Ewa Rajpert-De Meyts

Summary

Country: Denmark

Publications

  1. doi request reprint From gonocytes to testicular cancer: the role of impaired gonadal development
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann N Y Acad Sci 1120:168-80. 2007
  2. ncbi request reprint Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation
    E Rajpert-De Meyts
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 451:805-14. 2007
  3. ncbi request reprint Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod Update 12:303-23. 2006
  4. ncbi request reprint Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
  5. ncbi request reprint The emerging phenotype of the testicular carcinoma in situ germ cell
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:267-78; discussion 278-9. 2003
  6. ncbi request reprint CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
  7. ncbi request reprint Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility
    Martin Jensen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Reprod 19:65-70. 2004
  8. ncbi request reprint High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development
    Anne Marie Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, University Hospital of Copenhagen, Copenhagen, Denmark
    Genes Chromosomes Cancer 38:117-25. 2003
  9. ncbi request reprint Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
  10. ncbi request reprint Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cell Tissue Res 322:159-65. 2005

Detail Information

Publications84

  1. doi request reprint From gonocytes to testicular cancer: the role of impaired gonadal development
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann N Y Acad Sci 1120:168-80. 2007
    ..The effects of environmental factors are likely modulated by genomic variation (polymorphisms), thus explaining the individual susceptibility and population-level differences in the incidence of testicular cancer...
  2. ncbi request reprint Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation
    E Rajpert-De Meyts
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 451:805-14. 2007
    ....
  3. ncbi request reprint Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod Update 12:303-23. 2006
    ..The aetiology of TDS including testicular cancer remains to be elucidated, but epidemiological trends suggest a primary role for environmental factors, probably combined with genetic susceptibility...
  4. ncbi request reprint Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
    ..In this study we aimed to investigate the expression pattern of AP-2gamma and to shed light on this factor in germ cell differentiation and the pathogenesis of germ cell neoplasia...
  5. ncbi request reprint The emerging phenotype of the testicular carcinoma in situ germ cell
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:267-78; discussion 278-9. 2003
    ....
  6. ncbi request reprint CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
    ..In conclusion, despite high mRNA levels, the CDH1 protein is not expressed in CIS, suggesting translational suppression of CDH1 protein expression. CDH1 serum levels may be a serological marker for staging of TGCT patients...
  7. ncbi request reprint Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility
    Martin Jensen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Reprod 19:65-70. 2004
    ..In this study, we explored a possible role of the polymerase gamma (POLG) gene polymorphism, recently reported to be associated with male infertility in some populations...
  8. ncbi request reprint High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development
    Anne Marie Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, University Hospital of Copenhagen, Copenhagen, Denmark
    Genes Chromosomes Cancer 38:117-25. 2003
    ..The gain of extra chromosome 12 material may not be an early event in the neoplastic transformation, but is most likely associated with a more malignant progression of the CIS cell...
  9. ncbi request reprint Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
    ..Finally, some of the highly expressed genes identified in this study are promising candidates for new diagnostic markers for CIS and/or TGCTs...
  10. ncbi request reprint Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cell Tissue Res 322:159-65. 2005
    ..The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular germ cell cancer...
  11. doi request reprint Expression of FGFR3 during human testis development and in germ cell-derived tumours of young adults
    Katherine A Ewen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Dev Biol 57:141-51. 2013
    ..Signalling through this receptor is likely associated with spermatogonial survival rather than proliferation. FGFR3 is not expressed in gonocytes and may not be essential to the aetiology of TGCTs stemming from CIS...
  12. ncbi request reprint Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    APMIS 111:1-9; discussion 9-11. 2003
    ..We speculate that most of these abnormalities are caused by adverse environmental effects rather than specific gene mutations...
  13. ncbi request reprint Improved gene expression signature of testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Androl 30:292-302; discussion 303. 2007
    ..The merged CIS data from two different microarray platforms, to our knowledge, provide the most precise CIS gene expression signature to date...
  14. ncbi request reprint Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads
    Ewa Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 19:1338-44. 2004
    ....
  15. doi request reprint Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
    Martin Blomberg Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:1303-11. 2010
    ..Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa...
  16. ncbi request reprint Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    ..Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells...
  17. doi request reprint Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells
    Dina G Kristensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Int J Dev Biol 57:309-17. 2013
    ....
  18. pmc Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo
    Martin Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Neoplasia 14:952-63. 2012
    ....
  19. pmc Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
    Christina E Hoei-Hansen
    University Dept of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cancer 6:12. 2007
