Research Topics
Species | Gregor B E JemecSummaryAffiliation: Roskilde Hospital Country: Denmark Publications
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Publications
Medical treatment of hidradenitis suppurativaGregor B E Jemec
Roskilde Hospital, Division of Dermatology, Department of Medicine, DK 4000 Roskilde, Denmark
Expert Opin Pharmacother 5:1767-70. 2004..However, the main source of evidence for this are case series and there is a strong need for more formal studies in this potentially debilitating disease...
Time spent on treatment (TSOT). An independent assessment of disease severity in atopic dermatitisGregor B E Jemec
Department of Dermatology, University of Copenhagen, Roskilde Hospital, DK 4000 Roskilde, Denmark
Acta Dermatovenerol Alp Panonica Adriat 15:119-24. 2006..Our purpose was to examine the relationship between time spent on treatment and parental psychological parameters such as anxiety and depression...
Teledermatology on the Faroe IslandsGregor B E Jemec
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Denmark
Int J Dermatol 47:891-3. 2008..The service is based on a nurse-led dermatological clinic, and teledermatology is combined with specialist visits for more complex diagnosis or procedures...
Effects of topical corticosteroid and tacrolimus on ceramides and irritancy to sodium lauryl sulphate in healthy skinJakob Mutanu Jungersted
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Denmark
Acta Derm Venereol 91:290-4. 2011..In conclusion, treatment with betamethasone and tacrolimus has a positive effect on the ceramide/cholesterol ratio and susceptibility to irritant reaction compared with an emollient...
High body mass index in adolescent girls precedes psoriasis hospitalizationLars Erik Bryld
Department of Dermatology, Roskilde Hospital, Roskilde, Dernmark
Acta Derm Venereol 90:488-93. 2010..The female group showed a significant association between psoriasis and body mass index at ages 12 (p = 0.028) and 13 years (p = 0.010). This was not the case for males or for body mass index measured at ages 11 years and below...
Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramidesJakob Mutanu Jungersted
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Arch Dermatol Res 302:653-6. 2010..No significant changes in stratum corneum lipids were found after 2 months of treatment. In conclusion, systemic alitretinoin does not influence skin susceptibility to irritants or the ceramide profile of stratum corneum...
Optical coherence tomography imaging of psoriasis vulgaris: correlation with histology and disease severityHanan Morsy
Department of Dermatology, Health Sciences Faculty, Roskilde Hospital, University of Copenhagen, 4000 Roskilde, Denmark
Arch Dermatol Res 302:105-11. 2010..This implies that OCT assessment of psoriatic plaques may provide a useful method for non-invasive in vivo method to follow the evolution of psoriasis lesions...
The impact of ultraviolet therapy on stratum corneum ceramides and barrier functionJakob Mutanu Jungersted
Department of Dermatology, Roskilde Hospital, Copenhagen University, Roskilde, Denmark
Photodermatol Photoimmunol Photomed 27:331-3. 2011..We found that UV light treatment does not change the ratio of important stratum corneum lipids, but we confirm earlier findings of decreased susceptibility to irritants after UV- therapy...
Skin barrier response to occlusion of healthy and irritated skin: differences in trans-epidermal water loss, erythema and stratum corneum lipidsJakob Mutanu Jungersted
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
Contact Dermatitis 63:313-9. 2010..Occlusion of the skin is a risk factor for development of irritant contact dermatitis. Occlusion may, however, have a positive effect on skin healing. No consensus on the effect of occlusion has been reached...
Ceramides and barrier function in healthy skinJakob Mutanu Jungersted
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Acta Derm Venereol 90:350-3. 2010..Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02)...
Quality of life assessment among patients with peristomal skin diseaseHanne Nybaek
Department of Dermatology, Health Sciences Faculty, University of Copenhagen, Roskilde Hospital, DK 4000 Roskilde, Denmark
Eur J Gastroenterol Hepatol 22:139-43. 2010..No data exist to describe how a skin problem may additionally affect the quality of life (QOL) in ostomates. We have studied the QOL in patients with peristomal skin problems and the variables that may affect it...
Exposures related to hand eczema: a study of healthcare workersKristina S Ibler
Department of Dermatology, Roskilde University Hospital, 4000 Roskilde, Denmark
Contact Dermatitis 66:247-53. 2012..Hand eczema is common in healthcare workers, owing to intensive exposure to wet work and skin irritants. Targeted interventions and vocational guidance based on documented exposures and risk factors are needed...
