Else Marie Agger

Summary

Affiliation: Statens Serum Institut
Country: Denmark

Publications

  1. pmc Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 124:175-85. 2008
  2. pmc Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 110:507-12. 2003
  3. ncbi request reprint Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Adjuvant Research, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Vaccine 24:5452-60. 2006
  4. pmc Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
    Else Marie Agger
    Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 3:e3116. 2008
  5. doi request reprint Interview: an insight into cutting-edge tuberculosis vaccine research. Interview by Katie Lockwood
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, 5 Artillerivej, Denmark
    Immunotherapy 5:799-801. 2013
  6. ncbi request reprint A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity
    Claire S Andersen
    Department of Infectious Disease Immunology, Adjuvant Research, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:424-32. 2009
  7. doi request reprint Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:8047-55. 2009
  8. doi request reprint CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Vaccine Delivery and Formulation, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Int J Pharm 390:19-24. 2010
  9. pmc Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics
    Niels Peter H Knudsen
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 111:1096-101. 2014
  10. pmc T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection
    Karen Smith Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Immunology 129:75-86. 2010

Collaborators

Detail Information

Publications36

  1. pmc Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 124:175-85. 2008
    ..This study indicates that the adjuvant component of a tuberculosis vaccine may be crucial in determining the kinetics by which effective granulomas, pivotal in controlling bacterial growth, are formed...
  2. pmc Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 110:507-12. 2003
    ..In contrast, very limited responses were seen in M. bovis BCG-vaccinated donors. This study therefore emphasizes the diagnostic potential of proteins encoded by the RD1 region...
  3. ncbi request reprint Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, Adjuvant Research, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Vaccine 24:5452-60. 2006
    ..Furthermore, the combination of Ag85B-ESAT-6/IC31 was found to confer efficient protection in the guinea pig aerosol model of tuberculosis infection and is at present moving towards clinical testing...
  4. pmc Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements
    Else Marie Agger
    Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 3:e3116. 2008
    ..The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed...
  5. doi request reprint Interview: an insight into cutting-edge tuberculosis vaccine research. Interview by Katie Lockwood
    Else Marie Agger
    Department of Infectious Disease Immunology, Statens Serum Institut, 5 Artillerivej, Denmark
    Immunotherapy 5:799-801. 2013
    b>Else Marie Agger speaks to Katie Lockwood, Assistant Commissioning Editor Else Marie Agger was appointed Director of the Department of Infectious Disease Immunology, Statens Serum Institut in Denmark in 2011...
  6. ncbi request reprint A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity
    Claire S Andersen
    Department of Infectious Disease Immunology, Adjuvant Research, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:424-32. 2009
    ..Together, this development opens up the possibility of producing a novel class of chemically defined lipid adjuvants to enhance the activity of new vaccine formulations, directed against infectious agents including tuberculosis...
  7. doi request reprint Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:8047-55. 2009
    ....
  8. doi request reprint CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Vaccine Delivery and Formulation, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Int J Pharm 390:19-24. 2010
    ..CAF01 is thus a promising adjuvant for mucosal delivery...
  9. pmc Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics
    Niels Peter H Knudsen
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 111:1096-101. 2014
    ..H65 thus constitutes a promising vaccine candidate devoid of antigen 85 and fully compatible with current ESAT-6 and culture filtrate protein 10-based diagnostics. ..
  10. pmc T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection
    Karen Smith Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
    Immunology 129:75-86. 2010
    ..Thus, the adjuvants induced qualitatively distinct local inflammatory signals early after injection...
  11. pmc The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis
    Claire Swetman Andersen
    Staten Serum Institute, TB Vaccine Research, Department of Infectious Disease Immunology, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Infect Immun 75:408-16. 2007
    ..Thus, the results demonstrate the effectiveness of mucosal vaccination with Ag85B-ESAT-6 mixed with CTA1-DD/ISCOMs as adjuvant for stimulating TB-specific protective immunity in the lung...
  12. ncbi request reprint Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses
    Jesper Davidsen
    Vaccine Development, Adjuvant Research, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Biochim Biophys Acta 1718:22-31. 2005
    ..The lymphocyte subset releasing the interferon-gamma was identified as CD4 T cells...
  13. pmc Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system
    Ida Rosenkrands
    Statens Serum Institut, Department of Infectious Disease Immunology, Adjuvant Research, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Infect Immun 73:5817-26. 2005
    ..In a tuberculosis challenge model, the mycosomes combined with the Ag85B-ESAT-6 fusion protein were demonstrated to have a unique ability to maintain sustained immunological memory at a level superior to live BCG...
  14. ncbi request reprint Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation
    Joshua S Woodworth
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    J Immunol 192:3247-58. 2014
    ..Direct comparison of dominant/cryptic epitope-specific CD4 T cells within covaccinated mice confirmed the superior ability of protective cryptic epitope-specific T cells to resist M. tuberculosis infection-driven T cell differentiation. ..
  15. pmc Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subset
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Infect Immun 80:3533-44. 2012
    ..tuberculosis-infected lung. In the absence of overt inflammation, however, stable bona fide Th17 memory can indeed be induced by parenteral immunization...
