Laszlo Hegedus

Summary

Affiliation: Odense University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Thyroid ultrasound
    L Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Endocrinol Metab Clin North Am 30:339-60, viii-ix. 2001
  2. ncbi request reprint Management of simple nodular goiter: current status and future perspectives
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Endocr Rev 24:102-32. 2003
  3. ncbi request reprint Relationship between cigarette smoking and Graves' ophthalmopathy
    L Hegediüs
    Department of Endocrinology and Metabolism M, Odense University Hospital, Odense, Denmark
    J Endocrinol Invest 27:265-71. 2004
  4. ncbi request reprint Clinical practice. The thyroid nodule
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    N Engl J Med 351:1764-71. 2004
  5. doi request reprint Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 93:3981-4. 2008
  6. ncbi request reprint Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 92:3424-8. 2007
  7. ncbi request reprint B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark
    J Clin Endocrinol Metab 92:1769-72. 2007
  8. doi request reprint Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 95:3719-25. 2010
  9. ncbi request reprint Randomized prospective study comparing a single radioiodine dose and a single laser therapy session in autonomously functioning thyroid nodules
    Helle Døssing
    Department of Oto Rhino Laryngology and Neck Surgery, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 157:95-100. 2007
  10. ncbi request reprint The relative importance of genetic and environmental factors in the aetiology of thyroid nodularity: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, Odense C, Denmark
    Clin Endocrinol (Oxf) 62:380-6. 2005

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Thyroid ultrasound
    L Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Endocrinol Metab Clin North Am 30:339-60, viii-ix. 2001
    ..It is argued that more clinician endocrinologists should master and use this technology for diagnostic and therapeutic purposes...
  2. ncbi request reprint Management of simple nodular goiter: current status and future perspectives
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Endocr Rev 24:102-32. 2003
    ..Within a few years, the introduction of recombinant human TSH and laser therapy may profoundly alter the nonsurgical treatment of simple nodular goiter...
  3. ncbi request reprint Relationship between cigarette smoking and Graves' ophthalmopathy
    L Hegediüs
    Department of Endocrinology and Metabolism M, Odense University Hospital, Odense, Denmark
    J Endocrinol Invest 27:265-71. 2004
    ..The possibility of hindering GO or attenuating its course suggests that counselling on smoking cessation should be an integral part of the treatment of any patient with GD...
  4. ncbi request reprint Clinical practice. The thyroid nodule
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    N Engl J Med 351:1764-71. 2004
  5. doi request reprint Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 93:3981-4. 2008
    ..The impact on tracheal anatomy and respiratory function of recombinant human (rh)TSH-stimulated (131)I therapy in patients with goiter is not clarified...
  6. ncbi request reprint Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 92:3424-8. 2007
    ..The effect of (131)I therapy amplification by recombinant human (rh) TSH prestimulation in very large goiters has not been evaluated in a double-blinded, placebo-controlled study...
  7. ncbi request reprint B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense, Denmark
    J Clin Endocrinol Metab 92:1769-72. 2007
    ..Because B lymphocytes are important self-antigen presenting cells and precursors for antibody-secreting plasma cells, temporary B-lymphocyte depletion with the monoclonal antibody rituximab (RTX) might be of benefit in GD...
  8. doi request reprint Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 95:3719-25. 2010
    ..Observations indicate that rhTSH has a preconditioning effect beyond increasing thyroid (131)I uptake. We test the hypothesis that an equivalent GVR might be obtained by an absorbed thyroid dose well below what has been used previously...
  9. ncbi request reprint Randomized prospective study comparing a single radioiodine dose and a single laser therapy session in autonomously functioning thyroid nodules
    Helle Døssing
    Department of Oto Rhino Laryngology and Neck Surgery, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 157:95-100. 2007
    ..To compare the efficacy of interstitial laser photocoagulation (ILP) with radioiodine in hot thyroid nodules...
