J Nerup

Summary

Country: Denmark

Publications

  1. pmc A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions
    J Nerup
    Steno Diabetes Center, Gentofte, Denmark
    Am J Hum Genet 69:1301-13. 2001
  2. pmc Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Proc Natl Acad Sci U S A 98:12191-6. 2001
  3. ncbi Beta-cell maturation leads to in vitro sensitivity to cytotoxins
    K Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 48:2324-32. 1999
  4. ncbi NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiolog
    L Hansen
    Steno Diabetes Center, Panum Institute, University of Copenhagen, Denmark
    Diabetes 49:876-8. 2000
  5. ncbi IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
    A Johansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes Obes Metab 8:75-82. 2006
  6. ncbi Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene
    Z M Larsen
    Steno Diabetes Centre, Gentofte, Denmark
    Diabet Med 21:218-22. 2004
  7. ncbi Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
    A E Karlsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Endocrinol Metab 85:830-6. 2000
  8. ncbi Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
    R Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 8:232-8. 2007
  9. ncbi Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression
    J Johannesen
    Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark
    Eur Cytokine Netw 12:501-9. 2001
  10. ncbi Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 47:892-908. 2004

Collaborators

Detail Information

Publications32

  1. pmc A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions
    J Nerup
    Steno Diabetes Center, Gentofte, Denmark
    Am J Hum Genet 69:1301-13. 2001
    ..Our data support both the existence of non-HLA genes of significance for T1DM and interaction between HLA and non-HLA loci in the determination of the T1DM phenotype...
  2. pmc Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Proc Natl Acad Sci U S A 98:12191-6. 2001
    ....
  3. ncbi Beta-cell maturation leads to in vitro sensitivity to cytotoxins
    K Nielsen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 48:2324-32. 1999
    ..These two cell systems will be useful tools for identification of molecular mechanisms involved in beta-cell maturation and sensitivity to toxins in relation to type 1 diabetes...
  4. ncbi NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiolog
    L Hansen
    Steno Diabetes Center, Panum Institute, University of Copenhagen, Denmark
    Diabetes 49:876-8. 2000
    ..However, in the type 1 diabetic Danish population, the Ala45Thr variant of NeuroD/BETA2 may represent a susceptibility marker independent of IDDM7 on chromosome 2q32...
  5. ncbi IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
    A Johansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetes Obes Metab 8:75-82. 2006
    ..The objective of this study was to estimate the impact of four selected amino acid polymorphisms -IRS-1 Gly972Arg, Kir6.2 Glu23Lys, HNF-1alpha Ala98Val and PPARgamma2 Pro12Ala in a Danish population of T1DM families...
  6. ncbi Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene
    Z M Larsen
    Steno Diabetes Centre, Gentofte, Denmark
    Diabet Med 21:218-22. 2004
    ..To investigate whether the WFS1 gene, the gene for Wolfram syndrome, is a susceptibility gene for more common forms of diabetes in the Danish population...
  7. ncbi Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
    A E Karlsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Endocrinol Metab 85:830-6. 2000
    ....
  8. ncbi Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
    R Bergholdt
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 8:232-8. 2007
    ....
  9. ncbi Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression
    J Johannesen
    Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark
    Eur Cytokine Netw 12:501-9. 2001
    ..Conclusion: There was a strain-dependent difference in iNOS expression which was associated with IRF-1 and HSP70 expression...
  10. ncbi Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 47:892-908. 2004
    ..The aim of this study was to describe the relevance of these proteins in the development of diabetes in vivo...
  11. ncbi Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity
    T Gylvin
    Steno Diabetes Center, Niels Steensensvej 2 4, 2820, Gentofte, Denmark
    Diabetologia 47:1273-7. 2004
    ..The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus...
  12. ncbi Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population
    J N Jensen
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetologia 44:123-6. 2001
    ....
  13. ncbi Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1beta
    K Nielsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Diabetologia 47:62-74. 2004
    ..We have previously shown that this maturation is accompanied by acquired sensitivity to the toxic effects of IL-1beta...
  14. pmc Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA1c: the A1C-Derived Average Glucose (ADAG) study
    R Borg
    Steno Diabetes Center, Niels Steensens vej 2 4, DK 2820 Gentofte, Denmark
    Diabetologia 53:1608-11. 2010
    ..Real-life glycaemic profiles of healthy individuals are poorly studied. Our aim was to analyse to what extent individuals without diabetes exceed OGTT thresholds for impaired glucose tolerance (IGT) and diabetes...
  15. doi Functional SOCS1 polymorphisms are associated with variation in obesity in whites
    T Gylvin
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Obes Metab 11:196-203. 2009
    ..The objective was to perform mutation analysis of SOCS1 and to test the identified variations for association to T2D-related quantitative traits, T2D or T1D...
