K Henriksen

Summary

Affiliation: Nordic Bioscience
Country: Denmark

Publications

  1. pmc Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II
    Kim Henriksen
    Nordic Bioscience, Herlev, Denmark
    Am J Pathol 164:1537-45. 2004
  2. ncbi request reprint Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption
    Mette G Sørensen
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:1640-8. 2007
  3. pmc Will posttranslational modifications of brain proteins provide novel serological markers for dementias?
    Y Wang
    Department of Biomarker Development, Nordic Bioscience A S, Beijing 102206, China
    Int J Alzheimers Dis 2012:209409. 2012
  4. doi request reprint The future of blood-based biomarkers for Alzheimer's disease
    Kim Henriksen
    Nordic Bioscience Biomarkers and Research, Neurodegenerative Diseases, Herlev, Denmark Electronic address
    Alzheimers Dement 10:115-31. 2014
  5. pmc Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist
    Anita V Neutzsky-Wulff
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730, Herlev, Denmark
    J Transl Med 10:214. 2012
  6. pmc An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function
    Kim Henriksen
    Nordic Bioscience Biomarkers and Research, Herlev, Denmark
    PLoS ONE 8:e64990. 2013
  7. doi request reprint Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis
    K Henriksen
    Nordic Bioscience A S, Bone Biology, Herlev, Denmark
    Bone 53:160-6. 2013
  8. doi request reprint A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts
    Kim Henriksen
    Nordic Bioscience A S, Bone Biology and Biomarkers, Herlev, Denmark
    Bone 51:353-61. 2012
  9. pmc Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    PLoS ONE 6:e27482. 2011
  10. pmc Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
    Anita V Neutzsky-Wulff
    Nordic Bioscience A S, Herlev DK 2730, Denmark
    BMC Musculoskelet Disord 11:109. 2010

Collaborators

Detail Information

Publications72

  1. pmc Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II
    Kim Henriksen
    Nordic Bioscience, Herlev, Denmark
    Am J Pathol 164:1537-45. 2004
    ..We show normal osteoclastogenesis in ADOII osteoclasts. However, the residual activity of the ClC-7 channel in ADOII osteoclasts does not allow sufficient acidification and thereby resorption...
  2. ncbi request reprint Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption
    Mette G Sørensen
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:1640-8. 2007
    ..By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts...
  3. pmc Will posttranslational modifications of brain proteins provide novel serological markers for dementias?
    Y Wang
    Department of Biomarker Development, Nordic Bioscience A S, Beijing 102206, China
    Int J Alzheimers Dis 2012:209409. 2012
    ....
  4. doi request reprint The future of blood-based biomarkers for Alzheimer's disease
    Kim Henriksen
    Nordic Bioscience Biomarkers and Research, Neurodegenerative Diseases, Herlev, Denmark Electronic address
    Alzheimers Dement 10:115-31. 2014
    ....
  5. pmc Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist
    Anita V Neutzsky-Wulff
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730, Herlev, Denmark
    J Transl Med 10:214. 2012
    ..Serological biomarkers reflecting β-cell health status may also assist development of new drugs for T2DM and aid physicians in better characterization of individual patients and tailor individual treatments and patient care protocols...
  6. pmc An enzyme-generated fragment of tau measured in serum shows an inverse correlation to cognitive function
    Kim Henriksen
    Nordic Bioscience Biomarkers and Research, Herlev, Denmark
    PLoS ONE 8:e64990. 2013
    ..The objective of this study was to investigate whether a proteolytic fragment of the tau protein could serve as blood-based biomarker of cognitive function in AD...
  7. doi request reprint Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis
    K Henriksen
    Nordic Bioscience A S, Bone Biology, Herlev, Denmark
    Bone 53:160-6. 2013
    ..However, subcutaneous injections can be associated with discomfort and thus deteriorating compliance...
