B Klementiev

Summary

Affiliation: Protein Laboratory
Country: Denmark

Publications

  1. ncbi request reprint A peptide agonist of the neural cell adhesion molecule (NCAM), C3, protects against developmental defects induced by a teratogen pyrimethamine
    Boris Klementiev
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute Building 6 2, University of Copenhagen, Blegdamsvej 3C, Denmark
    Int J Dev Neurosci 20:527-36. 2002
  2. ncbi request reprint A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35
    B Klementiev
    ENKAM Pharmaceuticals A S, Copenhagen, Denmark
    Neuroscience 145:209-24. 2007
  3. doi request reprint The NCAM-derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury
    B Klementiev
    ENKAM Pharmaceuticals A S Department of Neuroscience and Pharmacology, School of Medicine, University of Copenhagen, Copenhagen, Denmark
    Eur J Neurosci 27:2885-96. 2008
  4. ncbi request reprint Effects of P2, a peptide derived from a homophilic binding site in the neural cell adhesion molecule on learning and memory in rats
    L Rizhova
    Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Building 6 2, DK 2200 Copenhagen N, Denmark
    Neuroscience 149:931-42. 2007
  5. ncbi request reprint A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention
    T Secher
    Protein Laboratory, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Neuroscience 141:1289-99. 2006
  6. ncbi request reprint A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo
    Galina G Skibo
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Bld 6 2, DK 2200 Copenhagen N, Denmark
    Eur J Neurosci 22:1589-96. 2005
  7. ncbi request reprint Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement
    Kamil Gotfryd
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute, University of Copenhagen, Blegdamsvej 3C Bld 6 2, DK 2200 Copenhagen N, Denmark
    Neuropharmacology 52:764-78. 2007

Collaborators

  • C Sandi
  • P S Walmod
  • Vladimir Berezin
  • T Secher
  • L Rizhova
  • Kamil Gotfryd
  • Elisabeth Bock
  • Galina G Skibo
  • Sylwia Owczarek
  • E Vershinina
  • Katrin Hoffmann
  • E Bock
  • E Vaudano
  • C Venero
  • K Cambon
  • Heinz Nau
  • Oksana Dmitrieva
  • Tatiana Novikova
  • Elisabetta Vaudano
  • Iryna V Lushnikova
  • Kyrill Y Voronin

Detail Information

Publications7

  1. ncbi request reprint A peptide agonist of the neural cell adhesion molecule (NCAM), C3, protects against developmental defects induced by a teratogen pyrimethamine
    Boris Klementiev
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute Building 6 2, University of Copenhagen, Blegdamsvej 3C, Denmark
    Int J Dev Neurosci 20:527-36. 2002
    ..In vitro, C3 promoted survival of PC12-E2 cells treated with pyrimethamine. Since C3 is a peptide mimetic of NCAM, our data strongly suggest that stimulating of NCAM results in neuroprotection in vivo and in vitro...
  2. ncbi request reprint A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35
    B Klementiev
    ENKAM Pharmaceuticals A S, Copenhagen, Denmark
    Neuroscience 145:209-24. 2007
    ....
  3. doi request reprint The NCAM-derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury
    B Klementiev
    ENKAM Pharmaceuticals A S Department of Neuroscience and Pharmacology, School of Medicine, University of Copenhagen, Copenhagen, Denmark
    Eur J Neurosci 27:2885-96. 2008
    ..P2 appeared rapidly in blood and cerebrospinal fluid after subcutaneous administration and remained detectable in blood for up to 5 h. The results suggest that P2 has therapeutic potential for the treatment of traumatic brain injury...
  4. ncbi request reprint Effects of P2, a peptide derived from a homophilic binding site in the neural cell adhesion molecule on learning and memory in rats
    L Rizhova
    Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Building 6 2, DK 2200 Copenhagen N, Denmark
    Neuroscience 149:931-42. 2007
    ..Taken together, these data indicate that in vivo P2 enhances short-term memory and protects against the amnestic effects of scopolamine, while modulating emotional behavior in a learning or novelty-related task...
  5. ncbi request reprint A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention
    T Secher
    Protein Laboratory, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Neuroscience 141:1289-99. 2006
    ..We found that FGL rapidly penetrated into the blood and cerebrospinal fluid after both intranasal and s.c. administration and remained detectable in the fluids for up to 5 hours...
  6. ncbi request reprint A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo
    Galina G Skibo
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute, University of Copenhagen, Blegdamsvej 3C, Bld 6 2, DK 2200 Copenhagen N, Denmark
    Eur J Neurosci 22:1589-96. 2005
    ..We conclude that FGL promotes neuronal survival after ischemic brain injury...
  7. ncbi request reprint Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement
    Kamil Gotfryd
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute, University of Copenhagen, Blegdamsvej 3C Bld 6 2, DK 2200 Copenhagen N, Denmark
    Neuropharmacology 52:764-78. 2007
    ....