Kirstine Roepstorff

Summary

Country: Denmark

Publications

  1. pmc Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Histochem Cell Biol 129:563-78. 2008
  2. ncbi request reprint Caveolae: stable membrane domains with a potential for internalization
    Anette M Hommelgaard
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Traffic 6:720-4. 2005
  3. pmc Differential effects of EGFR ligands on endocytic sorting of the receptor
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Building, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Traffic 10:1115-27. 2009
  4. pmc Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus
    Mads Lerdrup
    Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 18:3656-66. 2007
  5. ncbi request reprint Caveolae: anchored, multifunctional platforms in the lipid ocean
    Bo van Deurs
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Trends Cell Biol 13:92-100. 2003
  6. ncbi request reprint Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding
    Kirstine Roepstorff
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 277:18954-60. 2002
  7. ncbi request reprint Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers
    Bodil Vistisen
    Copenhagen Muscle Research Centre, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 45:603-9. 2004
  8. ncbi request reprint Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, 2200N Copenhagen, Denmark
    J Biol Chem 283:7983-93. 2008
  9. pmc Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking
    Peter Thomsen
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 13:238-50. 2002

Collaborators

Detail Information

Publications9

  1. pmc Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Histochem Cell Biol 129:563-78. 2008
    ..In addition, we outline how ErbB receptors can escape endocytic downregulation in cancer, and we discuss how targeted anti-cancer therapy may induce endocytic downregulation of ErbB receptors...
  2. ncbi request reprint Caveolae: stable membrane domains with a potential for internalization
    Anette M Hommelgaard
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Traffic 6:720-4. 2005
    ..Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data...
  3. pmc Differential effects of EGFR ligands on endocytic sorting of the receptor
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Building, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Traffic 10:1115-27. 2009
    ..The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and persistent EGFR phosphorylation and ubiquitination largely correlate with receptor degradation...
  4. pmc Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus
    Mads Lerdrup
    Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 18:3656-66. 2007
    ..Altogether, we suggest that geldanamycin leads to C-terminal cleavage of ErbB2, which releases the receptor from a retention mechanism and causes endocytosis and lysosomal degradation of ErbB2...
  5. ncbi request reprint Caveolae: anchored, multifunctional platforms in the lipid ocean
    Bo van Deurs
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Trends Cell Biol 13:92-100. 2003
    ..Rather than having a specific function, caveolae might be considered to be multifunctional organelles with a physiological role that varies depending on cell type and cellular needs...
  6. ncbi request reprint Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding
    Kirstine Roepstorff
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 277:18954-60. 2002
    ..We propose that non-caveolar lipid rafts function as negative regulators of EGF receptor signaling by sequestering a fraction of the EGF receptors in a state inaccessible for ligand binding...
  7. ncbi request reprint Sarcolemmal FAT/CD36 in human skeletal muscle colocalizes with caveolin-3 and is more abundant in type 1 than in type 2 fibers
    Bodil Vistisen
    Copenhagen Muscle Research Centre, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 45:603-9. 2004
    ..Furthermore, we provide evidence that FAT/CD36 expression is significantly higher in type 1 compared with type 2 fibers, whereas caveolin-3 expression is significantly higher in type 2 fibers than in type 1 fibers...
  8. ncbi request reprint Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, 2200N Copenhagen, Denmark
    J Biol Chem 283:7983-93. 2008
    ..Collectively, our findings define a VAV1-Rac1-PAK1 signaling axis in mononuclear phagocytes regulating superoxide production in a stimulus-dependent manner...
  9. pmc Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking
    Peter Thomsen
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 13:238-50. 2002
    ..We therefore conclude that caveolae are not involved in constitutive endocytosis but represent a highly stable plasma membrane compartment anchored by the actin cytoskeleton...