Preben B Mortensen

..Several studies have implicated early infections, including maternal infection with herpes simplex virus 2 (HSV-2), as an environmental risk factor for schizophrenia...

..Some of the cause(s) responsible for the urban-rural differences in schizophrenia risk are rooted in families, but some might also be rooted in individuals...

..However, increased mortality was found in patients who started SSRI therapy, particularly among those older than 80 years. We can only speculate on whether this finding is due to pharmacological action or confounding factors...

..To examine the risk of depressive and anxiety disorders according to psychosocial working conditions in a large population-based sample...

..Though unknown, the causes of these urban-rural differences have been hypothesized to include, e.g., infections, diet, toxic exposures, social class, or an artefact due to selective migration...

..The aims of this paper are twofold: (a) to explore seasonal patterns in a large, Danish Medical Birth Register, and (b) to explore models based on seasonal exposures and a non-linear exposure-risk relationship...

..Whole-genome amplified DNA from 24 neonatal dried blood spot samples stored between 15 to 25 years was tested, and high-quality genomic DNA from 8 of the same individuals was used as reference...

..We examined the robustness of using DBS samples for whole-genome amplification following genome-wide scanning, using arrays from Illumina and Affymetrix...

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..gondii. Causal linking mechanisms are at present speculative but include possible direct effects of maternal IgG on the developing central nervous system (CNS) of the offspring. Additional studies are underway...

..Few population-based studies have addressed risk factors for bipolar affective disorder...

..The aim of this study was to examine the association between neonatal markers of selected prenatal infections and risk for bipolar disorder...

..The objectives of this study were to study the association between serological markers for maternal and neonatal infection and the risk for schizophrenia, related psychoses, and affective disorders in a national cohort of newborns...

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..The authors therefore investigated whether autoimmune diseases combined with exposures to severe infections may increase the risk of schizophrenia..

..The aim of this study was to investigate whether atopic disorders in the individual or in a first-degree relative affect the risk of developing schizophrenia...

..Few studies have reported the age- and gender-specific incidence of schizophrenia in people aged up to 71 years, and no studies have reported the cumulative incidence of schizophrenia in people aged up to 71 years...

..Clinicians should be aware that first-onset psychiatric symptoms could be a sign of a yet undetected cancer...

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..The first hospital episode is followed by a period during which social status does not deteriorate further except for the transition into disability pension...

..0014). The associations reported add further support for the implication of BRD1 with SZ and BPD susceptibility...

..We examined whether discontinuing the use of thimerosal-containing vaccines in Denmark led to a decrease in the incidence of autism...

..Human data on the teratogenicity of selective serotonin reuptake inhibitors (SSRIs) are limited. We examined the association between SSRI use during early pregnancy and the risk of congenital malformations in the offspring...

..Furthermore, the results of these studies have been contradictory. The aim of this study was to investigate whether the risk of bipolar disorder is associated with exposure to indicators of fetal growth...

..This study compares these factors between suicide cases, their siblings, and population based controls in an attempt to evaluate both the familial and the individual element of these factors...

..To determine the cause(s) responsible for the urban-rural differences, we need direct measurements of genetic and/or environmental factors related to urban life...

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..A few studies have found that some men have symptoms of depression after becoming fathers, but these studies have not documented whether this exceeds the morbidity among men in general...

..To explore the risk of suicide associated with occupation while evaluating the impact of socio-economic, demographic and psychiatric differences...

..Studies investigating mortality secondary to electroconvulsive therapy (ECT) are few...

..37-2.03; p=0.0037), respectively. INTERPRETATION: The death of a child is associated with an overall increased mortality from both natural and unnatural causes in mothers, and an early increased mortality from unnatural causes in fathers...

..To investigate the association between maternal exposure to severe life events and fetal growth (birthweight and small for gestational age). Stress has been associated with adverse pregnancy outcome...

..To investigate natural-cause mortality risk in people with psychiatric admission histories in a national population-based cohort. To estimate risks in relation to psychiatric diagnostic categories and for specific causes of death...

