Claus Svarer

Summary

Affiliation: Neurobiology Research Unit
Country: Denmark

Publications

  1. ncbi request reprint MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
    Claus Svarer
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 24:969-79. 2005
  2. ncbi request reprint A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables
    Karen H Adams
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Neuroimage 21:1105-13. 2004
  3. ncbi request reprint Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 46:1119-27. 2005
  4. doi request reprint Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients
    David Erritzoe
    Neurobiology Research Unit, Center for Integrated Molecular Brain Imaging, University Hospital Rigshospitalet, Copenhagen, Denmark
    Neuropsychopharmacology 33:2435-41. 2008
  5. ncbi request reprint Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome
    Steven Haugbøl
    Neurobiology Research Unit, Copenhagen University Hospital, Denmark
    Int J Neuropsychopharmacol 10:245-52. 2007
  6. ncbi request reprint Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei
    Karen H Adams
    Neurobiology Research Unit NRU, University Hospital of Copenhagen, Denmark
    Int J Neuropsychopharmacol 8:391-401. 2005
  7. doi request reprint Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans
    Vibe G Frokjaer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 49:247-54. 2008
  8. ncbi request reprint Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling
    Matthew Liptrot
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neuroimage 21:483-93. 2004
  9. doi request reprint The personality trait openness is related to cerebral 5-HTT levels
    Jan Kalbitzer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark
    Neuroimage 45:280-5. 2009
  10. doi request reprint MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study
    Morten Ziebell
    Neurobiology Research Unit and Cimbi, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med Technol 38:61-8. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
    Claus Svarer
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 24:969-79. 2005
    ..In addition, the method applies well in elderly subjects, even in the presence of pronounced cerebral atrophy...
  2. ncbi request reprint A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables
    Karen H Adams
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Neuroimage 21:1105-13. 2004
    ..The correlations between different cortical regions' 5-HT(2A) binding and BMI should be explored in future studies...
  3. ncbi request reprint Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 46:1119-27. 2005
    ....
  4. doi request reprint Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients
    David Erritzoe
    Neurobiology Research Unit, Center for Integrated Molecular Brain Imaging, University Hospital Rigshospitalet, Copenhagen, Denmark
    Neuropsychopharmacology 33:2435-41. 2008
    ..However, a preliminary finding of increased 5-HT(2A) binding in the caudate nucleus requires further investigation to explore the relation of subcortical and cortical 5-HT(2A) receptor binding...
  5. ncbi request reprint Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome
    Steven Haugbøl
    Neurobiology Research Unit, Copenhagen University Hospital, Denmark
    Int J Neuropsychopharmacol 10:245-52. 2007
    ..Our data suggest that the serotonergic transmitter system is pathophysiologically involved in Tourette's syndrome and that a clinical trial with 5-HT2A receptor antagonists may be justified...
  6. ncbi request reprint Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei
    Karen H Adams
    Neurobiology Research Unit NRU, University Hospital of Copenhagen, Denmark
    Int J Neuropsychopharmacol 8:391-401. 2005
    ..The up-regulation in 5-HT(2A) receptors might be compensatory for a lack of serotonin in the feedback loop between the thalamus and orbito-frontal cortex, the caudate nuclei, and the globus pallidus...
  7. doi request reprint Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans
    Vibe G Frokjaer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 49:247-54. 2008
    ....
  8. ncbi request reprint Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling
    Matthew Liptrot
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neuroimage 21:483-93. 2004
    ....
  9. doi request reprint The personality trait openness is related to cerebral 5-HTT levels
    Jan Kalbitzer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark
    Neuroimage 45:280-5. 2009
    ..We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress...
  10. doi request reprint MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study
    Morten Ziebell
    Neurobiology Research Unit and Cimbi, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med Technol 38:61-8. 2010
    ..We also assessed the ability of the different approaches to identify striatal pathology in patients with parkinsonism...
  11. ncbi request reprint Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
    Morten Ziebell
    Neurobiology Research Unit, Rigshospitalet, N9201, 9 Blegdamsvej, Copenhagen, 2100, Denmark
    Eur J Nucl Med Mol Imaging 34:101-9. 2007
    ....
  12. ncbi request reprint Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach
    Steven Haugbøl
    Neurobiology Research Unit, Centre for Integrated Molecular Brain Imaging, Copenhagen University Hospital, 9 Blegdamsvej, 2100, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 34:910-5. 2007
    ..Further, to estimate the sample size needed to detect regional differences between two groups and, finally, to evaluate how partial volume correction affects reproducibility and the required sample size...
  13. doi request reprint In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users
    David Erritzoe
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Arch Gen Psychiatry 68:562-76. 2011
    ..In addition, MDMA is a potent releaser and reuptake inhibitor of presynaptic serotonin...
  14. doi request reprint Validation of a method for accurate and highly reproducible quantification of brain dopamine transporter SPECT studies
    Peter S Jensen
    Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Nucl Med Technol 39:271-8. 2011
    ....
  15. pmc Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET study
    Karine Madsen
    Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 31:1475-81. 2011
    ..The relatively stable 5-HT(4) receptor binding with aging contrasts others in subtypes of receptors, which generally decrease with aging...
  16. doi request reprint The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined
    Lars H Pinborg