  10. ncbi request reprint The relative importance of genetic and environmental factors in the aetiology of thyroid nodularity: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, Odense C, Denmark
    Clin Endocrinol (Oxf) 62:380-6. 2005
    ..Factors such as age, gender, iodine intake, smoking and parity are associated with nodularity of the thyroid. Whether there is a genetic susceptibility is unclear...
  11. pmc Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 18:254-7. 2010
    ..More likely, XCI and TPOAb are influenced by shared genetic determinants...
  12. ncbi request reprint Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Am J Physiol Endocrinol Metab 292:E765-70. 2007
    ..In conclusion, thyroid hormone levels are partly genetically correlated genes that affect free T4 levels and exert pleiotropic effects on free T3 levels, although most of the genetic variance for these measurements is trait specific...
  13. doi request reprint A randomized trial evaluating a block-replacement regimen during radioiodine therapy
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, Denmark
    Eur J Clin Invest 41:693-702. 2011
    ..Lack of consensus regarding the antithyroid drug regimen in relation to radioiodine ((131) I) therapy of hyperthyroidism prompted this randomized trial comparing two strategies...
  14. ncbi request reprint Continuous methimazole therapy and its effect on the cure rate of hyperthyroidism using radioactive iodine: an evaluation by a randomized trial
    Steen Joop Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:2946-51. 2006
    ..A randomized clinical trial was performed to clarify whether continuous use of methimazole (MTZ) during radioiodine ((131)I) therapy influences the final outcome of this therapy...
  15. pmc Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e66711. 2013
    ..However, our knowledge regarding the extent and temporal relation between hyperthyroidism and other diseases is fragmented. Here, we aimed at evaluating various morbidities before and after the diagnosis of hyperthyroidism...
  16. ncbi request reprint Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    Eur J Endocrinol 170:341-8. 2014
    ..In this study, we aimed to investigate the association and temporal relationship between hyperthyroidism and psychiatric morbidity...
  17. ncbi request reprint Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: a prospective randomized double-blind trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Arch Intern Med 166:1476-82. 2006
    ..Use of recombinant human thyrotropin increases the thyroid radioiodine (iodine 131 [(131)I]) uptake and may have a role in the context of (131)I therapy of benign goiter...
  18. ncbi request reprint Low birth weight is not associated with thyroid autoimmunity: a population-based twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:3499-502. 2006
    ..The effect of these confounders can be minimized through investigation of twin pairs...
  19. ncbi request reprint The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 66:827-32. 2007
    ....
  20. pmc Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 98:1069-75. 2013
    ..Although hypothyroidism is associated with increased morbidity, an association with increased mortality is still debated. Our objective was to investigate, at a nationwide level, whether a diagnosis of hypothyroidism influences mortality...
  21. pmc Excess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a danish nationwide register-based cohort study of twins and singletons
    Frans Brandt
    Consultant Physician, Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 97:4123-9. 2012
    ..However, it is unknown whether this increased mortality is explained by hyperthyroidism per se, comorbidity, and/or genetic confounding...
  22. ncbi request reprint Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)
    Esther A Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 44:991-8. 2006
    ..However, some young men without any of the risk factors have autoantibodies, and cannot be identified by the present tools. A model for reference intervals and cut-off values should not be influenced by the prevalence of risk factors...
  23. ncbi request reprint Biological variation of thyroid autoantibodies and thyroglobulin
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, 5000 Odense C, Denmark
    Clin Chem Lab Med 45:1058-64. 2007
    ..As the biological variation of these autoantibodies is unknown, we investigated this in fertile women during one complete regular menstrual cycle...
  24. doi request reprint Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhTSH
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 72:411-6. 2010
    ..Reports of acute thyroid swelling and hyperthyroidism warrant safety studies evaluating whether these side-effects are dose dependent...
  25. doi request reprint X Chromosome inactivation pattern is not associated with interindividual variations in thyroid volume: a study of euthyroid Danish female twins
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Twin Res Hum Genet 12:502-6. 2009
    ..In conclusion, in a sample of euthyroid Danish female twins, we found no evidence of a relationship between XCI pattern and thyroid volume...
