F Pociot

Summary

Affiliation: Novo Nordisk
Country: Denmark

Publications

  1. doi A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
    Caroline Brorsson
    Steno Diabetes Center, Niels Steensensvej 1, DK 2820 Gentofte, Denmark
    Mol Genet Metab 94:386-8. 2008
  2. ncbi Combined genome and proteome approach to identify new susceptibility genes
    Flemming Pociot
    Steno Diabetes Center, Gentofte, Denmark
    Am J Med Genet 115:55-60. 2002
  3. ncbi Genetics of type 1 diabetes mellitus
    F Pociot
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Genes Immun 3:235-49. 2002
  4. ncbi No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility
    F Pociot
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Metab Res Rev 17:292-5. 2001
  5. ncbi CTLA4 gene and autoimmune endocrinopathies: a new marker?
    F Pociot
    Steno Diabetes Center, Gentofte, Denmark
    J Endocrinol Invest 25:1001-5. 2002
  6. pmc Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Proc Natl Acad Sci U S A 98:12191-6. 2001
  7. ncbi NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiolog
    L Hansen
    Steno Diabetes Center, Panum Institute, University of Copenhagen, Denmark
    Diabetes 49:876-8. 2000
  8. ncbi Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity
    O P Kristiansen
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Immunol 59:582-91. 2004
  9. ncbi Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance
    R L Nolsøe
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 7:316-21. 2006
  10. ncbi IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
    A Johansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes Obes Metab 8:75-82. 2006

