Hanne B Rasmussen

Summary

Affiliation: Novo Nordisk A/S
Country: Denmark

Publications

  1. ncbi request reprint Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
    Per Sauerberg
    Novo Nordisk A S, Novo Nordisk Park E9 2 02, 2760 Måløv, Denmark
    J Med Chem 45:789-804. 2002
  2. ncbi request reprint Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
    Hanne B Rasmussen
    Protein Chemistry, Research and Development, Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Nat Struct Biol 10:19-25. 2003
  3. pmc Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa
    Katrine S Larsen
    Haemostasis Biochemistry, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Måløv, Denmark
    Biochem J 405:429-38. 2007
  4. ncbi request reprint A loop of coagulation factor VIIa influencing macromolecular substrate specificity
    Jais R Bjelke
    Protein Structure and Biophysics, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Måløv, Denmark
    FEBS Lett 581:71-6. 2007
  5. pmc Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV
    Jais R Bjelke
    Protein Structure and Biophysics, Novo Nordisk A S, Novo Alle, 2880 Bagsvaerd, Denmark
    Biochem J 396:391-9. 2006
  6. ncbi request reprint Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar
    Søren Ebdrup
    Novo Nordisk A S, Novo Nordisk Park, 2760 Måløv, Denmark
    J Med Chem 46:1306-17. 2003
  7. ncbi request reprint Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
    Jais R Bjelke
    Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Bledamsvej 3C, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:34691-7. 2004
  8. ncbi request reprint Pharmacological investigation of the role of ion channels in salivary secretion
    Tina C Stummann
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Pflugers Arch 446:78-87. 2003
  9. ncbi request reprint The 1.9 A crystal structure of heat-labile shrimp alkaline phosphatase
    Maaike de Backer
    European Synchrotron Radiation Facility, Grenoble, France
    J Mol Biol 318:1265-74. 2002
  10. ncbi request reprint Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment
    Hanne B Rasmussen
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    J Cell Sci 120:953-63. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity
    Per Sauerberg
    Novo Nordisk A S, Novo Nordisk Park E9 2 02, 2760 Måløv, Denmark
    J Med Chem 45:789-804. 2002
    ..Investigations of the pharmacokinetics of selected compounds suggested that extended drug exposure improved the in vivo activity of in vitro active compounds...
  2. ncbi request reprint Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
    Hanne B Rasmussen
    Protein Chemistry, Research and Development, Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Nat Struct Biol 10:19-25. 2003
    ..Both domains participate in inhibitor binding. The structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site...
  3. pmc Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa
    Katrine S Larsen
    Haemostasis Biochemistry, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Måløv, Denmark
    Biochem J 405:429-38. 2007
    ..Interestingly, these changes do not necessarily coincide with an altered ability to activate Factor X, demonstrating that inhibitor and macromolecular substrate selectivity may be engineered separately...
  4. ncbi request reprint A loop of coagulation factor VIIa influencing macromolecular substrate specificity
    Jais R Bjelke
    Protein Structure and Biophysics, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Måløv, Denmark
    FEBS Lett 581:71-6. 2007
    ..e. fix or fx)...
  5. pmc Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV
    Jais R Bjelke
    Protein Structure and Biophysics, Novo Nordisk A S, Novo Alle, 2880 Bagsvaerd, Denmark
    Biochem J 396:391-9. 2006
    ....
  6. ncbi request reprint Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar
    Søren Ebdrup
    Novo Nordisk A S, Novo Nordisk Park, 2760 Måløv, Denmark
    J Med Chem 46:1306-17. 2003
    ....
  7. ncbi request reprint Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
    Jais R Bjelke
    Institute of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Bledamsvej 3C, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:34691-7. 2004
    ....
  8. ncbi request reprint Pharmacological investigation of the role of ion channels in salivary secretion
    Tina C Stummann
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Pflugers Arch 446:78-87. 2003
    ..Other types of K+ channel, however, and particularly Cl- channels, are essential for ACh-induced salivary secretion...
  9. ncbi request reprint The 1.9 A crystal structure of heat-labile shrimp alkaline phosphatase
    Maaike de Backer
    European Synchrotron Radiation Facility, Grenoble, France
    J Mol Biol 318:1265-74. 2002
    ..It is generally accepted that optimization of the electrostatics is one of the characteristics related to cold-adaptation. SAP demonstrates this principle very clearly...
  10. ncbi request reprint Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment
    Hanne B Rasmussen
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    J Cell Sci 120:953-63. 2007
    ..By contrast, deletion of the ankyrin-G-binding motif in KCNQ3 significantly reduces AIS enrichment of the complex, implicating KCNQ3 as a major determinant of M channel localization to the AIS...