L Bathum

Summary

Affiliation: Odense University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Haplotype effects on human survival: logistic regression models applied to unphased genotype data
    Q Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Ann Hum Genet 69:168-75. 2005
  2. ncbi request reprint Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, DK 5000 Odense C, Denmark
    Clin Chem 47:81-7. 2001
  3. ncbi request reprint Association of mutations in the hemochromatosis gene with shorter life expectancy
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Sdr Blvd 29, DK 5000 Odense C, Denmark
    Arch Intern Med 161:2441-4. 2001
  4. ncbi request reprint Assessing genetic association with human survival at multi-allelic loci
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Biogerontology 5:89-97. 2004
  5. ncbi request reprint Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Ann Hum Genet 67:598-607. 2003
  6. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study
    K Brixen
    Department of Endocrinology, Odense University Hospital, 5000, Odense C, Denmark
    Calcif Tissue Int 81:421-9. 2007
  7. ncbi request reprint Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene
    K Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Diabetes Obes Metab 8:322-30. 2006
  8. ncbi request reprint Metabolic gene polymorphism frequencies in control populations
    S Garte
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Epidemiol Biomarkers Prev 10:1239-48. 2001
  9. ncbi request reprint Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus
    O Varcasia
    Cell Biology Department, University of Calabria, Rende, Italy
    Ann Hum Genet 65:371-6. 2001
  10. ncbi request reprint Paraoxonase 1 polymorphisms and survival
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Hum Genet 12:843-7. 2004

Detail Information

Publications14

  1. ncbi request reprint Haplotype effects on human survival: logistic regression models applied to unphased genotype data
    Q Tan
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Ann Hum Genet 69:168-75. 2005
    ..We show that our logistic regression based haplotype model can be a helpful tool for researchers interested in the genetics of human aging and longevity...
  2. ncbi request reprint Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, DK 5000 Odense C, Denmark
    Clin Chem 47:81-7. 2001
    ..The aim of the present study was to estimate the relative importance of genetic and environmental factors to variations in these tests among the elderly...
  3. ncbi request reprint Association of mutations in the hemochromatosis gene with shorter life expectancy
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Sdr Blvd 29, DK 5000 Odense C, Denmark
    Arch Intern Med 161:2441-4. 2001
    ..It is of value in the debate concerning screening for hereditary hemochromatosis to determine the significance of heterozygosity...
  4. ncbi request reprint Assessing genetic association with human survival at multi-allelic loci
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Biogerontology 5:89-97. 2004
    ..As an example, we apply the methods to empirical data on Renin gene polymorphism and longevity. We show that our models can serve as useful tools in searching for important genetic variations implicated in human aging and longevity...
  5. ncbi request reprint Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity
    Qihua Tan
    Department of Clinical Biochemistry and Genetics, KKA, Odense University Hospital, Odense, Denmark
    Ann Hum Genet 67:598-607. 2003
    ..Application has shown that these methods can serve as useful tools in searching for important gene variations that contribute to human aging and longevity...
  6. pmc Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study
    K Brixen
    Department of Endocrinology, Odense University Hospital, 5000, Odense C, Denmark
    Calcif Tissue Int 81:421-9. 2007
    ..To investigate the impact of the Ala1330Val (rs3736228, exon 18) and Val667Met (rs4988321, exon 9) polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene on peak bone mass in young men...
  7. ncbi request reprint Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene
    K Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark
    Diabetes Obes Metab 8:322-30. 2006
    ..In this, decreased rates of energy expenditure and impaired insulin secretion could play a role...
  8. ncbi request reprint Metabolic gene polymorphism frequencies in control populations
    S Garte
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Epidemiol Biomarkers Prev 10:1239-48. 2001
    ..No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles...
  9. ncbi request reprint Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus
    O Varcasia
    Cell Biology Department, University of Calabria, Rende, Italy
    Ann Hum Genet 65:371-6. 2001
    ..The different findings in Denmark and Italy suggest that gene/longevity associations are population-specific, and heavily affected by the population-specific genetic and environmental history...
  10. ncbi request reprint Paraoxonase 1 polymorphisms and survival
    L Christiansen
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Hum Genet 12:843-7. 2004
    ....
  11. ncbi request reprint Genetic influence on thrombotic risk markers in the elderly--a Danish twin study
    E M Bladbjerg
    Department for Thrombosis Research, University of Southern Denmark, Ribe County Hospital, Esbjerg, Denmark
    J Thromb Haemost 4:599-607. 2006
    ..The genetic contribution to cardiovascular disease (CVD) decreases with increasing age, and it is therefore important to determine the heritability of hemostasis also in the elderly...
  12. ncbi request reprint A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    Mech Ageing Dev 127:597-9. 2006
    ..To our knowledge, this is the first longitudinal study exploring the influence of GST gene polymorphisms on longevity and these data implies that GST gene copy numbers do affect mortality risk in the elderly...
  13. ncbi request reprint Modest implication of interleukin-6 promoter polymorphisms in longevity
    L Christiansen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Mech Ageing Dev 125:391-5. 2004
    ..We found a modest, but significant, increase in the frequency of interleukin-6 -174GG homozygotes with age suggesting that this genotype is advantageous for longevity...
  14. ncbi request reprint The Danish 1905 cohort: a genetic-epidemiological nationwide survey
    H Nybo
    Odense University
    J Aging Health 13:32-46. 2001
    ..Despite the known difficulties of conducting surveys among the extremely old, it was possible to conduct a nationwide survey, including collection of DNA, among more than 2,000 fairly nonselected nonagenarians using lay interviewers...