  16. doi request reprint alpha,alpha'-trehalose 6,6'-dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Adjuvant Research, DK 2300 Copenhagen S, Denmark
    Biochim Biophys Acta 1778:1365-73. 2008
    ..Furthermore the results indicate that direct interaction with liposome surfaces is necessary for trehalose to enable protection during freeze-drying...
  17. ncbi request reprint NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark
    Eur J Pharm Biopharm 70:914-20. 2008
    ..These studies therefore suggest that NIR can be used for real-time process control analysis in the production of CAF01 liposomes...
  18. doi request reprint Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin
    Claire A Swetman Andersen
    Department of Infectious Disease Immunology, Adjuvant Research, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 183:2294-302. 2009
    ....
  19. pmc PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family
    Limei Meng Okkels
    Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    Infect Immun 71:6116-23. 2003
    ..The immunodominant epitope (residues 118 to 135) for both TB patients and BCG-vaccinated individuals was found to be highly conserved among a large number of PPE family members...
  20. pmc A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice
    Gregers Jacob Gram
    Department of Virology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 4:e6950. 2009
    ..g. functional cell killing/lysis in addition to immunological markers that can be monitored by simple immunological laboratory methods...
  21. doi request reprint Liposome-based cationic adjuvant formulations (CAF): past, present, and future
    Dennis Christensen
    Vaccine Delivery and Formulation, Department Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Liposome Res 19:2-11. 2009
    ....
  22. pmc The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes
    Karen Smith Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Immunology 121:216-26. 2007
    ..10 T cells. Our data therefore suggest that the primary adjuvant mechanism of cationic DDA liposomes is to target the cell membrane of antigen-presenting cells, which subsequently leads to enhanced uptake and presentation of antigen...
  23. pmc Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Vaccine Delivery and Formulation Research, Copenhagen, Denmark
    PLoS ONE 5:e15043. 2010
    ..These results therefore advocate the further development of the Bioneedle devises and applicators for the delivery of human vaccines...
  24. ncbi request reprint Cationic liposomes as vaccine adjuvants
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, 81 306, DK 2300 Copenhagen S, Copenhagen, Denmark
    Expert Rev Vaccines 6:785-96. 2007
    ..In this article we review the recent progress on cationic liposomes as vehicles, enhancing the effect of immunomodulators and the presentation of vaccine antigens...
  25. doi request reprint Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells
    Thomas Lindenstrøm
    Tuberculosis Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, DK 2300 Copenhagen, Denmark
    J Immunol 190:6311-9. 2013
    ..These results suggest that the CD4(+) KLRG1(-) IL-2-secreting subsets are central memory T cells with the potential to continuously replenish the T cells at the site of infection and prevent attrition and functional exhaustion...
  26. ncbi request reprint Liposome delivery of Chlamydia muridarum major outer membrane protein primes a Th1 response that protects against genital chlamydial infection in a mouse model
    Jon Hansen
    Chlamydia and Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Infect Dis 198:758-67. 2008
    ..A need for Th1-polarizing adjuvants in experimental chlamydia vaccines has been demonstrated, and antigen conformation has also been reported as being important for raising protective immunity...
  27. doi request reprint A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog
    Dennis Christensen
    Dept Infectious Disease Immunology, Statens Serum Institut, Copenhagen S, Denmark
    J Control Release 160:468-76. 2012
    ....
  28. doi request reprint CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice
    Jon Hansen
    Infectious Disease Immunology, Statens Serum Institut, Building 81 306, Copenhagen S, Denmark
    Cancer Immunol Immunother 61:893-903. 2012
    ....
  29. ncbi request reprint Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes
    Ida Rosenkrands
    Department of Infectious Disease Immunology, Statens Serum Institut, 5 Orestads Boulevard, DK 2300 Copenhagen, Denmark
    Vaccine 29:6283-91. 2011
    ..Overall, the results suggest that CAF01 is a potent adjuvant system for future, improved influenza vaccines...
  30. pmc Broadening of the T-cell repertoire to HIV-1 Gag p24 by vaccination of HLA-A2/DR transgenic mice with overlapping peptides in the CAF05 adjuvant
    Karen S Korsholm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 8:e63575. 2013
    ....
  31. ncbi request reprint Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Adjuvant Research, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    Biochim Biophys Acta 1768:2120-9. 2007
    ....
  32. doi request reprint Determining adjuvant activity on T-cell function in vivo: Th cells
    Thomas Lindenstrøm
    Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    Methods Mol Biol 626:213-29. 2010
    ..Expanding our knowledge on these mechanisms will improve our chance of developing new successful vaccines designed to target specific diseases...
  33. pmc ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination
    Truc Hoang
    TB Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 8:e80579. 2013
    ..Our data demonstrate that there are specific requirements for the immune system to target an already established tuberculosis infection and that ESAT-6 has a unique potential in post-exposure vaccination strategies. ..
  34. doi request reprint Cationic liposomes as vaccine adjuvants
    Dennis Christensen
    Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen, Denmark
    Expert Rev Vaccines 10:513-21. 2011
    ..In this article we review the recent progress on the application of cationic liposomes as vaccine delivery systems/adjuvants...
  35. pmc CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets
    Cyril Jean Marie Martel
    Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e22891. 2011
    ..The data obtained in this human-relevant challenge model supports the potential of CAF01 in future influenza vaccines...
  36. pmc Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01
    Jes Dietrich
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 9:e100879. 2014
    ..Taken together, the IPV-CAF01 formulation constitutes a new promising vaccine against polio with the ability to generate strong humoral and cellular immunity against the polio virus. ..