Gunnar Damgård Nielsen

Summary

Affiliation: National Research Centre for the Working Environment
Country: Denmark

Publications

  1. pmc Experiences from occupational exposure limits set on aerosols containing allergenic proteins
    Gunnar D Nielsen
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Ann Occup Hyg 56:888-900. 2012
  2. pmc Recent trend in risk assessment of formaldehyde exposures from indoor air
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Arch Toxicol 87:73-98. 2013
  3. pmc Structure-activity relationship of immunostimulatory effects of phthalates
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Immunol 9:61. 2008
  4. doi request reprint Background, approaches and recent trends for setting health-based occupational exposure limits: a minireview
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Section of Airway Irritation and Allergy, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Regul Toxicol Pharmacol 51:253-69. 2008
  5. pmc Cancer effects of formaldehyde: a proposal for an indoor air guideline value
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen Ø, Denmark
    Arch Toxicol 84:423-46. 2010
  6. ncbi request reprint Sensory irritation: risk assessment approaches
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhage Ø, Denmark
    Regul Toxicol Pharmacol 48:6-18. 2007
  7. doi request reprint In vivo biology and toxicology of fullerenes and their derivatives
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Basic Clin Pharmacol Toxicol 103:197-208. 2008
  8. ncbi request reprint Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
    Søren Thor Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicology 235:119-29. 2007
  9. ncbi request reprint Development of sensitisation or tolerance following repeated OVA inhalation in BALB/cJ mice. Dose-dependency and modulation by the Al(OH)3 adjuvant
    Susanne Knoth Clausen
    Department of Chemical Working Environment, National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Toxicology 184:51-68. 2003
  10. ncbi request reprint Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Institute of Occupational Health, Copenhagen, Denmark
    J Toxicol Environ Health A 70:128-37. 2007

Collaborators

Detail Information

Publications16

  1. pmc Experiences from occupational exposure limits set on aerosols containing allergenic proteins
    Gunnar D Nielsen
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Ann Occup Hyg 56:888-900. 2012
    ..It is apparent that the scientific methodology is available for setting OELs for proteins and protein-containing aerosols where the critical effect is IgE sensitization and IgE-mediated airway diseases...
  2. pmc Recent trend in risk assessment of formaldehyde exposures from indoor air
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Arch Toxicol 87:73-98. 2013
    ..Reproductive and developmental toxicity are not considered relevant in the absence of sensory irritation. In conclusion, the WHO guideline has been strengthened...
  3. pmc Structure-activity relationship of immunostimulatory effects of phthalates
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Immunol 9:61. 2008
    ..To do so, a series of nine lipophilic compounds with structural and physicochemical relations to DEHP were investigated...
  4. doi request reprint Background, approaches and recent trends for setting health-based occupational exposure limits: a minireview
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Section of Airway Irritation and Allergy, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
    Regul Toxicol Pharmacol 51:253-69. 2008
    ..Also, more attention should be devoted to sensitive groups, toxicological mechanisms and interactions as most workplace exposures are mixtures...
  5. pmc Cancer effects of formaldehyde: a proposal for an indoor air guideline value
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen Ø, Denmark
    Arch Toxicol 84:423-46. 2010
    ..World Health Organization, Regional Office for Europe, Copenhagen, pp 87-91, 2000), 0.08 ppm (0.1 mg m(-3)) formaldehyde, is considered preventive of carcinogenic effects in compliance with epidemiological findings...
  6. ncbi request reprint Sensory irritation: risk assessment approaches
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhage Ø, Denmark
    Regul Toxicol Pharmacol 48:6-18. 2007
    ..In published studies, the combined UF is up to 300, highlighting the need of evidence-based UFs. Combined effects of sensory irritants can be considered additive as a first approximation...
  7. doi request reprint In vivo biology and toxicology of fullerenes and their derivatives
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Basic Clin Pharmacol Toxicol 103:197-208. 2008
    ..The data suggest that direct DNA damaging effects are low, but formation of reactive oxygen species may cause inflammation and genetic damage. Apparently, it is dose-dependent whether a beneficial or an adverse effect occurs...
  8. ncbi request reprint Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
    Søren Thor Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicology 235:119-29. 2007
    ..Furthermore, studies in mice have demonstrated an adjuvant effect from DEHP after parenteral administration with the model allergen ovalbumin (OVA)...
  9. ncbi request reprint Development of sensitisation or tolerance following repeated OVA inhalation in BALB/cJ mice. Dose-dependency and modulation by the Al(OH)3 adjuvant
    Susanne Knoth Clausen
    Department of Chemical Working Environment, National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Toxicology 184:51-68. 2003
    ..Overall, this study showed that airborne Al(OH)(3) was able to counteract tolerance and increase specific IgE and IgG1 production...
  10. ncbi request reprint Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Institute of Occupational Health, Copenhagen, Denmark
    J Toxicol Environ Health A 70:128-37. 2007
    ..These studies showed that effects of adjuvants not are necessarily due to their lipophilicity; that is, additional structural properties are required...
  11. doi request reprint Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment
    Søren Thor Larsen
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicol Appl Pharmacol 268:294-9. 2013
    ..8 and 4ppm FA. We speculate that increased mucus production in the OVA-sensitized mice has increased the "scrubber effect" in the nose, consequently protecting the conducting and lower airways...
  12. doi request reprint Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark
    Toxicol Lett 209:166-72. 2012
    ..Bronchoalveolar lavage after exposures to ozone, and limonene with and without ozone, respectively, did not show airway inflammation...
  13. ncbi request reprint Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice
    Søren Thor Larsen
    Department of Chemical Working Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 95:94-6. 2004
  14. ncbi request reprint Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicology 232:79-88. 2007
    ..03 mg/m(3) MEHP observed in the present study and estimated human exposure levels...
  15. ncbi request reprint Mechanisms of acute inhalation effects of (+) and (-)-alpha-pinene in BALB/c mice
    Gunnar Damgård Nielsen
    National Institute of Occupational Health Denmark, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
    Basic Clin Pharmacol Toxicol 96:420-8. 2005
    ..Overall, the enantiomers showed different time-dependent and stereoselective effects. The lower sensory irritation effect of the (-) enantiomer probably being due to less of the molecule being adsorbed to a sensory irritant receptor...
  16. ncbi request reprint Neurological Effects of White Spirit: Contribution of Animal Studies during a 30-Year Period*
    Gunnar Damgård Nielsen
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 98:115-23. 2006
    ..The differences in sensitivity of the test methods should be taken into consideration if new toxicological studies are conducted on this type of solvents...