent, can also be used as a reagent for monitoring vaccine efficacy. This may open a new way for monitoring vaccine efficacy in clinical trials... - TB vaccine strategies--what is needed to solve a complex problem?Jes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
Tuberculosis (Edinb) 86:163-8. 2006..In this review we will discuss some of the most advanced attempts to address this challenge... - Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunityJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen, Denmark
J Immunol 177:6353-60. 2006..tb in LTK63/Ag85B-ESAT-6-boosted mice, compared with BCG-vaccinated animals. Thus, LTK63/Ag85B-ESAT-6 represents an efficient preventive vaccine against tuberculosis with a strong ability to boost prior BCG immunity... 
Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine developmentJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
APMIS 117:440-57. 2009..In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies...- Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosisRolf Billeskov
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Eur J Immunol 40:1342-54. 2010..In conclusion, we show that different vectors can induce completely different recognition of the same protein... 
CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccinationTara Elvang
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
PLoS ONE 4:e5139. 2009..tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consisting of both CD4 and CD8 T cells...- Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen doseClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
PLoS ONE 4:e5930. 2009..4 delivered in the adjuvant IC31 for the ability to induce protection against infection with Mycobacterium tuberculosis. In addition, we examined if the antigen dose could influence the phenotype of the induced T cells... - Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosisTruc Thi Kim Thanh Hoang
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 4:e5928. 2009..tuberculosis protein TB10.4. This has enabled, for the first time, a comparative study of the dynamics and function of CD4 and CD8 T cells specific for epitopes within the same protein in various stages of TB infection... - Alteration of epitope recognition pattern in Ag85B and ESAT-6 has a profound influence on vaccine-induced protection against Mycobacterium tuberculosisThomas Bennekov
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Eur J Immunol 36:3346-55. 2006.... - Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subsetThomas Lindenstrøm
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Infect Immun 80:3533-44. 2012..tuberculosis-infected lung. In the absence of overt inflammation, however, stable bona fide Th17 memory can indeed be induced by parenteral immunization... - The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosisClaire Swetman Andersen
Staten Serum Institute, TB Vaccine Research, Department of Infectious Disease Immunology, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
Infect Immun 75:408-16. 2007..Thus, the results demonstrate the effectiveness of mucosal vaccination with Ag85B-ESAT-6 mixed with CTA1-DD/ISCOMs as adjuvant for stimulating TB-specific protective immunity in the lung... - Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1Rolf Billeskov
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
J Immunol 179:3973-81. 2007..4(3-11)-specific CD8 T cells, and exhibited increased virulence compared with BCG, our data suggest that virulence in itself is also involved in generating a robust CD8 T cell response against mycobacterial epitopes, such as TB10.4(3-11)... - Quality and vaccine efficacy of CD4+ T cell responses directed to dominant and subdominant epitopes in ESAT-6 from Mycobacterium tuberculosisClaus Sindbjerg Aagaard
Department of Infectious Immunology, Statens Serum Institute, Copenhagen, Denmark
J Immunol 183:2659-68. 2009.... - The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunityRolf Billeskov
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 7:e39909. 2012..A vaccine that could efficiently boost a BCG-induced immune response and thus prolong protective immunity would therefore have a significant impact on the global TB-burden... - A multistage tuberculosis vaccine that confers efficient protection before and after exposureClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Nat Med 17:189-94. 2011..In two mouse models of latent tuberculosis, we show that H56 vaccination after exposure is able to control reactivation and significantly lower the bacterial load compared to adjuvant control mice... - TB vaccines: current status and future perspectivesClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
Immunol Cell Biol 87:279-86. 2009..Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II... - The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomesKaren Smith Korsholm
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Immunology 121:216-26. 2007..10 T cells. Our data therefore suggest that the primary adjuvant mechanism of cationic DDA liposomes is to target the cell membrane of antigen-presenting cells, which subsequently leads to enhanced uptake and presentation of antigen... - Tuberculosis subunit vaccines: from basic science to clinical testingT Mark Doherty
Statens Serum Institute, Department of Infectious Disease Immunology, Copenhagen, Denmark
Expert Opin Biol Ther 7:1539-49. 2007..The challenges that confront these approaches and how they are being addressed are then discussed... - The CD3 gamma leucine-based receptor-sorting motif is required for efficient ligand-mediated TCR down-regulationMarina von Essen
Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
J Immunol 168:4519-23. 2002.... - Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosisSigne Smedegaard Helt
Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK 2800 Kgs Lyngby, Denmark
J Mol Biol 376:554-69. 2008..In the inactive conformation dephosphorylation cannot take place due to the absence of a water molecule otherwise hydrogen-bonded to O2 of the alpha-phosphate...