N Obel

Summary

Affiliation: Odense University Hospital
Country: Denmark

Publications

  1. ncbi Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Hvidovre, Denmark
    Clin Infect Dis 44:1625-31. 2007
  2. ncbi Mortality after discharge from the intensive care unit during the early weekend period: a population-based cohort study in Denmark
    N Obel
    Department of Internal Medicine C, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Acta Anaesthesiol Scand 51:1225-30. 2007
  3. ncbi The insufficient suppression of viral load by saquinavir hard gel is reversible: a retrospective cohort study
    S Jensen-Fangel
    Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, Denmark
    HIV Clin Trials 2:122-7. 2001
  4. ncbi The danish protease inhibitor study: a randomized study comparing the virological efficacy of 3 protease inhibitor-containing regimens for the treatment of human immunodeficiency virus type 1 infection
    T L Katzenstein
    Department of Infectious Disease, Rigshospitalet, 2100 O Copenhagen, Denmark
    J Infect Dis 182:744-50. 2000
  5. pmc Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e22476. 2011
  6. ncbi The effect of nevirapine in combination with nelfinavir in heavily pretreated HIV-1-infected patients: a prospective, open-label, controlled, randomized study
    S Jensen-Fangel
    Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, , DK-8000 Aarhus C, Denmark
    J Acquir Immune Defic Syndr 27:124-9. 2001
  7. ncbi Low body weight and type of protease inhibitor predict discontinuation and treatment-limiting adverse drug reactions among HIV-infected patients starting a protease inhibitor regimen: consistent results from a randomized trial and an observational cohort
    O Kirk
    Departments of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    HIV Med 2:43-51. 2001
  8. doi Impact of hepatitis B virus co-infection on response to highly active antiretroviral treatment and outcome in HIV-infected individuals: a nationwide cohort study
    L H Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 9:300-6. 2008
  9. doi No change in viral set point or CD4 cell decline among antiretroviral treatment-naïve, HIV-1-infected individuals enrolled in the Danish HIV Cohort Study in 1995-2010
    M Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    HIV Med 14:362-9. 2013
  10. doi Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study
    L H Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Viral Hepat 17:261-8. 2010

Detail Information

Publications88

  1. ncbi Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Hvidovre, Denmark
    Clin Infect Dis 44:1625-31. 2007
    ..We examined this issue in a nationwide cohort study of patients with human immunodeficiency virus (HIV) infection and a population-based control group...
  2. ncbi Mortality after discharge from the intensive care unit during the early weekend period: a population-based cohort study in Denmark
    N Obel
    Department of Internal Medicine C, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Acta Anaesthesiol Scand 51:1225-30. 2007
    ..We examined whether discharge from the ICU during the first part of the weekend was associated with an increased mortality and readmission to the ICU...
  3. ncbi The insufficient suppression of viral load by saquinavir hard gel is reversible: a retrospective cohort study
    S Jensen-Fangel
    Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, Denmark
    HIV Clin Trials 2:122-7. 2001
    ..To assess the effect of changing antiretroviral therapy in patients initially treated with saquinavir hard gel capsule (hgc)...
  4. ncbi The danish protease inhibitor study: a randomized study comparing the virological efficacy of 3 protease inhibitor-containing regimens for the treatment of human immunodeficiency virus type 1 infection
    T L Katzenstein
    Department of Infectious Disease, Rigshospitalet, 2100 O Copenhagen, Denmark
    J Infect Dis 182:744-50. 2000
    ....
  5. pmc Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e22476. 2011
    ..We also addressed the question whether prognosis differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity...
  6. ncbi The effect of nevirapine in combination with nelfinavir in heavily pretreated HIV-1-infected patients: a prospective, open-label, controlled, randomized study
    S Jensen-Fangel
    Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, , DK-8000 Aarhus C, Denmark
    J Acquir Immune Defic Syndr 27:124-9. 2001
    ..We conclude that the addition of nevirapine, when switching from one protease inhibitor-containing regimen to one containing nelfinavir, has a substantial effect on viral suppression...