  26. ncbi request reprint Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:1317-22. 2006
    ..01 to 0.9 mg, has been used to augment the effect of radioiodine ((131)I) therapy in patients with a benign nontoxic nodular goiter. Transient thyroid enlargement and thyrotoxicosis may be seen following (131)I therapy...
  27. ncbi request reprint The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins
    Pia S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Endocrinol 154:29-38. 2006
    ..We aimed to estimate the relative importance of genetic and environmental effects for the presence of thyroid autoantibodies in euthyroid subjects...
  28. doi request reprint Aggregation of thyroid autoantibodies in twins from opposite-sex pairs suggests that microchimerism may play a role in the early stages of thyroid autoimmunity
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 94:4439-43. 2009
    ..Microchimerism has recently been proposed to play a role in the pathogenesis of thyroid autoimmunity. In that case, twins from opposite-sex pairs (OS) should have an increased risk of thyroid autoantibodies (TA)...
  29. doi request reprint The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 73:666-70. 2010
    ..Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women...
  30. doi request reprint Time to reconsider nonsurgical therapy of benign non-toxic multinodular goitre: focus on recombinant human TSH augmented radioiodine therapy
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 160:517-28. 2009
    ..Thus, although in its infancy, and still experimental, rhTSH-augmented (131)I therapy may profoundly alter the non-surgical treatment of benign non-toxic MNG...
  31. doi request reprint Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 23:408-13. 2013
    ..Whether the underlying cause of hyperthyroidism influences this association is unclear. Our objectives were to explore whether mortality risk and cause of death differ between Graves' disease (GD) and toxic nodular goiter (TNG)...
  32. ncbi request reprint The effects of recombinant human thyrotropin, in normal subjects and patients with goitre
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital and University of Southern Denmark, DK 5000 Odense, Denmark
    Clin Endocrinol (Oxf) 61:655-63. 2004
  33. doi request reprint Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter
    Søren Fast
    Departments of Endocrinology, Odense University Hospital, DK 5000 Odense, Denmark
    J Clin Endocrinol Metab 97:2653-60. 2012
    ..The objective of the study was to evaluate the long-term outcome of recombinant human TSH (rhTSH)-augmented radioiodine ((131)I) therapy for benign multinodular nontoxic goiter...
  34. doi request reprint Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes
    Helena Gásdal Sørensen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 18:1087-94. 2008
    ..However, little is known about SNPs in the THRA (17q11.2) and THRB (3p24.2) genes. The aim of this study was to map THRA and THRB for the occurrence and frequencies of SNPs and relate these to thyroid parameters...
  35. ncbi request reprint Radioiodine therapy in non-toxic multinodular goitre. The possibility of effect-amplification with recombinant human TSH (rhTSH)
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Acta Oncol 45:1051-8. 2006
    ..A similar goitre swelling may cause problems in susceptible patients during rhTSH-augmented 131I therapy. Thus, this concept still needs a closer evaluation before routine use...
  36. pmc Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    PLoS ONE 8:e75789. 2013
    ..However, the temporal relationship between these diseases and the diagnosis of hypothyroidism is not well illuminated. Such information may provide insight into causal relationships between hypothyroidism and other morbidities...
  37. doi request reprint Interstitial laser photocoagulation (ILP) of benign cystic thyroid nodules--a prospective randomized trial
    Helle Døssing
    Department of Otorhinolaryngology and Neck Surgery, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 98:E1213-7. 2013
    ..Recurrence rate, after aspiration, in cystic thyroid nodules is very high. Interstitial laser photocoagulation (ILP) is a minimally invasive procedure that reduces the need for surgery in patients with a benign solid thyroid nodule...
  38. ncbi request reprint Evidence of intrathyroidal B-lymphocyte depletion after rituximab therapy in a patient with Graves' disease
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 92:3762-3. 2007
  39. doi request reprint Treating the thyroid in the presence of Graves' ophthalmopathy
    Laszlo Hegedus
    University of Southern Denmark, Odense, Denmark
    Best Pract Res Clin Endocrinol Metab 26:313-24. 2012
    ..Evidently, there is room for improving therapy of GO. Progress using novel drugs such as rituximab, which might potentially influence positively both GD and GO, are impatiently awaited...