..Such events during the first trimester have also been associated with risk of congenital malformations...

..The aim was to assess how a history of mental disorders in either a first-degree family member or partner affects the risk of admission or outpatient contact with PPMD...

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..Studies have linked epilepsy with an increased suicide risk, but the association might be modified by psychiatric, demographic, and socioeconomic factors...

..However, the magnitude of the excess mortality differs from one mental disorder to another, and the impact on mortality if a first-degree family member suffers from a mental disorder has never been examined in a population-based study...

..To examine the association of atypical and conventional antipsychotics with the risk of hospitalization for acute pancreatitis...

..Use of electroconvulsive therapy (ECT) may have changed during the last decades due to advances in psychopharmacology and organizational changes of psychiatric care...

..The aim of the current study was to examine both paternal and maternal age as risk factors for the broader category of psychosis...

..This study assesses whether patients with facial cleft have an increased risk of psychiatric diseases...

..CONCLUSIONS: The risk of hospitalization for a psychiatric disorder is not increased among survivors of cancer in childhood or adolescence, except among survivors of brain tumor...

..Although some studies suggest that parenthood is associated with a reduced suicide risk, the impact of children on parental suicide has rarely been documented...

..We investigated the risk of schizophrenia associated with parental age, adjusting for known risk factors for schizophrenia, including family psychiatric history, and controlling for socioeconomic and demographic factors...

..Suicide risk was addressed in relation to the joint effect of factors regarding family structure, socioeconomics, demographics, mental illness, and family history of suicide and mental illness, as well as gender differences in risk factors...

..A growing body of evidence suggests that migration is a risk factor for the development of schizophrenia, although the putative mechanism remains obscure...

..Reports of high relative risk associated with parental low socioeconomic status may be confounded and overestimated if not adjusted for the association with mental disorder and suicide in the family...

..Attention-deficit hyperactivity disorder (ADHD) is a common childhood condition, and is more prevalent in boys. The adult outcome of girls with ADHD has never been studied...

..We aimed to assess whether family history of completed suicide and mental illness that results in admission to hospital are risk factors for suicide, and whether these factors interact...

..The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated...

..The risk for schizophrenia has been associated with a family history of this and other psychiatric disorders. The relationship between age at first contact and family history of psychiatric illness is not certain...

..We conducted a prospective follow-up study based on national registers to investigate if the death of a child, one of the most severe stressors, increases the risk of myocardial infarction (MI) in parents...

..To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age...

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..Urbanicity of place of birth and during upbringing has been shown to be related to the risk of schizophrenia. Few studies of urbanicity in relation to bipolar affective disorder exist...

..The purpose of the study was to estimate the association of schizophrenia with these disorders as well as a range of other autoimmune diseases in a single large epidemiologic study...

..A population-based, nested, case-control study was carried out to quantify the risk of affective and stress-related disorders according to occupation in the entire Danish workforce...

..The etiology of autism is unknown. A strong genetic component has been detected but non-genetic factors may also be involved in the etiology...

..Schizoaffective disorder may be related to both schizophrenia and bipolar disorders, but no population-based studies, to our knowledge, have investigated this association in families...

..Very old people have higher suicide rates than the younger elderly population. Psychiatric disorders are known to have a strong association with suicide among elderly people...

..To investigate whether age at onset of epilepsy, type of epilepsy, family history of psychosis, or family history of epilepsy affect the risk of schizophrenia or schizophrenia-like psychosis among patients with epilepsy...

..Results suggest that prenatal environmental factors and parental psychopathology are associated with the risk of autism. These factors seem to act independently...

..CONCLUSIONS: The risk of psychiatric hospitalization was increased among parents, especially mothers, who lost a child...

..Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia...

..The aim of the present study was to investigate whether these findings also apply to bipolar disorder...

..To study the change in risk of suicide among patients with schizophrenia and related disorders...

..This study attempted to determine whether a genetic protection against cancer might be manifest in parents of offspring with schizophrenia...

..To estimate the risk of suicide in young people related to family and individual psychiatric and socioeconomic factors...