Does visible atopic dermatitis affect quality of life more in women than in men?Elisabeth A Holm
Roskilde Hospital, Roskilde, Denmark
Gend Med 1:125-30. 2004..The description of possible gender differences in morbidity in a skin disease with comparable prevalence in men and women may therefore provide relevant data...
Outcomes in randomized controlled trials in psoriasis: what has changed over the last 20 years?Hanan Morsy
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Denmark
J Dermatolog Treat 18:261-7. 2007..Our objective was to reproduce this seminal review to describe the changes over the last 20 years with regard to the evaluation of psoriasis severity in randomized clinical trials...
Morphology and epidermal thickness of normal skin imaged by optical coherence tomographyMette Mogensen
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
Dermatology 217:14-20. 2008..To identify skin pathologies using OCT, it is of prime importance to establish baseline morphological features of normal skin...
A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trialGregor B E Jemec
Department of Dermatology, Health Sciences Faculty University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
J Am Acad Dermatol 59:455-63. 2008..New topical treatments in scalp psoriasis are needed because many current topical treatments are disliked by patients and associated with poor compliance...
Dapsone therapy for hidradenitis suppurativa: a series of 24 patientsShiva Yazdanyar
Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Roskilde, Denmark
Dermatology 222:342-6. 2011..HS is difficult to treat, and the evidence for the effect of most treatments consists of smaller open studies. The use of dapsone in the treatment of HS is based on a few published cases successfully treated...
Psychosocial impact of hidradenitis suppurativa: a qualitative studySolveig Esmann
Department of Dermatology, Roskilde Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
Acta Derm Venereol 91:328-32. 2011..Shame and irritation are frequent and relate to smell, scars, itching and pain. Quality of life is adversely affected and professional support is needed...
How histological features of basal cell carcinomas influence image quality in optical coherence tomographyMette Mogensen
Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Koegevej 7 13, DK 4000 Roskilde, Denmark
J Biophotonics 4:544-51. 2011..Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters...
Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologistsMette Mogensen
Department of Dermatology, Roskilde Hospital, Faculty of Health Sciences, University of Copenhagen, Roskilde, Denmark
Dermatol Surg 35:965-72. 2009..Optical coherence tomography (OCT) is an optical imaging technique that may be useful in diagnosis of non-melanoma skin cancer (NMSC)...
OCT imaging of skin cancer and other dermatological diseasesMette Mogensen
Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Koegevej 7 13, 4000 Roskilde, Denmark
J Biophotonics 2:442-51. 2009....
Hydration and plasticity following long-term use of a moisturizer: a single-blind studyGregor B E Jemec
Department of Medicine, Roskilde Hospital, Denmark
Acta Derm Venereol 82:322-4. 2002..No dose-response effect was seen, however. Long-term use of moisturizers increases skin capacitance significantly, but does not change the mechanical properties. In vivo skin hydration is a poor predictor of skin mechanics...
[Patients' knowledge of the risk of skin cancer following kidney transplantation]Elisabeth Cramer
Dermatologisk afdeling, Roskilde Sygehus, DK 4000 Roskilde, Denmark
Ugeskr Laeger 171:3341-5. 2009..Organ-transplanted (OT) patients therefore constitute a known and growing risk population. Careful information of the patient and prophylactic measures are thus strongly indicated...
Successful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapyMichael Heidenheim
Department of Dermatology, Roskilde Hospital, Roskilde, Denmark
Arch Dermatol 142:1548-50. 2006
Hidradenitis suppurativa: a review of cause and treatmentShiva Yazdanyar
Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark
Curr Opin Infect Dis 24:118-23. 2011..This review discusses the different aetiological theories and management opportunities...
Pain and photodynamic therapyKatrine E K Lindeburg
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Copenhagen, Denmark
Dermatology 215:206-8. 2007..The main adverse effect in PDT treatment is pain. Each lesion is generally treated twice, and clinical experience suggests that the 2nd treatment causes more pain than the 1st and thus becomes a therapy-limiting factor...
Hidradenitis suppurativa complicating naevus comedonicus: the possible influence of mechanical stress on the development of hidradenitis suppurativaDeirdre Nathalie Dufour
Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Køgevej 7 13, Roskilde, Denmark
Dermatology 220:323-5. 2010..We hypothesise that this serendipitous observation provides a model for the way mechanical stress can account for the development of hidradenitis suppurativa in some patients...
