Ulla Vogel

Summary

Affiliation: National Institute of Occupational Health
Country: Denmark

Publications

  1. ncbi request reprint DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes
    U Vogel
    National Institute of Occupational Health, Lerso Parkalle 105, DK 2100, Copenhagen, Denmark
    Mutat Res 461:197-210. 2000
  2. ncbi request reprint Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Mol Mutagen 48:451-61. 2007
  3. doi request reprint Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer
    Signe Benzon Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Cancer Lett 295:191-7. 2010
  4. ncbi request reprint Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Free Radic Res 37:947-56. 2003
  5. ncbi request reprint ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Mutat Res 593:88-96. 2006
  6. ncbi request reprint No association between base excision repair gene polymorphisms and risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Copenhagen, Denmark
    Biochem Genet 42:453-60. 2004
  7. ncbi request reprint No association between GPX Pro198Leu and risk of basal cell carcinoma
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 13:1412-3. 2004
  8. ncbi request reprint Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen O, Denmark
    Mutat Res 546:65-74. 2004
  9. ncbi request reprint Inter-individual variation, seasonal variation and close correlation of OGG1 and ERCC1 mRNA levels in full blood from healthy volunteers
    Ulla Vogel
    National Institute of Occupational Health, Lersoe Parkalle 105, DK 2100 Copenhagen, Denmark
    Carcinogenesis 23:1505-9. 2002
  10. ncbi request reprint Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Lersoe Parkalle 105, DK 2100 Copenhagen O, Denmark
    Cancer Lett 222:67-74. 2005

