Peter Rasmussen

Summary

Country: Denmark

Publications

  1. doi Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Denmark
    Exp Physiol 94:1062-9. 2009
  2. ncbi Understanding central fatigue: where to go?
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, AN2041, Blegdamsvej 9, DK2100 Copenhagen, Denmark
    Exp Physiol 92:369-70. 2007
  3. ncbi Glycopyrrolate prevents extreme bradycardia and cerebral deoxygenation during electroconvulsive therapy
    Peter Rasmussen
    Department of Medical Biochemistry and Genetics, The Panum Institute, Denmark
    J ECT 23:147-52. 2007
  4. doi Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans
    Peter Rasmussen
    Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    FASEB J 25:2865-73. 2011
  5. ncbi Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
    Peter Rasmussen
    Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
    Med Sci Sports Exerc 45:1767-72. 2013
  6. doi Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans
    Peter Rasmussen
    University of Zurich, Building 23, Winterthurerstrasse 190, CH8057, Zurich, Switzerland
    FASEB J 26:1343-8. 2012
  7. doi Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans
    Peter Rasmussen
    1Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    J Appl Physiol (1985) 107:1799-805. 2009
  8. pmc Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: evaluation of the arterial and jugular venous metabolome
    Peter Rasmussen
    Department of Anaesthesia, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:1240-6. 2010
  9. pmc Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans
    P Rasmussen
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, AN2041, Blegdamsvej 9, DK2100 Copenhagen, Denmark
    J Physiol 588:1985-95. 2010
  10. doi In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice
    P Rasmussen
    Department of Anesthesia, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 201:475-82. 2011