  7. ncbi Low body weight and type of protease inhibitor predict discontinuation and treatment-limiting adverse drug reactions among HIV-infected patients starting a protease inhibitor regimen: consistent results from a randomized trial and an observational cohort
    O Kirk
    Departments of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    HIV Med 2:43-51. 2001
    ..To assess predictors for discontinuation and treatment-limiting adverse drug reactions (TLADR) among patients starting their first protease inhibitor (PI)...
  8. doi Impact of hepatitis B virus co-infection on response to highly active antiretroviral treatment and outcome in HIV-infected individuals: a nationwide cohort study
    L H Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 9:300-6. 2008
    ..The impact of HBeAg status is unknown...
  9. doi No change in viral set point or CD4 cell decline among antiretroviral treatment-naïve, HIV-1-infected individuals enrolled in the Danish HIV Cohort Study in 1995-2010
    M Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    HIV Med 14:362-9. 2013
    ..The aim of the present study was to examine if the virulence of HIV-1 infection changed in the period 1995-2010 among chronically HIV-infected individuals in Denmark...
  10. doi Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study
    L H Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Viral Hepat 17:261-8. 2010
    ..85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection...
  11. doi HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study
    L D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    HIV Med 12:202-10. 2011
    ..We examined the risk of VTE in HIV-infected individuals compared with the general population and estimated the impact of low CD4 cell count, highly active antiretroviral therapy (HAART) and injecting drug use (IDU)...
  12. ncbi Changing demographics in an HIV-infected population: results from an observational cohort study in Western Denmark
    S Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    Scand J Infect Dis 33:765-70. 2001
    ....
  13. ncbi 'Simply forgot' is the most frequently stated reason for missed doses of HAART irrespective of degree of adherence
    T S Barfod
    Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    HIV Med 7:285-90. 2006
    ..The objective of this study was to examine further patients' self-reported reasons for missing doses of HAART and to compare the reasons given by patients with lower adherence with those given by patients with higher adherence...
  14. doi Bone mineral density changes in protease inhibitor-sparing vs. nucleoside reverse transcriptase inhibitor-sparing highly active antiretroviral therapy: data from a randomized trial
    A B Hansen
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 12:157-65. 2011
    ....
  15. doi Phylogeny and resistance profiles of HIV-1 POL sequences from rectal biopsies and blood
    T L Katzenstein
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Med Virol 82:1103-9. 2010
    ..These findings suggest that additional information regarding the antiviral resistance profile of the patient might be obtained by testing different anatomical sites...
  16. doi Increased mortality among persons infected with hepatitis C virus
    Lars Haukali Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Clin Gastroenterol Hepatol 9:71-8. 2011
    ....
  17. ncbi Use of the protease inhibitor saquinavir hard gel in human immunodeficiency virus-infected patients in the early period of highly active antiretroviral therapy: does it affect long-term treatment outcome?
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Scand J Infect Dis 35:743-9. 2003
    ..39-2.58). The insufficient suppression of viral load in patients starting with saquinavir hgc subsided during follow-up, probably owing to the earlier discontinuation of saquinavir hcg in favour of newer and more potent HAART regimens...
  18. doi Hospitalization for pneumonia among individuals with and without HIV infection, 1995-2007: a Danish population-based, nationwide cohort study
    Ole S Sogaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Clin Infect Dis 47:1345-53. 2008
    ..We compared incidence rates of pneumonia among individuals with and without HIV infection and explored risk factors for pneumonia in the HIV-infected population...
  19. doi Causes of death among Danish HIV patients compared with population controls in the period 1995-2008
    M Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Infection 40:627-34. 2012
    ..To compare the mortality and causes of death in human immunodeficiency syndrome (HIV) patients with the background population...
  20. doi Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV-infected individuals from 1995 to 2007: a nationwide cohort study*
    M V Larsen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
    HIV Med 13:45-53. 2012
    ..Incidence rates (IRs) of Staphylococcus aureus bacteraemia (SAB) are known to be higher in HIV-infected individuals than in the general population, but have not been assessed in the era of highly active antiretroviral therapy...
  21. doi Risk of high-level viraemia in HIV-infected patients on successful antiretroviral treatment for more than 6 months
    F N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    HIV Med 11:457-61. 2010
    ..We estimated the risk that patients considered to have an undetectable viral load (VL) are actually viraemic...