  8. doi request reprint A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts
    Kim Henriksen
    Nordic Bioscience A S, Bone Biology and Biomarkers, Herlev, Denmark
    Bone 51:353-61. 2012
    ..In conclusion, we present evidence that osteoclasts, both dependent and independent of their resorptive activity, secrete factors stimulating osteoblastic bone formation...
  9. pmc Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    PLoS ONE 6:e27482. 2011
    ..In conclusion, these data show that attenuation of acid secretion in adult mice leads to uncoupling and improves bone strength...
  10. pmc Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality
    Anita V Neutzsky-Wulff
    Nordic Bioscience A S, Herlev DK 2730, Denmark
    BMC Musculoskelet Disord 11:109. 2010
    ..We treated human osteoclasts with different inhibitors and characterized their resulting function...
  11. pmc Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption
    Mette G Sørensen
    Nordic Bioscience A S, Herlev, Denmark
    BMC Musculoskelet Disord 11:250. 2010
    ..To shed light on the intracellular signalling controlling extracellular acidification, we screened a protein kinase inhibitor library in human osteoclasts...
  12. pmc Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities
    Morten A Karsdal
    Nordic Bioscience, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 13:215. 2011
    ....
  13. pmc Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 10:R63. 2008
    ..We investigated the capacity of repair of chondrocytes by analyzing their ability to initiate an anabolic response subsequent to three different levels of catabolic stimulation...
  14. doi request reprint Ion transporters involved in acidification of the resorption lacuna in osteoclasts
    Kim Henriksen
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    Calcif Tissue Int 83:230-42. 2008
    ..Furthermore, a group of other ion transporters, including carbonic anhydrase II, the NHEs, and potassium-chloride cotransporters, are all involved in resorption but do not seem to directly be involved in acidification of the lysosomes...
  15. doi request reprint Osteoclast activity and subtypes as a function of physiology and pathology--implications for future treatments of osteoporosis
    K Henriksen
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Endocr Rev 32:31-63. 2011
    ..Further insight into these osteoclast subtypes may be important for understanding cell-cell communication in the bone microenvironment, treatment effects, and ultimately bone quality...
  16. doi request reprint Oral salmon calcitonin--pharmacology in osteoporosis
    Kim Henriksen
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Expert Opin Biol Ther 10:1617-29. 2010
    ..This highlights the need for safe intervention possibilities, which have sustained beneficial effects post-treatment...
  17. doi request reprint Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Biochem Biophys Res Commun 378:804-9. 2009
    ..These data demonstrate that ClC-7 is essential for bone resorption, via its role in acidification of the lysosomes and resorption lacunae in osteoclasts...
  18. doi request reprint Use of bone turnover markers in clinical osteoporosis assessment in women: current issues and future options
    K Henriksen
    Department of Bone Biology and Biomarkers, Nordic Bioscience A S, Herlev, Denmark
    Womens Health (Lond Engl) 7:689-98. 2011
    ..In summary, a more targeted use of biomarkers could assist in the identification of high-risk patients, the process of drug discovery and monitoring of the efficacy of osteoporosis treatment in clinical settings...
  19. doi request reprint Efficacy and safety of the PPARγ partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Diabetes Metab Res Rev 27:392-401. 2011
    ....
  20. doi request reprint Local communication on and within bone controls bone remodeling
    Kim Henriksen
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Bone 44:1026-33. 2009
    ..e. we discuss the possibility that bone resorption can be attenuated pharmacologically without a secondary reduction in bone formation...
  21. pmc Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low-density lipoprotein receptor-related protein 5 are normal in vitro, but have decreased resorption capacity in vivo
    Kim Henriksen
    Pharmos Bioscience A S, Herlev Hovedgade 207, Herlev, DK 2730, Ribe County Hospital, Esbjerg, and the University Hospital of Copenhagen, Denmark
    Am J Pathol 167:1341-8. 2005
    ..We speculate that the mutations causing ADOI alter the osteoblastic phenotype toward a smaller potential for supporting osteoclastogenesis...
