Jes Dietrich

Summary

Affiliation: Statens Serum Institut
Country: Denmark

Publications

  1. ncbi request reprint Prospects for a novel vaccine against tuberculosis
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark
    Vet Microbiol 112:163-9. 2006
  2. pmc CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination
    Tara Elvang
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    PLoS ONE 4:e5139. 2009
  3. pmc Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose
    Claus Aagaard
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    PLoS ONE 4:e5930. 2009
  4. pmc Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis
    Truc Thi Kim Thanh Hoang
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 4:e5928. 2009
  5. pmc Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model
    Rolf Billeskov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 8:e72185. 2013
  6. doi request reprint Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    APMIS 117:440-57. 2009
  7. ncbi request reprint Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Immunol 177:6353-60. 2006
  8. ncbi request reprint TB vaccine strategies--what is needed to solve a complex problem?
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Tuberculosis (Edinb) 86:163-8. 2006
  9. ncbi request reprint Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    J Immunol 174:6332-9. 2005
  10. ncbi request reprint Synergistic effect of bacillus calmette guerin and a tuberculosis subunit vaccine in cationic liposomes: increased immunogenicity and protection
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, Copenhagen, Denmark
    J Immunol 178:3721-30. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Prospects for a novel vaccine against tuberculosis
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, 2300 Copenhagen S, Denmark
    Vet Microbiol 112:163-9. 2006
    ....
  2. pmc CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination
    Tara Elvang
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    PLoS ONE 4:e5139. 2009
    ..tb in fact involves both CD4 and CD8 T cells. To test this, we used a new vaccine strategy that generated a strong balanced T cell response consisting of both CD4 and CD8 T cells...
  3. pmc Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose
    Claus Aagaard
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    PLoS ONE 4:e5930. 2009
    ..4 delivered in the adjuvant IC31 for the ability to induce protection against infection with Mycobacterium tuberculosis. In addition, we examined if the antigen dose could influence the phenotype of the induced T cells...
  4. pmc Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis
    Truc Thi Kim Thanh Hoang
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 4:e5928. 2009
    ..tuberculosis protein TB10.4. This has enabled, for the first time, a comparative study of the dynamics and function of CD4 and CD8 T cells specific for epitopes within the same protein in various stages of TB infection...
  5. pmc Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model
    Rolf Billeskov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 8:e72185. 2013
    ..Moreover, our data demonstrated that the H28 vaccine antigen was able to induce strong protection in both a mouse and a non-human primate TB model. ..
  6. doi request reprint Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    APMIS 117:440-57. 2009
    ..In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies...
  7. ncbi request reprint Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen, Denmark
    J Immunol 177:6353-60. 2006
    ..tb in LTK63/Ag85B-ESAT-6-boosted mice, compared with BCG-vaccinated animals. Thus, LTK63/Ag85B-ESAT-6 represents an efficient preventive vaccine against tuberculosis with a strong ability to boost prior BCG immunity...
  8. ncbi request reprint TB vaccine strategies--what is needed to solve a complex problem?
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Tuberculosis (Edinb) 86:163-8. 2006
    ..In this review we will discuss some of the most advanced attempts to address this challenge...
  9. ncbi request reprint Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    J Immunol 174:6332-9. 2005
    ..4, we show that ESAT-6, apart from being an excellent diagnostic reagent, can also be used as a reagent for monitoring vaccine efficacy. This may open a new way for monitoring vaccine efficacy in clinical trials...
  10. ncbi request reprint Synergistic effect of bacillus calmette guerin and a tuberculosis subunit vaccine in cationic liposomes: increased immunogenicity and protection
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, Copenhagen, Denmark
    J Immunol 178:3721-30. 2007
    ..Thus, these studies suggest an immunization strategy where a novel TB subunit vaccine is administered as part of the child vaccination program together with BCG in neonates and followed by subunit boosting...
  11. doi request reprint Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis
    Rolf Billeskov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Eur J Immunol 40:1342-54. 2010
    ..In conclusion, we show that different vectors can induce completely different recognition of the same protein...
