P J Larsen

Summary

Affiliation: Rheoscience A/S
Country: Denmark

Publications

  1. ncbi request reprint Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit
    P J Larsen
    Rheoscience, Rødovre, Denmark
    J Neuroendocrinol 15:219-26. 2003
  2. doi request reprint Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats
    P J Larsen
    Rheoscience, Copenhagen, Denmark
    Diabetes Obes Metab 10:301-11. 2008
  3. ncbi request reprint Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter
    Philip J Larsen
    Rheoscience A S, The Panum Insitute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Regul Pept 128:97-107. 2005
  4. ncbi request reprint Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis
    Philip J Larsen
    Rheoscience, Rødovre, Denmark
    Diabetes 52:2249-59. 2003
  5. ncbi request reprint Central pre-proglucagon derived peptides: opportunities for treatment of obesity
    Philip J Larsen
    Rheoscience, Glerupvej 2, 2610 Rødovre, Denmark
    Curr Pharm Des 9:1373-82. 2003
  6. ncbi request reprint Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    P J Larsen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 138:4445-55. 1997
  7. ncbi request reprint Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment
    M Tang-Christensen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Diabetes 47:530-7. 1998
  8. ncbi request reprint Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour
    N Vrang
    Institute of Medical Anatomy, Department B, The Panum Institute, University of Copenhagen, Blegdamsvej 3 DK 2200, Copenhagen, Denmark
    Brain Res 818:499-509. 1999
  9. ncbi request reprint Glucagon-like peptide containing pathways in the regulation of feeding behaviour
    M Tang-Christensen
    Department of Medical Anatomy Sect B, University of Copenhagen, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 25:S42-7. 2001
  10. ncbi request reprint Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat
    N Vrang
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 141:794-801. 2000

