R B Weiskopf

Summary

Affiliation: Novo Nordisk A/S
Country: Denmark

Publications

  1. ncbi request reprint Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
    Anesthesiology 104:911-20. 2006
  2. ncbi request reprint Food and Drug Administration public hearing on the draft guidance for exception from informed consent requirements for emergency research: testimony of Novo Nordisk
    Richard B Weiskopf
    Research and Development, Novo Nordisk A S, Bagsvaerd, Denmark
    Acad Emerg Med 14:e71-3. 2007
  3. ncbi request reprint Recombinant-activated coagulation factor VIIa (NovoSeven): current development
    R B Weiskopf
    Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Vox Sang 92:281-8. 2007
  4. ncbi request reprint Human cardiovascular and metabolic response to acute, severe isovolemic anemia
    R B Weiskopf
    Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco 94143 0648, USA
    JAMA 279:217-21. 1998
  5. ncbi request reprint Acute severe isovolemic anemia impairs cognitive function and memory in humans
    R B Weiskopf
    Departments of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 92:1646-52. 2000
  6. ncbi request reprint Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans
    J M Leung
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 93:1004-10. 2000
  7. ncbi request reprint Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics
    M K Viele
    Department of Laboratory Medicine, University of California, San Francisco 94143 0100, USA
    Anesthesiology 86:848-58. 1997
  8. ncbi request reprint Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
  9. ncbi request reprint Cardiovascular effects of I653 in swine
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 69:303-9. 1988
  10. ncbi request reprint Efficacy of acute normovolemic hemodilution assessed as a function of fraction of blood volume lost
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 94:439-46. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
    Anesthesiology 104:911-20. 2006
    ..The authors tested the hypothesis that erythrocytes stored for 3 weeks are as effective in supplying oxygen to human tissues as are erythrocytes stored for less than 5 h...
  2. ncbi request reprint Food and Drug Administration public hearing on the draft guidance for exception from informed consent requirements for emergency research: testimony of Novo Nordisk
    Richard B Weiskopf
    Research and Development, Novo Nordisk A S, Bagsvaerd, Denmark
    Acad Emerg Med 14:e71-3. 2007
  3. ncbi request reprint Recombinant-activated coagulation factor VIIa (NovoSeven): current development
    R B Weiskopf
    Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Vox Sang 92:281-8. 2007
    ..This review summarizes the current development of rFVIIa, focusing on results of prospective, randomized clinical trials...
  4. ncbi request reprint Human cardiovascular and metabolic response to acute, severe isovolemic anemia
    R B Weiskopf
    Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco 94143 0648, USA
    JAMA 279:217-21. 1998
    ....
  5. ncbi request reprint Acute severe isovolemic anemia impairs cognitive function and memory in humans
    R B Weiskopf
    Departments of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 92:1646-52. 2000
    ..However, in those studies, sensitive, specific measures of critical organ function were not used. This study tested the hypothesis that acute severe decreases of hemoglobin concentration alters human cognitive function...
  6. ncbi request reprint Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans
    J M Leung
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 93:1004-10. 2000
    ....
  7. ncbi request reprint Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics
    M K Viele
    Department of Laboratory Medicine, University of California, San Francisco 94143 0100, USA
    Anesthesiology 86:848-58. 1997
    ..Historically, infusion in humans of acellular hemoglobin preparations has resulted in renal toxicity. This study was performed to evaluate the safety and pharmacokinetics of rHb1.1 when infused in humans...
  8. ncbi request reprint Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products
    E I Eger
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesthesiology 87:517-26. 1997
    ..The authors determined the kinetic characteristics of desflurane and sevoflurane and those of compound A [CH2F-O-C(=CF2)(CF3)], a nephrotoxic degradation product of sevoflurane...
  9. ncbi request reprint Cardiovascular effects of I653 in swine
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco
    Anesthesiology 69:303-9. 1988
    ..2 MAC, 120 +/- 4 at 1.6 MAC). Systemic vascular resistance increased slightly at 1.6 MAC compared to the values at 0.8 and 1.2 MAC, but was always less than in the conscious condition.(ABSTRACT TRUNCATED AT 250 WORDS)..
  10. ncbi request reprint Efficacy of acute normovolemic hemodilution assessed as a function of fraction of blood volume lost
    R B Weiskopf
