Ole Vang

Summary

Affiliation: Roskilde University
Location: Roskilde , Denmark
Summary:
Cellular mechanisms of health promoting substances in human diet. Resveratrol (from grape, berries, peanuts etc) and indoles from cruciferous vegetables. This includes indole-3-carbinol, N-methoxy-indole-3-carbinol and 4-methoxy-indole-3-carbinol). Their efficiency in modulating cell proliferation, cell morphology and cell adhesion are in focus and elucidation of the underlaying signaling mechanisms.

Publications

  1. ncbi request reprint Induction of cytochrome P-450IA1, IA2, IIB1, IIB2 and IIE1 by broccoli in rat liver and colon
    O Vang
    Laboratory of Environmental Carcinogenesis, Fibiger Institute, Danish Cancer Society, Copenhagen
    Chem Biol Interact 78:85-96. 1991
  2. ncbi request reprint Functional food ingredients against colorectal cancer. An example project integrating functional genomics, nutrition and health
    R Stierum
    TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ Zeist, Netherlands
    Nutr Metab Cardiovasc Dis 11:94-8. 2001
  3. ncbi request reprint Indolo[3,2-b]carbazole inhibits gap junctional intercellular communication in rat primary hepatocytes and acts as a potential tumor promoter
    Susan Herrmann
    Department of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde, Denmark
    Carcinogenesis 23:1861-8. 2002
  4. ncbi request reprint Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines
    Antje S Neave
    Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark
    Toxicol Sci 83:126-35. 2005
  5. ncbi request reprint [Recommendation with serious adverse effects]
    Wojciech Ruminski
    Ugeskr Laeger 168:928; author reply 928-9. 2006
  6. ncbi request reprint Time- and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells
    U Stervbo
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Cell Prolif 39:479-93. 2006
  7. ncbi request reprint Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat
    Birgitte Thuesen Olesen
    Department of Science, Systems and Models, Roskilde University, DK 4000 Roskilde, Denmark
    Neurotoxicology 29:13-21. 2008
  8. doi request reprint Bioactivities and chemical constituents of a Vietnamese medicinal plant Che Vang, Jasminum subtriplinerve Blume (Oleaceae)
    Dai Hue Ngan
    Department of Chemistry, College of Natural Sciences, National University of Ho Chi Minh City, 227 Nguyen Van Cu St, Dist 5, Ho Chi Minh City, Vietnam
    Nat Prod Res 22:942-9. 2008
  9. doi request reprint Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol
    Remy Kronbak
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
    J Agric Food Chem 58:8453-9. 2010
  10. ncbi request reprint Cytotoxic Coumarins from the Bark of Mammea siamensis
    Ngoc Trang Nhu Ngo
    Ho Chi Minh City University of Science, Ho Chi Minh City, Vietnam
    Chem Pharm Bull (Tokyo) 58:1487-91. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Induction of cytochrome P-450IA1, IA2, IIB1, IIB2 and IIE1 by broccoli in rat liver and colon
    O Vang
    Laboratory of Environmental Carcinogenesis, Fibiger Institute, Danish Cancer Society, Copenhagen
    Chem Biol Interact 78:85-96. 1991
    ....
  2. ncbi request reprint Functional food ingredients against colorectal cancer. An example project integrating functional genomics, nutrition and health
    R Stierum
    TNO Nutrition and Food Research, P.O. Box 360, 3700 AJ Zeist, Netherlands
    Nutr Metab Cardiovasc Dis 11:94-8. 2001
    ....
  3. ncbi request reprint Indolo[3,2-b]carbazole inhibits gap junctional intercellular communication in rat primary hepatocytes and acts as a potential tumor promoter
    Susan Herrmann
    Department of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde, Denmark
    Carcinogenesis 23:1861-8. 2002
    ..Further studies are needed in order to clarify the anticarcinogenic/carcinogenic effects of I3C and ICZ before high doses of I3C may be recommended as a dietary supplement...
  4. ncbi request reprint Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines
    Antje S Neave
    Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark
    Toxicol Sci 83:126-35. 2005
    ..These results indicate that both NI3C and I3C inhibit the proliferation of human colon cells but via different mechanisms...