  22. ncbi request reprint Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification
    Kim Henriksen
    Pharmos Bioscience, Nordic Bioscience and Center for Clinical and Basic Research A S, Herlev, Denmark
    J Bone Miner Res 21:58-66. 2006
    ....
  23. doi request reprint A comparison of glycemic control, water retention, and musculoskeletal effects of balaglitazone and pioglitazone in diet-induced obese rats
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Eur J Pharmacol 616:340-5. 2009
    ..Balaglitazone is a novel PPARgamma agonist, which potently lowers glucose levels, while it neither affects fluid retention nor bone formation parameters...
  24. doi request reprint Generation of human osteoclasts from peripheral blood
    Kim Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Methods Mol Biol 816:159-75. 2012
    ..In this chapter, we describe the method for generating human osteoclast from peripheral blood or buffy coats, as well as methods for studying both the differentiation and resorbing activity of these cells...
  25. doi request reprint Advances in osteoclast biology resulting from the study of osteopetrotic mutations
    T Segovia-Silvestre
    Nordic Bioscience A S, Herlev, Denmark
    Hum Genet 124:561-77. 2009
    ..We highlight the distinct possibility that osteoclast activities can be divided into two separate avenues: bone resorption and control of bone formation...
  26. ncbi request reprint Osteoclasts prefer aged bone
    K Henriksen
    Pharmos Bioscience A S and Nordic Bioscience A S, Herlev, DK 2730, Denmark
    Osteoporos Int 18:751-9. 2007
    ..These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones...
  27. ncbi request reprint Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation
    B C Sondergaard
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:738-48. 2006
    ..We investigated the relative contribution of MMP activity and CK activity in cartilage degradation using ex vivo and in vivo models...
  28. ncbi request reprint Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases
    K Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Osteoporos Int 18:681-5. 2007
    ....
  29. doi request reprint The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study
    M A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Osteoarthritis Cartilage 18:150-9. 2010
    ..The aim of this study was to investigate the pharmacokinetic and pharmacodynamic parameters of oral salmon calcitonin (oSCT) administered over 14 days to men and women presenting with osteoarthritis (OA)...
  30. pmc Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats
    M Feigh
    Nordic Bioscience, Herlev, Denmark Diabetes Research Centre, Department of Endocrinology M, Odense University Hospital, Odense, Denmark
    Br J Pharmacol 167:151-63. 2012
    ..Here, we have evaluated the anti-diabetic efficacy of oral sCT using parameters of glycaemic control and beta-cell morphology in male Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes...
  31. doi request reprint Severe developmental bone phenotype in ClC-7 deficient mice
    A V Neutzsky-Wulff
    Nordic Bioscience A S, Herlev, DK 2730, Denmark
    Dev Biol 344:1001-10. 2010
    ..Bone formation paremeters were reduced; however, bone formation and mineralization were found to be heterogenous and continuing...
  32. ncbi request reprint Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis
    H Skjøt-Arkil
    Nordic Bioscience A S, Herlev, Denmark
    Clin Exp Rheumatol 30:371-9. 2012
    ..We investigated whether these CRP degradation products would provide additional diagnostic value in AS patients compared to full-length CRP...
  33. doi request reprint The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet?
    M A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Menopause Int 18:139-46. 2012
    ..In conclusion, the pleiotropic effect of estrogens on several different tissues may match the complicated aetiology of OA in some important aspects...
  34. doi request reprint Should subchondral bone turnover be targeted when treating osteoarthritis?
    M A Karsdal
    Nordic Bioscience A S, Herlev, Denmark
    Osteoarthritis Cartilage 16:638-46. 2008
    ..We speculate whether a treatment for OA would be possible without targeting the bone compartment?..
  35. ncbi request reprint Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA?
    M A Karsdal
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:617-24. 2006
    ..The present review was sought to summarize emerging observations from the molecular level to the preliminary clinical findings of possible chondroprotective effects of calcitonin...