  22. pmc Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study
    Frederik N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    BMC Infect Dis 10:318. 2010
    ..We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART...
  23. doi Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study
    Frederik Neess Engsig
    Department of Infectious Diseases at Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Infect Dis 199:77-83. 2009
    ....
  24. ncbi Impact of hepatitis C virus coinfection on response to highly active antiretroviral therapy and outcome in HIV-infected individuals: a nationwide cohort study
    Nina Weis
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Clin Infect Dis 42:1481-7. 2006
    ..We determined the impact of HCV infection on response to highly active antiretroviral therapy and outcome among Danish patients with HIV-1 infection...
  25. doi The impact of HIV-1 co-infection on long-term mortality in patients with hepatitis C: a population-based cohort study
    L H Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 10:65-71. 2009
    ..To investigate the impact of HIV co-infection on mortality in patients infected with hepatitis C virus (HCV)...
  26. doi The prevalence of metabolic syndrome in Danish patients with HIV infection: the effect of antiretroviral therapy
    B R Hansen
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, Hvidovre DK 2650, Denmark
    HIV Med 10:378-87. 2009
    ..We investigated the prevalence of MS in a cohort of Danish HIV-infected patients and estimated the effect of the various classes of antiretroviral therapies on the prevalence of MS and its components...
  27. ncbi Resistance profiles and adherence at primary virological failure in three different highly active antiretroviral therapy regimens: analysis of failure rates in a randomized study
    B T Røge
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    HIV Med 5:344-51. 2004
    ..To investigate the interplay between resistance and adherence in the virological failure of three fundamentally different highly active antiretroviral therapy (HAART) regimens...
  28. ncbi K65R with and without S68: a new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine
    Birgit T Røge
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Antivir Ther 8:173-82. 2003
    ..The unexpected high incidence of S68G suggests a functional role of this mutation in viruses harbouring K65R...
  29. ncbi Tenofovir treatment in an unselected cohort of highly antiretroviral experienced HIV positive patients
    Anne Lerbaek
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:280-6. 2004
    ..In conclusion, we observed a significant decrease in HIV-RNA only when tenofovir was prescribed, in conjunction with other anti-retroviral drugs, to patients on a failing highly active antiretroviral drug regimen (HAART)...
  30. ncbi Demographics in HIV-infected children in Denmark: results from the Danish Paediatric HIV Cohort Study
    Johannes Schmid
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    Scand J Infect Dis 37:344-9. 2005
    ....
  31. pmc Mortality after hospitalization for pneumonia among individuals with HIV, 1995-2008: a Danish cohort study
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    PLoS ONE 4:e7022. 2009
    ..HIV-infected persons are at increased risk of pneumonia, even with highly active antiretroviral treatment (HAART). We examined the impact of pneumonia on mortality and identified prognostic factors for death among HIV-infected...
  32. ncbi Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population
    A B Hansen
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 7:38-45. 2006
    ..To establish the prevalence and quantify the severity of body fat redistribution and dyslipidaemia in HIV-infected men after long-term highly active antiretroviral therapy (HAART) compared with the background population...
  33. ncbi Incidence of granulomatosis with polyangiitis (Wegener's) in Greenland and the Faroe Islands: epidemiology of an ANCA-associated vasculitic syndrome in two ethnically distinct populations in the North Atlantic area
    M Faurschou
    Department of Infectious Diseases and Rheumatology, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Exp Rheumatol 31:S52-5. 2013
    ..0/million/year reported for the population of Northern Norway. In the present study, we assessed the incidence of GPA in the predominantly Inuit population of Greenland and in the Caucasian population of the Faroe Islands...
  34. ncbi Long-term effectiveness of highly active antiretroviral therapy (HAART) in perinatally HIV-infected children in Denmark
    Linda Bracher
    Department of Paediatrics, Copenhagen University Hospital, Hvidovre, Denmark
    Scand J Infect Dis 39:799-804. 2007
    ..During our observation period there were no signs of a waning impact. The challenge remains to maintain a high adherence to therapy as the children grow into adolescence and develop more independence from family and health care staff...