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit
    P J Larsen
    Rheoscience, Rødovre, Denmark
    J Neuroendocrinol 15:219-26. 2003
    ..The current study provides further evidence that CART is a neuroendocrine-releasing factor with a possible impact on anterior pituitary function during states of haemodynamic stress...
  2. doi request reprint Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats
    P J Larsen
    Rheoscience, Copenhagen, Denmark
    Diabetes Obes Metab 10:301-11. 2008
    ..Severe insulin resistance and impaired pancreatic beta-cell function are pathophysiological contributors to type 2 diabetes, and ideally, antihyperglycaemic strategies should address both...
  3. ncbi request reprint Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter
    Philip J Larsen
    Rheoscience A S, The Panum Insitute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Regul Pept 128:97-107. 2005
    ....
  4. ncbi request reprint Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis
    Philip J Larsen
    Rheoscience, Rødovre, Denmark
    Diabetes 52:2249-59. 2003
    ....
  5. ncbi request reprint Central pre-proglucagon derived peptides: opportunities for treatment of obesity
    Philip J Larsen
    Rheoscience, Glerupvej 2, 2610 Rødovre, Denmark
    Curr Pharm Des 9:1373-82. 2003
    ..This and other aspects of the current state of the role of central pre-proglucagon in energy homeostasis are reviewed...
  6. ncbi request reprint Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    P J Larsen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 138:4445-55. 1997
    ..Therefore, we conclude that GLP-1 activates the hypothalamo-pituitary-adrenocortical axis primarily through stimulation of CRH neurons, and this activation may also be responsible for the inhibition of feeding behavior...
  7. ncbi request reprint Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment
    M Tang-Christensen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Diabetes 47:530-7. 1998
    ..Thus it is evident that centrally acting GLP-1 modulates feeding and drinking behavior via neurones sensitive to MSG lesioning in the arcuate nucleus and circumventricular organs, respectively...
  8. ncbi request reprint Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour
    N Vrang
    Institute of Medical Anatomy, Department B, The Panum Institute, University of Copenhagen, Blegdamsvej 3 DK 2200, Copenhagen, Denmark
    Brain Res 818:499-509. 1999
    ..The present experiments suggest that CART peptide exerts its inhibitory effects on appetite by activating hypothalamic and brainstem neurones implicated in the central control of feeding behaviour and metabolism...
  9. ncbi request reprint Glucagon-like peptide containing pathways in the regulation of feeding behaviour
    M Tang-Christensen
    Department of Medical Anatomy Sect B, University of Copenhagen, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 25:S42-7. 2001
    ..Future experiments will elucidate whether or not GLP-1 and GLP-2 are involved in the long-term or short-term regulation of feeding behaviour and hence have an impact on bodyweight...
  10. ncbi request reprint Central administration of cocaine-amphetamine-regulated transcript activates hypothalamic neuroendocrine neurons in the rat
    N Vrang
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 141:794-801. 2000
    ..The effect of CART on CRH neurons most likely leads to corticosterone secretion from the adrenal gland, which may contribute to the inhibitory effects of CART on feeding behavior...
  11. ncbi request reprint Neurones projecting to the hypothalamus from the brainstem A1 catecholaminergic cell group express glutamate-R2,3 receptor immunoreactivity
    P J Larsen
    Department of Anatomy, University of Copenhagen, Denmark
    Brain Res 705:209-15. 1995
    ....
  12. ncbi request reprint PACAP gene expression in neurons of the rat hypothalamo-pituitary-adrenocortical axis is induced by endotoxin and interleukin-1beta
    J Hannibal
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Denmark
    Neuroendocrinology 70:73-82. 1999
    ..The findings suggest that PACAP may function as a hypothalamo-pituitary-releasing factor during acute inflammation...
  13. ncbi request reprint Activation of central neuropeptide Y Y1 receptors potently stimulates food intake in male rhesus monkeys
    P J Larsen
    Department of Anatomy, University of Copenhagen, Copenhagen N, Denmark
    J Clin Endocrinol Metab 84:3781-91. 1999
    ..Thus, endogenous NPY is likely to be involved in the regulation of food intake in the nonhuman primate, and this effect is at least partially mediated via Y1-like receptors...
  14. ncbi request reprint Effects of leptin on arcuate pro-opiomelanocortin and cocaine-amphetamine-regulated transcript expression are independent of circulating levels of corticosterone
    N Vrang
    Rheoscience, Rødovre, Denmark
    J Neuroendocrinol 14:880-6. 2002
    ..The present data support the view that leptin influences arcuate POMC and CART mRNA expression directly, and that the effect is not modulated by corticosterone across a wide range of circulating corticosterone concentrations...
  15. ncbi request reprint Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats
    P J Larsen
    Department of Anatomy, University of Copenhagen, Denmark
    Obes Res 8:590-6. 2000
    ..To assess the potential role of CART as a long-term regulator of food intake, we investigated the effects of continuous infusion of recombinant CART(42-89) on food consumption and body weight...
  16. ncbi request reprint The neuropeptide Y (Y4) receptor is highly expressed in neurones of the rat dorsal vagal complex
    P J Larsen
    Department of Medical Anatomy, University of Copenhagen, Novo Nordisk A S, Bagsvoerd, Denmark
    Brain Res Mol Brain Res 48:1-6. 1997
    ....
  17. doi request reprint Identification of cannabinoid type 1 receptor expressing cocaine amphetamine-regulated transcript neurons in the rat hypothalamus and brainstem using in situ hybridization and immunohistochemistry
    J Jelsing
    Rheoscience A S, Basic Research, Glerupvej 2, Rødovre, Denmark
    Neuroscience 154:641-52. 2008
    ....
  18. ncbi request reprint Central innervation of the rat ependyma and subcommissural organ with special reference to ascending serotoninergic projections from the raphe nuclei
    J D Mikkelsen
    Department of Anatomy, University of Copenhagen, Denmark
    J Comp Neurol 384:556-68. 1997
    ..This study shows that a specific group of predominantly serotoninergic neurons innervates both the ependyma and the SCO and is probably involved in cerebrospinal fluid regulation...
  19. ncbi request reprint Characterization of the multisynaptic neuronal control of the rat pineal gland using viral transneuronal tracing