  5. ncbi request reprint [Recommendation with serious adverse effects]
    Wojciech Ruminski
    Ugeskr Laeger 168:928; author reply 928-9. 2006
  6. ncbi request reprint Time- and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells
    U Stervbo
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Cell Prolif 39:479-93. 2006
    ..Furthermore, resveratrol treatment causes stimulation of apoptosis as well as an increase in nuclear size and granularity...
  7. ncbi request reprint Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat
    Birgitte Thuesen Olesen
    Department of Science, Systems and Models, Roskilde University, DK 4000 Roskilde, Denmark
    Neurotoxicology 29:13-21. 2008
    ..Thus, we could demonstrate a PQ-inducible effect of the mRNA of antioxidative enzymes, as well as the mRNAs of possible enzymes involved in the protection against oxidative stress...
  8. doi request reprint Bioactivities and chemical constituents of a Vietnamese medicinal plant Che Vang, Jasminum subtriplinerve Blume (Oleaceae)
    Dai Hue Ngan
    Department of Chemistry, College of Natural Sciences, National University of Ho Chi Minh City, 227 Nguyen Van Cu St, Dist 5, Ho Chi Minh City, Vietnam
    Nat Prod Res 22:942-9. 2008
    ..The data presented here indicate that J. subtriplinerve do contain compounds with interesting biological activity...
  9. doi request reprint Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol
    Remy Kronbak
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
    J Agric Food Chem 58:8453-9. 2010
    ..We conclude that 4MeOI3C might play a role in the cancer preventive effect of cruciferous vegetables...
  10. ncbi request reprint Cytotoxic Coumarins from the Bark of Mammea siamensis
    Ngoc Trang Nhu Ngo
    Ho Chi Minh City University of Science, Ho Chi Minh City, Vietnam
    Chem Pharm Bull (Tokyo) 58:1487-91. 2010
    ....
  11. ncbi request reprint [Evidence of dermatological effects of chamomile]
    Simone Danty Rügge
    Institut for Natur, Systemer og Modeller, Roskilde Universitet, Denmark
    Ugeskr Laeger 172:3492-6. 2010
    ..The absence of evidence is primarily caused by the design and quality of the studies identified...
  12. pmc What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    Ole Vang
    Department of Science, System and Models, Roskilde University, Roskilde, Denmark
    PLoS ONE 6:e19881. 2011
    ..Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark...
  13. pmc Challenges of translating basic research into therapeutics: resveratrol as an example
    James M Smoliga
    Department of Health and Physical Education, Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 67:158-67. 2012
    ..The evidence for benefits of resveratrol in humans remains too sparse to be conclusive; yet, the limited data that are available, combined with a growing list of animal studies, provide a strong justification for further study...
  14. ncbi request reprint Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities
    O Vang
    Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark
    Metabolism 50:1130-5. 2001
    ..These results indicate that substances other than glucosinolates in the complex mixtures modulate hepatic EROD, MROD, GSH Px, and GSSG Red activities or that the active glucosinolate metabolites vary in their systemic disposition...
  15. ncbi request reprint Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon
    O Vang
    Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark
    Metabolism 50:1123-9. 2001
    ..The different effects depending on the vegetable sample eaten have to be considered in future experiments and dietary recommendations...
  16. ncbi request reprint Induction of cytochrome P450IA1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone
    O Vang
    Laboratory of Environmental Carcinogenesis Fibiger Institute, Danish Cancer Society, Copenhagen
    Carcinogenesis 11:1259-63. 1990
    ..This suggests that one of the protective effects of cruciferous vegetables in the reduction of chemically induced cancer may be regulation of cytochrome P450s involved in the metabolism of the chemical carcinogens...
  17. ncbi request reprint Inhibition of intercellular communication by condensates of high and low tar cigarettes
    O Vang
    Laboratory of Environmental Carcinogenesis, Fibiger Institute, Danish Cancer Society, Copenhagen
    Arch Toxicol 69:415-20. 1995
    ..Furthermore, CSC and CSC fractions synergistically inhibit GJIC with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, indicating different mechanisms of action...