Instrumental assessment of atopic eczema: validation of transepidermal water loss, stratum corneum hydration, erythema, scaling, and edemaElisabeth A Holm
Department of Dermatology at Roskilde Hospital, Copenhagen University, Denmark
J Am Acad Dermatol 55:772-80. 2006..Quantification of skin diseases can be carried out in many ways. Clinical scores are widely used in atopic eczema (AE), and noninvasive instruments are a relevant supplement...
Imaging of cutaneous larva migrans by optical coherence tomographyHanan Morsy
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Travel Med Infect Dis 5:243-6. 2007..This technology could therefore potentially allow rapid, non-invasive, in vivo diagnosis of infestations...
[Diagnostic imaging of skin diseases. Danish Society of Dermatology]Elisabeth A Holm
Dermatologisk Funktion, Medicinsk afdeling, Roskilde Amts Sygehus, Roskilde, DK-4000 Roskilde
Ugeskr Laeger 167:1382. 2005
Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitorsPia Haslund
Department of Dermatology, Roskilde Hosital, Health Sciences Faculty, University of Copenhagen, Roskilde, Denmark
Acta Derm Venereol 89:595-600. 2009..However, several questions remain to be answered through specific studies. This review has also identified a need for more standardized reporting of the outcomes as well as randomized controlled trials in this disease...
Skin problems in ostomy patients: a case-control study of risk factorsHanne Nybaek
Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Acta Derm Venereol 89:64-7. 2009..Patients under-report the presence of peristomal skin problems and therefore it is suggested that they need to be assessed by a professional on a routine basis in order to avoid or better manage peristomal skin complications...
Photodynamic therapy in the treatment of rosaceaHanne Nybaek
Division of Dermatology, Department of Medicine, Roskilde Hospital, Roskilde, Denmark
Dermatology 211:135-8. 2005..In 2 patients, remissions lasted 3 months, during which time no additional or supplementary treatment was used. CONCLUSION: Our observation suggests that PDT may play a role in the future treatment of selected cases of rosacea...
Patient education and morbidity in atopic eczemaElisabeth A Holm
Eczema School Program, Division of Dermatology, Department of Medicine, Roskilde Hospital, Roskilde, Denmark
Dermatol Nurs 17:35-46. 2005..Effective treatment of atopic eczema is dependent upon good management by the patients and parents. It is possible to encourage patients and improve their compliance through nurse consultation and Web-based information...
The bacterial flora of the skin surface following routine MAL-PDTLars Eeik Bryld
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
J Dermatolog Treat 17:222-3. 2006..Therefore, the possible antibacterial effect of routine MAL-PDT is probably not the main explanation of its apparent effect on non-neoplastic skin disease...
Acne: comparing hormonal approaches to antibiotics and isotretinoinTina Holst Larsen
Department of Medicine, Roskilde Hospital, University of Copenhagen, Denmark
Expert Opin Pharmacother 4:1097-103. 2003..There is therefore a demand for future standardisation of further acne studies to enable direct comparison of different treatment efficacies...
Hand eczema: prevalence and risk factors of hand eczema in a population of 2274 healthcare workersKristina S Ibler
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Copenhagen, Denmark
Contact Dermatitis 67:200-7. 2012..Healthcare workers are at increased risk of developing hand eczema...
Have oral contraceptives reduced the prevalence of acne? a population-based study of acne vulgaris, tobacco smoking and oral contraceptivesGregor B E Jemec
Division of Dermatology, Department of Medicine, Roskilde University Hospital, Roskilde, Denmark
Dermatology 204:179-84. 2002..Both have been suggested to influence acne and are therefore potential confounders in studies of acne prevalence...
Lipids and skin barrier function--a clinical perspectiveJakob Mutanu Jungersted
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Køgevej 7 13, DK 4000 Roskilde, Denmark
Contact Dermatitis 58:255-62. 2008..It may be concluded that the number of human studies is very limited, and in the perspective of how important diseases of impaired barrier function are in dermatology, further research is needed...
A bibliometric study of dermatology in central Europe 1991-2002Gregor B E Jemec
Division of Dermatology, Department of Medicine, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Int J Dermatol 45:922-6. 2006..Central Europe has a long tradition of dermatological research which has been negatively impacted by general political developments for a long period. This study was undertaken in order to describe the progress made in recent years...