Collaborators

Detail Information

Publications61

  1. doi A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
    Caroline Brorsson
    Steno Diabetes Center, Niels Steensensvej 1, DK 2820 Gentofte, Denmark
    Mol Genet Metab 94:386-8. 2008
    ..We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1D could not be demonstrated...
  2. ncbi Combined genome and proteome approach to identify new susceptibility genes
    Flemming Pociot
    Steno Diabetes Center, Gentofte, Denmark
    Am J Med Genet 115:55-60. 2002
    ..Combining the information from this proteome approach with genetic studies makes us believe that it is possible to reach this goal...
  3. ncbi Genetics of type 1 diabetes mellitus
    F Pociot
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Genes Immun 3:235-49. 2002
    ..Elucidation of the function of particular genes ('functional genomics') in the pathogenesis of T1D will be a most important element in future studies in this field, in addition to more sophisticated methods of statistical analyses...
  4. ncbi No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility
    F Pociot
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Metab Res Rev 17:292-5. 2001
    ..Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11...
  5. ncbi CTLA4 gene and autoimmune endocrinopathies: a new marker?
    F Pociot
    Steno Diabetes Center, Gentofte, Denmark
    J Endocrinol Invest 25:1001-5. 2002
  6. pmc Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Proc Natl Acad Sci U S A 98:12191-6. 2001
    ....
  7. ncbi NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiolog
    L Hansen
    Steno Diabetes Center, Panum Institute, University of Copenhagen, Denmark
    Diabetes 49:876-8. 2000
    ..However, in the type 1 diabetic Danish population, the Ala45Thr variant of NeuroD/BETA2 may represent a susceptibility marker independent of IDDM7 on chromosome 2q32...
  8. ncbi Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity
    O P Kristiansen
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Immunol 59:582-91. 2004
    ..Thus, we report functional impact of a novel CD4-181C/G SNP on stimulated CD4 promoter activity and the identification of a novel CD4 haplotype with high constitutive promoter activity that is linked and associated with T1DM...
  9. ncbi Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance
    R L Nolsøe
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 7:316-21. 2006
    ..02 and 0.02). We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects...
  10. ncbi IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
    A Johansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes Obes Metab 8:75-82. 2006
    ..The objective of this study was to estimate the impact of four selected amino acid polymorphisms -IRS-1 Gly972Arg, Kir6.2 Glu23Lys, HNF-1alpha Ala98Val and PPARgamma2 Pro12Ala in a Danish population of T1DM families...
  11. ncbi Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene
    Z M Larsen
    Steno Diabetes Centre, Gentofte, Denmark
    Diabet Med 21:218-22. 2004
    ..To investigate whether the WFS1 gene, the gene for Wolfram syndrome, is a susceptibility gene for more common forms of diabetes in the Danish population...
  12. ncbi Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity
    T Gylvin
    Steno Diabetes Center, Niels Steensensvej 2 4, 2820, Gentofte, Denmark
    Diabetologia 47:1273-7. 2004
    ..The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus...
  13. ncbi Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
    A E Karlsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Endocrinol Metab 85:830-6. 2000
    ....
  14. ncbi Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression
    J Johannesen
    Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark
    Eur Cytokine Netw 12:501-9. 2001
    ..Conclusion: There was a strain-dependent difference in iNOS expression which was associated with IRF-1 and HSP70 expression...
  15. ncbi Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia
    R L Nolsøe
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Genes Immun 6:699-706. 2005
    ..We conclude that the FAS/FASL promoter haplotypes are functional and that polymorphisms in FAS may contribute to thrombocytopenia in SLE...
  16. ncbi Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families
    R L Nolsøe
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetologia 45:134-9. 2002
    ..We therefore evaluated the human FasL gene FASL on chromosome 1q23 as a candidate susceptibility gene for Type I diabetes...
  17. ncbi Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population
    J N Jensen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetologia 44:123-6. 2001
    ....
  18. ncbi Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 47:892-908. 2004
    ..The aim of this study was to describe the relevance of these proteins in the development of diabetes in vivo...
  19. doi Functional SOCS1 polymorphisms are associated with variation in obesity in whites
    T Gylvin
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Obes Metab 11:196-203. 2009
    ..The objective was to perform mutation analysis of SOCS1 and to test the identified variations for association to T2D-related quantitative traits, T2D or T1D...
  20. ncbi No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families
    P E Heding
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Genes Immun 2:398-400. 2001
    ..In contrast to what was observed in Japanese diabetic/control individuals, we find no evidence for association of the BCL2 Ala43Thr polymorphism to T1DM in Danish, Finnish and Basque Type 1 diabetes families...
  21. pmc Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data
    C Brorsson
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Obes Metab 11:60-6. 2009
    ....
  22. pmc A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions
    J Nerup
    Steno Diabetes Center, Gentofte, Denmark
    Am J Hum Genet 69:1301-13. 2001
    ..Our data support both the existence of non-HLA genes of significance for T1DM and interaction between HLA and non-HLA loci in the determination of the T1DM phenotype...