  18. ncbi request reprint Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular communication: a modified assay for tumour promotion
    O Vang
    Laboratory of Environmental Carcinogenesis, Fibiger Institute, Danish Cancer Society, Copenhagen
    Carcinogenesis 14:2365-71. 1993
    ..The assay also discloses that cytochrome P450 metabolism alters intercellular communication by a mechanism other than metabolism of the exogenous inhibitor...
  19. ncbi request reprint Bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine by liver microsomes from three different rat strains
    L O Dragsted
    National Food Agency of Denmark, Søborg
    Pharmacol Toxicol 72:388-93. 1993
    ..Except for a significantly higher concentration of P450IA2 in microsomes from control and PCB induced Wistar rats, no major differences between the strains were found...
  20. ncbi request reprint Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism
    M A Kall
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Carcinogenesis 17:793-9. 1996
    ..On the other hand, the catalytic activity of CYP2E1 is not affected to the same degree by dietary broccoli...
  21. ncbi request reprint Effects of dietary broccoli on human drug metabolising activity
    M A Kall
    National Food Agency of Denmark, Mørkhøj Bygade, Søborg
    Cancer Lett 114:169-70. 1997
    ..The average activity of CYP1A2 and the average 2/16alpha-hydroxyestrone ratio were increased 19% (P < 0.0005) and 29.5% (P < 0.05), respectively; however, no effects were observed on the CYP2E1 activity...
  22. ncbi request reprint Combined effects of complex mixtures of potentially anti-carcinogenic compounds on antioxidant enzymes and carcinogen metabolizing enzymes in the rat
    O Vang
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Cancer Lett 114:283-6. 1997
    ..The responses were related to the levels of different specific glucosinolates...
  23. ncbi request reprint Modulation of drug-metabolising enzyme expression by condensation products of indole-3-ylcarbinol, an inducer in cruciferous vegetables
    O Vang
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Pharmacol Toxicol 84:59-65. 1999
    ..Also, the enzyme inducing potency of indole-3-ylcarbinol containing vegetable juice is apparently enhanced by incubation in vitro before the intake...
  24. ncbi request reprint Modulation of cytochrome P-450 and glutathione S-transferase isoform expression in vivo by intact and degraded indolyl glucosinolates
    C Bonnesen
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Nutr Cancer 33:178-87. 1999
    ..Neither CYP 2B1/2 nor 2E1 was induced by the indolyl glucosinolates. None of the hepatic GST subunits analyzed, rGST A1/2, A3, or M3, was induced significantly by the purified indolyl glucosinolates...
  25. ncbi request reprint Modulation of cytochrome P4501A1 activity by ascorbigen in murine hepatoma cells
    P U Stephenson
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Biochem Pharmacol 58:1145-53. 1999
    ..Taken together, the results indicate that ASG inhibits CYP1A1 activity at low concentrations, but induces the same activity at higher concentrations...
  26. ncbi request reprint N-methoxyindole-3-carbinol is a more efficient inducer of cytochrome P-450 1A1 in cultured cells than indol-3-carbinol
    P U Stephensen
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Nutr Cancer 36:112-21. 2000
    ..In conclusion, NI3C is a more efficient inducer of CYP 1A1 in cultured cells than I3C but is less active when administered to rodents...
  27. ncbi request reprint Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication
    M Nielsen
    Department of Chemistry and Life Sciences, Roskilde University, Roskilde, DK 4000, Denmark
    Biochem Biophys Res Commun 275:804-9. 2000
    ..In conclusion, resveratrol was found to enhance GJIC and counteract the effects of tumor promoters on GJIC, and this is likely a mechanism that contributes to the antipromotional and anticarcinogenic properties of resveratrol...
  28. doi request reprint What is new for resveratrol? Is a new set of recommendations necessary?
    Ole Vang
    Department of Science, System, and Models, Roskilde University, Roskilde, Denmark
    Ann N Y Acad Sci 1290:1-11. 2013
    ..However, since 2010, results from the first clinical trials on resveratrol have been made available. Because of these emerging results, it is necessary to formulate updated versions of the recommendations. ..