Steffen Loft

Summary

Country: Denmark

Publications

  1. pmc An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter
    Dorina Gabriela Karottki
    Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Farimagsgade 5A K, DK 1014 Copenhagen, Denmark
    Environ Health 12:116. 2013
  2. ncbi request reprint Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study
    Steffen Loft
    Department of Public Health, Section of Enviromental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 22:1289-96. 2013
  3. pmc Out-of-hospital cardiac arrests and outdoor air pollution exposure in Copenhagen, Denmark
    Janine Wichmann
    Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e53684. 2013
  4. doi request reprint Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study
    Steffen Loft
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Biol Med 52:167-72. 2012
  5. ncbi request reprint Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Lotte Risom
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Res 41:172-81. 2007
  6. pmc Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage
    Elvira Vaclavik Bräuner
    Institute of Public Health, Department of Environmental and Occupational Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 115:1177-82. 2007
  7. doi request reprint Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort
    Kirsten Thorup Eriksen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    J Toxicol Environ Health A 73:583-95. 2010
  8. ncbi request reprint DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles
    Marianne Dybdahl
    Department of Chemical Work Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 24:1759-66. 2003
  9. ncbi request reprint Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Free Radic Res 37:947-56. 2003
  10. ncbi request reprint Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats
    Lotte Risom
    Institute of Public Health c o Department of Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Arch Toxicol 77:651-6. 2003

Detail Information

Publications84

  1. pmc An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter
    Dorina Gabriela Karottki
    Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Farimagsgade 5A K, DK 1014 Copenhagen, Denmark
    Environ Health 12:116. 2013
    ..Exposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction...
  2. ncbi request reprint Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study
    Steffen Loft
    Department of Public Health, Section of Enviromental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 22:1289-96. 2013
    ..The urinary excretion of oxidatively generated biomolecules, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), represents biomarkers of oxidative stress, reflecting the rate of global damage to DNA in steady state...
  3. pmc Out-of-hospital cardiac arrests and outdoor air pollution exposure in Copenhagen, Denmark
    Janine Wichmann
    Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e53684. 2013
    ..None of the other daily lags or other pollutants was significantly associated with OHCA events. Adjustment for O(3) slightly increased the association between OHCA and PM(2.5) and PM(10). No susceptible groups were identified...
  4. doi request reprint Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study
    Steffen Loft
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Biol Med 52:167-72. 2012
    ..14 (0.98-1.34) among subjects homozygous for Cys326. The association between urinary 8-oxoGua excretion and lung cancer risk among former and never-smokers suggests that oxidative stress with damage to DNA is important in this group...
  5. ncbi request reprint Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice
    Lotte Risom
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Res 41:172-81. 2007
    ..In conclusion, Ogg1-/- mice have elevated pulmonary levels of FPG sites and accumulate genomic 8-oxodG after repeated inhalations of DEP...
  6. pmc Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage
    Elvira Vaclavik Bräuner
    Institute of Public Health, Department of Environmental and Occupational Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 115:1177-82. 2007
    ..Particulate matter, especially ultrafine particles (UFPs), may cause health effects through generation of oxidative stress, with resulting damage to DNA and other macromolecules...
  7. doi request reprint Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort
    Kirsten Thorup Eriksen
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    J Toxicol Environ Health A 73:583-95. 2010
    ..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population...
  8. ncbi request reprint DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles
    Marianne Dybdahl
    Department of Chemical Work Environment, National Institute of Occupational Health, Copenhagen, Denmark
    Carcinogenesis 24:1759-66. 2003
    ....
  9. ncbi request reprint Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver
    Ulla Vogel
    National Institute of Occupational Health, Lersø Parkallé 105, DK 2100, Copenhagen, Denmark
    Free Radic Res 37:947-56. 2003
    ....
  10. ncbi request reprint Dietary elevated sucrose modulation of diesel-induced genotoxicity in the colon and liver of Big Blue rats
    Lotte Risom
    Institute of Public Health c o Department of Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen, Denmark
    Arch Toxicol 77:651-6. 2003
    ..In conclusion, sucrose feeding did not increase DEP-induced DNA damage in colon or liver...
  11. ncbi request reprint DNA damage in rats after a single oral exposure to diesel exhaust particles
    Pernille Høgh Danielsen
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Mutat Res 637:49-55. 2008
    ..The oral exposure route should be taken into account in risk assessment of particulate matter...
