Gunnar Sørensen

Summary

Country: Denmark

Publications

  1. ncbi request reprint Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 77:723-9. 2004
  2. doi request reprint An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine
    Ditte Dencker
    Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, Copenhagen University Hospital, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Psychopharmacology (Berl) 224:277-87. 2012
  3. doi request reprint Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Psychopharmacology (Berl) 222:565-77. 2012
  4. doi request reprint Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Department O and Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Pharmacol Biochem Behav 105:151-6. 2013
  5. pmc PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
    Birgitte Holst
    Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    PLoS Biol 11:e1001542. 2013
  6. doi request reprint Mice lacking neuropeptide Y show increased sensitivity to cocaine
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    Synapse 66:840-3. 2012
  7. ncbi request reprint Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Copenhagen Mental Health Center Rigshospitalet, and Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Neuroreport 20:1023-6. 2009
  8. doi request reprint Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Rigshospitalet University Hospital, University of Copenhagen, 9 Blegdamsvej, DK 2100, Copenhagen, Denmark
    Psychopharmacology (Berl) 199:37-46. 2008
  9. doi request reprint Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures
    Casper R Gøtzsche
    Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Neurobiol Dis 45:288-96. 2012
  10. pmc A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
    Mattias Rickhag
    Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Nat Commun 4:1580. 2013

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 77:723-9. 2004
    ..These results indicate that anxiolytic-like effects of i.c.v.-administered NPY in rats are mediated via both Y1 and Y5 receptors, whereas sedation is mediated via Y5 receptors...
  2. doi request reprint An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine
    Ditte Dencker
    Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, Copenhagen University Hospital, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Psychopharmacology (Berl) 224:277-87. 2012
    ..Consequently, striatal M₄ receptors could be a novel target for modulating psychostimulant effects of cocaine...
  3. doi request reprint Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Psychopharmacology (Berl) 222:565-77. 2012
    ..Several studies suggest a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. However, the NPY receptors mediating addiction-related effects remain to be determined...
  4. doi request reprint Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Department O and Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Pharmacol Biochem Behav 105:151-6. 2013
    ..Prevention of relapse is considered to be of pivotal importance for the development of an effective treatment against cocaine addiction and therefore Y5 receptors could be a potential future therapeutic target in cocaine addiction...
  5. pmc PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
    Birgitte Holst
    Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    PLoS Biol 11:e1001542. 2013
    ..The data link two BAR domain proteins to membrane remodeling processes in the secretory pathway of peptidergic endocrine cells and support an important role of PICK1/ICA69 in maintenance of metabolic homeostasis...
  6. doi request reprint Mice lacking neuropeptide Y show increased sensitivity to cocaine
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    Synapse 66:840-3. 2012
    ..Whether this is due to an observed compensatory increase in striatal dopamine transporter binding or an anxiogenic phenotype of the transgenic mice remains to be determined...
  7. ncbi request reprint Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Copenhagen Mental Health Center Rigshospitalet, and Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Neuroreport 20:1023-6. 2009
    ..NPY was found to dose-dependently increase extracellular dopamine levels, indicating that NPY could play an important role in drug reinforcement by modulating accumbal dopamine levels..
  8. doi request reprint Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice
    Gunnar Sørensen
    Laboratory of Neuropsychiatry, Rigshospitalet University Hospital, University of Copenhagen, 9 Blegdamsvej, DK 2100, Copenhagen, Denmark
    Psychopharmacology (Berl) 199:37-46. 2008
    ..Cocaine is believed to exert an important part of its rewarding effect by increasing extracellular levels of dopamine that subsequently act at dopamine D2 receptors...
  9. doi request reprint Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures
    Casper R Gøtzsche
    Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Denmark
    Neurobiol Dis 45:288-96. 2012
    ..These results suggest that overexpression of Y5 receptors in combination with neuropeptide Y could be an alternative approach for more effective suppression of hippocampal seizures...
  10. pmc A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
    Mattias Rickhag
    Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Nat Commun 4:1580. 2013
    ..Our findings suggest that PDZ-domain interactions are critical for synaptic distribution of dopamine transporter in vivo and thereby for proper maintenance of dopamine homoeostasis...