Jens Damsgaard Mikkelsen

Summary

Affiliation: NeuroSearch A/S
Country: Denmark

Publications

  1. ncbi request reprint The KCNQ channel activator retigabine blocks haloperidol-induced c-Fos expression in the striatum of the rat
    Jens D Mikkelsen
    Department of Molecular Physiology and Anatomy, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Neurosci Lett 362:240-3. 2004
  2. doi request reprint Comparison of the effects of peripherally administered kisspeptins
    Jens D Mikkelsen
    Copenhagen University Hospital Rigshospitalet, Denmark
    Regul Pept 152:95-100. 2009
  3. ncbi request reprint Effects of stress and adrenalectomy on activity-regulated cytoskeleton protein (Arc) gene expression
    Jens D Mikkelsen
    Department of Functional Neuroanatomy and Biomarkers, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Neurosci Lett 403:239-43. 2006
  4. ncbi request reprint Accumulated increase in neuropeptide Y and somatostatin gene expression of the rat in response to repeated electroconvulsive stimulation
    Jens D Mikkelsen
    Department of Molecular Anatomy and Physiology, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    J Psychiatr Res 40:153-9. 2006
  5. ncbi request reprint Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis
    Jens D Mikkelsen
    Department of Functional Neuroanatomy and Biomarkers, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Eur J Pharmacol 519:223-30. 2005
  6. ncbi request reprint [Drug targets: identification and evaluation]
    Jens Damsgaard Mikkelsen
    Neurosearch A S, Ballerup
    Ugeskr Laeger 167:2156-60. 2005
  7. doi request reprint GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes
    Jens D Mikkelsen
    Department of Translational Neurobiology, Neurosearch A S, Ballerup, Denmark
    Ann N Y Acad Sci 1148:384-92. 2008
  8. ncbi request reprint Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors
    Jens D Mikkelsen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Ann N Y Acad Sci 1018:65-70. 2004
  9. doi request reprint The neuroanatomy of the kisspeptin system in the mammalian brain
    Jens D Mikkelsen
    Department of Translational Neuroscience, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark
    Peptides 30:26-33. 2009
  10. ncbi request reprint The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat
    Søren E Kristensen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Neurosci Lett 418:154-8. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The KCNQ channel activator retigabine blocks haloperidol-induced c-Fos expression in the striatum of the rat
    Jens D Mikkelsen
    Department of Molecular Physiology and Anatomy, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Neurosci Lett 362:240-3. 2004
    ....
  2. doi request reprint Comparison of the effects of peripherally administered kisspeptins
    Jens D Mikkelsen
    Copenhagen University Hospital Rigshospitalet, Denmark
    Regul Pept 152:95-100. 2009
    ..These data show that all peptides tested are active and supports the concept that their effect is mediated by a target upstream of the pituitary, such as the median eminence...
  3. ncbi request reprint Effects of stress and adrenalectomy on activity-regulated cytoskeleton protein (Arc) gene expression
    Jens D Mikkelsen
    Department of Functional Neuroanatomy and Biomarkers, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Neurosci Lett 403:239-43. 2006
    ..These data are consistent with the role of Arc as an integrative modulator of synaptic plasticity by emphasizing the potential role of stress and glucocorticoids in the control of Arc gene expression...
  4. ncbi request reprint Accumulated increase in neuropeptide Y and somatostatin gene expression of the rat in response to repeated electroconvulsive stimulation
    Jens D Mikkelsen
    Department of Molecular Anatomy and Physiology, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    J Psychiatr Res 40:153-9. 2006
    ....
  5. ncbi request reprint Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis
    Jens D Mikkelsen
    Department of Functional Neuroanatomy and Biomarkers, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Eur J Pharmacol 519:223-30. 2005
    ....
  6. ncbi request reprint [Drug targets: identification and evaluation]
    Jens Damsgaard Mikkelsen
    Neurosearch A S, Ballerup
    Ugeskr Laeger 167:2156-60. 2005
  7. doi request reprint GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes
    Jens D Mikkelsen
    Department of Translational Neurobiology, Neurosearch A S, Ballerup, Denmark
    Ann N Y Acad Sci 1148:384-92. 2008
    ....
  8. ncbi request reprint Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors
    Jens D Mikkelsen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Ann N Y Acad Sci 1018:65-70. 2004
    ..In conclusion, 5-HT(1A) and 5-HT(2A) receptors regulate corticotrophin-releasing hormone (CRH) neurons via distinct but strongly interacting pathways, probably converging on the same neurons in the hypothalamus...
  9. doi request reprint The neuroanatomy of the kisspeptin system in the mammalian brain
    Jens D Mikkelsen
    Department of Translational Neuroscience, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark
    Peptides 30:26-33. 2009
    ..In addition, kisspeptin nerve terminals and receptors are found in other hypothalamic area suggesting that kisspeptins are involved in regulation of other yet unknown homeostatic or neuroendocrine functions...