    P J Larsen
    Department of Anatomy, University of Copenhagen, Denmark
    Eur J Neurosci 10:128-45. 1998
    ..The data provide further detail on the cellular identity and synaptology of neural circuitry controlling the rhythmic secretion of melatonin by the rat pineal gland...
  20. ncbi request reprint Pituitary adenylate cyclase activating peptide (PACAP) in the retinohypothalamic tract: a daytime regulator of the biological clock
    J Hannibal
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Denmark
    Ann N Y Acad Sci 865:197-206. 1998
    ..Thus, in addition to its role in nocturnal regulation by glutamatergic neurotransmission, the RHT can adjust the biological clock by a PACAP-cAMP-dependent mechanism during the daytime...
  21. ncbi request reprint Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y
    M Tang-Christensen
    Institute of Medical Anatomy Section B, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Endocrinol 159:307-12. 1998
    ....
  22. ncbi request reprint Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat
    A Hay-Schmidt
    Department of Medical Anatomy B, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Neuroendocrinology 73:215-26. 2001
    ..Thus leptin, the adipose tissue-derived ligand of the leptin receptor, may in some brain areas directly influence serotonergic, dopaminergic, adrenergic and noradrenergic inputs to the periventricular and medial hypothalamic nuclei...
  23. ncbi request reprint Tracing autonomic innervation of the rat pineal gland using viral transneuronal tracing
    P J Larsen
    Department of Anatomy, University of Copenhagen, 2200 Copenhagen, Denmark
    Microsc Res Tech 46:296-304. 1999
    ..However, an additional parasympathetic projection from the superior salivatory nucleus via the sphenopalatine ganglion to the pineal gland was observed in SCGX animals...
  24. ncbi request reprint The role of CART in body weight homeostasis
    Philip J Larsen
    Rheoscience A S, The Panum Institute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Peptides 27:1981-6. 2006
    ..Research to date has demonstrated a role for CART in the control of food intake at a number of levels within the brain of both animals and man...
  25. doi request reprint The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance
    Kirsten Lykkegaard
    Rheoscience A S, Glerupvej 2, DK 2610 Roedovre, Denmark
    Schizophr Res 103:94-103. 2008
    ..It may therefore be relevant to study these effects of liraglutide in patients treated with atypically antipsychotics...
  26. ncbi request reprint Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  27. ncbi request reprint Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides
    Philip J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750, Denmark
    Eur J Pharmacol 440:159-72. 2002
    ..The present review summarises the available evidence that both families of peptides constitute endogenous transmitters mediating satiety and touch upon potential pharmacological exploitation of this knowledge...
  28. ncbi request reprint Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids
    Niels Vrang
    Rheoscience, Glerupvej 2, 2610, Rodovre, Denmark
    Brain Res 965:45-50. 2003
    ..Unlike CART mRNA levels hypothalamic POMC expression was unaltered by adrenenalectomy. The present results show that the CART gene is influenced by glucocorticoids, presumably via a GR dependent mechanism...
  29. ncbi request reprint Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine
    Niels Vrang
    Rheoscience, Glerupvej 2, 2610 Rodovre, Denmark
    Neuroreport 13:1215-8. 2002
    ..The present results question the acronym chosen for this predominantly hyopthalamic neuropeptide...
  30. ncbi request reprint Projections from the raphe nuclei to the suprachiasmatic nucleus of the rat
    Anders Hay-Schmidt
    Department of Medical Anatomy, The Panum Institute, 18 2, University of Copenhagen, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Chem Neuroanat 25:293-310. 2003
    ..PHA-L injections into RMg gave rise to labelling of a few processes within the SCN. In conclusion, the main serotonergic input to the rat SCN originates from a few neurones in the MnR...
  31. ncbi request reprint Light-induced c-Fos expression in suprachiasmatic nuclei neurons targeting the paraventricular nucleus of the hamster hypothalamus: phase dependence and immunochemical identification
    Inger Christine Munch
    Department of Medical Anatomy, University of Copenhagen, 2200 Copenhagen, Denmark
    J Comp Neurol 442:48-62. 2002
    ..The present findings provide functional evidence of light activation of central pathways involved in the regulation of circadian output rhythms...
  32. ncbi request reprint ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Obes Res 13:2113-21. 2005
    ....
  33. ncbi request reprint [Molecular pathogenesis in monogenic and polygenic obesity]
    Philip J Larsen
    Steno Diabetes Center, DK 2820 Gentofte
    Ugeskr Laeger 168:152-5. 2006
    ..These insights have brought us closer to the development of rational therapies of obesity, the epidemic of which is continuing in the post-industrial society, which is characterised by sedentary behaviour patterns...
  34. ncbi request reprint [Central fat deposits contribute to atherosclerosis and insulin resistance and peripheral fat deposits protect against atherosclerosis and insulin resistance in postmenopausal women--secondary publication]
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup
    Ugeskr Laeger 167:3597-601. 2005
    ..In postmenopausal women, body fat distribution has more critical implications for metabolic and cardiovascular risk than overall obesity per se...
  35. ncbi request reprint Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
    ..Whether EWET offers superior disease and event prediction in postmenopausal women, however, remains unknown...
  36. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
    ..Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated...
  37. ncbi request reprint Variations in percentage of body fat within different BMI groups in young, middle-aged and old women
    Lusine Movsesyan
    Center for Clinical and Basic Research A S, Ballerup Byvej, Ballerup, Denmark
    Clin Physiol Funct Imaging 23:130-3. 2003
    ..The objective of the present study was to characterize age-dependent variations in percentage of body fat within different body mass index (BMI) classes in healthy Danish women...
  38. ncbi request reprint Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Eur Heart J 24:1531-7. 2003
    ..To investigate the long-term effects of central fat mass (CFM) and peripheral fat mass (PFM) on atherogenic risk profile and the progression of aortic calcification (AC) in postmenopausal women...