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 94:439-46. 2001
    ....
  11. ncbi request reprint Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans
    M A Neumann
    Department of Anesthesia, University of California, San Francisco, 94143, USA
    Anesthesiology 88:914-21. 1998
    ..The authors tried to determine whether substituting desflurane for isoflurane in the last 30 min of a 120-min anesthetic would accelerate recovery...
  12. ncbi request reprint The role of data and safety monitoring in acute trauma resuscitation research
    Howard R Champion
    Uniformed Services University of Health Sciences, Bethesda, MD 20910, USA
    J Am Coll Surg 204:73-83. 2007
    ..Many of the difficulties conducting acute resuscitation research are exacerbated because multiinstitutional studies are needed to adequately power such research...
  13. ncbi request reprint Acute isovolemic anemia impairs central processing as determined by P300 latency
    Richard B Weiskopf
    Departments of Anesthesia and Physiology, Cardiovascular Research Institute, University of California, San Francisco, 94143 0648, USA
    Clin Neurophysiol 116:1028-32. 2005
    ..Acute anemia slows the responses to clinical tests of cognitive function. We tested the hypothesis that these slowed responses during acute severe isovolemic anemia in healthy unmedicated humans result from impaired central processing...
  14. ncbi request reprint Heart rate increases linearly in response to acute isovolemic anemia
    Richard B Weiskopf
    Department of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94122, USA
    Transfusion 43:235-40. 2003
    ..The hypothesis that heart rate in humans increases in response to acute isovolemic anemia and that the increase is affected by gender was tested...
  15. ncbi request reprint Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia
    Richard B Weiskopf
    Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 96:871-7. 2002
    ....
  16. ncbi request reprint Acute isovolemic anemia does not impair peripheral or central nerve conduction
    Richard B Weiskopf
    Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, 94143 0648, USA
    Anesthesiology 99:546-51. 2003
    ..In this study, the authors tested the hypothesis that such changes relate to the slowing of afferent neural traffic...
  17. ncbi request reprint Intraoperative use of recombinant activated coagulation factor vII
    Richard B Weiskopf
    Anesthesiology 96:1287-9. 2002
  18. ncbi request reprint Hemodilution and candles
    Richard B Weiskopf
    Anesthesiology 97:773-5. 2002
  19. ncbi request reprint If you prick us, do we not bleed?
    Richard B Weiskopf
    Anesthesiology 105:873-6. 2006
  20. pmc The use of recombinant activated coagulation factor VII for spine surgery
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Eur Spine J 13:S83-8. 2004
    ....
  21. ncbi request reprint Anemia and perioperative red blood cell transfusion: a matter of tolerance
    Caveh Madjdpour
    Department of Anesthesiology, University Hospital CHUV, Lausanne, Switzerland
    Crit Care Med 34:S102-8. 2006
    ..Therefore, knowing the compensatory mechanisms during acute anemia is crucial. This review focuses on acute anemia tolerance, its limits, and physiologic transfusion triggers in the perioperative period...
  22. ncbi request reprint Extracellular potassium concentrations in red blood cell suspensions after irradiation and washing
    Richard B Weiskopf
    Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
    Transfusion 45:1295-301. 2005
    ..AABB standards permit storage of washed RBCs at 4 degrees C for 24 hours. The [K(+)e] of washed RBCs during storage is not known. Experiments were performed to provide those data...
  23. ncbi request reprint A procedure for rapid issue of red cells for emergency use
    Richard B Weiskopf
    Department of Anesthesia and Physiology, University of California, San Francisco 94143 0648, USA
    Arch Pathol Lab Med 129:492-6. 2005
    ..These times may not be adequate to permit the red cells to provide sufficiently rapid delivery of oxygen in massively bleeding patients...
  24. ncbi request reprint Solubility of volatile anesthetics in bovine white matter, cortical gray matter, thalamus, hippocampus, and hypothalamic area
    Mireille A Neumann
    Department of Anesthesia and Periopertive Care, University of California, San Francisco, San Francisco, CA 94143 0464, USA
    Anesth Analg 100:1003-6. 2005
    ..These data may be useful in defining the parts of the brain involved with return to consciousness during recovery from anesthesia...
  25. ncbi request reprint Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch
    Sweeta D Gandhi
    Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center and the Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 106:1120-7. 2007
    ..4; Fresenius Kabi, Bad Homburg, Germany) and hetastarch (HES 670/0.75 in saline) for intravascular volume replacement therapy during major orthopedic surgery...