  36. doi request reprint Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats
    M Feigh
    Nordic Bioscience, Herlev, Denmark
    Horm Metab Res 44:130-4. 2012
    ..This and previous studies suggest oral sCT is a promising agent for the treatment of obesity-related insulin resistance and type 2 diabetes...
  37. pmc Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation
    M A Karsdal
    Nordic Bioscience A S, Herlev, Herlev, Denmark
    BMC Musculoskelet Disord 11:125. 2010
    ..This study investigated correlations between bone and cartilage degradation in patients with OA as a function of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation...
  38. doi request reprint The development and characterization of an ELISA specifically detecting the active form of cathepsin K
    S Sun
    Nordic Bioscience Biomarkers and Research, Herlev, Denmark Electronic address
    Clin Biochem 46:1601-6. 2013
    ..Hence an assessment of the active form of cathepsin K may provide important biological information in metabolic bone diseases, such as osteoporosis or ankylosing spondylitis...
  39. doi request reprint Is bone quality associated with collagen age?
    D J Leeming
    Nordic Bioscience, Herlev Hovedgade 207, 2730, Herlev, Denmark
    Osteoporos Int 20:1461-70. 2009
    ....
  40. doi request reprint Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials
    M A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    J Clin Pharmacol 51:460-71. 2011
    ..These key findings may aid researchers in the development of other oral formulations...
  41. doi request reprint Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP)--assessment of corresponding epitopes
    D J Leeming
    Nordic Bioscience A S, Herlev, Denmark Department of Systems Biology, Technical University of Denmark, Kgs Lyngby, Denmark
    Clin Biochem 43:1249-56. 2010
    ..The present study describes two newly developed N-terminal pro-peptides of collagen type I (PINP) competitive enzyme-linked immunosorbent assays (ELISAs) for the assessment of corresponding PINP epitopes in the rat- and human species...
  42. ncbi request reprint Biochemical markers in preclinical models of osteoporosis
    M G Sørensen
    Pharmos Bioscience A S, Herlev Hovedgade, Herlev, Denmark
    Biomarkers 12:266-86. 2007
    ..We discuss the relevance of the markers in the individual models, and compare their responses to those observed using 'golden standard' methods...
  43. doi request reprint Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus
    B C Sondergaard
    Cartilage Biology and Biomarker R and D, Nordic Bioscience, Herlev, Denmark
    Osteoarthritis Cartilage 20:136-43. 2012
    ..We investigated effects of salmon calcitonin (sCT) on the articular cartilage and bone, after destabilization of the medial meniscus (DMM) in normal and sCT over-expressing mice...
  44. doi request reprint A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats
    M Feigh
    Nordic Bioscience, Herlev, Denmark
    Diabetes Obes Metab 13:911-20. 2011
    ....
  45. ncbi request reprint The role of chloride channels in osteoclasts: ClC-7 as a target for osteoporosis treatment
    S Schaller
    Nordic Bioscience A S, Herlev, Denmark
    Drug News Perspect 18:489-95. 2005
    ..Thus, ClC-7 inhibitors may prove to be potent for prevention and treatment of osteoporosis...
  46. doi request reprint The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
    M A Karsdal
    Nordic Bioscience, Herlev, Denmark
    Ann Rheum Dis 73:336-48. 2014
    ..The patient subgroups for whom these therapies are most appropriate have yet to be fully defined but would likely include, at a minimum, those with high bone turnover. ..
  47. doi request reprint A pharmacokinetic and pharmacodynamic comparison of synthetic and recombinant oral salmon calcitonin
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    J Clin Pharmacol 49:229-34. 2009
    ..In conclusion, oral synthetic and recombinant calcitonin displayed comparable pharmacodynamic and kinetic properties...
  48. ncbi request reprint Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
    B C Sondergaard
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:759-68. 2006
    ..We investigated direct effects of calcitonin on chondrocytes by assessing expression of the receptor and pharmacological effects on collagen type II degradation under ex vivo and in vivo conditions...