  12. pmc Traffic air pollution and mortality from cardiovascular disease and all causes: a Danish cohort study
    Ole Raaschou-Nielsen
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Environ Health 11:60. 2012
    ..Traffic air pollution has been linked to cardiovascular mortality, which might be due to co-exposure to road traffic noise. Further, personal and lifestyle characteristics might modify any association...
  13. pmc Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function
    Lykke Forchhammer
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    Part Fibre Toxicol 9:7. 2012
    ..We investigated effects on systemic inflammation, oxidative stress and microvascular function (MVF) after controlled wood smoke exposure...
  14. ncbi request reprint Dietary exposure to diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase 1 deficient mice
    Lotte Risom
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Øster Farimagsgade 5, DK 1014 Copenhagen K, Denmark
    Toxicol Lett 175:16-23. 2007
    ..In conclusion, although Ogg1(-/-) mice have high levels of oxidized guanine lesions, they do not appear to be markedly vulnerable to the genotoxicity by oral administration of DEP...
  15. ncbi request reprint Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-) mice
    Lise K Vesterdal
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Nanotoxicology 8:61-71. 2014
    ..The exposure to DEP and SWCNT was associated with elevated ROS production in cultured cells, whereas i.t. instillation of the same particles had no effect on biomarkers of pulmonary oxidative stress and dilatory dysfunction in the aorta...
  16. pmc Lung cancer incidence and long-term exposure to air pollution from traffic
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health Perspect 119:860-5. 2011
    ..Previous studies have shown associations between air pollution and risk for lung cancer...
  17. ncbi request reprint Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers
    Peter Møller
    Institute of Public Health c o Dept of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
    Eur J Nutr 43:267-74. 2004
    ..Such effects have been shown in mononuclear blood cells in the first few hours after ingestion, whereas studies of longer-term effects in well-nourished humans have been mainly negative...
  18. doi request reprint Cytotoxicity, oxidative stress and expression of adhesion molecules in human umbilical vein endothelial cells exposed to dust from paints with or without nanoparticles
    Lone Mikkelsen
    Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen K, Denmark
    Nanotoxicology 7:117-34. 2013
    ....
  19. doi request reprint Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    ..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...
  20. doi request reprint Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and artery segments
    Lise K Vesterdal
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Denmark
    Toxicol Lett 214:19-26. 2012
    ..In conclusion, nanosized CB exposure activates endothelial cells and generates oxidative stress, which is associated with vasomotor dysfunction...
  21. doi request reprint Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity
    Annie Jensen
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Biol Med 52:118-25. 2012
    ....
  22. ncbi request reprint Aging and defense against generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA
    Lone Mikkelsen
    Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, 2 Floor, DK 1014 Copenhagen K, Denmark
    Free Radic Biol Med 47:608-15. 2009
    ..The accumulation of 8-oxodG with age is not a direct consequence of decreased enzyme activity toward singlet oxygen-induced substrate DNA. An age-related higher level of 8-oxodG even occurs concomitantly with high 8-oxodGTPase activity...
  23. ncbi request reprint Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter
    Pernille Høgh Danielsen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, DK 1014 Copenhagen, Denmark
    Toxicol Sci 118:574-85. 2010
    ..These results indicate that WSPM and CB exert the strongest effect in terms of oxidative stress-induced response, inflammation, and genotoxicity in the organ closest to the port of entry...
  24. ncbi request reprint OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study
    Lotte Hatt
    Institute of Public Health, Department of Environmental Health, Copenhagen, Denmark
    Mutat Res 639:45-54. 2008
    ..The results suggest that OGG1 mRNA levels should be regarded as a biomarker of exposure to oxidative stress with induction of DNA rather than a marker of inborn DNA repair capacity...
  25. pmc Air pollution from traffic and cancer incidence: a Danish cohort study
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health 10:67. 2011
    ..Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer...
  26. ncbi request reprint Prospective study of 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and the risk of lung cancer
    Steffen Loft
    Department of Environmental and Occupational Health, University of Copenhagen, Denmark
    Carcinogenesis 27:1245-50. 2006
    ..8 (1.21-115) per doubling of 8-oxodG excretion. The association between 8-oxodG excretion and lung cancer risk among never-smokers suggests that oxidative damage to DNA nucleotides is important in this group...