    ..We investigated the origin of malignant OGCTs and underlying molecular events in the development of the various histological subtypes of this neoplasia...
  20. doi request reprint Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry
    Anne Jørgensen
    Department of Growth and Reproduction, University of Copenhagen, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Mol Hum Reprod 18:523-34. 2012
    ..The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis...
  21. doi request reprint Androgen receptor CAG repeat length is associated with body fat and serum SHBG in boys: a prospective cohort study
    Annette Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E605-9. 2013
    ..Furthermore, short AR (CAG)n have been associated with premature adrenarche...
  22. doi request reprint Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: targeting estrogen signalling
    Martin Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cell Endocrinol 377:93-102. 2013
    ..In conclusion, vitamin D seems dispensable for murine spermatogenesis and sex hormone production, but aberrant estrogen-signalling may elicit some of the VDR-mediated effects on male reproduction...
  23. ncbi request reprint Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Pathol 200:370-4. 2003
    ..The findings therefore support the hypothesis that this cancer is part of a testicular dysgenesis syndrome. The presence of contralateral carcinoma in situ was higher in the present study than previously reported...
  24. ncbi request reprint Testicular carcinoma in situ in subfertile Danish men
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen
    Int J Androl 30:406-11; discussion 412. 2007
    ....
  25. ncbi request reprint Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  26. ncbi request reprint ATM activation in normal human tissues and testicular cancer
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 4:838-45. 2005
    ..The new tools characterized here should facilitate monitoring of ATM activation in clinical specimens, and help develop future treatment strategies...
  27. ncbi request reprint Environment, testicular dysgenesis and carcinoma in situ testis
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 21:462-78. 2007
    ..It is of great importance that clinicians in different specialties treating patients with TDS are aware of the association between the different symptoms...
  28. doi request reprint MicroRNA expression profiling of carcinoma in situ cells of the testis
    Guy Wayne Novotny
    Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Endocr Relat Cancer 19:365-79. 2012
    ..We conclude that the miRNA expression profile changes during testis development and that the miRNA profile of adult testis with CIS cells shares characteristic similarities with the expression in foetal gonocytes...
  29. pmc A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
    Marlene D Dalgaard
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Med Genet 49:58-65. 2012
    ..The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population...
  30. doi request reprint Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms
    David M Kristensen
    University Department of Growth and Reproduction, Section GR5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 23:775-82. 2008
    ....
  31. ncbi request reprint Inhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor C microdeletions
    Lone Frydelund-Larsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 87:5618-24. 2002
    ....
  32. doi request reprint Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome
    Grete Lottrup
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:2223-9. 2013
    ....
  33. ncbi request reprint Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio
    Mette Holm
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 199:378-86. 2003
    ..The presence of micronodules thus seems to be a histological marker of testicular failure in man...
  34. ncbi request reprint Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development
    David Møbjerg Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cell Endocrinol 288:111-8. 2008
    ....
  35. ncbi request reprint No AZF deletion in 160 patients with testicular germ cell neoplasia
    Lone Frydelund-Larsen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Hum Reprod 9:517-21. 2003
    ..Malignant transformation of germ cells is thus caused by the dysfunction of some other genes that still need to be identified...
  36. doi request reprint Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer
    Camilla Nymann Rud
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark University Department of Oncology, Rigshospitalet, Copenhagen, Denmark
    J Urol 190:2074-80. 2013
    ..We investigated whether semen quality or some easily attainable clinical parameters might be used to estimate the risk of contralateral carcinoma in situ in patients with unilateral testicular germ cell tumors...
  37. ncbi request reprint Current approaches for detection of carcinoma in situ testis
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:398-404; discussion 404-5. 2007
    ..In conclusion, one difficulty is to determine in which males CIS should be suspected; secondly, there does not as yet exist an optimal noninvasive method of diagnosis that is more acceptable than an open surgical biopsy...
  38. ncbi request reprint From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
    Kristian Almstrup
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Androl 29:211-8. 2006
    ....
  39. ncbi request reprint Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype
    Dina G Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Genet 205:425-31. 2012
    ....
  40. doi request reprint Testicular dysgenesis syndrome and the origin of carcinoma in situ testis
    Si Brask Sonne
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 31:275-87. 2008
    ..The post-pubertal proliferation of CIS cells combined with aberrant signalling then leads to an accumulation of genetic changes in the CIS cells, which eventually results in the development of invasive testicular cancer in the adult...
  41. ncbi request reprint Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer
    Ewa Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Int J Cancer 102:201-4. 2002
    ..We conclude that the high risk of testicular germ cell cancer in the Danish population is not associated with the (CAG)n polymorphism in the AR gene...