  49. ncbi request reprint Disruption of the V-ATPase functionality as a way to uncouple bone formation and resorption - a novel target for treatment of osteoporosis
    C S Thudium
    Nordic Bioscience A S, Bone Biology and Biomarkers, Denmark
    Curr Protein Pept Sci 13:141-51. 2012
    ....
  50. ncbi request reprint Estrogen directly attenuates human osteoclastogenesis, but has no effect on resorption by mature osteoclasts
    M G Sørensen
    Nordic Bioscience A S, Herlev, Denmark
    DNA Cell Biol 25:475-83. 2006
    ..In conclusion, these results suggest that the in vivo effects of estrogen are mediated by reduction of osteoclastogenesis rather than direct inhibition of the resorptive activity of mature osteoclasts...
  51. doi request reprint Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development
    M A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, Herlev, Denmark
    Biomarkers 14:181-202. 2009
    ..Biochemical markers of tissue degradation may provide optimal tools, which in combination with other techniques, prove essential to drug discovery and development...
  52. doi request reprint Post-translational modifications of the extracellular matrix are key events in cancer progression: opportunities for biochemical marker development
    D J Leeming
    Nordic Bioscience A S, Herlev Hovedgade 207, Herlev, Denmark
    Biomarkers 16:193-205. 2011
    ..Here we highlight the importance of remodeling of the ECM in cancer and the generation of PTMs, which may be cancer specific and reflect disease progression; thus having potential for biochemical marker development...
  53. ncbi request reprint The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation
    Sophie Schaller
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 19:1144-53. 2004
    ..This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis...
  54. doi request reprint Should biochemical markers of bone turnover be considered standard practice for safety pharmacology?
    K Henriksen
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 15:195-204. 2010
    ..Recent findings have identified bone as a possible endocrine organ and the availability of valid biochemical bone markers suggests that assessing bone turnover should also play an important role in general safety pharmacology...
  55. pmc Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Am J Pathol 166:467-76. 2005
    ..Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation...
  56. ncbi request reprint Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
    Morten A Karsdal
    Nordic Bioscience A S, CCBR, Herlev Ballerup, Herlev DK 2730, Denmark
    J Biol Chem 278:44975-87. 2003
    ....
  57. ncbi request reprint Alpha CTX as a biomarker of skeletal invasion of breast cancer: immunolocalization and the load dependency of urinary excretion
    Diana J Leeming
    Nordic Bioscience A S, Herlev, Denmark
    Cancer Epidemiol Biomarkers Prev 15:1392-5. 2006
    ..Taken into account the 17% intraindividual variation of the assay, alphaalphaCTX could be a sensitive biochemical marker for the close monitoring of cancer patients aiming the facilitation of early metastasis detection...
  58. ncbi request reprint Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation
    Svetlana Oestergaard
    Nordic Bioscience, Herlev, Denmark
    Arthritis Rheum 54:2441-51. 2006
    ....
  59. ncbi request reprint Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood
    Mette Grøndahl Sørensen
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730, Herlev, Denmark
    J Bone Miner Metab 25:36-45. 2007
    ....
  60. doi request reprint Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers--are they the cause or the consequence of the disease?
    Morten Asser Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730, Denmark
    Clin Biochem 43:793-804. 2010
    ..For some of these markers it may be interesting to also investigate whether the PTMs are the cause or consequence of a certain disease...
  61. doi request reprint Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?
    Anne Christine Bay-Jensen
    Nordic Bioscience A S, Herlev Hovedgade 207, Herlev, Denmark
    Rheumatol Int 30:435-42. 2010
    ..We highlight different stages of OA, and speculate whether different intervention strategies (e.g. DMOAD vs. SMOADs) may only be efficacious at distinct stages of OA...