  35. ncbi A randomized trial comparing initial HAART regimens of nelfinavir/nevirapine and ritonavir/saquinavir in combination with two nucleoside reverse transcriptase inhibitors
    Ole Kirk
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark
    Antivir Ther 8:595-602. 2003
    ..A triple-class HAART regimen may be associated with a better virological effect than conventional regimens, but may also lead to toxicity and more profound resistance...
  36. ncbi Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    AIDS 18:89-97. 2004
    ....
  37. ncbi Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations
    Sofie Mathiesen
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    AIDS 18:1076-8. 2004
  38. ncbi Patients' answers to simple questions about treatment satisfaction and adherence and depression are associated with failure of HAART: a cross-sectional survey
    Toke S Barfod
    Rigshospitalet, University Hosital of Copenhagen, Denmark
    AIDS Patient Care STDS 19:317-25. 2005
    ..Because of the cross-sectional nature of the study, causality could not be determined. These questions, however, may be relevant screening tools in clinical practice and in follow-up studies...
  39. doi Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    HIV Med 11:130-6. 2010
    ..The aim of the study was to examine whether exposure to abacavir increases the risk for myocardial infarction (MI)...
  40. ncbi Dynamics of 103K/N and 184M/V HIV-1 drug resistant populations: relative comparison in plasma virus RNA versus CD45RO+T cell proviral DNA
    M R Jakobsen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardvej 100, 8200 Aarhus N, Denmark
    J Clin Virol 39:215-21. 2007
    ..Viral populations defined by 103K/N and 184M/V as linked or single mutations in the HIV-1 reverse transcriptase gene were investigated in plasma samples and compared with previous findings in the CD45RO(+)T cell compartment...
  41. ncbi The use of calcium carbonate in nelfinavir-associated diarrhoea in HIV-1-infected patients
    S Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    HIV Med 4:48-52. 2003
    ..To evaluate the efficacy of oral calcium supplements in HIV-infected patients with nelfinavir (NFV)-associated diarrhoea, and to investigate the influence on the pharmacokinetics of nelfinavir and the active metabolite M8...
  42. ncbi Ten years of extrapulmonary tuberculosis in a Danish university clinic
    L Ebdrup
    Department of Infectious Diseases, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Scand J Infect Dis 35:244-6. 2003
    ..The patients' subjective complaints on admission should guide the diagnostic procedures...
  43. ncbi Survival of persons with and without HIV infection in Denmark, 1995-2005
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Ann Intern Med 146:87-95. 2007
    ..The expected survival of HIV-infected patients is of major public health interest...
  44. ncbi Unmeasured confounding caused slightly better response to HAART within than outside a randomized controlled trial
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, Kløvervaenget 2, Odense C, Denmark
    J Clin Epidemiol 61:87-94. 2008
    ..To compare the outcome of highly active antiretroviral therapy (HAART) in HIV-infected patients initiating equivalent regimens within and outside a randomized controlled trial (RCT)...
  45. ncbi Demographics of HIV-1 infection in Denmark: results from the Danish HIV Cohort Study
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Scand J Infect Dis 37:338-43. 2005
    ..In this period 14.5% had AIDS at the time of HIV diagnosis. Our data do not confirm concerns about unmonitored evolution in the HIV epidemic in Denmark...
  46. ncbi HIV-1 reverse transcriptase gene 103K/N and 184M/V combinations in tandem: detection and quantification of HIV-1 populations in the CD45RO+ T-cell compartment by a double-ARMS real-time PCR assay
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    J Acquir Immune Defic Syndr 41:160-7. 2006
    ..The proviral HIV-1 reverse transcriptase gene for the 103K/N and 184M/V combinations were studied in tandem. The CD45RO T (memory) cell compartment was investigated...
  47. ncbi Declining risk of triple-class antiretroviral drug failure in Danish HIV-infected individuals
    Nicolai Lohse
    Odense University Hospital, and University of Southern Denmark, Odense, Denmark
    AIDS 19:815-22. 2005
    ..To analyse the incidence, prevalence, and predictors for development of triple-class antiretroviral drug failure (TCF) in individuals infected with HIV...
