Søren Thor Larsen

Summary

Affiliation: National Research Centre for the Working Environment
Country: Denmark

Publications

  1. ncbi request reprint Mechanism of action of lung damage caused by a nanofilm spray product
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicol Sci 140:436-44. 2014
  2. pmc Lung damage in mice after inhalation of nanofilm spray products: the role of perfluorination and free hydroxyl groups
    Asger W Nørgaard
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicol Sci 116:216-24. 2010
  3. doi request reprint Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment
    Søren Thor Larsen
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicol Appl Pharmacol 268:294-9. 2013
  4. doi request reprint Airway effects of inhaled quaternary ammonium compounds in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 110:537-43. 2012
  5. pmc Sub-chronic lung inflammation after airway exposures to Bacillus thuringiensis biopesticides in mice
    Kenneth K Barfod
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Microbiol 10:233. 2010
  6. pmc Acute airway irritation of methyl formate in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 86:285-92. 2012
  7. pmc Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 106:114-7. 2010
  8. ncbi request reprint Acute airway effects of diacetyl in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Inhal Toxicol 21:1123-8. 2009
  9. pmc Structure-activity relationship of immunostimulatory effects of phthalates
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Immunol 9:61. 2008
  10. ncbi request reprint Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
    Søren Thor Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicology 235:119-29. 2007

Detail Information

Publications20

  1. ncbi request reprint Mechanism of action of lung damage caused by a nanofilm spray product
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicol Sci 140:436-44. 2014
    ....
  2. pmc Lung damage in mice after inhalation of nanofilm spray products: the role of perfluorination and free hydroxyl groups
    Asger W Nørgaard
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicol Sci 116:216-24. 2010
    ..The number of free hydroxyl groups in the silanes/alkylsiloxanes was also critical for the toxicity...
  3. doi request reprint Acute airway effects of airborne formaldehyde in sensitized and non-sensitized mice housed in a dry or humid environment
    Søren Thor Larsen
    The National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicol Appl Pharmacol 268:294-9. 2013
    ..8 and 4ppm FA. We speculate that increased mucus production in the OVA-sensitized mice has increased the "scrubber effect" in the nose, consequently protecting the conducting and lower airways...
  4. doi request reprint Airway effects of inhaled quaternary ammonium compounds in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 110:537-43. 2012
    ..Furthermore, inhalation of BAC and CPC aerosols gave rise to pulmonary inflammation as apparent from bronchoalveolar lavage. Stimulation of nasal trigeminal nerve endings by QAC, which may serve as a warning signal, was absent...
  5. pmc Sub-chronic lung inflammation after airway exposures to Bacillus thuringiensis biopesticides in mice
    Kenneth K Barfod
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Microbiol 10:233. 2010
    ..Control mice were instilled with sterile water. BALFs were collected and the inflammatory cells were counted and differentiated. The BALFs were also subjected to CFU counts...
  6. pmc Acute airway irritation of methyl formate in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 86:285-92. 2012
    ....
  7. pmc Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 106:114-7. 2010
    ..However, the two substances were comparable regarding the level of eosinophilic inflammation and interleukins present in BALF...
  8. ncbi request reprint Acute airway effects of diacetyl in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Inhal Toxicol 21:1123-8. 2009
    ..Furthermore, high-level diacetyl exposures decreased the sensory irritation warning signal in mice upon repeated exposure, which suggests that the compound is especially insidious...
  9. pmc Structure-activity relationship of immunostimulatory effects of phthalates
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    BMC Immunol 9:61. 2008
    ..To do so, a series of nine lipophilic compounds with structural and physicochemical relations to DEHP were investigated...
  10. ncbi request reprint Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice
    Søren Thor Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Toxicology 235:119-29. 2007
    ..Furthermore, studies in mice have demonstrated an adjuvant effect from DEHP after parenteral administration with the model allergen ovalbumin (OVA)...
  11. doi request reprint Adjuvant and inflammatory effects in mice after subchronic inhalation of allergen and ozone-initiated limonene reaction products
    Jitka Stilund Hansen
    a National Research Centre for the Working Environment, Copenhagen, Denmark
    J Toxicol Environ Health A 76:1085-95. 2013
    ..In conclusion, the study does not support an allergic inflammatory effect attributed to O3-initiated limonene reaction products in the indoor environment. ..
  12. ncbi request reprint Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Institute of Occupational Health, Copenhagen, Denmark
    J Toxicol Environ Health A 70:128-37. 2007
    ..These studies showed that effects of adjuvants not are necessarily due to their lipophilicity; that is, additional structural properties are required...
  13. ncbi request reprint Adjuvant effects of inhaled mono-2-ethylhexyl phthalate in BALB/cJ mice
    Jitka Stilund Hansen
    Airway Allergy and Irritation Group, National Research Centre for the Working Environment, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Toxicology 232:79-88. 2007
    ..03 mg/m(3) MEHP observed in the present study and estimated human exposure levels...
  14. doi request reprint Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures
    Peder Wolkoff
    National Research Centre for the Working Environment, Denmark
    Toxicol Lett 209:166-72. 2012
    ..Bronchoalveolar lavage after exposures to ozone, and limonene with and without ozone, respectively, did not show airway inflammation...
  15. ncbi request reprint Mechanisms of acute inhalation effects of (+) and (-)-alpha-pinene in BALB/c mice
    Gunnar Damgård Nielsen
    National Institute of Occupational Health Denmark, Lersø Parkallé 105, DK 2100 Copenhagen O, Denmark
    Basic Clin Pharmacol Toxicol 96:420-8. 2005
    ..Overall, the enantiomers showed different time-dependent and stereoselective effects. The lower sensory irritation effect of the (-) enantiomer probably being due to less of the molecule being adsorbed to a sensory irritant receptor...
  16. ncbi request reprint Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice
    Søren Thor Larsen
    Department of Chemical Working Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 95:94-6. 2004
  17. doi request reprint Acute airway effects of ozone-initiated d-limonene chemistry: importance of gaseous products
    Peder Wolkoff
    National Research Centre for the Working Environment, DK 2100 Copenhagen Ø, Denmark
    Toxicol Lett 181:171-6. 2008
    ..The result was statistically indistinguishable from clean dry air. It is concluded that ultrafine particles that are generated from ozone-initiated d-limonene chemistry and denuded are not causative of sensory effects in the airways...
  18. pmc Recent trend in risk assessment of formaldehyde exposures from indoor air
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
    Arch Toxicol 87:73-98. 2013
    ..Reproductive and developmental toxicity are not considered relevant in the absence of sensory irritation. In conclusion, the WHO guideline has been strengthened...
  19. ncbi request reprint In vivo biology and toxicology of fullerenes and their derivatives
    Gunnar Damgård Nielsen
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Basic Clin Pharmacol Toxicol 103:197-208. 2008
    ..The data suggest that direct DNA damaging effects are low, but formation of reactive oxygen species may cause inflammation and genetic damage. Apparently, it is dose-dependent whether a beneficial or an adverse effect occurs...