  27. ncbi request reprint X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    Free Radic Res 37:957-66. 2003
    ..In conclusion, this study shows the feasibility of partial-body X-ray irradiation as an in vivo model for induction and repair of oxidative DNA damage, and expression of relevant DNA repair and antioxidant defense genes...
  28. doi request reprint Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers
    Anne Thoustrup Saber
    The National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:453-71. 2012
    ..The uncoated titanium dioxide was not DNA damaging by the comet assay 24 h after exposure despite being highly inflammogenic. This suggests that inflammation is not a prerequisite to DNA damage in titanium dioxide-based products...
  29. pmc Diabetes incidence and long-term exposure to air pollution: a cohort study
    Zorana J Andersen
    1Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Diabetes Care 35:92-8. 2012
    ..We studied the association between long-term exposure to traffic-related air pollution and incidence of diabetes...
  30. pmc Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2)
    Lone Mikkelsen
    Department of Public Health, University of Copenhagen, 1014 Copenhagen K, Denmark
    Part Fibre Toxicol 8:32. 2011
    ..There is growing evidence that exposure to small size particulate matter increases the risk of developing cardiovascular disease...
  31. pmc Pulmonary exposure to carbon black nanoparticles and vascular effects
    Lise K Vesterdal
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Part Fibre Toxicol 7:33. 2010
    ..Exposure to small size particulates is regarded as a risk factor for cardiovascular diseases...
  32. ncbi request reprint Air pollution, oxidative damage to DNA, and carcinogenesis
    Peter Møller
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Oster Farimagsgade 5, Build 5, 2nd Floor, P O 2099, DK 1014 Copenhagen K, Denmark
    Cancer Lett 266:84-97. 2008
    ..Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer...
  33. doi request reprint Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles
    Lise K Vesterdal
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Toxicol Appl Pharmacol 274:350-60. 2014
    ..Collectively, exposure to particles is associated with oxidative stress and steatosis in hepatocytes. ..
  34. doi request reprint Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter
    Lykke Forchhammer
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark
    Toxicol Lett 209:121-8. 2012
    ..In conclusion, our results indicate that the adherence of monocytes on endothelial cells in wood smoke particle exposed cultures depend on activation of both cell types...
  35. ncbi request reprint Oxidatively damaged DNA and its repair after experimental exposure to wood smoke in healthy humans
    Pernille Høgh Danielsen
    Department of Environmental Health, University of Copenhagen, Denmark
    Mutat Res 642:37-42. 2008
    ..Our findings support that exposure to wood smoke causes systemic effects, although we could not demonstrate genotoxic effects, possibly explained by enhanced repair and timing of sampling...
  36. ncbi request reprint Oxidatively damaged DNA and inflammation in the liver of dyslipidemic ApoE-/- mice exposed to diesel exhaust particles
    Janne Kjaersgaard Folkmann
    Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Øster Farimagsgade 5, Building 5, 2nd Floor, 1014 Copenhagen K, Denmark
    Toxicology 237:134-44. 2007
    ....
  37. ncbi request reprint Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue rats
    Peter Møller
    Institute of Public Health, Department of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Mutat Res 527:91-7. 2003
    ..In conclusion, sucrose feeding increases IQ-induced genotoxicity in liver but not in colon, suggesting different mechanisms for sucrose and IQ in colon mutagenesis...
  38. ncbi request reprint Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation
    Anne T Saber
    National Institute of Occupational Health, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 79:177-82. 2005
    ..The data indicate that an inflammatory response was not a prerequisite for DNA damage, and TNF was not required for the induction of inflammation by DEP and CB particles...
  39. ncbi request reprint Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models
    Peter Møller
    Institute of Public Health, University of Copenhagen, The Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen K, Denmark
    IUBMB Life 60:707-23. 2008
    ..Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity...
  40. pmc Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: effects on liver DNA strand breaks in dams and offspring
    Petra Jackson
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Nanotoxicology 6:486-500. 2012
    ..Neither inhalation nor instillation affected gestation and lactation. Maternal inhalation exposure to Printex 90-induced liver DNA damage in the mothers and the in utero exposed offspring...
  41. ncbi request reprint Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study
    Helle Bak
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 118:1618-22. 2006
    ..Our results indicate that bulky DNA adducts may have a weak association with lung cancer risk...
  42. doi request reprint Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines
    Pernille Høgh Danielsen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark
    Chem Res Toxicol 24:168-84. 2011
    ....