  48. ncbi Low effectiveness of highly active antiretroviral therapy and high mortality in the Greenland HIV-infected population
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital, 5000 Odense, Denmark
    Scand J Infect Dis 36:738-42. 2004
    ..Our findings underline the difficulties of implementing successful HIV treatment even with unlimited economic resources and free access to health care...
  49. ncbi Dynamics of proviral HIV-1 184M/V in circulating CD4+ T-cells: a 90 days follow-up study after initiation/switch of HAART
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    Scand J Infect Dis 38:119-23. 2006
    ..Reduction in the quantity of 184V when therapy is switched to an effective non-lamivudine regime indicates that the mutation in this compartment is dynamic...
  50. ncbi Virological control during the first 6-18 months after initiating highly active antiretroviral therapy as a predictor for outcome in HIV-infected patients: a Danish, population-based, 6-year follow-up study
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    Clin Infect Dis 42:136-44. 2006
    ....
  51. ncbi The effect of race/ethnicity on the outcome of highly active antiretroviral therapy for human immunodeficiency virus type 1-infected patients
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Skejby Hospital, DK 8200 Aarhus N, Denmark
    Clin Infect Dis 35:1541-8. 2002
    ..Race and ethnic origin play no major role in the outcome associated with HAART if access to health care is free...
  52. ncbi Declining prevalence of HIV-infected individuals at risk of transmitting drug-resistant HIV in Denmark during 1997-2004
    Nicolai Lohse
    Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Antivir Ther 11:591-600. 2006
    ..5%) in our population, we estimated acquisition of HIV drug resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV...
  53. ncbi Mortality in siblings of patients coinfected with HIV and hepatitis C virus
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, DK 5000 Odense C, Denmark
    J Infect Dis 195:230-5. 2007
    ..We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death...
  54. doi Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Hepatol 53:36-42. 2010
    ..We examined the impact of chronic HCV replication on mortality among Danish patients testing positive for HCV antibodies...
  55. ncbi Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial
    Ulrik Bak Dragsted
    Hvidovre University Hospital, Hvidovre, Denmark
    J Infect Dis 188:635-42. 2003
    ..A greater number of treatment-limiting adverse events were observed in the Idv/Rtv arm, relative to the Sqv/Rtv arm. In conclusion, Rtv-boosed Sqv and Idv were found to have comparable antiretroviral effects in the doses studied...
  56. pmc Risk of myocardial infarction in parents of HIV-infected Individuals: a population-based Cohort Study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    BMC Infect Dis 10:169. 2010
    ..To establish whether the increased risk of myocardial infarction in HIV patients partly reflects an increased risk of MI in their families, we estimated the relative risk of MI in parents of HIV-infected individuals...
  57. ncbi Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1,000 copies/ml
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    J Clin Virol 34:257-67. 2005
    ..However, the role of low-level viremia (viral-load less than 1,000 copies/ml) on mutation genesis and incorporation of resistant forms in the long-lived CD4(+) T cellular DNA compartment is not clear...
  58. ncbi Trends in the use of highly active antiretroviral therapy in western Denmark 1996-2000
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    Scand J Infect Dis 34:460-5. 2002
    ..Major new strategies implemented in the region in 1999 and 2000 included treatment with boosted protease inhibitors and non-nucleoside reverse transcriptase inhibitors...
  59. ncbi Pharmacokinetics of two randomized trials evaluating the safety and efficacy of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir: the MaxCmin1 and 2 trials
    Ulrik S Justesen
    Department of Infectious Diseases, Odense University Hospital, Odense C, Denmark
    Basic Clin Pharmacol Toxicol 101:339-44. 2007
    ..Associations between high C(min) and toxicity were identified in the saquinavir arm; therefore, dose reductions may be appropriate in certain patients with C(min) several times above the minimum effective concentration...
  60. pmc Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    PLoS ONE 2:e738. 2007
    ..This indicates that risk factors shared by family members partially account for the excess mortality of HIV/HCV-co-infected patients. We aimed to explore the causes of death contributing to the excess sibling mortality...