  62. doi request reprint Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy
    Morten A Karsdal
    Nordic Bioscience A S, CCBR, Herlev Ballerup Hovedgade 207, DK 2730, Herlev, Denmark
    Eur J Clin Pharmacol 66:29-37. 2010
    ..We also investigated correlations between exposure to sCT and levels of the bone resorption biomarker serum C-terminal telopeptide of collagen type I (CTX-I)...
  63. doi request reprint Characterization of the bone phenotype in ClC-7-deficient mice
    Anita Vibsig Neutzsky-Wulff
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730, Herlev, Denmark
    Calcif Tissue Int 83:425-37. 2008
    ..In summary, we present evidence supporting a pivotal role for ClC-7 in acidification of the resorption lacuna and evidence indicating that bone formation and bone resorption are no longer balanced in ClC-7(-/-) mice...
  64. ncbi request reprint Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality
    Morten A Karsdal
    Pharmacology Department, Nordic Bioscience A S, Herlev, Denmark
    BioDrugs 22:137-44. 2008
    ..There are promising clinical data available for this formulation from both osteoarthritis and osteoporosis clinical trials, although the antifracture efficacy is not yet known...
  65. ncbi request reprint Are nonresorbing osteoclasts sources of bone anabolic activity?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:487-94. 2007
    ..Finally, we describe the likely possibility that bone resorption can be attenuated pharmacologically without the undesirable reduction in bone formation...
  66. doi request reprint Osteoarthritis--a case for personalized health care?
    M A Karsdal
    Nordic Bioscience, Herlev Hovedgade, DK 2730 Herlev, Denmark Electronic address
    Osteoarthritis Cartilage 22:7-16. 2014
    ..Finally we highlight methods for possible segregation of OA patients that would allow identification of patient subtypes, such as OA driven by inflammation that may be ideally suited for PHC and for targeted therapies. ..
  67. ncbi request reprint Osteoclasts secrete non-bone derived signals that induce bone formation
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, DK 2730, Denmark
    Biochem Biophys Res Commun 366:483-8. 2008
    ..These data show that osteoclasts secrete non-bone derived factors, which induce preosteoblasts to form bone-like nodules, potentially explaining the imbalanced coupling seen in osteopetrotic patients...
  68. ncbi request reprint Dissolution of the inorganic phase of bone leading to release of calcium regulates osteoclast survival
    Rasmus H Nielsen
    Nordic Bioscience A S, Herlev Hovedgade 207, Herlev, DK 2730, Denmark
    Biochem Biophys Res Commun 360:834-9. 2007
    ..In summary, we found that acidification leading to calcium release from bone during resorption controls osteoclast survival, potentially explaining the increased numbers of osteoclasts in patients with osteopetrosis...
  69. ncbi request reprint In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?
    S Schaller
    Pharmos Bioscience A S, Herlev, Denmark
    Assay Drug Dev Technol 3:553-80. 2005
    ..In addition to describing and discussing the advantages and limitations of each assay and their methods of evaluation, we added experimental and clinical data illustrating the utility of biomarkers for these methodological approaches...
  70. ncbi request reprint RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
    Kim Henriksen
    Nordic Bioscience, Herlev DK 2730, Denmark
    J Biol Chem 278:48745-53. 2003
    ..Taken together, these results show that RANKL and VEGF, in addition to their role in osteoclast differentiation and activation of resorption, are important components of the processes regulating osteoclast chemotaxis...
  71. ncbi request reprint Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities
    Jean Marie Delaisse
    Nordic Bioscience, Center for Clinical and Basic Research, DK 2730 Herlev, Denmark
    Microsc Res Tech 61:504-13. 2003
    ..Although the understanding of MMPs in osteoclast biology is rapidly expanding, it is suspected that important roles remain to be discovered...
  72. ncbi request reprint Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones
    Riccardo Chiusaroli
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520, USA
    Dev Biol 261:537-47. 2003
    ..These results confirm that c-Cbl plays an important role in osteoclast motility and resorbing activity...