Research Topics
Genomes and Genes | C AagaardSummaryAffiliation: Statens Serum Institut Country: Denmark Publications
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Detail Information
Publications
Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cellsThomas Lindenstrøm
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
J Immunol 182:8047-55. 2009....- A multistage tuberculosis vaccine that confers efficient protection before and after exposureClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Nat Med 17:189-94. 2011..In two mouse models of latent tuberculosis, we show that H56 vaccination after exposure is able to control reactivation and significantly lower the bacterial load compared to adjuvant control mice... - Detection of bovine tuberculosis in herds with different disease prevalence and influence of paratuberculosis infection on PPDB and ESAT-6/CFP10 specificityC Aagaard
Statens Serum Institut, Department of Infectious Immunology, Artilleirvej 5, 2300 Copenhagen, Denmark
Prev Vet Med 96:161-9. 2010..In high prevalence herds, PPDB or ESAT-6+CFP10 can be used as antigen whereas in low and medium prevalence herds ESAT-6+CFP10 is the preferred choice... 
Genomic approach to identification of Mycobacterium bovis diagnostic antigens in cattleClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
J Clin Microbiol 41:3719-28. 2003..4 responsiveness. The results suggest that combinations of specific antigens such as these have great potential in development of optimized diagnostic systems for bovine tuberculosis...
Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complexClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
J Infect Dis 189:812-9. 2004..Rv2654 is a strongly recognized T cell antigen that is highly specific for TB and has potential as a novel cell-mediated immunity-based TB diagnostic agent...- Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificityC Aagaard
Statens Serum Institut, Department of TB Immunology, Copenhagen, Denmark
J Clin Microbiol 44:4326-35. 2006..Furthermore, TB10.4, PE13, and PE5 have the potential to supplement ESAT6 and CFP10 in a future five-component diagnostic cocktail... - Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen doseClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
PLoS ONE 4:e5930. 2009..4 delivered in the adjuvant IC31 for the ability to induce protection against infection with Mycobacterium tuberculosis. In addition, we examined if the antigen dose could influence the phenotype of the induced T cells... - Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosisTruc Thi Kim Thanh Hoang
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 4:e5928. 2009..tuberculosis protein TB10.4. This has enabled, for the first time, a comparative study of the dynamics and function of CD4 and CD8 T cells specific for epitopes within the same protein in various stages of TB infection... - Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosisRolf Billeskov
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Eur J Immunol 40:1342-54. 2010..In conclusion, we show that different vectors can induce completely different recognition of the same protein... - Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirementsElse Marie Agger
Adjuvant Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
PLoS ONE 3:e3116. 2008..The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed... - Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosisIda Rosenkrands
Department of Infectious Disease Immunology, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
Tuberculosis (Edinb) 88:335-43. 2008.... - Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacyJes Dietrich
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
J Immunol 174:6332-9. 2005..4, we show that ESAT-6, apart from being an excellent diagnostic reagent, can also be used as a reagent for monitoring vaccine efficacy. This may open a new way for monitoring vaccine efficacy in clinical trials... - Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteinsIda Rosenkrands
Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark
J Bacteriol 184:3485-91. 2002..These results extend our understanding of the hypoxic response in M. tuberculosis and potentially provide important insights into the physiology of the latent bacilli... - TB vaccines: current status and future perspectivesClaus Aagaard
Department of Infectious Disease Immunology, Statens Serum Institute, Copenhagen, Denmark
Immunol Cell Biol 87:279-86. 2009..Three such fusion proteins are currently in clinical trials, the two most advanced have already passed phase I trials and are entering phase II... - Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6Jan A M Langermans
Department of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands
Vaccine 23:2740-50. 2005..As far as we are aware this is the first report of protection in primates with a subunit vaccine... - Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosisSigne Smedegaard Helt
Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK 2800 Kgs Lyngby, Denmark
J Mol Biol 376:554-69. 2008..In the inactive conformation dephosphorylation cannot take place due to the absence of a water molecule otherwise hydrogen-bonded to O2 of the alpha-phosphate... - Improved serodetection of Mycobacterium bovis infection in badgers (Meles meles) using multiantigen test formatsRena Greenwald
Chembio Diagnostic Systems, Inc, Medford, NY, USA
Diagn Microbiol Infect Dis 46:197-203. 2003..This is the first report of a diagnostic test for badger tuberculosis that can be performed alongside the captive animal...