S Aznar

Summary

Affiliation: Neurobiology Research Unit
Country: Denmark

Publications

  1. ncbi request reprint The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain
    Susana Aznar
    Neurobiology Research Unit, Unit 9201, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Brain Res 959:58-67. 2003
  2. doi request reprint Depression and Alzheimer's disease: is stress the initiating factor in a common neuropathological cascade?
    Susana Aznar
    Center for Integrated Molecular Imaging, Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    J Alzheimers Dis 23:177-93. 2011
  3. ncbi request reprint Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum
    S Aznar
    Neurobiology Research Unit 9201, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neuroscience 124:573-81. 2004
  4. ncbi request reprint Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Synapse 55:196-200. 2005
  5. doi request reprint Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Synapse 64:561-5. 2010
  6. ncbi request reprint Novelty-induced activity-regulated cytoskeletal-associated protein (Arc) expression in frontal cortex requires serotonin 2A receptor activation
    M A Santini
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Neuroscience 190:251-7. 2011
  7. pmc Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice
    A B Klein
    Neurobiology Research Unit and Center for Integrated and Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Neuroscience 169:1007-16. 2010
  8. doi request reprint The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration
    Cecilie L Licht
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Neurochem 109:1363-74. 2009
  9. doi request reprint BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures
    V Trajkovska
    Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Denmark
    Neurochem Int 55:697-702. 2009
  10. ncbi request reprint Serotonin induces a decrease of 5-HT(1A) immunoreactivity in organotypic hippocampal cultures
    S Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, Unit 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neuroreport 12:3909-12. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain
    Susana Aznar
    Neurobiology Research Unit, Unit 9201, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Brain Res 959:58-67. 2003
    ..These results suggest a diverse function of the 5-HT(1A) receptor in modulating neuronal circuitry in different brain areas, that may depend on the type of neuron the receptor is predominantly located on...
  2. doi request reprint Depression and Alzheimer's disease: is stress the initiating factor in a common neuropathological cascade?
    Susana Aznar
    Center for Integrated Molecular Imaging, Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    J Alzheimers Dis 23:177-93. 2011
    ....
  3. ncbi request reprint Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum
    S Aznar
    Neurobiology Research Unit 9201, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neuroscience 124:573-81. 2004
    ..These results indicate that the raphe nuclei may exert their control on hippocampal and septal activity not only through a serotonergic projection, but also through a significant non-serotonergic pathway...
  4. ncbi request reprint Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Synapse 55:196-200. 2005
    ..A low degree of colocalization between alpha-bungarotoxin and serotonin-positive neurons suggest that the alpha 7 subunit may be transported anterogradely to the serotonergic axonal terminals...
  5. doi request reprint Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness
    Susana Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Synapse 64:561-5. 2010
    ....
  6. ncbi request reprint Novelty-induced activity-regulated cytoskeletal-associated protein (Arc) expression in frontal cortex requires serotonin 2A receptor activation
    M A Santini
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Neuroscience 190:251-7. 2011
    ....
  7. pmc Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice
    A B Klein
    Neurobiology Research Unit and Center for Integrated and Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Neuroscience 169:1007-16. 2010
    ..These findings illustrate the context-dependent effects of deficient BDNF signaling on the 5-HT receptor system and 5-HT(2A)-receptor functional output...
  8. doi request reprint The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration
    Cecilie L Licht
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Neurochem 109:1363-74. 2009
    ..Thus, the 5-HT(4) receptor binding was decreased in the Flinders Sensitive Line depression model and in response to chronic paroxetine administration...
  9. doi request reprint BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures
    V Trajkovska
    Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Denmark
    Neurochem Int 55:697-702. 2009
    ..This interaction may be an important mechanism in the role of BDNF in affective disorders emphasizing the need for further elucidating the specificity and the mechanism behind this regulation...
  10. ncbi request reprint Serotonin induces a decrease of 5-HT(1A) immunoreactivity in organotypic hippocampal cultures
    S Aznar
    Neurobiology Research Unit, Copenhagen University Hospital, Unit 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neuroreport 12:3909-12. 2001
    ..5-HT(1A) levels decreased with increasing serotonin concentrations, being significant at 10, 50 and 100 microM. These results indicate that at increasing serotonin levels the density of postsynaptic 5-HT(1A) receptors is down-regulated...
  11. doi request reprint Activation of glucocorticoid receptors increases 5-HT2A receptor levels
    Viktorija Trajkovska
    Neurobiology Research Unit and Centre for Integrated Molecular Brain Imaging CIMBI, Copenhagen University Hospital, Unit 9201, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Exp Neurol 218:83-91. 2009
