Lene Juel Rasmussen

Summary

Affiliation: Roskilde University
Country: Denmark

Publications

  1. pmc Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)
    Nina Østergaard Knudsen
    Department of Science, Systems and Models, Roskilde University, Denmark
    Nucleic Acids Res 35:2609-19. 2007
  2. pmc Expression profiles for six zebrafish genes during gonadal sex differentiation
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Reprod Biol Endocrinol 6:25. 2008
  3. ncbi request reprint [DNA repair--a fundamental factor in ageing and development of cancer]
    Lene Juel Rasmussen
    Roskilde Universitetscenter, Institut for Biologi og Kemi, Aarhus Universitet, DK 4000 Roskilde
    Ugeskr Laeger 168:2332-5. 2006
  4. ncbi request reprint Helicobacter pylori infection generates genetic instability in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, University of Roskilde, Denmark
    Biochim Biophys Acta 1806:58-65. 2010
  5. doi request reprint 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
    Sofie Dabros Andersen
    Department of Science, Systems and Models, Roskilde University, Denmark
    DNA Repair (Amst) 11:267-77. 2012
  6. doi request reprint Functional characterization of MLH1 missense variants identified in Lynch syndrome patients
    Sofie Dabros Andersen
    Department of Science, Systems, and Models, Roskilde University, Roskilde, Denmark
    Hum Mutat 33:1647-55. 2012
  7. ncbi request reprint Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, University of Roskilde, Denmark IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
    Mech Ageing Dev 134:460-6. 2013
  8. ncbi request reprint Influence of biotransformation on trophic transfer of the PAH, fluoranthene
    Annemette Palmqvist
    Department of Environmental, Social and Spatial Change, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Aquat Toxicol 80:309-19. 2006
  9. ncbi request reprint Cadmium inhibits human DNA mismatch repair in vivo
    Anne Lützen
    Department of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 321:21-5. 2004
  10. ncbi request reprint Differences in PAH tolerance between Capitella species: underlying biochemical mechanisms
    Lis Bach
    Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Aquat Toxicol 74:307-19. 2005