  40. doi request reprint Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    J Nucl Med 50:732-7. 2009
    ..The purpose of this study was to determine the optimal time interval between rhTSH and (131)I administration to enhance thyroid radioactive iodine uptake (RAIU)...
  41. doi request reprint Benefit of measuring basal serum calcitonin to detect medullary thyroid carcinoma in a Danish population with a high prevalence of thyroid nodules
    Martin Hasselgren
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Head Neck 32:612-8. 2010
    ..Routine measurement of serum calcitonin to detect medullary thyroid carcinoma (MTC) continues to be fiercely debated, although less attention has been paid to the positive predictive value (PPV) of this method...
  42. doi request reprint Approach to management of the patient with primary or secondary intrathoracic goiter
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 3, DK 5000 Odense, Denmark
    J Clin Endocrinol Metab 95:5155-62. 2010
    ..Future studies should also explore the use of radioiodine in primary intrathoracic goiter and compare surgery and radioiodine, head to head...
  43. ncbi request reprint Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 42:824-32. 2004
    ..Consequently, a common reference interval for serum TSH of 0.58-4.07 mlU/l for all adults between 17 and 66 years of age was established. This reference interval is much higher than expected from the NACB-guidelines...
  44. doi request reprint No link between X chromosome inactivation pattern and simple goiter in females: evidence from a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 19:165-9. 2009
    ....
  45. pmc Regulation of the pituitary-thyroid axis in adulthood is not related to birth weight: evidence from extremely birth weight-discordant monozygotic Danish twin pairs
    Morten Frost
    The Danish Twin Registry, Danish Aging Research Center, University of Southern Denmark, Odense, Denmark
    Thyroid 23:785-90. 2013
    ..We hypothesized that birth weight influences the pituitary-thyroid set point in adults...
  46. ncbi request reprint Improved sensitivity of a thyrotropin receptor antibody assay
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Denmark
    Clin Chem 51:2186-7. 2005
  47. ncbi request reprint Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments
    Helle Døssing
    Department of Oto Rhino Laryngology and Neck Surgery, Odense University Hospital, Odense, Denmark
    Thyroid 16:763-8. 2006
    ..Interstitial laser photocoagulation (ILP) is a safe and effective procedure when inducing thyroid nodule necrosis. In this prospective randomized study, we evaluated a possible dose-response relationship as well as patient satisfaction...
  48. ncbi request reprint Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules - a randomised study
    Helle Døssing
    Department of Oto Rhino Laryngology, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 152:341-5. 2005
    ....
  49. ncbi request reprint Recombinant human thyrotropin markedly changes the 131I kinetics during 131I therapy of patients with nodular goiter: an evaluation by a randomized double-blinded trial
    Viveque Egsgaard Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 90:79-83. 2005
    ..Whether this also leads to a significant increase in goiter size reduction needs additional study...
  50. ncbi request reprint Effects of 0.9 mg recombinant human thyrotropin on thyroid size and function in normal subjects: a randomized, double-blind, cross-over trial
    Viveque E Nielsen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:2242-7. 2004
    ..Further dose-response studies are needed to clarify the potential hazards before routine use, for example in the context of (131)I therapy and goiter...
  51. doi request reprint Non-surgical approach to the benign nodular goiter: new opportunities by recombinant human TSH-stimulated 131I-therapy
    Steen Joop Bonnema
    Department of Endocrinology, Odense University Hospital, 5000, Odense C, Denmark
    Endocrine 40:344-53. 2011
    ..A major hindrance of widespread and routine use of rhTSH-stimulated (131)I-therapy is its present status as an off-label treatment...
  52. doi request reprint Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints"
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Autoimmunity 44:188-94. 2011
    ..This finding may have implications with respect to inheritance of autoantibody specificities in other autoimmune diseases...