  61. ncbi Herpesvirus type 1-8 in sinus aspirates from HIV-infected patients and immunocompetent individuals
    B Tarp
    Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Rhinology 39:98-102. 2001
    ..It remains to be established whether the herpesviruses play a pathogenic role in the development of sinusitis in HIV-infected patients...
  62. doi Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study
    N Hansen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
    J Viral Hepat 16:659-65. 2009
    ..We found that several of the factors predicting initiation of antiviral treatment correlate with factors known to predict a better response to treatment and factors known to increase the progression of liver disease...
  63. ncbi The plasma level of soluble urokinase receptor is elevated in patients with Streptococcus pneumoniae bacteraemia and predicts mortality
    P Wittenhagen
    Clinical Research Unit, Copenhagen University Hospitals, Hvidovre, Denmark
    Clin Microbiol Infect 10:409-15. 2004
    ..This plasma protein may be used to identify patients who are severely ill with pneumococcal bacteraemia...
  64. doi Long-term mortality in patients diagnosed with pneumococcal meningitis: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark
    Am J Epidemiol 172:309-17. 2010
    ..To improve survival in patients surviving the acute phase of pneumococcal meningitis, physicians should meticulously screen this patient population for neurologic sequelae and comorbidity predisposing to the disease...
  65. pmc Retrivability in The Danish National Hospital Registry of HIV and hepatitis B and C coinfection diagnoses of patients managed in HIV centers 1995-2004
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    BMC Med Res Methodol 8:25. 2008
    ..We examined completeness of registration of HIV infections and of chronic hepatitis B (HBV) and hepatitis C (HCV) coinfections in the Danish National Hospital Registry (DNHR) covering all Danish hospitals...
  66. ncbi Mortality after myocardial infarction in HIV-infected patients who have initiated HAART
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    AIDS 21:873-5. 2007
    ..Mortality in HIV-infected MI patients was not significantly different to that of MI only patients in the first 90 days post-MI and thereafter was not significantly different to that of HIV patients without MI...
  67. ncbi Novel mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infections
    M Storgaard
    Department of Infectious Diseases, Arhus University Hospital, Aarhus N, Denmark
    Scand J Immunol 64:137-9. 2006
    ..The genetic defect was passed on to his daughter who was diagnosed with non-tuberculous mycobacterial osteomyelitis at the age of 7 years...
  68. ncbi Decreased urokinase receptor expression on granulocytes in HIV-infected patients
    M Storgaard
    Department of Infectious Diseases, Skejby University Hospital, Denmark
    Scand J Immunol 55:409-13. 2002
    ..001, n = 10) with the number of CD4+ blood cells. In contrast, the expression of IL-8 receptor, CD11b, CD18 and CD62 was not significantly altered in HIV-patients compared with healthy controls...
  69. doi Impact of injecting drug use on mortality in Danish HIV-infected patients: a nation-wide population-based cohort study
    Mette V Larsen
    Department of Infectious Diseases, Copenhagen University Hospital, DK 2650 Hvidovre, Denmark
    Addiction 105:529-35. 2010
    ..To estimate the impact of injecting drug use (IDU) on mortality in HIV-infected patients in the highly active antiretroviral therapy (HAART) era...
  70. pmc Genetic and environmental influences on risk of death due to infections assessed in Danish twins, 1943-2001
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Am J Epidemiol 171:1007-13. 2010
    ..The concordance rates were generally low, and, although a genetic influence on the risk of death from infectious diseases could be demonstrated, the absolute effect of the genetic component on mortality was small...
  71. ncbi Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease
    Gitte Kronborg
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 34:323-6. 2002
    ..002). In conclusion, high serum levels of YKL40 indicated a poorer prognosis for patients with S. pneumoniae bacteremia...
  72. ncbi [Changes in immunological status among newly-diagnosed HIV-infected in Denmark 1995-2005]
    Simon Høegh
    Odense Universitetshospital, Medicinsk afdeling C
    Ugeskr Laeger 170:740-4. 2008
    ....