Detail Information

Publications68

  1. ncbi request reprint DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes
    U Vogel
    National Institute of Occupational Health, Lerso Parkalle 105, DK 2100, Copenhagen, Denmark
    Mutat Res 461:197-210. 2000
    ..Thus, there is no indication that neither XPD nor ERCC1 limits the DNA repair capacity. However, our results indicate that ERCC1 and XPD mRNA levels may be used as a proxy for DNA repair capacity in lymphocytes...
  2. ncbi request reprint Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Mol Mutagen 48:451-61. 2007
    ..More studies are essential for understanding the biological significance of these findings, and clearly documenting DNA sequence changes. The results do not necessarily imply that other carbonaceous nano materials are genotoxic...
  3. doi request reprint Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer
    Signe Benzon Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Cancer Lett 295:191-7. 2010
    ..04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk...
  4. ncbi request reprint Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Free Radic Res 37:947-56. 2003
    ....
  5. ncbi request reprint ERCC1, XPD and RAI mRNA levels in lymphocytes are not associated with lung cancer risk in a prospective study of Danes
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Mutat Res 593:88-96. 2006
    ..41) for ERCC1, 1.00 (CI=0.83-1.21) for XPD and 1.25 (0.89-1.74) for RAI. In conclusion, this study indicated no association between mRNA expression of the DNA-repair genes ERCC1 and XPD and risk of subsequent development of lung cancer...
  6. ncbi request reprint No association between base excision repair gene polymorphisms and risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Copenhagen, Denmark
    Biochem Genet 42:453-60. 2004
    ..This is the first study of polymorphisms in base excision repair genes in relation to lung cancer among Danes...
  7. ncbi request reprint No association between GPX Pro198Leu and risk of basal cell carcinoma
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 13:1412-3. 2004
  8. ncbi request reprint Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen O, Denmark
    Mutat Res 546:65-74. 2004
    ..We found no interaction between genotypes and duration of smoking. In conclusion, two regions of chromosome 19q13.2-3 seem to be associated with risk of lung cancer...
  9. ncbi request reprint Inter-individual variation, seasonal variation and close correlation of OGG1 and ERCC1 mRNA levels in full blood from healthy volunteers
    Ulla Vogel
    National Institute of Occupational Health, Lersoe Parkalle 105, DK 2100 Copenhagen, Denmark
    Carcinogenesis 23:1505-9. 2002
    ..Thus, despite seasonal variation of the individual mRNA levels, the inter-person variation is still far larger than the intra-person variation, supporting the use as biomarkers...
  10. ncbi request reprint Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer
    Ulla Vogel
    National Institute of Occupational Health, Lersoe Parkalle 105, DK 2100 Copenhagen O, Denmark
    Cancer Lett 222:67-74. 2005
    ..We found that XPA A23G and XPC Lys939Gln polymorphisms may be risk factors for lung cancer and evidence that positive interactions between the polymorphisms in XPA/XPD and XPC/XPD may occur...
  11. ncbi request reprint No association between OGG1 Ser326Cys and risk of basal cell carcinoma
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 13:1680-1. 2004
  12. ncbi request reprint Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Lett 247:159-65. 2007
    ..At high smoking intensity (>20g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day)...
  13. ncbi request reprint Polymorphisms of the DNA repair gene XPD: correlations with risk of basal cell carcinoma revisited
    U Vogel
    National Institute for Occupational Health, DK 2100 Copenhagen O, Denmark
    Carcinogenesis 22:899-904. 2001
    ..Our results indicate that the exon 6(A) allele is a risk factor in basal cell carcinoma...
  14. ncbi request reprint No association between OGG1 Ser326Cys polymorphism and breast cancer risk
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 12:170-1. 2003
  15. ncbi request reprint Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes
    Ulla Vogel
    National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 28:427-34. 2007
    ..We also observe interaction between NSAID, alcohol consumption and PPARgamma2 Pro12Ala genotype in relation to breast cancer risk...
  16. pmc Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study
    Camilla F Skjelbred
    Department of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, N 3710 Skien, Norway
    BMC Cancer 6:175. 2006
    ..In this study, we aimed to evaluate whether the recently identified haplotype encompassing genes of DNA repair and apoptosis, is associated with increased risk of colorectal adenomas and carcinomas...
  17. pmc The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
    Lotte K Vogel
    Department of Medical Biochemistry and Genetics, University of Copenhagen, Blegdamsvej 3, Denmark
    BMC Cancer 6:176. 2006
    ....
  18. pmc Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas
    Mona Saebø
    Telemark University College, Faculty of Arts and Sciences, Department of Environmental and Health Studies, Hallvard Eikas plass, N 3800 Bø i Telemark, Norway
    BMC Cancer 6:208. 2006
    ..If an increase in DNA repair expression is detected in both early adenomas and carcinomas it may indicate that low repair capacity in the normal mucosa is a risk factor for adenoma formation...
  19. pmc Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
    Camilla Furu Skjelbred
    Department of Laboratory Medicine, Telemark Hospital, N 3710 Skien, Norway
    BMC Cancer 6:67. 2006
    ..In this study we have focused on the XRCC1, XRCC3 and XPD genes, involved in base excision repair, homologous recombinational repair and nucleotide excision repair, respectively...
  20. ncbi request reprint Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Lotte Risom
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Res 41:172-81. 2007
    ..In conclusion, Ogg1-/- mice have elevated pulmonary levels of FPG sites and accumulate genomic 8-oxodG after repeated inhalations of DEP...
  21. ncbi request reprint XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer
    Rikke Dalgaard Hansen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Mutat Res 619:68-80. 2007
    ..Overall, the results of the present study indicate that the four polymorphisms are not of major importance in colorectal cancer carcinogenesis...
  22. pmc A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study
    Rikke D Hansen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    BMC Cancer 8:54. 2008
    ....
  23. ncbi request reprint OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study
    Lotte Hatt
    Institute of Public Health, Department of Environmental Health, Copenhagen, Denmark
    Mutat Res 639:45-54. 2008