  42. ncbi request reprint Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle
    Mette Holm
    University Department of Growth and Reproduction, Copenhagen University Hospital, Denmark
    J Urol 170:1163-7. 2003
    ..We compared clinical and histological data regarding the contralateral testicle in a population of men diagnosed with testicular germ cell cancer to find features associated with an increased risk of bilateral neoplasia...
  43. ncbi request reprint Cytogenetic investigation of testicular carcinoma in situ and early seminoma by high-resolution comparative genomic hybridization analysis of subpopulations flow sorted according to DNA content
    Anne Marie Ottesen
    Department of Growth and Reproduction, 5064, Juliane Marie Centre, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Genet Cytogenet 149:89-97. 2004
    ....
  44. doi request reprint Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy
    Anne Marie Ottesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Med Genet A 152:1206-12. 2010
    ..0 (-3.5 to -0.8) in 49,XXXXX (n = 3). Height increased with an increasing number of extra X or Y chromosomes, except in males with five, and in females with four or five sex chromosomes, consistent with a nonlinear effect on height...
  45. pmc Optimizing staining protocols for laser microdissection of specific cell types from the testis including carcinoma in situ
    Si Brask Sonne
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 4:e5536. 2009
    ..Both protocols retain a morphology that is compatible with laser microdissection and yield RNA of a quality suitable for PCR and microarray analysis...
  46. ncbi request reprint Deregulation of the RB pathway in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    J Pathol 200:149-56. 2003
    ..We hope that this study will inspire further immunohistochemical applications of phosphospecific antibodies in pathology, and examination of the RB pathway defects in relation to curability of TGCTs...
  47. doi request reprint Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model
    Anne Jørgensen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Science, University of Copenhagen, Denmark
    J Steroid Biochem Mol Biol 136:238-46. 2013
    ..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  48. doi request reprint Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia
    Tine Hvarness
    Department of Growth and Reproduction, Copenhagen University Hospital, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Reprod Immunol 100:135-45. 2013
    ..This study showed a phenotypically comparable composition of infiltrating immune cells independently of the presence of neoplasia, suggesting the absence of active immune surveillance in testicular germ cell cancer...
  49. pmc Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte
    Si Brask Sonne
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Res 69:5241-50. 2009
    ..The further development of CIS into invasive germ cell tumors may depend on signals from their postpubertal niche of somatic cells, including hormones and growth factors from Leydig and Sertoli cells...
  50. ncbi request reprint Analysis of gene expression in normal and neoplastic human testis: new roles of RNA
    G W Novotny
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:316-26; discussion 326-7. 2007
    ..Additionally, we show through cloning the presence of both known and new miRNAs in the testis emphasizing the necessity for following up mRNA expression data by investigating expression at the protein level...
  51. pmc UGT2B17 Genotype and the Pharmacokinetic Serum Profile of Testosterone during Substitution Therapy with Testosterone Undecanoate. A Retrospective Experience from 207 Men with Hypogonadism
    Anne Kirstine Bang
    Department of Growth and Reproduction, Faculty of Health and Medical Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Front Endocrinol (Lausanne) 4:94. 2013
    ..Only subtle differences in serum T and LH were noted according to UGT2B17 genotype, which however suggest that the UGT2B17 genotype exert modest influence on the pharmacokinetic profile of T after TU treatment. ..
  52. doi request reprint 45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study
    Marie Lindhardt Johansen
    Department of Growth and Reproduction, Rigshospitalet and Copenhagen University, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:E1540-9. 2012
    ..Most previous studies of 45,X/46,XY mosaicism are case reports or have described single aspects of the disease...
  53. ncbi request reprint Natural history of seminiferous tubule degeneration in Klinefelter syndrome
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod Update 12:39-48. 2006
    ....
  54. doi request reprint Testicular dysgenesis syndrome and Leydig cell function
    Ulla Nordström Joensen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 102:155-61. 2008
    ..We present our view of the emerging role of Leydig cell dysfunction with subsequent decreased testosterone levels in the pathogenesis of TDS...
  55. pmc Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours
    K Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Br J Cancer 92:1934-41. 2005
    ....
  56. ncbi request reprint Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours
    C E Hoei-Hansen
    University Department of Growth and Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark
    Histopathology 47:48-56. 2005
    ..In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens...
  57. ncbi request reprint Testicular neoplasia in childhood and adolescence
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Endocr Dev 5:110-23. 2003
  58. doi request reprint Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:e207-15. 2010
    ..A high expression of EL and abundance of lipid in tubules with CIS may have a diagnostic value...
  59. ncbi request reprint Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Lab Invest 72:223-31. 1995
    ..In order to corroborate this hypothesis, we undertook the present study...
  60. ncbi request reprint DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Int J Androl 30:282-91; discussion 291. 2007
    ....
  61. ncbi request reprint Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    N E Skakkebaek
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:198-204; discussion 204-5. 2007
    ....
  62. ncbi request reprint Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours
    E Rajpert De Meyts
    University Department of Growth and Reproduction, Righospitalet, Copenhagen, Denmark
    Int J Androl 17:85-92. 1994
    ..High expression of the proto-oncogene in CIS cells supports the hypothesis of their origin from primordial germ cells. In addition, we propose that the c-kit protein product is a new marker for carcinoma-in-situ of the testis...
  63. ncbi request reprint Carcinoma in situ testis, the progenitor of testicular germ cell tumours: a clinical review
    C E Hoei-Hansen
    University Department of Growth, Rigshospitalet, Copenhagen, Denmark
    Ann Oncol 16:863-8. 2005
    ..Further research is warranted to identify causal factors explaining the increasing incidence of TGCT and to obtain a method of non-invasive CIS detection...
  64. ncbi request reprint The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma
    E Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Denmark
    Histopathology 42:217-26. 2003
    ....
  65. ncbi request reprint Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls
    A M Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
    J Clin Endocrinol Metab 89:3161-7. 2004
    ..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
  66. ncbi request reprint Immunohistochemical identification of androgen receptors in germ cell neoplasia
    E Rajpert De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Endocrinol 135:R1-4. 1992
    ..4.1 was used. The presence of AR protein immunoreactivity in neoplastic germ cells suggests that androgens may be involved in the pathogenesis of the disease...
  67. ncbi request reprint Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
    ..Otherwise, important biological information may be lost...
  68. ncbi request reprint Management of males with 45,X/46,XY gonadal dysgenesis
    J Muller
    Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Horm Res 52:11-4. 1999
    ..On the basis of our current knowledge we propose a strategy for management and follow-up of these boys in order to detect possible premalignant histological changes early and prevent development of a gonadal tumour...
  69. ncbi request reprint Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells
    E Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Denmark
    J Clin Endocrinol Metab 84:3836-44. 1999
    ..In fetal ovaries, AMH was first detected at 36 weeks gestation in granulosa cells of preantral follicles. Thus, the onset of ovarian expression is at the end of fetal life and not in infancy as previously reported...
  70. ncbi request reprint New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 209:25-33. 2006
    ....
  71. ncbi request reprint Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 22:167-73. 2007
    ..Diagnosis at the CIS stage is desirable as it minimizes the necessary treatment. A detailed clinical evaluation of an approach to detect CIS cells in the ejaculate using primordial germ cell/gonocyte markers is presented...
  72. pmc Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
    K Almstrup
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Br J Cancer 103:1269-76. 2010
    ..The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells...
  73. doi request reprint Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer
    M Blomberg Jensen
    Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
    Ann Oncol 19:1910-4. 2008
    ....
  74. ncbi request reprint DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 26:7414-22. 2007
    ....
  75. ncbi request reprint Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
    ....
  76. ncbi request reprint Deregulation of the G1/S-phase control in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    APMIS 111:252-65; discussion 265-6. 2003
    ....
  77. ncbi request reprint Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Urol Oncol 25:141-6. 2007
    ..These findings support the candidacy of TSPY as the gene for the gonadoblastoma locus on Y chromosome and suggest that TSPY could be a significant marker for these types of germ cell tumors...
  78. ncbi request reprint The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ
    Anne Pascale Satie
    GERM INSERM U 435, Universite de Rennes I, Campus de Beaulieu, Rennes, France
    Lab Invest 82:775-80. 2002
    ....
  79. ncbi request reprint Recent advances and future directions in research on testicular germ cell cancer
    Ewa Rajpert-De Meyts
    Int J Androl 30:192-7. 2007
  80. ncbi request reprint Immunoexpression of androgen receptor and nine markers of maturation in the testes of adolescent boys with Klinefelter syndrome: evidence for degeneration of germ cells at the onset of meiosis
    Anne M Wikström
    Hospital for Children and Adolescents, Helsinki University Central Hospital, P O Box 281, 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:714-9. 2007
    ..The pathogenesis and mechanisms behind the degeneration of the seminiferous tubules in testes of subjects with Klinefelter syndrome (KS) are yet unknown...
  81. ncbi request reprint Development and descent of the testis in relation to cryptorchidism
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Acta Paediatr 96:622-7. 2007
    ..Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis...
  82. ncbi request reprint Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis
    Michel Samson
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Clin Endocrinol Metab 89:4078-88. 2004
    ..2-fold higher than seminoma. These findings argue that human EG-VEGF may play a role in angiogenesis both during the early endocrine development of testis and in the adult testis as well as in Leydig cell tumor growth...
  83. ncbi request reprint Cryptorchidism: classification, prevalence and long-term consequences
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Acta Paediatr 96:611-6. 2007
    ..There is an urgent need to identify factors that adversely affect testicular development and optimize treatment. Conclusion: Cryptorchidism may reflect a primary testicular maldevelopment with long-term consequences...
  84. ncbi request reprint Gene polymorphisms and male infertility--a meta-analysis and literature review
    Frank Tüttelmann
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Reprod Biomed Online 15:643-58. 2007
    ..The genetic studies performed so far emphasize the complexity of male infertility as a presumably polygenetic trait amended by environmental, lifestyle or occupational factors...