  53. ncbi request reprint Genetic and environmental causes of individual differences in thyroid size: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:2071-7. 2004
    ..This fits the observation that goiter may be seen also in the absence of evident environmental goitrogens such as iodine deficiency and that not all individuals develop goiter even in iodine-deficient areas...
  54. doi request reprint A 30-year perspective on radioiodine therapy of benign nontoxic multinodular goiter
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Curr Opin Endocrinol Diabetes Obes 16:379-84. 2009
    ..Recombinant human thyrotropin (rhTSH) is a very potent stimulator of the thyroid gland and this review focuses on rhTSH-stimulated (131)I therapy...
  55. ncbi request reprint Aggregation of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid disease is mainly due to genes: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology M, Odense University Hospital, Denmark
    Clin Endocrinol (Oxf) 60:329-34. 2004
    ..However, family studies cannot determine whether the observed familial aggregation of these antibodies is due to shared genes or shared environment...
  56. ncbi request reprint Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: a nationwide register study
    Marianne Thvilum
    1 Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 24:802-8. 2014
    ..Our objective was to investigate, at a nationwide level, whether a diagnosis of hypothyroidism is associated with psychiatric morbidity...
  57. ncbi request reprint Glucocorticoids do not influence the effect of radioiodine therapy in Graves' disease
    Berit E Jensen
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000, Odense C, Denmark
    Eur J Endocrinol 153:15-21. 2005
    ..We evaluated, in a retrospective study, whether glucocorticoids given in order to avoid initiation or aggravation of ophthalmopathy during radioiodine (131I) therapy have an inadvertent effect on the final thyroid function...
  58. ncbi request reprint Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation--initial experience
    Helle Døssing
    Department of Otorhinolaryngology, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Radiology 225:53-7. 2002
    ..To evaluate the effects of ultrasonography (US)-guided interstitial laser photocoagulation (ILP) on the volume of benign solitary solid cold thyroid nodules and any nodule-related symptoms...
  59. doi request reprint The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy
    Søren Fast
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Clin Endocrinol (Oxf) 69:653-8. 2008
    ..Our aim was to determine, in consecutive nontoxic goitre patients, the proportion ineligible for LT4-therapy. Exclusion criteria were set up in agreement with recent guidelines...
  60. ncbi request reprint Resumption of methimazole after 131I therapy of hyperthyroid diseases: effect on thyroid function and volume evaluated by a randomized clinical trial
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, DK 5000, Odense, Denmark
    Eur J Endocrinol 149:485-92. 2003
    ..Retrospective studies have indicated that anti-thyroid drugs (ATD) might possess a radioprotective effect, leading to a higher rate of recurrence of hyperthyroidism after iodine-131 ((131)I) therapy...
  61. ncbi request reprint High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity
    Thomas Heiberg Brix
    Department of Endocrinology, Odense University Hospital, Sonder Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 90:5949-53. 2005
    ..They are characterized by loss of immunological self-tolerance and female preponderance. Theoretically, X chromosome inactivation (XCI) and resultant tissue chimerism could offer an explanation for the female predisposition to AITD...
  62. doi request reprint Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Immunol 130:252-8. 2009
    ..The possible mechanisms underlying this hitherto unappreciated phenomenon are discussed...
  63. ncbi request reprint MR imaging of large multinodular goiters: observer agreement on volume versus observer disagreement on dimensions of the involved trachea
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense, Denmark
    AJR Am J Roentgenol 179:259-66. 2002
    ..Additionally, we compared the goiter volume estimates from MR imaging with those from sonography...
  64. doi request reprint Risk of malignancy in thyroid incidentalomas detected by 18F-fluorodeoxyglucose positron emission tomography: a systematic review
    Kerstin Kathrine Soelberg
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 22:918-25. 2012
    ..SUV are significantly higher in malignant than in benign nodules. The pronounced inhomogeneity and other shortcomings of the studies are discussed...
  65. doi request reprint A review of the evidence for and against increased mortality in hypothyroidism
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Nat Rev Endocrinol 8:417-24. 2012
    ..Future studies, however, should take the above-mentioned shortcomings and potential genetic confounding into consideration...