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 40:1175-80. 2008
    ....
  17. ncbi request reprint Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach
    Lars H Pinborg
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cereb Blood Flow Metab 23:985-96. 2003
    ..3% h-1; range -7.3-7.2% h-1) and no correlation of DV(3)' versus time was demonstrated. It is concluded that 5-HT(2A) receptor studies can be conducted within 2 h of [18F]altanserin infusion, yielding reliable results...
  18. doi request reprint Methods for motion correction evaluation using 18F-FDG human brain scans on a high-resolution PET scanner
    Sune H Keller
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, University Hospital, Copenhagen, Denmark
    J Nucl Med 53:495-504. 2012
    ..The purpose of this work was the development of quality control (QC) methods for MC procedures based on external motion tracking (EMT) for human scanning using an optical motion tracking system...
  19. doi request reprint A probabilistic approach to delineating functional brain regions
    Jan Kalbitzer
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    J Nucl Med Technol 37:91-5. 2009
    ..The case is made for the raphé nuclei, a collection of nuclei situated in the brain stem known to be densely packed with serotonin transporters (5-hydroxytryptaminic [5-HTT] system)...
  20. doi request reprint No change in [¹¹C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human
    Lars H Pinborg
    Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen University Hospital, Denmark
    Synapse 66:880-4. 2012
    ..The mean receptor occupancy was 0.03 (range -0.14 to 0.17). Our data imply that [¹¹C]CUMI-101 binding is not sensitive to citalopram infusion in humans...
  21. doi request reprint Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern
    Gerda Thomsen
    Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 35:2212-9. 2008
    ..This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min...
  22. ncbi request reprint Quantification of [(123)I]PE2I binding to dopamine transporters with SPET
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, N9201, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 29:623-31. 2002
    ..The distribution volume ratio (DVR) (6.6+/-1.4) was in good agreement with the DVR calculated with blood (6.7+/-1.4)...
  23. doi request reprint Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo
    Lisbeth Marner
    Neurobiology Research Unit, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 50:900-8. 2009
    ..We evaluated for the first time the quantification of a novel 5-HT(4) receptor radioligand, (11)C-SB207145, for in vivo brain imaging with PET in humans...
  24. doi request reprint Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET
    Lisbeth Marner
    The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark
    Neuroimage 50:855-61. 2010
    ..In conclusion, the 5-HT(4) receptor binding in human brain can be reliably assessed with [(11)C]SB207145, which is encouraging for future PET studies of drug occupancy or patients with neuropsychiatric disorders...
  25. doi request reprint A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans
    David Erritzoe
    Neurobiology Research Unit and PET and Cyclotron Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Neurosci 30:3391-7. 2010
    ..That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand...
  26. doi request reprint Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
    Vibe G Frokjaer
    Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Copenhagen, Denmark
    Psychoneuroendocrinology 35:1311-20. 2010
    ..This study was undertaken to examine if baseline levels of endogenous sex hormones are associated with cerebral serotonin 2A (5-HT(2A)) receptor binding in men...
  27. doi request reprint High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding
    Vibe G Frokjaer
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Denmark
    Neuroimage 46:360-6. 2009
    ..In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders...
  28. ncbi request reprint Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
    Vibe G Frokjaer
    Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Biol Psychiatry 63:569-76. 2008
    ..In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders...
  29. doi request reprint Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response
    Vibe Gedsoe Frokjaer
    Center for Integrated Molecular Brain Imaging, DK 2100 Copenhagen, Denmark Neurobiology Research Unit, DK 2100 Copenhagen, Denmark Electronic address
    Eur Neuropsychopharmacol 23:285-94. 2013
    ..We speculate that in mentally healthy individuals prefrontal serotonergic neurotransmission may exert an inhibitory control on the cortisol awakening response...
  30. doi request reprint Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36
    Anders Ettrup
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Mol Imaging Biol 15:376-83. 2013
    ..We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology...
  31. ncbi request reprint Cluster analysis of activity-time series in motor learning
    Daniela Balslev
    Neurobiology Research Unit, N 9201, Copenhagen University Hospital, Rigshospitalet, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Hum Brain Mapp 15:135-45. 2002
    ..These voxels were separated from a group of voxels showing an unspecific time-effect and another group of voxels, whose activation was an artifact from smoothing...
  32. ncbi request reprint Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction
    Mario Quarantelli
    Biostructure and Bioimaging Institute, National Council for Research, Building 10, Via Pansini 5, 80131 Naples, Italy
    J Nucl Med 45:192-201. 2004
    ..The accuracy and precision of these methods have been measured using 4 simulated (18)F-FDG PET studies with increasing degrees of atrophy...
  33. ncbi request reprint Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender
    Birte Y Glenthoj
    Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Department of Psychiatry E, Bispebjerg Hospital, Copenhagen, Denmark
    Biol Psychiatry 60:621-9. 2006
    ..The aim of the study was to examine extrastriatal dopamine D(2/3) receptor binding and psychopathology in schizophrenic patients, and to relate binding potential (BP) values to psychopathology...
  34. ncbi request reprint [The working brain--how does it look like?]
    Olaf B Paulson
    Ugeskr Laeger 164:2267-75. 2002
    ..Finally, several examples of the authors' results on functional activation are dealt with. These examples aim to illustrate the research area and its contribution to our increased knowledge of the working brain...