Lars Hageman Pinborg

Summary

Affiliation: Neurobiology Research Unit
Country: Denmark

Publications

  1. ncbi request reprint Quantification of [(123)I]PE2I binding to dopamine transporters with SPET
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, N9201, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 29:623-31. 2002
  2. doi request reprint To transfer fresh or thawed embryos?
    Anja Pinborg
    Fertility Clinic, University of Copenhagen, Denmark
    Semin Reprod Med 30:230-5. 2012
  3. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
  4. doi request reprint Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis
    A Pinborg
    Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod Update 19:87-104. 2013
  5. doi request reprint No change in [¹¹C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human
    Lars H Pinborg
    Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen University Hospital, Denmark
    Synapse 66:880-4. 2012
  6. doi request reprint Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006
    Anja Pinborg
    Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:1320-7. 2010
  7. doi request reprint Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 24:991-9. 2009
  8. ncbi request reprint [Fewer twin pregnancies after fertilization in vitro. The Danish Society of Gynecology and Obstetrics]
    Anja Pinborg
    Fertilitetsklinikken, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 170:1047. 2008
  9. ncbi request reprint Vanishing twins: a predictor of small-for-gestational age in IVF singletons
    Anja Pinborg
    The Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 22:2707-14. 2007
  10. ncbi request reprint Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 46:1119-27. 2005

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Quantification of [(123)I]PE2I binding to dopamine transporters with SPET
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, N9201, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 29:623-31. 2002
    ..The distribution volume ratio (DVR) (6.6+/-1.4) was in good agreement with the DVR calculated with blood (6.7+/-1.4)...
  2. doi request reprint To transfer fresh or thawed embryos?
    Anja Pinborg
    Fertility Clinic, University of Copenhagen, Denmark
    Semin Reprod Med 30:230-5. 2012
    ..Because larger and more detailed data sets are available for early cleavage-stage embryo freezing and slow freezing, they are the main focus of this review...
  3. pmc No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
    Gerda Thomsen
    Neurobiology Research Unit 9201, Rigshospitalet and Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100, Denmark
    EJNMMI Res 3:39. 2013
    ..We used the database to test the hypothesis that striatal DAT availability is changed in active smokers compared to non-smokers and ex-smokers...
  4. doi request reprint Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis
    A Pinborg
    Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod Update 19:87-104. 2013
    ..Possible explanatory factors for the well-known adverse perinatal outcome in ART singletons were evaluated...
  5. doi request reprint No change in [¹¹C]CUMI-101 binding to 5-HT(1A) receptors after intravenous citalopram in human
    Lars H Pinborg
    Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen University Hospital, Denmark
    Synapse 66:880-4. 2012
    ..The mean receptor occupancy was 0.03 (range -0.14 to 0.17). Our data imply that [¹¹C]CUMI-101 binding is not sensitive to citalopram infusion in humans...
  6. doi request reprint Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006
    Anja Pinborg
    Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:1320-7. 2010
    ..To examine infant outcome of singletons born after cryopreservation of embryos (Cryo)...
  7. doi request reprint Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 24:991-9. 2009
    ..The objective was to assess crude 5-year delivery rates after assisted reproductive technology (ART) treatment, intrauterine inseminations (IUI), spontaneous conceptions (SC) and adoptions in a large infertile cohort...
  8. ncbi request reprint [Fewer twin pregnancies after fertilization in vitro. The Danish Society of Gynecology and Obstetrics]
    Anja Pinborg
    Fertilitetsklinikken, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 170:1047. 2008
  9. ncbi request reprint Vanishing twins: a predictor of small-for-gestational age in IVF singletons
    Anja Pinborg
    The Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 22:2707-14. 2007
    ..The purpose of this study was to assess the effect of a vanishing twin on the risk of being small-for-gestational age (SGA) in in vitro fertilization (IVF) singletons...
  10. ncbi request reprint Quantification of 123I-PE2I binding to dopamine transporter with SPECT after bolus and bolus/infusion
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 46:1119-27. 2005
    ....
