A E Karlsen
Affiliation: Novo Nordisk A/S
Egefjord L, Jensen J, Bang Berthelsen C, Petersen A, Smidt K, Schmitz O, et al
. Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?. BMC Endocr Disord. 2009;9:7 pubmed publisher
..The zinc transporting system in beta-cells is influenced by the exposure to cytokines. Particularly ZnT8, which has been associated with the development of diabetes, seems to be cytokine sensitive. ..
Karlsen A, Rønn S, Lindberg K, Johannesen J, Galsgaard E, Pociot F, et al
. Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity. Proc Natl Acad Sci U S A. 2001;98:12191-6 pubmed
Karlsen A, Heding P, Frobøse H, Rønn S, Kruhøffer M, Orntoft T, et al
. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia. 2004;47:1998-2011 pubmed
Karlsen A, Størling Z, Sparre T, Larsen M, Mahmood A, Størling J, et al
. Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. Biochem Biophys Res Commun. 2006;344:406-15 pubmed
..In summary, combined proteome-transcriptome-genome and functional analyses identify gal-3 as a candidate gene/protein in T1D susceptibility that may prove valuable in future intervention/prevention strategies. ..