  23. ncbi Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Diabetologia 47:1998-2011. 2004
    ..However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown...
  24. ncbi Identification and characterization of secretagogin promoter activity
    K V Skovhus
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Immunol 64:639-45. 2006
    ..The promoter region was furthermore screened by direct sequencing, and 11 polymorphisms were identified. Genotyping in a large homogenous Type 1 diabetes (T1D) family collection did not reveal association with T1D...
  25. pmc No association of the IRS1 and PAX4 genes with type I diabetes
    R Bergholdt
    Hagedorn Research Institute and Steno Diabetes Center, Niels Steensens Vej 1, Gentofte, Denmark
    Genes Immun 10:S49-53. 2009
    ....
  26. ncbi Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level
    R Bergholdt
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Genes Immun 1:495-500. 2000
    ..04). In both diabetic and non-diabetic subjects, the wt/wt genotype correlated with the highest IL-1RI plasma level, whereas the plasma levels were lowest for the mt/mt genotype...
  27. ncbi Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark
    Dis Markers 17:205-16. 2001
    ..Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidate-gene approaches, we believe that it is possible to reach this goal...
  28. ncbi Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes
    J Johannesen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 86:2792-6. 2001
    ..In conclusion, linkage of the human NOS2 gene to IDDM in a subset of patients supports a pathogenic role of nitric oxide in human IDDM...
  29. ncbi IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 45:1550-61. 2002
    ..The aim of this study was to identify the proteins in these 82 spots by mass spectrometry and compare these changes with those seen in IL-1beta exposed Wistar Furth (WF) rat islets...
  30. ncbi Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
    R Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 8:232-8. 2007
    ....
  31. ncbi Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
    A M Wagner
    Steno Diabetes Center, Niels Steensens Vej 2, Gentofte, 2820, Denmark
    Diabetologia 50:676-81. 2007
    ..The aim of this study was to assess the role of PIMT in the development of type 1 diabetes...
  32. ncbi Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Acta Diabetol 42:95-8. 2005
    ..0075 and 0.0324 and p-values at 0.56 and 0.23 respectively). We were not able to identify any association or correlation between the induced temporary hyperglycaemia in 30-day-old BB-DP rats and later development of diabetes...
  33. ncbi A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group
    T Lorenzen
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 16:472-6. 1999
    ..The aim of the present Danish population-based study of 33% of the Danish population was to describe the pattern of self-reported miscarriage and stillbirths from 1304 women with Type 1 DM...
  34. ncbi No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood
    O P Kristiansen
    Steno Diabetes Center, Gentofte, Denmark
    Hum Mutat 14:67-70. 1999
    ..82), to index cases (P(tdt) = 0.77), as well as to unaffected offspring (P(tdt) = 0.93). Hence, the NQO1 polymorphism is not likely to be an etiological mutation underlying the reported linkage of the 16q22-q24 region...
  35. ncbi Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families
    T Gylvin
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 3:430-2. 2002
    ..In conclusion, we could not confirm the highly significant T1DM association of certain alleles of the NFKB1 marker previously reported...
  36. ncbi Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes
    A M Møller
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetologia 41:1528-31. 1998
    ..Clinical awareness of family history of diabetes and mode of inheritance might help to identify and reclassify these diabetic subjects as MODY3 patients...
  37. ncbi Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene). Association with urinary albumin excretion in IDDM patients
    P M Hansen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 46:1658-9. 1997
  38. pmc Novel analytical methods applied to type 1 diabetes genome-scan data
    Flemming Pociot
    Steno Diabetes Center, Gentofte, Denmark
    Am J Hum Genet 74:647-60. 2004
    ..Furthermore, the approach outlined here permits combined analyses of genetic-marker data and information on environmental and clinical covariates...
  39. ncbi Prophylactic insulin treatment of syngeneically transplanted pre-diabetic BB-DP rats
    Thomas Sparre
    Steno Diabetes Center, Nis Steensensvej 2, DK 2820 Gentofte, Denmark
    Autoimmunity 36:99-109. 2003
    ..In the present study we tested if prophylactic insulin treatment of syngeneically transplanted BB-DP rats would protect both islets in situ and transplanted islets from destruction...
  40. ncbi Application of genomics and proteomics in Type 1 diabetes pathogenesis research
    Thomas Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Expert Rev Mol Diagn 3:743-57. 2003
    ..This review will describe the use of large-scale genomics and proteomics in studying the pathogenesis of Type 1 diabetes, and will discuss future directions of research in the field...
  41. ncbi Type 1 database mellitus: an inflammatory disease of the islet
    Regine Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Adv Exp Med Biol 552:129-53. 2004
  42. ncbi Is mortalin a candidate gene for T1DM ?
    Jesper Johannesen
    Steno Diabetes Center, Niels Steensens Vej, Gentofte, Denmark
    Autoimmunity 37:423-30. 2004
    ....
  43. pmc Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
    Regine Bergholdt
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Genome Biol 8:R253. 2007
    ..We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases...
  44. ncbi Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study
    Stefanie Eising
    Steno Diabetes Centre, Gentofte, Denmark
    Paediatr Perinat Epidemiol 21:507-17. 2007