Collaborators

Detail Information

Publications33

  1. pmc Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)
    Nina Østergaard Knudsen
    Department of Science, Systems and Models, Roskilde University, Denmark
    Nucleic Acids Res 35:2609-19. 2007
    ..Taken together, we infer that hEXO1, hMLH1 and hMSH2 form complexes and are imported to the nucleus together, and that redundant NLS import signals in the proteins may safeguard nuclear import and thereby MMR activity...
  2. pmc Expression profiles for six zebrafish genes during gonadal sex differentiation
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Reprod Biol Endocrinol 6:25. 2008
    ..The current study investigates the expression of all six genes in the same individual fish with extensive sampling dates during sex determination and -differentiation...
  3. ncbi request reprint [DNA repair--a fundamental factor in ageing and development of cancer]
    Lene Juel Rasmussen
    Roskilde Universitetscenter, Institut for Biologi og Kemi, Aarhus Universitet, DK 4000 Roskilde
    Ugeskr Laeger 168:2332-5. 2006
    ..DNA repair capacity is an important cellular marker that should be considered as a standard clinical test...
  4. ncbi request reprint Helicobacter pylori infection generates genetic instability in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, University of Roskilde, Denmark
    Biochim Biophys Acta 1806:58-65. 2010
    ....
  5. doi request reprint 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif
    Sofie Dabros Andersen
    Department of Science, Systems and Models, Roskilde University, Denmark
    DNA Repair (Amst) 11:267-77. 2012
    ..Altogether, these results suggest that association may be related to regulation of hEXO1 availability during the DNA damage response to plausibly prevent extensive DNA resection at the damage site, as supported by recent studies...
  6. doi request reprint Functional characterization of MLH1 missense variants identified in Lynch syndrome patients
    Sofie Dabros Andersen
    Department of Science, Systems, and Models, Roskilde University, Roskilde, Denmark
    Hum Mutat 33:1647-55. 2012
    ..Moreover, the obtained results correlate well with reported MMR activity and with in silico analysis for a majority of the variants...
  7. ncbi request reprint Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, University of Roskilde, Denmark IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
    Mech Ageing Dev 134:460-6. 2013
    ..Our results suggest that both APE-1 and YB-1 are involved in mtDNA repair during H. pylori infection, furthermore, the results demonstrate that multiple DNA repair activities are involved in protecting mtDNA during infection. ..
  8. ncbi request reprint Influence of biotransformation on trophic transfer of the PAH, fluoranthene
    Annemette Palmqvist
    Department of Environmental, Social and Spatial Change, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Aquat Toxicol 80:309-19. 2006
    ..However, from the present study it cannot be concluded whether differences in biotransformation ability among prey species can lead to different effects in their predators...
  9. ncbi request reprint Cadmium inhibits human DNA mismatch repair in vivo
    Anne Lützen
    Department of Life Sciences and Chemistry, Roskilde University, DK 4000 Roskilde, Denmark
    Biochem Biophys Res Commun 321:21-5. 2004
    ..Thus, our studies show that exposure of human cells to Cd suppresses MMR activity, a repair activity known to play an important role in colon cancer and that this effect can be reversed by Zn treatment...
  10. ncbi request reprint Differences in PAH tolerance between Capitella species: underlying biochemical mechanisms
    Lis Bach
    Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Aquat Toxicol 74:307-19. 2005
    ..g., membrane disruption) are more relevant than DNA damage for predicting tolerance differences between these species...
  11. ncbi request reprint Nuclear and mitochondrial DNA repair: similar pathways?
    Nicolai Balle Larsen
    Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
    Mitochondrion 5:89-108. 2005
    ..In this review, we make comparisons between nDNA and mtDNA repair pathways and propose a model for how these pathways interact in mitochondria...
  12. ncbi request reprint Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases
    Nicolai Balle Larsen
    Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    APMIS 117:839-48. 2009
    ..This may have functional importance for the chemosensitivity of metastases compared to the primary tumor...
  13. doi request reprint Nuclear translocation contributes to regulation of DNA excision repair activities
    Nina Østergaard Knudsen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark
    DNA Repair (Amst) 8:682-9. 2009
    ..Protein co-import appears to be a mechanism employed by the composite repair systems NER and MMR to enhance and regulate nuclear accumulation of repair proteins thereby ensuring faithful DNA repair...
  14. ncbi request reprint Biotransformation of the polycyclic aromatic hydrocarbon pyrene in the marine polychaete Nereis virens
    Anne Jørgensen
    Department of Life Sciences and Chemistry, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Environ Toxicol Chem 24:2796-805. 2005
    ..Our findings show that N. virens has a high biotransformation capacity for PAHs, with inducible pyrene hydroxylase activity, and that the most prominent phase II pathway in this organism is glucuronidation...
  15. ncbi request reprint Is hEXO1 a cancer predisposing gene?
    Sascha Emilie Liberti
    Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark
    Mol Cancer Res 2:427-32. 2004
  16. doi request reprint Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, DK 4000 Roskilde, Denmark
    Chem Biol Interact 177:212-7. 2009
    ..In cell cultures, NER was responsible for the repair of anthanthrene metabolite-induced DNA damage. However, when the NER pathway was inactivated, a residual repair pathway performed the DNA repair...