  10. ncbi request reprint The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat
    Søren E Kristensen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Neurosci Lett 418:154-8. 2007
    ..These data show that alpha7 nAChR activates a subset of neurons in the rat prefrontal cortex and this activation likely is important for the attentional effects of this new class of drugs...
  11. ncbi request reprint Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine
    Marianne H Larsen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Eur J Pharmacol 555:115-21. 2007
    ..This study shows that Tesofensine enhances hippocampal gene expression and new cell formation indicative for an antidepressant potential of this novel drug substance...
  12. ncbi request reprint The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat
    Henrik H Hansen
    Department of Functional Neuroanatomy, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 318:1006-19. 2006
    ..Collectively, these observations indicate that retigabine negatively modulates dopaminergic neurotransmission, likely originating from stimulation of mesencephalic KCNQ4 channels...
  13. pmc Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat
    Anne Marie D Axel
    CNS Pharmacology Psychiatry, Neurosearch A S, Ballerup, Copenhagen, Denmark
    Neuropsychopharmacology 35:1464-76. 2010
    ..Hence, the mechanism underlying the suppression of feeding by tesofensine in the obese rat is dependent on the drug's ability to indirectly stimulate alpha(1) adrenoceptor and DA D(1) receptor function...
  14. doi request reprint Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice
    Peter Holm
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Alzheimers Dis 20:1201-13. 2010
    ..These observations point towards a direct association between Abeta accumulation and changes in 5-HT2A receptor expression that is independent of upstream changes in the serotonergic system...
  15. ncbi request reprint Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics
    Henrik H Hansen
    Department of Translational Neurobiology, Neurosearch A S, Ballerup, Denmark
    J Neurosci Res 85:1810-8. 2007
    ..In conclusion, these results show that selective pharmacologic stimulation of alpha7 nAChR function results in activation of forebrain regions similar to conventional antipsychotics...
  16. doi request reprint The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42
    Andreas Søderman
    Institute of Anatomy, University of Aarhus, Wilhelm Meyers Alle, 8000 Arhus C, Denmark NeuroSearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Brain Res 1227:240-7. 2008
    ....
  17. doi request reprint The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant
    Henrik H Hansen
    Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Copenhagen, Denmark
    Eur J Pharmacol 636:88-95. 2010
    ..In conclusion, the robust weight loss with long-term tesofensine treatment is likely due to a combined synergistic effect of appetite suppression and increased energy expenditure...
  18. ncbi request reprint Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain
    Signe F Bomholt
    Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750, Ballerup, Denmark
    Neuropharmacology 48:252-63. 2005
    ....
  19. doi request reprint alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment
    Morten S Thomsen
    Department of Translational Neurobiology, Neurosearch A S, Ballerup, Denmark
    Neuropharmacology 56:1001-9. 2009
    ....
  20. ncbi request reprint Normal hypothalamo-pituitary-adrenal axis function in a rat model of peripheral neuropathic pain
    Signe F Bomholt
    Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, DK 2750, Ballerup, Denmark
    Brain Res 1044:216-26. 2005
    ..Furthermore, the HPA axis responds normally to a novel stressor in the face of ongoing nociceptive input, a stimulus known to activate the HPA axis...
  21. ncbi request reprint Rapid activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway by electroconvulsive shock in the rat prefrontal cortex is not associated with TrkB neurotrophin receptor activation
    Henrik H Hansen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, DK 2750, Ballerup, Copenhagen, Denmark
    Cell Mol Neurobiol 27:585-94. 2007
    ..Akt phosphorylation levels remained unchanged following acute or chronic ECS. Hence, although ECS effectively stimulates the ERK1/2 pathway in the PFC, this effect does not appear to involve upstream activation of TrkB...
  22. pmc Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS
    Henrik H Hansen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    J Physiol 586:1823-32. 2008
    ..g. schizophrenia and drug abuse) and serotonergic neurotransmission (e.g. anxiety)...
  23. ncbi request reprint Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants
    Marianne H Larsen
    Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 578:114-22. 2008
    ....
  24. ncbi request reprint The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine
    Henrik H Hansen
    Department of Translational Neurobiology, Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 570:77-88. 2007
    ..KCNQ channel openers may therefore be of potential relevance in the treatment of addiction states caused by abuse of psychostimulants...