  16. pmc Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark
    Dis Markers 17:205-16. 2001
    ..Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidate-gene approaches, we believe that it is possible to reach this goal...
  17. ncbi Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity
    K Nielsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820, Gentofte, Denmark
    Diabetologia 47:2185-99. 2004
    ..The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure...
  18. ncbi Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
    A E Karlsen
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Diabetologia 47:1998-2011. 2004
    ..However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown...
  19. ncbi Identification and characterization of secretagogin promoter activity
    K V Skovhus
    Steno Diabetes Center, Gentofte, Denmark
    Scand J Immunol 64:639-45. 2006
    ..The promoter region was furthermore screened by direct sequencing, and 11 polymorphisms were identified. Genotyping in a large homogenous Type 1 diabetes (T1D) family collection did not reveal association with T1D...
  20. ncbi No evidence of a functionally significant polymorphism of the BCL2 gene in Danish, Finnish and Basque type 1 diabetes families
    P E Heding
    Steno Diabetes Center, Niels Steensensvej 2, 2820 Gentofte, Denmark
    Genes Immun 2:398-400. 2001
    ..In contrast to what was observed in Japanese diabetic/control individuals, we find no evidence for association of the BCL2 Ala43Thr polymorphism to T1DM in Danish, Finnish and Basque Type 1 diabetes families...
  21. ncbi No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility
    F Pociot
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Metab Res Rev 17:292-5. 2001
    ..Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11...
  22. ncbi Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level
    R Bergholdt
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Genes Immun 1:495-500. 2000
    ..04). In both diabetic and non-diabetic subjects, the wt/wt genotype correlated with the highest IL-1RI plasma level, whereas the plasma levels were lowest for the mt/mt genotype...
  23. ncbi Intrauterine programming of fetal islet gene expression in rats--effects of maternal protein restriction during gestation revealed by proteome analysis
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 46:1497-511. 2003
    ..We hypothesise that the effects of a low-protein diet in utero are caused by intrauterine programming of beta-cell gene expression...
  24. ncbi Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes
    J Johannesen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 86:2792-6. 2001
    ..In conclusion, linkage of the human NOS2 gene to IDDM in a subset of patients supports a pathogenic role of nitric oxide in human IDDM...
  25. ncbi Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase?
    A M Wagner
    Steno Diabetes Center, Niels Steensens Vej 2, Gentofte, 2820, Denmark
    Diabetologia 50:676-81. 2007
    ..The aim of this study was to assess the role of PIMT in the development of type 1 diabetes...
  26. ncbi Anaesthesia-induced hyperglycaemia early in life is not predictive for development of diabetes in diabetes-prone BB rats
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Acta Diabetol 42:95-8. 2005
    ..0075 and 0.0324 and p-values at 0.56 and 0.23 respectively). We were not able to identify any association or correlation between the induced temporary hyperglycaemia in 30-day-old BB-DP rats and later development of diabetes...
  27. ncbi IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis
    T Sparre
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 45:1550-61. 2002
    ..The aim of this study was to identify the proteins in these 82 spots by mass spectrometry and compare these changes with those seen in IL-1beta exposed Wistar Furth (WF) rat islets...
  28. ncbi A population-based survey of frequencies of self-reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus. Danish IDDM Epidemiology and Genetics Group
    T Lorenzen
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 16:472-6. 1999
    ..The aim of the present Danish population-based study of 33% of the Danish population was to describe the pattern of self-reported miscarriage and stillbirths from 1304 women with Type 1 DM...
  29. ncbi Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families
    T Gylvin
    Steno Diabetes Center, Gentofte, Denmark
    Genes Immun 3:430-2. 2002
    ..In conclusion, we could not confirm the highly significant T1DM association of certain alleles of the NFKB1 marker previously reported...
  30. ncbi No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood
    O P Kristiansen
    Steno Diabetes Center, Gentofte, Denmark
    Hum Mutat 14:67-70. 1999
    ..82), to index cases (P(tdt) = 0.77), as well as to unaffected offspring (P(tdt) = 0.93). Hence, the NQO1 polymorphism is not likely to be an etiological mutation underlying the reported linkage of the 16q22-q24 region...
  31. ncbi Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes
    A M Møller
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Diabetologia 41:1528-31. 1998
    ..Clinical awareness of family history of diabetes and mode of inheritance might help to identify and reclassify these diabetic subjects as MODY3 patients...
  32. pmc HbA₁(c) and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study
    R Borg
    Steno Diabetes Center A S, Gentofte, Denmark
    Diabetologia 54:69-72. 2011
    ..We examined the association between various indices of glycaemia measured during everyday activities and metabolic CVD risk factors in the A1C-Derived Average Glucose (ADAG) study...