    ..The results suggest that OGG1 mRNA levels should be regarded as a biomarker of exposure to oxidative stress with induction of DNA rather than a marker of inborn DNA repair capacity...
  24. ncbi request reprint DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles
    Marianne Dybdahl
    Department of Chemical Work Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 24:1759-66. 2003
    ....
  25. doi request reprint Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
    ..p for interaction was 3 x 10(-6) for COX-2 A-1195G and 9 x 10(-5) for PPARgamma2 Pro(12)Ala. The results suggest that NSAID use may modify risk of lung cancer differently depending on the genotype...
  26. doi request reprint Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Nanotoxicology 6:776-88. 2012
    ....
  27. pmc Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver DNA strand breaks in dams and offspring
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:486-500. 2012
    ..Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring...
  28. doi request reprint Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort
    Kirsten Thorup Eriksen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    J Toxicol Environ Health A 73:583-95. 2010
    ..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population...
  29. ncbi request reprint Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen O, Denmark
    Cancer Detect Prev 29:209-14. 2005
    ..While it cannot be ruled out that the present findings are due to chance, the present results are consistent with previous findings that XPD Arg156Arg is a weak risk factor for basal cell carcinoma...
  30. ncbi request reprint DNA damage in rats after a single oral exposure to diesel exhaust particles
    Pernille Høgh Danielsen
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Mutat Res 637:49-55. 2008
    ..The oral exposure route should be taken into account in risk assessment of particulate matter...
  31. ncbi request reprint Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes
    Ulla Vogel
    National Research Centre for Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 617:138-46. 2007
    ..While it cannot be ruled out that the present findings are due to chance, the results indicate that high COX-2 expression may increase risk of BCC while NSAID use may be protective...
  32. ncbi request reprint Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats
    Lotte Risom
    Institute of Public Health c o Department of Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Arch Toxicol 77:651-6. 2003
    ..In conclusion, sucrose feeding did not increase DEP-induced DNA damage in colon or liver...
  33. ncbi request reprint XRCC3 polymorphisms and risk of lung cancer
    Nicklas R Jacobsen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Cancer Lett 213:67-72. 2004
    ..34-14.96) times higher risk of lung cancer compared with homozygous carriers of the wild type allele. Our results indicate that XRCC3 IVS6 C1571T and the associated haplotype AAC are associated with relatively high risk of lung cancer...
  34. doi request reprint Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:453-71. 2012
    ..The uncoated titanium dioxide was not DNA damaging by the comet assay 24 h after exposure despite being highly inflammogenic. This suggests that inflammation is not a prerequisite to DNA damage in titanium dioxide-based products...
  35. ncbi request reprint Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Mutat Res 624:88-100. 2007
    ..02). Moreover, an interaction between DLG5 R30Q and NSAID use was found (P for interaction=0.02). Our results do not suggest that inborn variations in the inflammatory response play any major role in risk of colorectal cancer...
  36. ncbi request reprint X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    Free Radic Res 37:957-66. 2003
    ..In conclusion, this study shows the feasibility of partial-body X-ray irradiation as an in vivo model for induction and repair of oxidative DNA damage, and expression of relevant DNA repair and antioxidant defense genes...
  37. doi request reprint Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study
    Steffen Loft
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Biol Med 52:167-72. 2012
    ..14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group...
  38. ncbi request reprint No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer
    Nicklas Raun Jacobsen
    National Institute of Occupational Health, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 12:584-5. 2003
  39. doi request reprint Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Environ Mol Mutagen 52:331-7. 2011
    ....
  40. pmc Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    PLoS ONE 8:e69020. 2013
    ..Acute phase response is causally linked to cardiovascular disease. Here, we propose that particle-induced pulmonary acute phase response provides an underlying mechanism for particle-induced cardiovascular risk...
  41. pmc Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, Denmark
    Part Fibre Toxicol 9:4. 2012
    ..We compared the toxic effects of the titanium dioxide nanoparticle UV-Titan L181 (NanoTiO2), pure or embedded in a paint matrix. We also compared the effects of the same paint with and without NanoTiO2...
  42. ncbi request reprint Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark
    Free Radic Res 40:885-91. 2006
    ..The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking...
  43. doi request reprint Diesel exhaust particles are mutagenic in FE1-MutaMouse lung epithelial cells
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Mutat Res 641:54-7. 2008
    ....
  44. ncbi request reprint Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation
    Anne T Saber
    National Institute of Occupational Health, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 79:177-82. 2005
    ..The data indicate that an inflammatory response was not a prerequisite for DNA damage, and TNF was not required for the induction of inflammation by DEP and CB particles...
  45. ncbi request reprint Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study
    Helle Bak
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 118:1618-22. 2006
    ..Our results indicate that bulky DNA adducts may have a weak association with lung cancer risk...
  46. pmc Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay
    Petra Jackson
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen Ø DK 2100, Denmark
    Mutagenesis 28:699-707. 2013
    ..The use of frozen tissues; however, requires great care during preparation before analysis, with handling as a major risk factor. ..
  47. ncbi request reprint GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
    Rikke Hansen
    National Institute of Occupational Health, Copenhagen, Denmark
    Cancer Lett 229:85-91. 2005
    ..56 (95% confidence interval 0.33-0.95), while no association were found with risk of adenomas. This indicates that a low repair capacity of oxidative DNA damage may not be a risk factor for development of colorectal adenomas or carcinoma...