  11. doi request reprint The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined
    Lars H Pinborg
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 40:1175-80. 2008
    ....
  12. doi request reprint Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples
    A Pinborg
    Fertility Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
    Reprod Biomed Online 23:490-9. 2011
    ..04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P=0.037), women's BMI (P=0.034) and men's age (P=0.040)...
  13. ncbi request reprint [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge
    Lars H Pinborg
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 24:1037-45. 2004
    ..The biochemical and cellular events possibly affecting the unsuccessful translation of the citalopram/pindolol challenge into a change in 5-HT2A receptor binding of [18F]altanserin are discussed...
  14. ncbi request reprint Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach
    Lars H Pinborg
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cereb Blood Flow Metab 23:985-96. 2003
    ..3% h-1; range -7.3-7.2% h-1) and no correlation of DV(3)' versus time was demonstrated. It is concluded that 5-HT(2A) receptor studies can be conducted within 2 h of [18F]altanserin infusion, yielding reliable results...
  15. ncbi request reprint [123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region
    Lars H Pinborg
    Neurobiology Research Unit, University of Copenhagen, N9201, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 34:1450-3. 2007
    ....
  16. ncbi request reprint Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10,362 non-IVF/ICSI twins born between 1995 and 2000
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, Denmark
    Hum Reprod 19:435-41. 2004
    ..In Denmark, one-third of twin pregnancies are the result of IVF/ICSI treatment. Limited data on neonatal outcome in IVF/ICSI twins are available in the literature...
  17. ncbi request reprint Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, Denmark
    Hum Reprod 18:1234-43. 2003
    ..There is a lack of knowledge on child health as well as family well-being in IVF/ICSI twins...
  18. pmc Neurological sequelae in twins born after assisted conception: controlled national cohort study
    Anja Pinborg
    Fertility Clinic, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 329:311. 2004
    ....
  19. ncbi request reprint Consequences of vanishing twins in IVF/ICSI pregnancies
    Anja Pinborg
    The Fertility Clinic, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Denmark
    Hum Reprod 20:2821-9. 2005
    ..The aim of this study was to assess incidence rates of spontaneous reductions in IVF/ICSI twin pregnancies and to compare short- and long-term morbidity in survivors of a vanishing co-twin with singletons and born twins...
  20. ncbi request reprint Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: the role of twin pregnancy
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, Denmark
    Acta Obstet Gynecol Scand 83:1071-8. 2004
    ..In Denmark, 4% of all infants are born after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and 40% of these children are twins...
  21. ncbi request reprint IVF/ICSI twin pregnancies: risks and prevention
    Anja Pinborg
    The Fertility Clinic, The Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
    Hum Reprod Update 11:575-93. 2005
    ..Furthermore vanishing twins account for another hazard of DET. These problems can be resolved by implementing eSET, diminishing the twin birth rate without affecting the overall goal of achieving a healthy infant...
  22. ncbi request reprint Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: a controlled Danish national cohort study
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, National Board of Health, Health Statistics, Copenhagen, Denmark
    Hum Reprod 19:2529-36. 2004
    ..IVF/ICSI twins are likely to have a higher risk of prematurity associated with higher morbidity. The aim of this study was to assess the use of hospital care resources in IVF/ICSI twins on data retrieved until 2-7 years of child age...
  23. ncbi request reprint The vanishing twin: a major determinant of infant outcome in IVF singleton births
    Anja Pinborg
    Juliane Marie Centre, University of Copenhagen, Rigshopitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Br J Hosp Med (Lond) 67:417-20. 2006
    ..This article attempts to assess the frequency of vanishing twins in assisted reproductive and spontaneously conceived pregnancies, including in-vitro fertilization (IVF), and its impact on the live-born surviving twin...
  24. ncbi request reprint Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization
    Anja Pinborg
    The Fertility Clinic, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Acta Obstet Gynecol Scand 83:75-84. 2004
    ..Twin pregnancies constitute 25% of all in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) pregnancies. There is a lack of knowledge on maternal risks and perinatal outcome of IVF/ICSI twin pregnancies...