HuMax-CD4: a fully human monoclonal anti-CD4 antibody for the treatment of psoriasis vulgarisLone Skov
Department of Dermatology, Gentofte University Hospital, Gentofte, Denmark
Arch Dermatol 139:1433-9. 2003..The efficacy results obtained after only 4 weeks of treatment suggest that longer treatment would lead to even further reduction of PASI...
Diagnosis of nonmelanoma skin cancer/keratinocyte carcinoma: a review of diagnostic accuracy of nonmelanoma skin cancer diagnostic tests and technologiesMette Mogensen
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
Dermatol Surg 33:1158-74. 2007..Noninvasive treatment is increasingly used for NMSC patients with superficial lesions, making the development of noninvasive diagnostic technologies highly relevant...
Mechanical properties and barrier function of healthy human skinLouise Pedersen
Division of Dermatology, Department of Medicine, University of Copenhagen, Roskilde Hospital, Denmark
Acta Derm Venereol 86:308-11. 2006..These observations suggest that the mechanical strength of the skin barrier may play a role in the development of, for example, friction dermatitis and other skin diseases affected by mechanical stress...
Treatment of Nail Psoriasis With TNF-? or IL12/23 InhibitorsGregor B E Jemec
Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Denmark
J Drugs Dermatol 11:939-42. 2012..The effect only appears to be delayed due to the rate of growth of the nail plate. J Drugs Dermatol. 2012;11(8):939-942...
Permanent disability pension due to skin diseases in Denmark 2003-2008Kristina S Ibler
Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Denmark
Acta Dermatovenerol Croat 19:161-4. 2011..This may reflect that skin diseases either have less impact on the individual or are not considered by the authorities as debilitating as other high prevalence diseases such as musculoskeletal, psychiatric or circulatory diseases...
Hedgehog pathway does not play a role in hidradenitis suppurativa pathogenesisElga Mozeika
Division of Doctoral Studies, Faculty of Continuing Education, Riga Stradins University, Riga, Latvia Department of Dermatology, Roskilde Hospital, Roskilde, Denmark Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Department of Pathology, Roskilde Hospital, Roskilde, Denmark
Exp Dermatol 20:841-2. 2011..According to our findings, we have to conclude that there is no evidence that sonic hedgehog pathway is part of hidradenitis suppurativa pathogenesis...
Hidradenitis suppurativaGregor B E Jemec
Division of Dermatology, Department of Medicine, Roskilde Hospital, Roskilde, Denmark
J Cutan Med Surg 7:47-56. 2003..Hidradenitis suppurativa is a clinically defined disease that causes considerable morbidity for patients. The results of recent studies, which have increased the understanding of this disease, are reviewed...
Nonmelanoma skin cancer in organ transplant patientsGregor B E Jemec
Division of Dermatology, Department of Medicine, Roskilde Hospital, 4000 Roskilde, Denmark
Transplantation 75:253-7. 2003..It is suggested that the optimal use of these new developments occurs if patients are seen in specialized clinics aimed at providing preventive measures, diagnosis, and treatment...
Lipid raft-enriched stem cell-like keratinocytes in the epidermis, hair follicles and sinus tracts in hidradenitis suppurativaRobert Gniadecki
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
Exp Dermatol 13:361-3. 2004..Sinus tract formation may represent an aberrant epidermal repair response executed by the activated CD29(bright)CTx(bright) keratinocytes capable of non-malignant infiltrative growth in the dermis and subcutis...
Acne: treatment of scarsGregor B E Jemec
Division of Dermatology, Department of Medicine, Roskilde Hospital, University of Copenhagen, DK 4000 Roskilde, Denmark
Clin Dermatol 22:434-8. 2004..The scarring causes long-term morbidity that requires specific therapy.(7)..
Management of actinic keratosis patients: a qualitative studySolveig Esmann
Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
J Dermatolog Treat 18:53-8. 2007..In order to reinforce the appropriate UV-related behaviour of patients with actinic keratosis (AK), it is of importance to understand the underlying psychological aspects of having AK...
Imaging of intradermal tattoos by optical coherence tomographyHanan Morsy
Department of Dermatology, Roskilde Hospital, University of Copenhagen, Denmark
Skin Res Technol 13:444-8. 2007..The purpose of this pilot study is to describe optical coherence tomography image characteristics of intradermal tattoos...
