E Ø Nielsen

Summary

Affiliation: NeuroSearch A/S
Country: Denmark

Publications

  1. ncbi Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent
    N R Mirza
    Vernalis PLC, Neuropharmacology Department, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 154:8-12. 2001
  2. ncbi The role of GABA(A) receptor subtypes as analgesic targets
    Naheed R Mirza
    Neurosearch A S, Ballerup, Denmark
    Drug News Perspect 23:351-60. 2010
  3. ncbi NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy
    N R Mirza
    Department of Pharmacology, Neurosearch A S, Ballerup, Denmark
    J Pharmacol Exp Ther 327:954-68. 2008
  4. ncbi Serotonin transporter density and anxiolytic-like effects of antidepressants in mice
    N R Mirza
    Neurosearch A S, 93 Pederstrupvej, Ballerup, DK 2750, Denmark
    Prog Neuropsychopharmacol Biol Psychiatry 31:858-66. 2007
  5. ncbi Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?
    N R Mirza
    Department of In Vivo Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 316:1378-85. 2006
  6. ncbi Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination
    N R Mirza
    Department of In Vivo Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 316:1291-9. 2006
  7. ncbi Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?
    N R Mirza
    Department of Neuropharmacology, Vernalis PLC, Oakdene Court, 613 Reading Road, Winnersh, Wokingham RG41 5UA, UK
    Psychopharmacology (Berl) 180:159-68. 2005
  8. ncbi Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists
    Naheed R Mirza
    Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, Ballerup, Denmark
    CNS Drug Rev 9:159-86. 2003
  9. ncbi Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors
    D B Timmermann
    Neurosearch A S, Drug Discovery, Ballerup, Denmark
    Br J Pharmacol 167:164-82. 2012
  10. ncbi Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
    G Munro
    Neurosearch A S, Ballerup, Denmark
    J Pharmacol Exp Ther 327:969-81. 2008

Collaborators

Detail Information

Publications11

  1. ncbi Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent
    N R Mirza
    Vernalis PLC, Neuropharmacology Department, Winnersh, Wokingham, UK
    Psychopharmacology (Berl) 154:8-12. 2001
    ..Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotine would only improve performance in this strain...
  2. ncbi The role of GABA(A) receptor subtypes as analgesic targets
    Naheed R Mirza
    Neurosearch A S, Ballerup, Denmark
    Drug News Perspect 23:351-60. 2010
    ..Further clinical exploration in pain of available positive and negative subtype-selective modulators that have been administered to humans would considerably aid back translation, allowing for improved therapeutic development...
  3. ncbi NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy
    N R Mirza
    Department of Pharmacology, Neurosearch A S, Ballerup, Denmark
    J Pharmacol Exp Ther 327:954-68. 2008
    ....
  4. ncbi Serotonin transporter density and anxiolytic-like effects of antidepressants in mice
    N R Mirza
    Neurosearch A S, 93 Pederstrupvej, Ballerup, DK 2750, Denmark
    Prog Neuropsychopharmacol Biol Psychiatry 31:858-66. 2007
    ....
  5. ncbi Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?
    N R Mirza
    Department of In Vivo Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 316:1378-85. 2006
    ....
  6. ncbi Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination
    N R Mirza
    Department of In Vivo Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 316:1291-9. 2006
    ....
  7. ncbi Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?
    N R Mirza
    Department of Neuropharmacology, Vernalis PLC, Oakdene Court, 613 Reading Road, Winnersh, Wokingham RG41 5UA, UK
    Psychopharmacology (Berl) 180:159-68. 2005
    ..Many anticonvulsants are used in disorders other than epilepsy. For example, lamotrigine is reported to be effective in post-traumatic stress disorder and mania...
  8. ncbi Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists
    Naheed R Mirza
    Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, Ballerup, Denmark
    CNS Drug Rev 9:159-86. 2003
    ..The preclinical data on the whole are promising for an antipsychotic-like profile. If in a new formulation (i.e., transdermal) xanomeline has less adverse effects, this drug may be valuable in the treatment of patients with psychosis...
  9. ncbi Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors
    D B Timmermann
    Neurosearch A S, Drug Discovery, Ballerup, Denmark
    Br J Pharmacol 167:164-82. 2012
    ..Positive allosteric modulation of α4β2 nicotinic acetylcholine (nACh) receptors could add a new dimension to the pharmacology and therapeutic approach to these receptors. The novel modulator NS9283 was therefore tested extensively...
  10. ncbi Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
    G Munro
    Neurosearch A S, Ballerup, Denmark
    J Pharmacol Exp Ther 327:969-81. 2008
    ..The robust therapeutic window seen with NS11394 in animals suggests that compounds with this in vitro selectivity profile could have potential benefit in clinical treatment of pain in humans...
  11. ncbi Positive allosteric modulation of α4β2 nAChR agonist induced behaviour
    F Rode
    Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Brain Res 1458:67-75. 2012
    ..Together these results emphasize involvement of α4β2 nAChR in rotational and analgesic responses and confirm striatal α4β2 receptors to be of the HS form...