  25. doi request reprint Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study
    Anna Karina Aaris Henningsen
    Fertility Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Fertil Steril 95:959-63. 2011
    ..To compare the perinatal outcome of singleton siblings conceived differently...
  26. doi request reprint A Danish national cohort study on neonatal outcome in singleton pregnancies with placenta previa
    Lone N Nørgaard
    Department of Obstetrics and Gynecology, Hillerød University Hospital, Hillerød Fertility Clinic 4071, Rigshospitalet University Hospital, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 91:546-51. 2012
    ..To describe the incidence of placenta previa and to assess neonatal morbidity and mortality in pregnancies with placenta previa after adjustment for previous cesarean section, smoking, multiparity, maternal age and in vitro fertilization...
  27. doi request reprint Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study
    Sara S Malchau
    Fertility Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Fertil Steril 99:1637-43. 2013
    ..To describe perinatal outcomes in children born after oocyte donation (OD) compared with in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and spontaneous conception (SC)...
  28. ncbi request reprint [The prognosis for children born after assisted reproduction]
    Anna Karina Aaris Henningsen
    Fertilitetsklinikken, Rigshospitalet, Blegdamsvej 9, Copenhagen
    Ugeskr Laeger 174:2462-6. 2012
    ..A milder hormone stimulation and elective single embryo transfer, which reduces the number of multiples after ART, have improved the overall health of children born as a result of ART...
  29. doi request reprint Infant and maternal health monitoring using a combined Nordic database on ART and safety
    Anna Karina A Henningsen
    Fertility Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 90:683-91. 2011
    ..Outcome data on the mothers of ART children can be used to study risks during pregnancy and obstetric complications after ART...
  30. doi request reprint Serotonin transporters in dopamine transporter imaging: a head-to-head comparison of dopamine transporter SPECT radioligands 123I-FP-CIT and 123I-PE2I
    Morten Ziebell
    Neurobiology Research Unit and Cimbi, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    J Nucl Med 51:1885-91. 2010
    ....
  31. ncbi request reprint Cluster analysis in kinetic modelling of the brain: a noninvasive alternative to arterial sampling
    Matthew Liptrot
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Neuroimage 21:483-93. 2004
    ....
  32. ncbi request reprint Attitudes of IVF/ICSI-twin mothers towards twins and single embryo transfer
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 18:621-7. 2003
    ..Our aim was to study attitudes towards twins and single embryo transfer (SET) among IVF/ICSI-twin mothers with 3 to 4-year old children...
  33. ncbi request reprint A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables
    Karen H Adams
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Neuroimage 21:1105-13. 2004
    ..The correlations between different cortical regions' 5-HT(2A) binding and BMI should be explored in future studies...
  34. doi request reprint The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study
    Gitte Lindved Petersen
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    Fertil Steril 99:1654-62. 2013
    ....
  35. doi request reprint Congenital anomalies after assisted reproductive technology
    Anja Pinborg
    Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 99:327-32. 2013
    ..Trends over time in ART and congenital anomalies will also be discussed...
  36. doi request reprint Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans
    Vibe G Frokjaer
    Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Nucl Med 49:247-54. 2008
    ....
  37. ncbi request reprint MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
    Claus Svarer
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 24:969-79. 2005
    ..In addition, the method applies well in elderly subjects, even in the presence of pronounced cerebral atrophy...
  38. ncbi request reprint Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender
    Birte Y Glenthoj
    Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Department of Psychiatry E, Bispebjerg Hospital, Copenhagen, Denmark
    Biol Psychiatry 60:621-9. 2006
    ..The aim of the study was to examine extrastriatal dopamine D(2/3) receptor binding and psychopathology in schizophrenic patients, and to relate binding potential (BP) values to psychopathology...
  39. ncbi request reprint Reproducibility of [123I]PE2I binding to dopamine transporters with SPECT
    Morten Ziebell
    Neurobiology Research Unit, Rigshospitalet, N9201, 9 Blegdamsvej, Copenhagen, 2100, Denmark
    Eur J Nucl Med Mol Imaging 34:101-9. 2007
    ....