  43. pmc Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes
    Janne K Folkmann
    Institute of Public Health, Department of Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 117:703-8. 2009
    ..The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event in the development of cancer...
  44. ncbi request reprint Effects of ambient air particulate exposure on blood-gas barrier permeability and lung function
    Elvira Vaclavik Bräuner
    Institute of Public Health, Department of Environmental Health, Faculty of Health Sciences, University of Copenhagen, Øster Farimagsgade 5A, Copenhagen, Denmark
    Inhal Toxicol 21:38-47. 2009
    ....
  45. ncbi request reprint Cell-specific oxidative DNA damage induced by estrogen in rat testicular cells in vitro
    Anja Wellejus
    Department of Environmental and Occupational Health, The Panum Institute, Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Toxicol Lett 150:317-23. 2004
    ..The mRNA level of rOGG1 in testes cells was unaffected by EE, whereas, baseline levels were higher than in liver tissue and similar to colon tissue...
  46. doi request reprint Oxidatively damaged DNA in animals exposed to particles
    Peter Møller
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    Crit Rev Toxicol 43:96-118. 2013
    ..However, there is a paucity of studies on pulmonary exposure to low doses of particles that are relevant for hazard/risk assessment...
  47. doi request reprint Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages
    Kim Jantzen
    Department of Environmental Health, Faculty of Health Science, University of Copenhagen, Øster Farimagsgade, 5A DK 1014 Copenhagen K, Denmark
    Mutagenesis 27:693-701. 2012
    ..In conclusion, exposure of mono-cultured cells to DEPs generated oxidative stress to DNA, whereas co-cultures with macrophages had lower levels of oxidatively damaged DNA than A549 epithelial cells...
  48. ncbi request reprint Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns
    Marie Pedersen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, CSS, Oester Farimagsgade, Copenhagen K, Denmark
    Mutat Res 734:12-9. 2012
    ..Relationship between food preparation and bulky DNA adducts appear to be captured by a FFQ while potential associations for other biomarkers might be more complex or need larger sample size...
  49. ncbi request reprint Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases
    Steffen Loft
    Department of Environmental and Occupational Health, University of Copenhagen, Denmark
    Int J Cancer 121:1579-84. 2007
    ..The finding of an association between m(7)Gua excretion and lung cancer risk mainly among current smokers and subjects with GSTM1 null genotype supports causality in this respect...
  50. pmc Apparent temperature and cause-specific mortality in Copenhagen, Denmark: a case-crossover analysis
    Janine Wichmann
    Section of Environmental Health, Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5A, Copenhagen DK 1014, Denmark
    Int J Environ Res Public Health 8:3712-27. 2011
    ..In the cold period all associations were inverse, although insignificant...
  51. pmc Personal exposure to ultrafine particles and oxidative DNA damage
    Peter S Vinzents
    Department of Occupational and Environmental Health, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 113:1485-90. 2005
    ..The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution...
  52. doi request reprint Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends
    Jette Gjerke Hemmingsen
    Department of Public Health, Section of Environmental Health, Faculty of Health Sciences, University of Copenhagen
    Environ Sci Technol 45:8545-51. 2011
    ..ICAM-1 and VCAM-1 expression in HUVECs was only increased by D(100) particles from the Euro4 engine. This suggests that particle emissions from biodiesel in equal mass concentration are less toxic than conventional diesel...
  53. ncbi request reprint Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
    Steffen Loft
    Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Eur J Nutr 47:19-28. 2008
    ..Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer...
  54. doi request reprint Intake of whole grain products and risk of breast cancer by hormone receptor status and histology among postmenopausal women
    Rikke Egeberg
    Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 124:745-50. 2009
    ..In conclusion, intake of whole grain products was not associated with risk of breast cancer in a cohort of Danish postmenopausal women...
  55. ncbi request reprint No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers
    Peter Møller
    Institute of Public Health, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Cancer Epidemiol Biomarkers Prev 12:1016-22. 2003
    ..This suggests that the inherent antioxidant defense mechanisms are sufficient to protect circulating mononuclear blood cells from reactive oxygen species...
