Genomes and Genes


Lene Juel Rasmussen


Country: Denmark


  1. Keijzers G, Bohr V, Rasmussen L. Human exonuclease 1 (EXO1) activity characterization and its function on flap structures. Biosci Rep. 2015;35: pubmed publisher
  2. Drost M, Tiersma Y, Thompson B, Frederiksen J, Keijzers G, Glubb D, et al. A functional assay-based procedure to classify mismatch repair gene variants in Lynch syndrome. Genet Med. 2018;: pubmed publisher
    ..Quantitative combination of assay results with in silico analysis correctly classified the majority of variants. Using this calibration, CIMRA assay results can be integrated into the diagnostic algorithm for MMR gene variants. ..
  3. Rasmussen L, Sander M, Wewer U, Bohr V. Aging, longevity and health. Mech Ageing Dev. 2011;132:522-32 pubmed publisher
    ..and was organized by Center for Healthy Aging (CEHA) under the leadership of CEHA Managing Director Lene Juel Rasmussen and Prof. Vilhelm Bohr, National Institute on Aging, NIH, Baltimore, USA (associated to CEHA)...
  4. Rasmussen L, Heinen C, Royer Pokora B, Drost M, Tavtigian S, Hofstra R, et al. Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future. Hum Mutat. 2012;33:1617-25 pubmed publisher
    ..Furthermore, we call attention to common misconceptions about functional assays and endorse development of an integrated approach comprising validated assays for diagnosis of VUS in patients suspected of LS. ..
  5. Strickertsson J, Rasmussen L, Friis Hansen L. Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture. Genes (Basel). 2014;5:726-38 pubmed publisher
    ..E. faecalis infection as well as ROS stimulation down-regulated the expression of the miR-17-92 cluster. We believe that these changes could reflect a general response of gastric epithelial cells to bacterial infections. ..
  6. Durhuus J, Desler C, Rasmussen L. Mitochondria in health and disease - 3rd annual conference of society for mitochondrial research and medicine - 19-20 December 2013 - Bengaluru, India. Mitochondrion. 2015;20:7-12 pubmed publisher
    ..This review summarizes key outcomes of the conference. ..
  7. Desler C, Frederiksen J, Angleys M, Maynard S, Keijzers G, Fagerlund B, et al. Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. Mitochondrion. 2015;25:34-7 pubmed publisher
    ..Levels of dTTP in PBMCs are indicators of relative cognitive change suggesting a role of deoxyribonucleotides in the etiology of AD. ..
  8. Pena Diaz J, Rasmussen L. Approaches to diagnose DNA mismatch repair gene defects in cancer. DNA Repair (Amst). 2016;38:147-154 pubmed publisher
    ..This review describes current tools and future strategies for addressing the relevance of MMR gene alterations in human disease. ..
  9. Fakouri N, Durhuus J, Regnell C, Angleys M, Desler C, Hasan Olive M, et al. Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis. Sci Rep. 2018;8:4245 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ..

More Information


  1. Liu D, Keijzers G, Rasmussen L. DNA mismatch repair and its many roles in eukaryotic cells. Mutat Res. 2017;773:174-187 pubmed publisher
    ..Although the molecular mechanism of MMR in the eukaryotic cell is still not completely understood, increased used of single-molecule analyses in the future may yield new insight into these unsolved questions. ..
  2. Fakouri N, Durhuus J, Regnell C, Angleys M, Desler C, Hasan Olive M, et al. Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis. Sci Rep. 2017;7:12480 pubmed publisher
    ..We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis. ..
  3. Strickertsson J, Desler C, Rasmussen L. Bacterial infection increases risk of carcinogenesis by targeting mitochondria. Semin Cancer Biol. 2017;47:95-100 pubmed publisher
    ..The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis. ..