  40. ncbi request reprint Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
    Vibe G Frokjaer
    Center for Integrated Molecular Brain Imaging and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Biol Psychiatry 63:569-76. 2008
    ..In this study we investigated whether neuroticism is associated with serotonin 2A receptor binding in brain regions of relevance for affective disorders...
  41. ncbi request reprint Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach
    Steven Haugbøl
    Neurobiology Research Unit, Centre for Integrated Molecular Brain Imaging, Copenhagen University Hospital, 9 Blegdamsvej, 2100, Copenhagen, Denmark
    Eur J Nucl Med Mol Imaging 34:910-5. 2007
    ..Further, to estimate the sample size needed to detect regional differences between two groups and, finally, to evaluate how partial volume correction affects reproducibility and the required sample size...
  42. doi request reprint MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study
    Morten Ziebell
    Neurobiology Research Unit and Cimbi, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Nucl Med Technol 38:61-8. 2010
    ..We also assessed the ability of the different approaches to identify striatal pathology in patients with parkinsonism...
  43. doi request reprint The impact of social relations among men and women in fertility treatment on the decision to terminate treatment
    Ditte Vassard
    Department of Public Health, University of Copenhagen, 5 Oester Farimagsgade, Copenhagen K DK 1014, Denmark
    Hum Reprod 27:3502-12. 2012
    ..Do social support and social strain from social relations have an impact on the decision to terminate fertility treatment among men and women after 1 year of unsuccessful treatment?..
  44. ncbi request reprint Ages and Stages Questionnaire used to measure cognitive deficit in children born extremely preterm
    Anja Klamer
    The Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 94:1327-9. 2005
    ..To validate the Ages and Stages Questionnaire (ASQ) and to measure average cognitive deficit in children born extremely preterm...
  45. ncbi request reprint What is the most relevant standard of success in assisted reproduction? Is there a single 'parameter of excellence'?
    Anja Pinborg
    The Fertility Clinic, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 19:1052-4. 2004
    ..If these standards are implemented as national gold standards, the future goal of homogeneous reporting of success rates in ART is within reach...
  46. ncbi request reprint Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome
    Steven Haugbøl
    Neurobiology Research Unit, Copenhagen University Hospital, Denmark
    Int J Neuropsychopharmacol 10:245-52. 2007
    ..Our data suggest that the serotonergic transmitter system is pathophysiologically involved in Tourette's syndrome and that a clinical trial with 5-HT2A receptor antagonists may be justified...
  47. ncbi request reprint Imprinting disorders after assisted reproductive technologies
    Øjvind Lidegaard
    Gynaecologic Clinic Juliane, Marie Centre, Copenhagen, Denmark
    Curr Opin Obstet Gynecol 18:293-6. 2006
    ..To assess the evidence of an increased risk of imprinting diseases in children born after use of assisted reproductive technologies...
  48. doi request reprint Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia
    Hans Rasmussen
    Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Copenhagen University Hospital, Psychiatric University Center Glostrup, Glostrup, Denmark
    Arch Gen Psychiatry 67:9-16. 2010
    ..Furthermore, the relationships between serotonin(2A) binding, psychopathology, and central neurocognitive deficits in schizophrenia are unclear...
  49. ncbi request reprint Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907
    Heidi Kristiansen
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    Synapse 58:249-57. 2005
    ..Overall, the binding of [(18)F]altanserin and [(3)H]MDL 100907 to the 5-HT(2A) receptor was very comparable, showing selective high affinity binding in the subnanomolar range...
  50. ncbi request reprint Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei
    Karen H Adams
    Neurobiology Research Unit NRU, University Hospital of Copenhagen, Denmark
    Int J Neuropsychopharmacol 8:391-401. 2005
    ..The up-regulation in 5-HT(2A) receptors might be compensatory for a lack of serotonin in the feedback loop between the thalamus and orbito-frontal cortex, the caudate nuclei, and the globus pallidus...