Ib Jonassen

Summary

Affiliation: Novo Nordisk A/S
Country: Denmark

Publications

  1. ncbi request reprint Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives
    Ib Jonassen
    Preformulation and Delivery, Novo Nordisk A S, Novo Alle, 6B2 56 2, DK 2880, Bagsvaerd, Denmark
    Pharm Res 23:49-55. 2006
  2. pmc Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    Ib Jonassen
    Diabetes Research Unit, Novo Nordisk, Novo Nordisk Park, 2760, Måløv, Denmark
    Pharm Res 29:2104-14. 2012
  3. ncbi request reprint The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
    Svend Havelund
    Research and Development, Novo Nordisk A S, Bagsvaerd, Denmark
    Pharm Res 21:1498-504. 2004
  4. ncbi request reprint Insulins with built-in glucose sensors for glucose responsive insulin release
    Thomas Hoeg-Jensen
    Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Pept Sci 11:339-46. 2005
  5. doi request reprint Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec
    Dorte B Steensgaard
    Diabetes Protein Engineering, Novo Nordisk A S, Novo Nordisk Park, 2760 Maaloev, Denmark
    Biochemistry 52:295-309. 2013

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Biochemical and physiological properties of a novel series of long-acting insulin analogs obtained by acylation with cholic acid derivatives
    Ib Jonassen
    Preformulation and Delivery, Novo Nordisk A S, Novo Alle, 6B2 56 2, DK 2880, Bagsvaerd, Denmark
    Pharm Res 23:49-55. 2006
    ....
  2. pmc Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    Ib Jonassen
    Diabetes Research Unit, Novo Nordisk, Novo Nordisk Park, 2760, Måløv, Denmark
    Pharm Res 29:2104-14. 2012
    ..A series of insulins, acylated at B29 with fatty acids via glutamic acid spacers, were examined to deduce the structural requirements...
  3. ncbi request reprint The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
    Svend Havelund
    Research and Development, Novo Nordisk A S, Bagsvaerd, Denmark
    Pharm Res 21:1498-504. 2004
    ..Insulin detemir has been found in clinical trials to be absorbed with very low variability. A series of experiments were performed to elucidate the underlying mechanisms...
  4. ncbi request reprint Insulins with built-in glucose sensors for glucose responsive insulin release
    Thomas Hoeg-Jensen
    Novo Nordisk A S, DK 2880 Bagsvaerd, Denmark
    J Pept Sci 11:339-46. 2005
    ..Notably, two of the boronated insulins displayed enhanced insulin receptor affinity relative to native insulin (113%-122%) which is unusual for insulin LysB29 derivatives...
  5. doi request reprint Ligand-controlled assembly of hexamers, dihexamers, and linear multihexamer structures by the engineered acylated insulin degludec
    Dorte B Steensgaard
    Diabetes Protein Engineering, Novo Nordisk A S, Novo Nordisk Park, 2760 Maaloev, Denmark
    Biochemistry 52:295-309. 2013
    ....