The therapeutic potential of calcipotriol in diseases other than psoriasisElisabeth A Holm
Division of Dermatology, Department of Medicine, Roskilde Hospital, Denmark
Int J Dermatol 41:38-43. 2002..Calcipotriol is a vitamin D analog, which has antiproliferative and anti- inflammatory effects, and stimulates terminal differentiation. It has been an established treatment for psoriasis since 1991 in Europe and 1994 in the USA...
Involuntary autonomy: patients' perceptions of physicians, conventional medicines and risks in the management of atopic dermatitisMikkel Noerreslet
University of Copenhagen, The Faculty of Pharmaceutical Sciences, Department of Pharmacology and Pharmacotherapy, Universitetsparken 2, 2100 Copenhagen, Denmark
Soc Sci Med 69:1409-15. 2009..Ultimately, the findings stress that health care politicians and professionals need to reflect upon patient's wants and needs when designing future health care. Turning health care into self-care may not be an appropriate strategy...
The mechanical properties of skin in osteogenesis imperfectaBirgitte Hansen
Osteoporosis Research Clinic, Hvidovre University Hospital, University of Copenhagen, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
Arch Dermatol 138:909-11. 2002..The functional changes may reflect general changes and may give insight into the pathogenesis of clinical problems in these patients...
[Relevant public information about malignant melanoma]Mette Mogensen
Ugeskr Laeger 169:616. 2007
[Dermatovenereology. The Danish Society of Dermatology]Robert Gniadecki
Dermatologisk afsnit, Medicinsk afdeling, Roskilde Amtssygehus, DK-4000 Roskilde
Ugeskr Laeger 164:1656. 2002
Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histologyFrancisco Bobadilla
Dermatology Department, Hospital Barros Luco Trudeau, Santiago de Chile, Chile
Cancer Imaging 8:163-72. 2008..It has a good thickness correlation with histology and may be used as a technique to monitor disease changes following non-invasive medical treatments in the future...
Methotrexate use and monitoring in Switzerland and DenmarkTomas N Dam
Dermatology 210:253. 2005
[Dermatologic treatment. The Danish Society of Dermatology]Anne K Braae Olesen
Medicinsk afdeling, Amtssygehuset Roskilde, DK-4000 Roskilde
Ugeskr Laeger 165:1228. 2003
Real-time spatial compound ultrasound imaging of skinXimena C Wortsman
Imaging Department, Hospital del Profesor, Alameda 4860, Santiago, Chile
Skin Res Technol 10:23-31. 2004..This new method may, however, become an important adjunct method for the study of skin lesions...
[Screening for skin cancer in organ transplant recipients in Denmark]Janne Horn
Medicinsk Afdeling og Dermatologisk Funktion, Roskilde Amts Sygehus Roskilde, Plastikkirurgisk Afdeling
Ugeskr Laeger 167:2762-5. 2005..e., a dermatologist. We investigated the routine level of monitoring for NMSC in organ transplant recipients in Denmark...
[Infliximab treatment of peristomal pyoderma gangrenosum in ulcerative colitis]Hanne Nybaek
Ugeskr Laeger 167:2920-1. 2005
[Picture of the month: erythema toxicum neonatorum]Jane Sandby-Møller
Roskilde Amts Sygebus Roskilde, Medicinsk afdeling, Dematologisk Ambulatorium of Patologiafdelingen
Ugeskr Laeger 168:2682-3. 2006
Real-time compound imaging ultrasound of hidradenitis suppurativaXimena Wortsman
Radiology Department, Clinica Hospital del Profesor and Clinica Servet, Santiago, Chile
Dermatol Surg 33:1340-2. 2007..Hidradenitis suppurativa (HS) is a difficult disease to treat. Surgery may be curative, but just like cancer surgery, it must be complete to effect a cure. Preoperative imaging of hidradenitis lesions is therefore of interest...
Combined imiquimod and acitretin for non-surgical treatment of basal cell carcinomaChristoffer Ingves
Department of Plastic Surgery, Roskilde Amtssygehus, Roskilde, Denmark
Scand J Plast Reconstr Surg Hand Surg 37:293-5. 2003....
[Prolonged skin rash as sequelae of cytomegalovirus infection in non-immunocompromised patients]Marianne Hald
H:S Bispebjerg Hospital, Dermato-venerologisk afdeling
Ugeskr Laeger 167:296-8. 2005