    ..05). The corticosterone-induced 5-HT2A receptor up-regulation was blocked by addition of either spironolactone or mifepristone...
  12. doi request reprint The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide
    C Clemmensen
    Center for Integrated Molecular Brain Imaging CIMBI, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Cell Mol Neurobiol 32:561-6. 2012
    ..Moreover, our data support the notion of microtubule-stabilizing agents as effective AD drugs...
  13. doi request reprint Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice
    Peter Holm
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Alzheimers Dis 20:1201-13. 2010
    ..These observations point towards a direct association between Abeta accumulation and changes in 5-HT2A receptor expression that is independent of upstream changes in the serotonergic system...
  14. ncbi request reprint Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes
    Birgitte Rahbek Kornum
    Neurobiology Research Unit, N9201, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Denmark
    Neurosci Lett 392:129-34. 2006
    ..While the pattern of 5-HT depletion using pCPA alone was comparable to the one seen with the combined treatment, the 5-HT depletion using FEN alone showed a different pattern with 5-HT distributed in several brain regions...
  15. ncbi request reprint Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism
    Viktorija Trajkovska
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Section 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Affect Disord 108:165-9. 2008
    ..Depression has been associated with decreased blood BDNF concentrations; but it is unclear if low blood BDNF levels are a state or a trait marker of depression...
  16. ncbi request reprint Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data
    Viktorija Trajkovska
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen University Hospital, Section 9201, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Brain Res Bull 73:143-9. 2007
    ..Female gender is associated with higher whole blood BDNF concentrations whereas age, thrombocyte count and BDNF Val66Met polymorphism were un-associated...
  17. doi request reprint Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice
    Cecilie L Licht
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging Cimbi, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Neurochem Int 56:603-10. 2010
    ..In conclusion, we have found brain regional changes in 5-HT(4) receptor and 5-HTT transporter binding in two murine models of depression-related states, characterized by 5-HT and HPA system changes...
  18. ncbi request reprint Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
    Birgitte R Kornum
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Brain Res 1073:262-8. 2006
    ..It is concluded that 5-HT mediates part of the ACh-induced hippocampal neuronal activation, possibly mediated via locally released 5-HT...
  19. doi request reprint Blood BDNF concentrations reflect brain-tissue BDNF levels across species
    Anders B Klein
    Centre for Integrated Molecular Brain Imaging CIMBI, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Neuropsychopharmacol 14:347-53. 2011
    ..81, p=0.0139). Our data support the view that measures of blood and plasma BDNF levels reflect brain-tissue BDNF levels...
  20. ncbi request reprint Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels
    R Christensen
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Exp Neurol 210:164-71. 2008
    ..This suggests that the BDNF and 5-HT2A changes observed in AD are related to the presence of Abeta(1-42) deposits...
  21. pmc Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels
    Anders Bue Klein
    Neurobiology Research Unit, The Neuroscience Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 30:e1-7. 2010
    ..In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding...
  22. ncbi request reprint 5-HT(2A) and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains
    A B Klein
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Neuroscience 263:36-45. 2014
    ..We suggest that the differences in the serotonergic system may mediate some of the phenotypic characteristics in this strain such as hyper-impulsivity and susceptibility to drug addiction...
  23. ncbi request reprint Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex
    Maurizio Severino
    Neurobiology Research Unit, CIMBI, Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Copenhagen, Denmark
    Neurosci Lett 428:47-51. 2007
    ..This is probably a consequence of the interaction between the serotonergic and the cholinergic system that may vary depending on the brain region...
  24. ncbi request reprint No effect of MDMA (ecstasy) on cell death and 5-HT2A receptor density in organotypic rat hippocampal cultures
    Marie Louise Sveen
    Neurobiology Research Unit, Copenhagen University Hospital, Unit 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Neurosci Lett 362:6-9. 2004
    ..MDMA's neurotoxicity and regulation of post-synaptic 5-HT2A receptors thus seems to require the presence of intact serotonergic terminals...
  25. ncbi request reprint Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin
    Kirsten Nielsen
    Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark
    Synapse 59:270-6. 2006
    ..We conclude that the rapid metabolism of serotonin leads to an underestimation of immunodetected serotonergic fibers and that in many instances, SERT immunostaining may be a better indicator of serotonergic fibers...
  26. pmc Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS
    Henrik H Hansen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    J Physiol 586:1823-32. 2008
    ..g. schizophrenia and drug abuse) and serotonergic neurotransmission (e.g. anxiety)...