Lauge Schäffer

Summary

Affiliation: Novo Nordisk A/S
Country: Denmark

Publications

  1. doi request reprint A novel high-affinity peptide antagonist to the insulin receptor
    Lauge Schäffer
    Diabetes Research Unit, Novo Nordisk A S, Novo Nordisk Park G8 1 77, DK 2760 Maaloev, Denmark
    Biochem Biophys Res Commun 376:380-3. 2008
  2. pmc Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks
    Lauge Schäffer
    Novo Nordisk AS, DK 2800 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 100:4435-9. 2003
  3. ncbi request reprint Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
    Rita Slaaby
    Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    J Biol Chem 281:25869-74. 2006
  4. ncbi request reprint Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses
    Maja Jensen
    Receptor Systems Biology Laboratory, Hagedorn Research Institute, 2820 Gentofte, Denmark
    J Biol Chem 282:35179-86. 2007
  5. ncbi request reprint Insulins with built-in glucose sensors for glucose responsive insulin release
    Thomas Hoeg-Jensen
    Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Pept Sci 11:339-46. 2005

Collaborators

Detail Information

Publications5

  1. doi request reprint A novel high-affinity peptide antagonist to the insulin receptor
    Lauge Schäffer
    Diabetes Research Unit, Novo Nordisk A S, Novo Nordisk Park G8 1 77, DK 2760 Maaloev, Denmark
    Biochem Biophys Res Commun 376:380-3. 2008
    ..These antagonists provide a useful research tool for unraveling biochemical mechanisms involving the insulin receptor and could form the basis for treatment of hypoglycemic conditions...
  2. pmc Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks
    Lauge Schäffer
    Novo Nordisk AS, DK 2800 Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 100:4435-9. 2003
    ..The ability to construct such peptide derivatives may offer a path for developing agonists or antagonists for treatment of a wide variety of diseases...
  3. ncbi request reprint Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
    Rita Slaaby
    Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    J Biol Chem 281:25869-74. 2006
    ..The binding characteristics of insulin and IGF-I to both splice variants of the hybrid receptors were similar to classical homodimer IGF-IR...
  4. ncbi request reprint Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses
    Maja Jensen
    Receptor Systems Biology Laboratory, Hagedorn Research Institute, 2820 Gentofte, Denmark
    J Biol Chem 282:35179-86. 2007
    ..We show for the first time that it is possible to design insulin receptor ligand mimetics with metabolic equipotency but low mitogenicity...
  5. ncbi request reprint Insulins with built-in glucose sensors for glucose responsive insulin release
    Thomas Hoeg-Jensen
    Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Pept Sci 11:339-46. 2005
    ..Notably, two of the boronated insulins displayed enhanced insulin receptor affinity relative to native insulin (113%-122%) which is unusual for insulin LysB29 derivatives...