Kim F Rewitz

Summary

Affiliation: Roskilde University
Country: Denmark

Publications

  1. ncbi request reprint CYP330A1 and CYP4C39 enzymes in the shore crab Carcinus maenas: sequence and expression regulation by ecdysteroids and xenobiotics
    Kim Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 310:252-60. 2003
  2. pmc Daphnia Halloween genes that encode cytochrome P450s mediating the synthesis of the arthropod molting hormone: evolutionary implications
    Kim F Rewitz
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280 USA
    BMC Evol Biol 8:60. 2008
  3. ncbi request reprint The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone
    K F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Soc Trans 34:1256-60. 2006
  4. ncbi request reprint Marine invertebrate cytochrome P450: emerging insights from vertebrate and insects analogies
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Comp Biochem Physiol C Toxicol Pharmacol 143:363-81. 2006
  5. pmc Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila
    Morten E Moeller
    Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark
    Development 140:4730-9. 2013
  6. pmc Accessory gland as a site for prothoracicotropic hormone controlled ecdysone synthesis in adult male insects
    Julie L Hentze
    Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    PLoS ONE 8:e55131. 2013
  7. ncbi request reprint Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 36:188-99. 2006
  8. doi request reprint Cytochrome P450 expression is moult stage specific and regulated by ecdysteroids and xenobiotics in the crab Carcinus maenas
    Esben Dam
    Department of Science, Systems and Models, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 377:1135-40. 2008
  9. doi request reprint A phosphoproteomics approach to elucidate neuropeptide signal transduction controlling insect metamorphosis
    Kim F Rewitz
    The Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 39:475-83. 2009
  10. ncbi request reprint Molecular evolution of the insect Halloween family of cytochrome P450s: phylogeny, gene organization and functional conservation
    Kim F Rewitz
    Department of Science, Systems and Models, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 37:741-53. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint CYP330A1 and CYP4C39 enzymes in the shore crab Carcinus maenas: sequence and expression regulation by ecdysteroids and xenobiotics
    Kim Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 310:252-60. 2003
    ..The fact that both ecdysteroids and xenobiotics affect CYP330A1 gene expression indicates that mutual interactions between chemical exposures and endocrine functions may exist in the shore crab...
  2. pmc Daphnia Halloween genes that encode cytochrome P450s mediating the synthesis of the arthropod molting hormone: evolutionary implications
    Kim F Rewitz
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280 USA
    BMC Evol Biol 8:60. 2008
    ..In insects, the CYP enzymes mediating 20E biosynthesis have been identified, but evidence of their probable presence in crustaceans is indirect, relying solely on the ability of crustaceans to synthesize 20E...
  3. ncbi request reprint The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone
    K F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Soc Trans 34:1256-60. 2006
    ..The results indicate that these Halloween genes are transcriptionally regulated to support the high biosynthetic activity that produces the cyclic ecdysteroid pulses triggering moulting...
  4. ncbi request reprint Marine invertebrate cytochrome P450: emerging insights from vertebrate and insects analogies
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Comp Biochem Physiol C Toxicol Pharmacol 143:363-81. 2006
    ..Emphasis should be put on the elucidation of the function and regulation of the ever-increasing number of marine invertebrate P450s...
  5. pmc Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila
    Morten E Moeller
    Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark
    Development 140:4730-9. 2013
    ..Activation of this switch-like mechanism ensures a rapid, self-limiting PG response that functions in producing steroid oscillations that can guide the decision to terminate growth and promote maturation...
  6. pmc Accessory gland as a site for prothoracicotropic hormone controlled ecdysone synthesis in adult male insects
    Julie L Hentze
    Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    PLoS ONE 8:e55131. 2013
    ..Furthermore this study provides the first evidence that PTTH regulates ecdysteroid synthesis in the adult stage and could explain the original finding that some adult insects are a rich source of PTTH...
  7. ncbi request reprint Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 36:188-99. 2006
    ..The consistent expression of the Halloween genes confirms the importance of the prothoracic glands in pupal-adult development. These studies establish Manduca as an excellent model for examining the regulation of the Halloween genes...
  8. doi request reprint Cytochrome P450 expression is moult stage specific and regulated by ecdysteroids and xenobiotics in the crab Carcinus maenas
    Esben Dam
    Department of Science, Systems and Models, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 377:1135-40. 2008
    ..The developmental variations of CYP expression suggest a molecular mechanism for the stage specific susceptibility of crabs exposed to environmental pollutants...
  9. doi request reprint A phosphoproteomics approach to elucidate neuropeptide signal transduction controlling insect metamorphosis
    Kim F Rewitz
    The Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 39:475-83. 2009
    ..This directly connects PTTH signaling to the pathway that produces E. A new mechanism for regulation of E biosynthesis in insects is proposed...
  10. ncbi request reprint Molecular evolution of the insect Halloween family of cytochrome P450s: phylogeny, gene organization and functional conservation
    Kim F Rewitz
    Department of Science, Systems and Models, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 37:741-53. 2007
    ..The results suggest that duplications of ancestral P450 genes that acquired novel functions may have been an important mechanism for evolving the ecdysteroidogenic pathway...
  11. doi request reprint Developmental checkpoints and feedback circuits time insect maturation
    Kim F Rewitz
    Department of Biology, Cell and Neurobiology, University of Copenhagen, Copenhagen, Denmark
    Curr Top Dev Biol 103:1-33. 2013
    ..Conservation of the genetic mechanisms that coordinate the juvenile-adult transition suggests that insights from the fruit fly Drosophila will provide a framework for future investigation of developmental timing in metazoans...
  12. ncbi request reprint Developmental expression of Manduca shade, the P450 mediating the final step in molting hormone synthesis
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Mol Cell Endocrinol 247:166-74. 2006
    ..The data suggest that precise tissue-specific transcriptional regulation controls the levels, and thereby the activity, of the Manduca E20MO...
  13. pmc Steroid hormone inactivation is required during the juvenile-adult transition in Drosophila
    Kim F Rewitz
    Department of Science, Roskilde University, Denmark
    Dev Cell 19:895-902. 2010
    ..The coupling of hormone clearance to βFTZ-F1 expression suggests a general mechanism by which transient signaling drives unidirectional progression through a multistep process...
  14. doi request reprint Nutrient signaling and developmental timing of maturation
    E Thomas Danielsen
    Department of Biology, Cell and Neurobiology, University of Copenhagen, Copenhagen, Denmark
    Curr Top Dev Biol 105:37-67. 2013
    ..Here, we provide an overview of the system underlying developmental timing of maturation in Drosophila and review recent success in understanding its coupling to nutrition and growth. ..
  15. ncbi request reprint Identification of two Nereis virens (Annelida: Polychaeta) cytochromes P450 and induction by xenobiotics
    K F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Comp Biochem Physiol C Toxicol Pharmacol 138:89-96. 2004
    ..The present study demonstrates that these N. virens CYP genes are transcriptionally inducible, and suggests that N. virens CYP4 enzymes may be involved in the metabolism of both exogenous and endogenous compounds...
  16. ncbi request reprint Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera
    Hajime Ono
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 298:555-70. 2006
    ..These studies suggest an evolutionary split between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during development...