  73. pmc Implementation and effectiveness of antiretroviral therapy in Greenland
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark
    Emerg Infect Dis 14:56-9. 2008
    ..However, implementation and quality of care improved considerably in recent years...
  74. ncbi Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study
    Jacob Sode
    Department of Infectious Medicine, Odense University Hospital, 5000, Odense C, Denmark
    Eur J Clin Pharmacol 63:499-503. 2007
    ..Several case-control studies have reported that the use of fluoroquinolone increases the risk of rupture of the Achilles tendon. Our aim was to estimate this risk by means of a population-based cohort approach...
  75. ncbi [HIV in Western Denmark. Demographic data from a population-based cohort study]
    Søren Jensen-Fangel
    Infektionsmedicinsk Afdeling Q, Skejby Sygehus, Arhus Universitetshospital, DK 8200 Arhus N
    Ugeskr Laeger 164:3964-7. 2002
    ..The course of HIV infection has changed since the introduction of highly active anti-retroviral treatment...
  76. doi Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  77. ncbi Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine
    Jan Gerstoft
    Department of Infectious Diseases at Rigshospitalet, Copenhagen, Denmark
    AIDS 17:2045-52. 2003
    ..Highly active antiretroviral therapy containing three nucleoside reverse transcriptase inhibitors has been somewhat successful, but the clinical efficacy is unclear...
  78. doi Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naïve patients in Greenland
    Tina Vasehus Madsen
    Statens Serum Institut, Department of Virology, Copenhagen, Denmark
    AIDS Res Hum Retroviruses 24:1073-7. 2008
    ....
  79. ncbi Improved survival in HIV-infected persons: consequences and perspectives
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, DK 8000 Arhus C, Denmark
    J Antimicrob Chemother 60:461-3. 2007
    ....
  80. ncbi Prevalence of drug resistance mutations and non-B subtypes in newly diagnosed HIV-1 patients in Denmark
    Louise B Jørgensen
    Department of Virology Statens Serum Institut, Copenhagen, Denmark
    Scand J Infect Dis 35:800-7. 2003
    ..We found 2 patients (2%) with mutations associated with resistance in the RT-gene and none in the protease gene indicating a low prevalence of resistant HIV-1 in Denmark in the year 2000...
  81. ncbi Introduction of HIV type 1 into an isolated population: molecular epidemiologic study from Greenland
    Tina V Madsen
    Department of Virology, Statens Serum Institut, Copenhagen, Denmark
    AIDS Res Hum Retroviruses 23:675-81. 2007
    ..The large diversity between the main Greenland cluster and the rest of the sequences is most likely due to a founder effect...
  82. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  83. ncbi Genotypic drug resistance and long-term mortality in patients with triple-class antiretroviral drug failure
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark
    Antivir Ther 12:909-17. 2007
    ..To examine the prevalence of drug-resistance-associated mutations in HIV patients with triple-drug class virological failure (TCF) and their association with long-term mortality...
  84. ncbi [Stable long-term effect of HIV therapy. The Danish Society for Infectious Diseases]
    Nicolai Lohse
    Klinisk Epidemiologisk Afdeling, Arhus Universitetshospital, DK 8000 Arhus C
    Ugeskr Laeger 169:1109. 2007
  85. ncbi [Reporting chronic hepatitis B and C in Denmark]
    Nanna Hansen
    Infektionsmedicinsk Afdeling, Hvidovre Hospital, DK 2650 Hvidovre
    Ugeskr Laeger 170:1567-70. 2008
    ....
  86. pmc Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care
    Anette Holm
    Department of Infectious Diseases C, Odense University Hospital, Denmark
    Br J Gen Pract 57:555-60. 2007
    ..There is no study on the value of procalcitonin measurements in adults with lower respiratory tract infection (LRTI) treated in primary care...
  87. ncbi [Post-exposure prophylaxis after sexual or occupational exposure to HIV]
    Suzanne Lunding
    epidemiafdelingen, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 165:3709-12. 2003
  88. ncbi [Administration of medications. Joint charts for prescription--transcription and dispensing errors]
    Henning K Nielsen
    Randers Centralsygehus, Medicinsk afdeling
    Ugeskr Laeger 166:2800-3. 2004