  56. ncbi request reprint Variation in assessment of oxidatively damaged DNA in mononuclear blood cells by the comet assay with visual scoring
    Lykke Forchhammer
    Department of Environmental Health, Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, Building 5, 2nd Floor, PO Box 2099, DK 1014 Copenhagen K, Denmark
    Mutagenesis 23:223-31. 2008
    ..20-0.55) for strand breaks (SBs) and oxidized guanines, respectively. In conclusion, our results indicate that inter-investigator difference in scoring is a strong determinant of DNA damage levels measured by the comet assay...
  57. doi request reprint Biomarkers of oxidative damage to DNA and repair
    Steffen Loft
    Department of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Biochem Soc Trans 36:1071-6. 2008
    ....
  58. doi request reprint Prenatal exposure to diesel exhaust particles and effect on the male reproductive system in mice
    Jette Gjerke Hemmingsen
    Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Toxicology 264:61-8. 2009
    ..In conclusion, prenatal exposure to SRM2975 was associated with reduced daily sperm production in adulthood, which was not possible to clearly associate with altered endocrine function or expression of aquaporins in the testes...
  59. ncbi request reprint Acute hypoxia and reoxygenation-induced DNA oxidation in human mononuclear blood cells
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5A, Postbox 2099, DK 1014 Copenhagen K, Denmark
    Mutat Res 625:125-33. 2007
    ....
  60. doi request reprint Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells
    Henriette Frikke-Schmidt
    Section of Biomedicine, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Denmark
    Toxicol Lett 203:181-9. 2011
    ..The study shows that exposure to carbon black and DEP in HUVECs can generate both oxidative stress and expression of cell surface adhesion molecules and that these effects can in part be attenuated by vitamin C and desferrioxamine...
  61. ncbi request reprint Oxidative DNA damage in vitamin C-supplemented guinea pigs after intratracheal instillation of diesel exhaust particles
    Peter Møller
    Institute of Public Health, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Toxicol Appl Pharmacol 189:39-44. 2003
    ..Guinea pigs, which are similar to humans with respect to vitamin C metabolism, may serve as a new model for the study of oxidative damage induced by particulate matter...
  62. ncbi request reprint Physical activity and risk of colon cancer in a cohort of Danish middle-aged men and women
    Nina Føns Johnsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark
    Eur J Epidemiol 21:877-84. 2006
    ..To investigate the effects of occupational activity and leisure time activity on incident colon cancer risk in a Danish middle-aged population...
  63. doi request reprint Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study
    Rikke Egeberg
    Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Cancer Causes Control 22:1133-9. 2011
    ..The aim of the present study was to investigate the relationship between the intake of whole-grain products and risk of prostate cancer in a large prospective cohort...
  64. ncbi request reprint Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Carcinogenesis 24:1847-52. 2003
    ....
  65. doi request reprint Inter-laboratory variation in DNA damage using a standard comet assay protocol
    Lykke Forchhammer
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen K, Denmark
    Mutagenesis 27:665-72. 2012
    ..This study indicates that future comet assay validation trials should take steps to evaluate the implementation of standard procedures in participating laboratories...
  66. ncbi request reprint Linking exposure to environmental pollutants with biological effects
    Mette Sørensen
    Institute of Public Health, c o Department of Pharmacology, The Panum Institute, room 18 5 32, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, N, Denmark
    Mutat Res 544:255-71. 2003
    ..Future developments include personal time-resolved monitors for exposure to ultrafine PM and PM(2.5,) use of GPS, as well as genomics and proteomics based biomarkers...
  67. ncbi request reprint Oxidatively damaged DNA in aging dyslipidemic ApoE-/- and wild-type mice
    Janne Kjaersgaard Folkmann
    Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, Building 5, 2nd Floor, 1014 Copenhagen K, Denmark
    Mutagenesis 22:105-10. 2007
    ..In conclusion, the results of this study suggest that dyslipidemic ApoE(-/-) mice suffer from hepatic oxidative stress in terms of oxidized DNA, and this effect could be due to the dysfunction of lipid metabolism...
  68. doi request reprint Role of oxidative damage in toxicity of particulates
    Peter Møller
    Department of Public Health, Section of Environment Health, University of Copenhagen, Copenhagen, Denmark
    Free Radic Res 44:1-46. 2010
    ..The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates...
  69. doi request reprint Aging and oxidatively damaged nuclear DNA in animal organs
    Peter Møller
    Section of Environmental Health, Department of Public Health, University of Copenhagen, DK 1014 Copenhagen K, Denmark
    Free Radic Biol Med 48:1275-85. 2010
    ..There is compelling evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation...