  48. doi request reprint Daily sperm production: application in studies of prenatal exposure to nanoparticles in mice
    Zdenka Orabi Kyjovska
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Reprod Toxicol 36:88-97. 2013
    ..F2 offspring, whose fathers were prenatally exposed to Printex90, showed lowered sperm production. Furthermore, we report statistically significant differences in sperm production between mouse strains...
  49. doi request reprint Prenatal exposure to carbon black (printex 90): effects on sexual development and neurofunction
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 109:434-7. 2011
    ..The female offspring prenatally exposed to 268 μg Printex 90/animal displayed altered habituation pattern during the Open field test...
  50. ncbi request reprint Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549
    Jette Bornholdt
    National Research Centre for the Working Environment, Lersø Park Alle 105, DK 2100 Copenhagen, Denmark
    Mutat Res 632:78-88. 2007
    ..Although hardwoods are often considered more harmful than softwoods by regulatory agencies, the current experiments do not provide evidence for a clear-cut distinction between toxicities of hardwood and softwood dust...
  51. ncbi request reprint Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
    ..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...
  52. ncbi request reprint Inflammation but no DNA (deoxyribonucleic acid) damage in mice exposed to airborne dust from a biofuel plant
    Anne Mette Madsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen, Denmark
    Scand J Work Environ Health 34:278-7. 2008
    ..This study investigated whether exposure to dust from biofuel plants induces DNA (deoxyribonucleic acid) damage and inflammation in exposed mice...
  53. doi request reprint In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells
    Anne Mette Zenner Boisen
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Reprod Toxicol 41:45-8. 2013
    ..ESTR mutation rates in CB-exposed F2 female offspring were not statistically different from those of F2 female control offspring. ..
  54. doi request reprint Nonsteroidal anti-inflammatory drug use and breast cancer risk: a Danish cohort study
    Søren Friis
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Eur J Cancer Prev 17:88-96. 2008
    ..The increased breast cancer incidence among NSAID users may reflect a noncausal association, but our study provides no evidence of a chemopreventive effect of NSAIDs against breast cancer over the durations studied...
  55. doi request reprint Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 38:489-94. 2010
    ..We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking...
  56. pmc NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice
    Anne Mette Zenner Boisen
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Part Fibre Toxicol 9:19. 2012
    ..Here we investigate the effects of nanoparticles on the female germline. Since pulmonary exposure to nanosized titanium dioxide (nanoTiO(2)) produces a long-lasting inflammatory response in mice, it was chosen for the present study...
  57. doi request reprint An experimental protocol for maternal pulmonary exposure in developmental toxicology
    Petra Jackson
    National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen Ø, Denmark
    Basic Clin Pharmacol Toxicol 108:202-7. 2011
    ..We suggest that this procedure can be used as a means of exposure through the airways in studies of developmental toxicity...
  58. doi request reprint Physical-chemical and microbiological characterization, and mutagenic activity of airborne PM sampled in a biomass-fueled electrical production facility
    Corey A Cohn
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Environ Mol Mutagen 52:319-30. 2011
    ..The results suggest that exposure to combustion PM in a biomass-fueled facility, which likely includes PM from biomass combustion as well as internal combustion vehicles, may contribute to an elevated risk of adverse health effects...
  59. ncbi request reprint Inhalation of ozone induces DNA strand breaks and inflammation in mice
    Jette Bornholdt
    National Institute of Occupational Health, Lersø Park Alle 105, DK 2100, Copenhagen, Denmark
    Mutat Res 520:63-71. 2002
    ..This was not reflected by an induction of mutations in the lung of Muta Mice...
  60. doi request reprint The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer
    Shoaib Afzal
    Rigshospitalet, Copenhagen, Denmark
    Pharmacogenomics 12:1257-67. 2011
    ..The purpose of this study was to investigate whether specific combinations of polymorphisms in 5-fluorouracil (5-FU) metabolism-related genes were associated with outcome in 5-FU-based adjuvant treatment of colorectal cancer...
  61. pmc K-ras mutations in sinonasal cancers in relation to wood dust exposure
    Jette Bornholdt
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    BMC Cancer 8:53. 2008
    ..In previous small studies of this cancer, ras mutations were suggested to be related to wood dust exposure, but these studies were too limited to detect statistically significant associations...
  62. doi request reprint Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake
    Nela Gorovic
    Laboratory of Clinical Pharmacology Q7642, Rigshospitalet, Department of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Scand J Clin Lab Invest 71:274-9. 2011
    ..This indicates that non-genetic factors may have more influence on dietary choice than genetics...
  63. pmc The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Atherosclerosis 219:200-4. 2011
    ..We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women...
  64. doi request reprint PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
    Rasmus Koefoed Petersen
    Department of Biology, University of Copenhagen, Denmark
    Cancer Lett 315:59-68. 2012
    ..Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer...
  65. pmc Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation
    Anne T Saber
    National Research Centre for the Working Environment, DK 2100 Copenhagen, Denmark
    Part Fibre Toxicol 6:12. 2009
    ..abstract:..
  66. pmc Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice
    Nicklas Raun Jacobsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Part Fibre Toxicol 6:2. 2009
    ..abstract:..
  67. doi request reprint Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial
    Lykke Forchhammer
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Mutagenesis 25:113-23. 2010
    ..In summary, adjustment of primary comet assay results by reference standards reduces inter-laboratory variation in the level of DNA damage measured by the alkaline version of the comet assay...
  68. pmc Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice
    Karin S Hougaard
    National Research Centre of the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Part Fibre Toxicol 5:3. 2008
    ..abstract:..