Thomas H Brix

Summary

Affiliation: Odense University Hospital
Country: Denmark

Publications

  1. doi Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 76:457-64. 2012
  2. doi Twins as a tool for evaluating the influence of genetic susceptibility in thyroid autoimmunity
    T H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Ann Endocrinol (Paris) 72:103-7. 2011
  3. doi Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints"
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Autoimmunity 44:188-94. 2011
  4. doi The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 73:666-70. 2010
  5. pmc Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 18:254-7. 2010
  6. doi No link between X chromosome inactivation pattern and simple goiter in females: evidence from a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 19:165-9. 2009
  7. doi Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 69:491-6. 2008
  8. ncbi The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins
    Pia S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Endocrinol 154:29-38. 2006
  9. ncbi Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)
    Esther A Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 44:991-8. 2006
  10. ncbi Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 42:824-32. 2004

Collaborators

Detail Information

Publications18

  1. doi Twin studies as a model for exploring the aetiology of autoimmune thyroid disease
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 76:457-64. 2012
    ..Future twin studies should incorporate information on genetic, epigenetic and environmental variation thereby enhancing our ability to quantify the precise effect of specific risk factors...
  2. doi Twins as a tool for evaluating the influence of genetic susceptibility in thyroid autoimmunity
    T H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark
    Ann Endocrinol (Paris) 72:103-7. 2011
    ..Future twin studies will incorporate information on genetic and epigenetic variation making it possible to quantify the precise effect of specific susceptibility genes and/or epigenetic variation on estimates of heritability...
  3. doi Monozygotic twin pairs discordant for Hashimoto's thyroiditis share a high proportion of thyroid peroxidase autoantibodies to the immunodominant region A. Further evidence for genetic transmission of epitopic "fingerprints"
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Autoimmunity 44:188-94. 2011
    ..This finding may have implications with respect to inheritance of autoantibody specificities in other autoimmune diseases...
  4. doi The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 73:666-70. 2010
    ..Theoretically, as shown for autoimmune thyroid disease, the pattern of X chromosome inactivation (XCI) could offer a novel explanation for the observed variability of the PTA set point in women...
  5. pmc Preliminary evidence of a noncausal association between the X-chromosome inactivation pattern and thyroid autoimmunity: a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Hum Genet 18:254-7. 2010
    ..More likely, XCI and TPOAb are influenced by shared genetic determinants...
  6. doi No link between X chromosome inactivation pattern and simple goiter in females: evidence from a twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Thyroid 19:165-9. 2009
    ....
  7. doi Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 69:491-6. 2008
    ..This potential confounding can be minimized by investigation of twin pairs discordant for GD...
  8. ncbi The relative importance of genetic and environmental effects for the early stages of thyroid autoimmunity: a study of healthy Danish twins
    Pia S Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Eur J Endocrinol 154:29-38. 2006
    ..We aimed to estimate the relative importance of genetic and environmental effects for the presence of thyroid autoantibodies in euthyroid subjects...
  9. ncbi Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)
    Esther A Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 44:991-8. 2006
    ..However, some young men without any of the risk factors have autoantibodies, and cannot be identified by the present tools. A model for reference intervals and cut-off values should not be influenced by the prevalence of risk factors...
  10. ncbi Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
    Esther Jensen
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Clin Chem Lab Med 42:824-32. 2004
    ..Consequently, a common reference interval for serum TSH of 0.58-4.07 mlU/l for all adults between 17 and 66 years of age was established. This reference interval is much higher than expected from the NACB-guidelines...
  11. doi Treating the thyroid in the presence of Graves' ophthalmopathy
    Laszlo Hegedus
    University of Southern Denmark, Odense, Denmark
    Best Pract Res Clin Endocrinol Metab 26:313-24. 2012
    ..Evidently, there is room for improving therapy of GO. Progress using novel drugs such as rituximab, which might potentially influence positively both GD and GO, are impatiently awaited...
  12. doi The excess risk of major osteoporotic fractures in hypothyroidism is driven by cumulative hyperthyroid as opposed to hypothyroid time: an observational register-based time-resolved cohort analysis
    Bo Abrahamsen
    Odense Patient Data Explorative Network OPEN, Institute of Clinical Research University of Southern Denmark, Odense, Denmark Department of Medicine M, Research Centre for Ageing and Osteoporosis, Glostrup Hospital, Glostrup, Denmark
    J Bone Miner Res 30:898-905. 2015
    ..An independent effect of elevated TSH could only be observed in young and middle-aged men, suggesting gender-discrepant consequences on risk. © 2015 American Society for Bone and Mineral Research. ..
  13. ncbi The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors
    Birgitte B Rasmussen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Pharmacogenetics 12:473-8. 2002
    ..725 (95% confidence interval 0.577-0.822). Unique environmental effects seem to account for the remainder 0.275 (95% confidence interval, 0.178-0.423). Our study shows that the CYP1A2 activity is mainly governed by genetic factors...
  14. doi A review of the evidence for and against increased mortality in hypothyroidism
    Marianne Thvilum
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Nat Rev Endocrinol 8:417-24. 2012
    ..Future studies, however, should take the above-mentioned shortcomings and potential genetic confounding into consideration...
  15. doi A critical review and meta-analysis of the association between overt hyperthyroidism and mortality
    Frans Brandt
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000 Odense C, Denmark
    Eur J Endocrinol 165:491-7. 2011
    ..This inconsistency may be due to differences in study design, characteristics of participants, or confounders. In order to test whether hyperthyroidism influences mortality, we performed a critical review and statistical meta-analysis...
  16. doi A randomized trial evaluating a block-replacement regimen during radioiodine therapy
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, Denmark
    Eur J Clin Invest 41:693-702. 2011
    ..Lack of consensus regarding the antithyroid drug regimen in relation to radioiodine ((131) I) therapy of hyperthyroidism prompted this randomized trial comparing two strategies...
  17. doi Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures-the OPENTHYRO register cohort
    Bo Abrahamsen
    Odense Patient data Explorative Network, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark Research Centre for Ageing and Osteoporosis, Department of Medicine M, Glostrup Hospital, Copenhagen, Denmark
    J Bone Miner Res 29:2040-50. 2014
    ..Moreover, the risk of both hip fracture and MOF increased exponentially by the length of time during which TSH had remained low...
  18. doi Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study
    Thomas H Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, UK
    Clin Endocrinol (Oxf) 81:440-4. 2014
    ....