  66. doi request reprint Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 76:457-64. 2012
    ..Future twin studies should incorporate information on genetic, epigenetic and environmental variation thereby enhancing our ability to quantify the precise effect of specific risk factors...
  67. doi request reprint Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules
    Helle Døssing
    Department of Oto Rhino Laryngology and Neck Surgery, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 165:123-8. 2011
    ..To evaluate the long-term efficacy of interstitial laser photocoagulation (ILP) in solitary benign thyroid nodules...
  68. ncbi request reprint Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins
    Pia Skov Hansen
    Department of Endocrinology M, Odense University Hospital, and The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 89:1181-7. 2004
    ..Whether this is of importance when treating individuals in whom pituitary-thyroid function has been disrupted by, e.g. hypo- or hyperthyroidism, remains to be clarified...
  69. doi request reprint Treatment of Graves' hyperthyroidism: evidence-based and emerging modalities
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    Endocrinol Metab Clin North Am 38:355-71, ix. 2009
    ..Prospective, randomized studies comparing available and any novel therapeutic options for GD are needed. The focus of these studies should include, but not be limited to, cost and quality of life...
  70. doi request reprint Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 69:491-6. 2008
    ..This potential confounding can be minimized by investigation of twin pairs discordant for GD...
  71. ncbi request reprint Management of the nontoxic multinodular goiter: a North American survey
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 87:112-7. 2002
    ..There is, however, still a wide variation in the perceived optimal management of this condition among members of both organizations...
  72. ncbi request reprint Does radioiodine therapy have an equal effect on substernal and cervical goiter volumes? Evaluation by magnetic resonance imaging
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Thyroid 12:313-7. 2002
    ..However, because the overall effect is modest, this therapy should primarily be considered for the patient with a high surgical risk...
  73. ncbi request reprint Long-term effects of radioiodine on thyroid function, size and patient satisfaction in non-toxic diffuse goitre
    Steen J Bonnema
    Department of Endocrinology and Metabolism, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Endocrinol 150:439-45. 2004
    ..The long-term effects of (131)I-therapy in patients with symptomatic non-toxic diffuse goitre were evaluated...
  74. pmc Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with Rituximab
    Laszlo Hegedus
    Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Denmark
    Clin Endocrinol (Oxf) 74:1-8. 2011
    ..Further studies will hopefully lead to improved and better tailored, individualized therapy for GD and especially TAO...
  75. ncbi request reprint Ultrasound-guided interstitial laser photocoagulation of an autonomous thyroid nodule: the introduction of a novel alternative
    Helle Døssing
    Department of Oto Rhino Laryngology, Odense University Hospital, Denmark
    Thyroid 13:885-8. 2003
    ..US-guided thermic tissue coagulation with ILP could become a useful alternative for the AFTN in patients who cannot or will not undergo surgery or treatment with (131)I...
  76. ncbi request reprint Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial
    Finn Noe Bennedbaek
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 88:5773-7. 2003
    ..Our study demonstrates that flushing with ethanol is a clinically significant nonsurgical alternative for thyroid cysts that recur despite repeat aspirations...
  77. doi request reprint A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Eur J Endocrinol 165:491-7. 2011
    ..This inconsistency may be due to differences in study design, characteristics of participants, or confounders. In order to test whether hyperthyroidism influences mortality, we performed a critical review and statistical meta-analysis...
  78. ncbi request reprint The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option
    Daniel El Fassi
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    Eur J Endocrinol 154:623-32. 2006
    ....
  79. ncbi request reprint Preliminary evidence of genetic anticipation in Graves' disease
    Thomas Heiberg Brix
    Department of Endocrinology, Odense University Hospital, Denmark
    Thyroid 13:447-51. 2003
    ..In conclusion, our data suggest that patients in the second affected generation seem to acquire their disease at an earlier time in life in familial cases of Graves' disease, indicating that genetic anticipation might occur...
  80. doi request reprint GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    Laszlo Hegedus
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    J Clin Endocrinol Metab 96:853-60. 2011
    ....