Detail Information

Publications33

  1. doi Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Denmark
    Exp Physiol 94:1062-9. 2009
    ..These results suggest that the brain is a major but not the sole contributor to circulating BDNF. Moreover, the importance of the cortex and hippocampus as a source for plasma BDNF becomes even more prominent in response to exercise...
  2. ncbi Understanding central fatigue: where to go?
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, AN2041, Blegdamsvej 9, DK2100 Copenhagen, Denmark
    Exp Physiol 92:369-70. 2007
  3. ncbi Glycopyrrolate prevents extreme bradycardia and cerebral deoxygenation during electroconvulsive therapy
    Peter Rasmussen
    Department of Medical Biochemistry and Genetics, The Panum Institute, Denmark
    J ECT 23:147-52. 2007
    ..The results demonstrate that ECT is associated with hemodynamic effects severe enough to affect cerebral oxygenation and perfusion, and that these effects can be attenuated by Glp treatment...
  4. doi Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans
    Peter Rasmussen
    Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    FASEB J 25:2865-73. 2011
    ....
  5. ncbi Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
    Peter Rasmussen
    Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
    Med Sci Sports Exerc 45:1767-72. 2013
    ..The time course and the contribution of the red cell volume expansion are not clear. The purpose of the present meta-analysis was to explore how much altitude exposure is required to induce polycythemia in healthy lowlanders...
  6. doi Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans
    Peter Rasmussen
    University of Zurich, Building 23, Winterthurerstrasse 190, CH8057, Zurich, Switzerland
    FASEB J 26:1343-8. 2012
    ..05), therefore, reflected vasoconstriction. Thus, administration of EPO to healthy humans lowers systemic and cerebral conductance independent of its effect on hematocrit...
  7. doi Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans
    Peter Rasmussen
    1Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    J Appl Physiol (1985) 107:1799-805. 2009
    ..These findings support brain tissue redox state and oxygenation as potential modulators of an increase in cerebral blood flow at the onset of exercise...
  8. pmc Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: evaluation of the arterial and jugular venous metabolome
    Peter Rasmussen
    Department of Anaesthesia, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:1240-6. 2010
    ..We conclude that during exercise, the surplus carbohydrate uptake by the brain cannot be accounted for by changes in the NMR-derived plasma metabolome across the brain...
  9. pmc Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans
    P Rasmussen
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, AN2041, Blegdamsvej 9, DK2100 Copenhagen, Denmark
    J Physiol 588:1985-95. 2010
    ....
  10. doi In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice
    P Rasmussen
    Department of Anesthesia, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 201:475-82. 2011
    ..Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels...
  11. ncbi Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 27:1082-93. 2007
    ....
  12. ncbi MCA Vmean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip
    Peter Rasmussen
    Deapartment of Anesthesia, Copenhagen Muscle Center, University of Copenhagen, Denmark
    J Appl Physiol (1985) 101:1406-11. 2006
    ..These results support that the arterial plasma L/P ratio modulates cerebral blood flow during cerebral activation independently from the plasma glucose concentration...
  13. doi Cerebral oxygenation is reduced during hyperthermic exercise in humans
    P Rasmussen
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 199:63-70. 2010
    ..Heat stress challenges exercise capacity as expressed by increased rating of perceived exertion (RPE)...
  14. ncbi Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral oxygen saturation during administration of norepinephrine
    Henrik Sørensen
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesthesiology 117:263-70. 2012
    ..We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction...
  15. doi Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain
    Morten Overgaard
    Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    FASEB J 26:3012-20. 2012
    ..These results support the existence of a cell-cell lactate shuttle that may involve neurons and astrocytes...
  16. ncbi A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow
    Shigehiko Ogoh
    From the Department of Biomedical Engineering, Toyo University, Kawagoe shi, Saitama Research Institute of Physical Fitness, Japan Women s College of Physical Education, Tokyo Department of Environmental Physiology for Exercise, Osaka City University Graduate School of Medicine Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan Department of Anesthesia, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Anesth Analg 118:823-9. 2014
    ..We hypothesized that extracranial vasoconstriction explains the effect of phenylephrine on ScO2...
  17. doi Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O₂ uptake
    Christoph Siebenmann
    Zurich Centre for Integrative Human Physiology, Zurich, Switzerland
    Respir Physiol Neurobiol 185:461-7. 2013
    ..99). We conclude that although hypocapnia promotes a decrease in MCAv(mean) and cerebral oxygenation, this does not limit maximal O(2)-uptake. Furthermore, hypocapnia does not restrict ventilation during maximal hypoxic exercise...
  18. doi Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
    ..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
  19. pmc Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline
    Thomas S Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 587:285-93. 2009
    ..05). These results support that non-oxidative carbohydrate consumption for the brain is driven by a beta(2)-adrenergic mechanism, giving neurons an abundant provision of energy when plasma adrenaline increases...
  20. doi "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study
    Christoph Siebenmann
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 112:106-17. 2012
    ..In conclusion, 4 wk of LHTL, using 16 h/day of normobaric hypoxia, did not improve endurance performance or any of the measured, associated physiological variables...
  21. doi Blood lactate is an important energy source for the human brain
    Gerrit van Hall
    Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 29:1121-9. 2009
    ..In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions...
  22. ncbi Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise
    Lars Nybo
    Institute of Exercise and Sport Sciences and Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 35:110-8. 2007
    ....
  23. doi The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes
    Paul Robach
    Département médical, Ecole Nationale de Ski et d Alpinisme, site de l Ecole Nationale des Sports de Montagne, Chamonix, France
    Br J Sports Med 46:822-7. 2012
    ....
  24. doi Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans
    Peter Rasmussen
    Department of Physiology, Winterthurerstrasse 190, CH8057 Zurich, Switzerland
    FASEB J 26:1831-4. 2012
    ..Thus, neither dermal oxygen exposure nor cerebral EPO production appears to be important for the systemic EPO response to acute hypoxia in healthy humans...
  25. doi Maintained cerebral metabolic ratio during exercise in patients with beta-adrenergic blockade
    Christiane M B Gam
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Physiol Funct Imaging 29:420-6. 2009
    ..We evaluated to what extent cirrhotic patients in oral treatment with propranolol are able to mobilize brain non-oxidative carbohydrate metabolism...
  26. pmc Beta-adrenergic receptor desensitization in man: insight into post-exercise attenuation of cardiac function
    Emma Hart
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK, and Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 577:717-25. 2006
    ..05). Desensitization of the beta-AR contributes to an attenuated left ventricular systolic but not diastolic function following prolonged exercise...
  27. pmc Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans
    Thomas Seifert Larsen
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    J Physiol 586:2807-15. 2008
    ....
  28. doi Interindividual variation in platelets and the cardiovascular response to haemorrhage in the pig
    Morten Zaar
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:92-7. 2011
    ..These results support that platelets exert functions during bleeding beyond their importance for clot formation...
  29. pmc Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression
    Henning Piilgaard
    Department of Neuroscience and Pharmacology, Center for Healthy Aging, The Panum Institute, University of Copenhagen, Copenhagen N, Denmark
    J Cereb Blood Flow Metab 31:1588-98. 2011
    ..Our data suggest that blockade of mPTP formation and CaN activation may prevent persistent CBF reduction and vascular dysfunction after CSD...
  30. ncbi Environmental heat stress, hyperammonemia and nucleotide metabolism during intermittent exercise
    Magni Mohr
    Institute of Exercise and Sport Sciences, Department of Human Physiology, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark
    Eur J Appl Physiol 97:89-95. 2006
    ....
  31. ncbi Performance in the heat-physiological factors of importance for hyperthermia-induced fatigue
    Lars Nybo
    Department of Nutrition, Exercise and Sport Sciences, University of Copenhagen, Denmark
    Compr Physiol 4:657-89. 2014
    ....
  32. ncbi Effects of hyperglycemia on the cerebrovascular response to rhythmic handgrip exercise
    Yu Sok Kim
    Medium Care Unit, Department of Internal Medicine, F7 205 Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 293:H467-73. 2007
    ..These findings suggest that elevated blood glucose does not explain that dynamic CA is affected during intense exercise...
  33. ncbi Peripheral markers of brain damage and blood-brain barrier dysfunction
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Restor Neurol Neurosci 21:109-21. 2003
    ....