  12. pmc The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis
    Claire Swetman Andersen
    Staten Serum Institute, TB Vaccine Research, Department of Infectious Disease Immunology, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Infect Immun 75:408-16. 2007
    ..Thus, the results demonstrate the effectiveness of mucosal vaccination with Ag85B-ESAT-6 mixed with CTA1-DD/ISCOMs as adjuvant for stimulating TB-specific protective immunity in the lung...
  13. ncbi request reprint Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1
    Rolf Billeskov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 179:3973-81. 2007
    ..4(3-11)-specific CD8 T cells, and exhibited increased virulence compared with BCG, our data suggest that virulence in itself is also involved in generating a robust CD8 T cell response against mycobacterial epitopes, such as TB10.4(3-11)...
  14. doi request reprint Quality and vaccine efficacy of CD4+ T cell responses directed to dominant and subdominant epitopes in ESAT-6 from Mycobacterium tuberculosis
    Claus Sindbjerg Aagaard
    Department of Infectious Immunology, Statens Serum Institute, Copenhagen, Denmark
    J Immunol 183:2659-68. 2009
    ....
  15. ncbi request reprint Alteration of epitope recognition pattern in Ag85B and ESAT-6 has a profound influence on vaccine-induced protection against Mycobacterium tuberculosis
    Thomas Bennekov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Eur J Immunol 36:3346-55. 2006
    ....
  16. ncbi request reprint Ligand-induced TCR down-regulation is not dependent on constitutive TCR cycling
    Jes Dietrich
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 168:5434-40. 2002
    ..In conclusion, ligand-induced TCR internalization and constitutive cycling of the TCR represents two independent pathways regulated by different mechanisms...
  17. pmc Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subset
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Infect Immun 80:3533-44. 2012
    ..tuberculosis-infected lung. In the absence of overt inflammation, however, stable bona fide Th17 memory can indeed be induced by parenteral immunization...
  18. pmc The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunity
    Rolf Billeskov
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 7:e39909. 2012
    ..A vaccine that could efficiently boost a BCG-induced immune response and thus prolong protective immunity would therefore have a significant impact on the global TB-burden...
  19. pmc ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination
    Truc Hoang
    TB Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 8:e80579. 2013
    ..Our data demonstrate that there are specific requirements for the immune system to target an already established tuberculosis infection and that ESAT-6 has a unique potential in post-exposure vaccination strategies. ..
  20. pmc The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes
    Karen Smith Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 121:216-26. 2007
    ..10 T cells. Our data therefore suggest that the primary adjuvant mechanism of cationic DDA liposomes is to target the cell membrane of antigen-presenting cells, which subsequently leads to enhanced uptake and presentation of antigen...
  21. doi request reprint A multistage tuberculosis vaccine that confers efficient protection before and after exposure
    Claus Aagaard
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Nat Med 17:189-94. 2011
    ..In two mouse models of latent tuberculosis, we show that H56 vaccination after exposure is able to control reactivation and significantly lower the bacterial load compared to adjuvant control mice...
  22. ncbi request reprint Tuberculosis subunit vaccines: from basic science to clinical testing
    T Mark Doherty
    Statens Serum Institute, Department of Infectious Disease Immunology, Copenhagen, Denmark
    Expert Opin Biol Ther 7:1539-49. 2007
    ..The challenges that confront these approaches and how they are being addressed are then discussed...
  23. doi request reprint TB vaccines: current status and future perspectives
    Claus Aagaard
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Immunol Cell Biol 87:279-86. 2009
    ..Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II...
  24. pmc Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 9:e100879. 2014
    ..Taken together, the IPV-CAF01 formulation constitutes a new promising vaccine against polio with the ability to generate strong humoral and cellular immunity against the polio virus. ..
  25. ncbi request reprint The CD3 gamma leucine-based receptor-sorting motif is required for efficient ligand-mediated TCR down-regulation
    Marina von Essen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 168:4519-23. 2002
    ....
  26. doi request reprint Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis
    Signe Smedegaard Helt
    Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK 2800 Kgs Lyngby, Denmark
    J Mol Biol 376:554-69. 2008
    ..In the inactive conformation dephosphorylation cannot take place due to the absence of a water molecule otherwise hydrogen-bonded to O2 of the alpha-phosphate...