  17. ncbi request reprint Biotransformation of polycyclic aromatic hydrocarbons in marine polychaetes
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Mar Environ Res 65:171-86. 2008
    ....
  18. doi request reprint Relative impact of coexposure compared to single-substance exposure on the biotransformation and toxicity of benzo[a]pyrene and fluoranthene in the marine polychaete Capitella sp. I
    Annemette Palmqvist
    Department of Environmental, Social, and Spatial Change, Roskilde University, Roskilde, Denmark
    Environ Toxicol Chem 27:375-86. 2008
    ..These results therefore are relevant for assessing risks from contaminated sediments...
  19. ncbi request reprint Mitochondria as determinant of nucleotide pools and chromosomal stability
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Mutat Res 625:112-24. 2007
    ..Our results suggest that mitochondria are central players in maintaining genomic stability and in controlling essential nuclear processes such as upholding a balanced supply of nucleotides...
  20. ncbi request reprint Targeting of O6-MeG DNA methyltransferase (MGMT) to mitochondria protects against alkylation induced cell death
    Anne Karin Rasmussen
    Department of Life Sciences and Chemistry, Roskilde University, 4000 Roskilde, Denmark
    Mitochondrion 5:411-7. 2005
    ..We show that overexpression of this repair protein in mitochondria increases cell survival after treatment with the DNA damaging agent MNNG...
  21. doi request reprint Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells
    Ana Manuel Dantas Machado
    Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    Clin Cancer Res 15:2995-3002. 2009
    ..pylori infection on known cellular repair pathways in vitro and in vivo. Moreover, various types of genetic instabilities in the nuclear and mitochondrial DNA (mtDNA) were examined...
  22. doi request reprint Functional analysis of HNPCC-related missense mutations in MSH2
    Anne Lützen
    Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark
    Mutat Res 645:44-55. 2008
    ..In conclusion, all mutant proteins (except for MSH2-A305T) have defects; either in mismatch binding, ATP-release, mismatch repair activity, subcellular localization or protein-protein interactions...
  23. pmc In Silico screening for functional candidates amongst hypothetical proteins
    Claus Desler
    Department of Science, Systems and Models, Roskilde University, DK 4000 Roskilde, Denmark
    BMC Bioinformatics 10:289. 2009
    ....
  24. ncbi request reprint Identification and characterisation of an androgen receptor from zebrafish Danio rerio
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Comp Biochem Physiol C Toxicol Pharmacol 146:561-8. 2007
    ..The characterisation of this zfAR provides a new perspective for understanding the mechanisms underlying androgen actions in a model vertebrate species commonly used for studies investigating potential endocrine disrupters...
  25. ncbi request reprint Cyclin D1 expression and cell cycle response in DNA mismatch repair-deficient cells upon methylation and UV-C damage
    Anne Lützen
    Department of Life Sciences and Chemistry, Roskilde University, 4000 Roskilde, Denmark
    Exp Cell Res 292:123-34. 2004
    ..Finally, we show that cyclin D1 is degraded by the proteasome in response to alkylation damage...
  26. ncbi request reprint Biotransformation and genotoxicity of fluoranthene in the deposit-feeding polychaete Capitella sp. I
    Annemette Palmqvist
    Department of Life Sciences and Chemistry, Roskilde University, 4000 Roskilde, Denmark
    Environ Toxicol Chem 22:2977-85. 2003
    ....
  27. ncbi request reprint Characterisation of two novel CYP4 genes from the marine polychaete Nereis virens and their involvement in pyrene hydroxylase activity
    Anne Jørgensen
    Department of Life Sciences and Chemistry, Roskilde University, Denmark
    Biochem Biophys Res Commun 336:890-7. 2005
    ..virens in estuarine environments that accumulates organic xenobiotics, our results are important in understanding the molecular mechanism of biotransformation in marine polychaetes...
  28. ncbi request reprint Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus
    Robert L Delsite
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 212312, USA
    Mutagenesis 18:497-503. 2003
    ..It also provides insights into the development of mitochondrial disease as a consequence of cancer therapy...
  29. ncbi request reprint Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Ann N Y Acad Sci 1011:284-98. 2004
    ..Together, our data suggest that gene(s) involved in mitochondria-to-nucleus communication play a role in mutagenesis and may be implicated in carcinogenesis...
  30. ncbi request reprint Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes
    Jianghua Ou
    Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands
    Hum Mutat 28:1047-54. 2007
    ..We conclude that a large proportion of MMR UVs are likely to be pathogenic, suggesting that missense variants of MMR proteins do indeed play a role in HNPCC...
  31. ncbi request reprint Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
    Finn Cilius Nielsen
    Department of Clinical Biochemistry, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Oncogene 23:1457-68. 2004
    ..Taken together, the results support a model in which hEXO1 plays a role in events at the replication sites as well as a functional role in the MMR and/or recombination processes...
  32. pmc Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae
    Anne Karin Rasmussen
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Nucleic Acids Res 31:3909-17. 2003
    ..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype...
  33. pmc Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1
    Hanne Cathrine Bisgaard
    Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Am J Pathol 161:1187-98. 2002
    ....