    ..It combined genetic, immunological and demographic data to develop prediction algorithms. It also provided a resource for future studies in which new genetic markers can be included as they are identified...
  45. pmc Expression profiling of human genetic and protein interaction networks in type 1 diabetes
    Regine Bergholdt
    Hagedorn Research Institute and Steno Diabetes Center, Gentofte, Denmark
    PLoS ONE 4:e6250. 2009
    ..To understand biological systems, integration of genetic and functional information is necessary, and the current study has used this approach to improve understanding of T1D and the underlying biological mechanisms...
  46. ncbi Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
    Ole P Kristiansen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Hum Mol Genet 12:1101-10. 2003
    ..In conclusion, higher IL6 promoter activity may confer risk to T1DM in very young females. This excess risk is negated with increasing age, possibly by the increasing E(2) levels in puberty...
  47. ncbi Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats
    Ulla Bjerre Christensen
    Steno Diabetes Center, Niels Steensensvej 2, Gentofte, Denmark
    Autoimmunity 39:315-21. 2006
    ..Whether this reflects activation of distinct signalling pathways in islet cells is currently unknown and need to be further investigated...
  48. ncbi CBLB variants in type 1 diabetes and their genetic interaction with CTLA4
    Regine Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    J Leukoc Biol 77:579-85. 2005
    ....
  49. ncbi Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions
    Thomas Sparre
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Mol Cell Proteomics 4:441-57. 2005
    ..Rather the cumulative pattern of changes seems to be what favors a transition from dynamic stability in the unperturbed beta-cell to dynamic instability and eventually to beta-cell destruction...
  50. ncbi Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene
    Runa L Nolsøe
    Steno Diabetes Center, Gentofte, Denmark
    Ann N Y Acad Sci 1005:332-9. 2003
    ..However, none of these were frequent enough to permit association studies in T1DM and we conclude that IL18BP does not contribute to the overall genetic susceptibility to type 1 diabetes...
  51. pmc Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
    Trine W Boesgaard
    Steno Diabetes Centre and Hagedorn Research Institute, Gentofte, Denmark
    BMC Med Genet 11:42. 2010
    ..Insulin gene (INS) mutations have recently been described as a common cause of permanent neonatal diabetes (PNDM) and a rare cause of diabetes diagnosed in childhood or adulthood...
  52. ncbi Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3
    Allan E Karlsen
    Steno Diabetes Center, Gentofte, Denmark
    Biochem Biophys Res Commun 344:406-15. 2006
    ..In summary, combined proteome-transcriptome-genome and functional analyses identify gal-3 as a candidate gene/protein in T1D susceptibility that may prove valuable in future intervention/prevention strategies...
  53. ncbi A human phenome-interactome network of protein complexes implicated in genetic disorders
    Kasper Lage
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Building 208, DK 2800 Lyngby, Denmark
    Nat Biotechnol 25:309-16. 2007
    ..Our publicly available draft of protein complexes associated with pathology comprises 506 complexes, which reveal functional relationships between disease-promoting genes that will inform future experimentation...
  54. ncbi The Type 1 Diabetes Genetics Consortium
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann N Y Acad Sci 1079:1-8. 2006
    ..From these families, the T1DGC is establishing banks of DNA, serum, plasma, and cell lines, as well as useful databases. The T1DGC also sponsors training opportunities (bioinformatics) and technology transfer (HLA genotyping)...
  55. ncbi OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes
    L Leigh Field
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Diabetes 54:1588-91. 2005
    ..0025). The results suggest that host genetic response to virus infection could influence susceptibility to type 1 diabetes...
  56. ncbi No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex
    Stefan Johansson
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Hum Immunol 64:951-9. 2003
    ..In conclusion, our data argue against the presence of any strong genetic susceptibility factors for T1D in the region centromeric of the HLA complex...
  57. ncbi PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits
    Claude Chelala
    Genetics of Infectious and Autoimmune Diseases, INSERM U730, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris 15, France
    Diabetes 56:522-6. 2007
    ....
  58. ncbi Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
    Patrick Concannon
    Benaroya Research Institute, Seattle, Washington, USA
    Diabetes 54:2995-3001. 2005
    ..The results demonstrate some consistency emerging for the existence of susceptibility loci on chromosomes 2q31-q33, 6q21, 10p14-q11, and 16q22-q24 but diminished support for some previously reported locations...
  59. ncbi Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes
    Pegah Ghandil
    Genetics of Infectious and Autoimmune Diseases, INSERM U730, Institut Pasteur, Paris, France
    Mol Genet Metab 86:379-83. 2005
    ....
  60. ncbi The relevance of international consortia in studies on the pathogenesis of type 1 diabetes: the role of ET1DGN
    Flemming Pociot
    Steno Diabetes Center, Gentofte Denmark and Department of Clinical Sciences, University of Lund, Malmo, Sweden
    Diabetes Metab Res Rev 22:238-40. 2006
    ..ET1DGN suggests going beyond the tasks of T1DGC and establishing a well-organized network for additional and future studies in Europe...
  61. ncbi Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease
    Benedicte A Lie
    Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, and Institute of Medical Genetics, University of Oslo, Norway
    Hum Immunol 68:592-8. 2007
    ..Our data suggest that it is unlikely that polymorphisms within the PRSS16 gene are involved in the predisposition to T1D. However, we cannot rule out that regulatory polymorphisms located some distance away from the gene may be involved...