  70. doi request reprint Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells
    Kirsten Thorup Eriksen
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Mutat Res 700:39-43. 2010
    ..This was not related to ROS generation. Collectively, these results indicate that PFCs induce only modest effects in terms of ROS production and DNA damage in a cell line representing the human liver...
  71. ncbi request reprint Personal exposure to PM2.5, black smoke and NO2 in Copenhagen: relationship to bedroom and outdoor concentrations covering seasonal variation
    Mette Sørensen
    Institute of Public Health, University of Copenhagen, Denmark
    J Expo Anal Environ Epidemiol 15:413-22. 2005
    ..5), BS and NO(2) depends on many factors besides the outdoor levels, and that information on, for example, time of season or outdoor temperature and residence exposure, could improve the accuracy of the personal exposure estimation...
  72. pmc Apparent temperature and acute myocardial infarction hospital admissions in Copenhagen, Denmark: a case-crossover study
    Janine Wichmann
    Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Environ Health 11:19. 2012
    ..Sixteen studies reported inconsistent results and two considered confounding by air pollution. We addressed some of the methodological limitations of the previous studies in this study...
  73. doi request reprint Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
    Steffen Loft
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Denmark
    Arch Biochem Biophys 518:142-50. 2012
    ..One prospective study found increased risk of developing lung cancer among non-smokers associated with high excretion of 8-oxoGua. Urinary excretion of 8-oxoGua is a promising biomarker of oxidatively damaged DNA...
  74. doi request reprint Harmonising measurements of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cellular DNA and urine
    Peter Møller
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark
    Free Radic Res 46:541-53. 2012
    ..In this case, standardising calibrants is aimed at improving within technique agreement...
  75. doi request reprint PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
    Rasmus Koefoed Petersen
    Department of Biology, University of Copenhagen, Denmark
    Cancer Lett 315:59-68. 2012
    ..Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer...
  76. ncbi request reprint Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
    ..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...
  77. doi request reprint Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis
    Peter Møller
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Crit Rev Toxicol 41:339-68. 2011
    ..Overall, assessment of vasomotor dysfunction and progression of atherosclerosis are promising tools for understanding the effects of particulate matter...
  78. ncbi request reprint Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink
    Peter Møller
    Institute of Public Health, c o Department of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Mutat Res 551:119-26. 2004
    ..In conclusion, this study shows that even large amounts of dietary antioxidants did not decrease the already low steady state levels of oxidative DNA damage in healthy adequately nourished humans...
  79. pmc Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals
    Elvira V Bräuner
    Institute of Public Health, Department of Environmental Health, Health Science Faculty, University of Copenhagen, Denmark
    Part Fibre Toxicol 5:13. 2008
    ..abstract:..
  80. ncbi request reprint Oxidative DNA damage and human cancer: need for cohort studies
    Steffen Loft
    Institute of Public Health, University of Copenhagen, Copenhagen K, Denmark
    Antioxid Redox Signal 8:1021-31. 2006
    ..However, this represents a real challenge considering the large number of subjects and long followup time required with likely spurious oxidation of DNA during collection, assay and/or storage of samples...
  81. doi request reprint Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines
    Pernille Høgh Danielsen
    Institute of Public Health, Department of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Mutat Res 674:116-22. 2009
    ..This suggests that exposure to WSPM might be more hazardous than PM collected from vehicle exhaust with respect to development of lung cancer...
  82. ncbi request reprint Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
    Nina Føns Johnsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 125:902-8. 2009
    ....
  83. ncbi request reprint Increased rOGG1 expression in regenerating rat liver tissue without a corresponding increase in incision activity
    Bente Riis
    Department of Clinical Pharmacology Q7642, Copenhagen University Hospital, DK 2100, Copenhagen, Denmark
    DNA Repair (Amst) 1:419-24. 2002
    ..Thus, we can conclude that the rOGG1 expression is temporarily up-regulated by the proliferating events elicited by partial hepatectomy...
  84. ncbi request reprint Oxidative stress-induced DNA damage by particulate air pollution
    Lotte Risom
    Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark
    Mutat Res 592:119-37. 2005
    ..Oxidative stress-induced DNA damage appears to an important mechanism of action of urban particulate air pollution. Related biomarkers and personal monitoring may be useful tools for risk characterization...