Research Topics
| Gunnar Damgård NielsenSummaryAffiliation: National Research Centre for the Working Environment Country: Denmark Publications
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Detail Information
Publications
Experiences from occupational exposure limits set on aerosols containing allergenic proteinsGunnar D Nielsen
National Research Centre for the Working Environment, Copenhagen Ø, Denmark
Ann Occup Hyg 56:888-900. 2012..It is apparent that the scientific methodology is available for setting OELs for proteins and protein-containing aerosols where the critical effect is IgE sensitization and IgE-mediated airway diseases...
Recent trend in risk assessment of formaldehyde exposures from indoor airGunnar Damgård Nielsen
National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
Arch Toxicol 87:73-98. 2013..Reproductive and developmental toxicity are not considered relevant in the absence of sensory irritation. In conclusion, the WHO guideline has been strengthened...- Structure-activity relationship of immunostimulatory effects of phthalatesSøren T Larsen
National Research Centre for the Working Environment, Copenhagen, Denmark
BMC Immunol 9:61. 2008..To do so, a series of nine lipophilic compounds with structural and physicochemical relations to DEHP were investigated... - Cancer effects of formaldehyde: a proposal for an indoor air guideline valueGunnar Damgård Nielsen
National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen Ø, Denmark
Arch Toxicol 84:423-46. 2010..World Health Organization, Regional Office for Europe, Copenhagen, pp 87-91, 2000), 0.08 ppm (0.1 mg m(-3)) formaldehyde, is considered preventive of carcinogenic effects in compliance with epidemiological findings... - In vivo biology and toxicology of fullerenes and their derivativesGunnar Damgård Nielsen
National Research Centre for the Working Environment, Copenhagen Ø, Denmark
Basic Clin Pharmacol Toxicol 103:197-208. 2008..The data suggest that direct DNA damaging effects are low, but formation of reactive oxygen species may cause inflammation and genetic damage. Apparently, it is dose-dependent whether a beneficial or an adverse effect occurs... - Background, approaches and recent trends for setting health-based occupational exposure limits: a minireviewGunnar Damgård Nielsen
National Research Centre for the Working Environment, Section of Airway Irritation and Allergy, Lersø Parkallé 105, DK 2100 Copenhagen Ø, Denmark
Regul Toxicol Pharmacol 51:253-69. 2008..Also, more attention should be devoted to sensitive groups, toxicological mechanisms and interactions as most workplace exposures are mixtures... 
Sensory irritation: risk assessment approachesGunnar Damgård Nielsen
National Research Centre for the Working Environment, Copenhage Ø, Denmark
Regul Toxicol Pharmacol 48:6-18. 2007..In published studies, the combined UF is up to 300, highlighting the need of evidence-based UFs. Combined effects of sensory irritants can be considered additive as a first approximation...- Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c miceSøren Thor Larsen
National Research Centre for the Working Environment, Copenhagen, Denmark
Toxicology 235:119-29. 2007..Furthermore, studies in mice have demonstrated an adjuvant effect from DEHP after parenteral administration with the model allergen ovalbumin (OVA)... - Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitizationJitka Stilund Hansen
Airway Allergy and Irritation Group, National Institute of Occupational Health, Copenhagen, Denmark
J Toxicol Environ Health A 70:128-37. 2007..These studies showed that effects of adjuvants not are necessarily due to their lipophilicity; that is, additional structural properties are required... - Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixturesPeder Wolkoff
National Research Centre for the Working Environment, Denmark
Toxicol Lett 209:166-72. 2012..Bronchoalveolar lavage after exposures to ozone, and limonene with and without ozone, respectively, did not show airway inflammation... - Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ miceSøren Thor Larsen
Department of Chemical Working Environment, National Institute of Occupational Health, Copenhagen, Denmark
Basic Clin Pharmacol Toxicol 95:94-6. 2004 - Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ miceJitka Stilund Hansen
Airway Allergy and Irritation Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
Toxicology 232:79-88. 2007..03 mg/m(3) MEHP observed in the present study and estimated human exposure levels... - Mechanisms of acute inhalation effects of (+) and (-)-alpha-pinene in BALB/c miceGunnar Damgård Nielsen
National Institute of Occupational Health Denmark, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
Basic Clin Pharmacol Toxicol 96:420-8. 2005..Overall, the enantiomers showed different time-dependent and stereoselective effects. The lower sensory irritation effect of the (-) enantiomer probably being due to less of the molecule being adsorbed to a sensory irritant receptor... - Neurological Effects of White Spirit: Contribution of Animal Studies during a 30-Year Period*Gunnar Damgård Nielsen
National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
Basic Clin Pharmacol Toxicol 98:115-23. 2006..The differences in sensitivity of the test methods should be taken into consideration if new toxicological studies are conducted on this type of solvents...